Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 6, putative

Species:

Leishmania braziliensis

UniProt:

A4HND6_LEIBR

TriTrypDb:

LbrM.34.4670 , LBRM2903_340057300

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	7
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	7
GO:0005730	nucleolus	5	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HND6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HND6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.360
CLV_NRD_NRD_1	321	323	PF00675	0.262
CLV_NRD_NRD_1	338	340	PF00675	0.328
CLV_NRD_NRD_1	430	432	PF00675	0.338
CLV_NRD_NRD_1	462	464	PF00675	0.485
CLV_PCSK_KEX2_1	321	323	PF00082	0.254
CLV_PCSK_KEX2_1	338	340	PF00082	0.159
CLV_PCSK_KEX2_1	430	432	PF00082	0.338
CLV_PCSK_KEX2_1	442	444	PF00082	0.350
CLV_PCSK_KEX2_1	453	455	PF00082	0.475
CLV_PCSK_KEX2_1	470	472	PF00082	0.686
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.509
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.469
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.620
CLV_PCSK_SKI1_1	257	261	PF00082	0.395
CLV_PCSK_SKI1_1	442	446	PF00082	0.413
CLV_PCSK_SKI1_1	471	475	PF00082	0.510
DEG_APCC_DBOX_1	321	329	PF00400	0.255
DEG_SCF_FBW7_1	82	89	PF00400	0.454
DEG_SPOP_SBC_1	309	313	PF00917	0.274
DOC_CKS1_1	83	88	PF01111	0.454
DOC_MAPK_gen_1	257	266	PF00069	0.386
DOC_MAPK_gen_1	321	329	PF00069	0.254
DOC_MAPK_gen_1	338	346	PF00069	0.159
DOC_MAPK_JIP1_4	260	266	PF00069	0.240
DOC_MAPK_MEF2A_6	321	329	PF00069	0.231
DOC_MAPK_MEF2A_6	364	373	PF00069	0.395
DOC_MAPK_MEF2A_6	390	398	PF00069	0.464
DOC_MAPK_RevD_3	325	339	PF00069	0.231
DOC_PP2B_LxvP_1	316	319	PF13499	0.240
DOC_USP7_MATH_1	124	128	PF00917	0.386
DOC_USP7_MATH_1	307	311	PF00917	0.308
DOC_USP7_UBL2_3	470	474	PF12436	0.624
DOC_WW_Pin1_4	160	165	PF00397	0.163
DOC_WW_Pin1_4	320	325	PF00397	0.271
DOC_WW_Pin1_4	347	352	PF00397	0.288
DOC_WW_Pin1_4	82	87	PF00397	0.393
LIG_14-3-3_CanoR_1	116	125	PF00244	0.379
LIG_14-3-3_CanoR_1	306	316	PF00244	0.386
LIG_14-3-3_CanoR_1	322	328	PF00244	0.159
LIG_14-3-3_CanoR_1	339	345	PF00244	0.159
LIG_14-3-3_CanoR_1	364	369	PF00244	0.251
LIG_14-3-3_CterR_2	477	480	PF00244	0.427
LIG_Actin_WH2_2	168	184	PF00022	0.386
LIG_Actin_WH2_2	19	37	PF00022	0.506
LIG_BRCT_BRCA1_1	162	166	PF00533	0.284
LIG_BRCT_BRCA1_1	48	52	PF00533	0.290
LIG_Clathr_ClatBox_1	264	268	PF01394	0.255
LIG_deltaCOP1_diTrp_1	255	265	PF00928	0.386
LIG_FHA_1	112	118	PF00498	0.282
LIG_FHA_1	133	139	PF00498	0.260
LIG_FHA_1	149	155	PF00498	0.304
LIG_FHA_1	166	172	PF00498	0.369
LIG_FHA_1	287	293	PF00498	0.386
LIG_FHA_1	311	317	PF00498	0.268
LIG_FHA_1	324	330	PF00498	0.206
LIG_FHA_1	339	345	PF00498	0.240
LIG_FHA_1	373	379	PF00498	0.347
LIG_FHA_1	83	89	PF00498	0.437
LIG_FHA_2	172	178	PF00498	0.245
LIG_FHA_2	186	192	PF00498	0.240
LIG_FHA_2	296	302	PF00498	0.240
LIG_FHA_2	404	410	PF00498	0.394
LIG_FHA_2	43	49	PF00498	0.355
LIG_HP1_1	124	128	PF01393	0.386
LIG_LIR_Apic_2	255	261	PF02991	0.242
LIG_LIR_Apic_2	407	413	PF02991	0.446
LIG_LIR_Gen_1	15	23	PF02991	0.362
LIG_LIR_Gen_1	170	180	PF02991	0.253
LIG_LIR_Gen_1	362	373	PF02991	0.243
LIG_LIR_LC3C_4	80	83	PF02991	0.387
LIG_LIR_Nem_3	15	20	PF02991	0.363
LIG_LIR_Nem_3	152	158	PF02991	0.368
LIG_LIR_Nem_3	170	175	PF02991	0.229
LIG_LIR_Nem_3	449	455	PF02991	0.349
LIG_SH2_PTP2	410	413	PF00017	0.433
LIG_SH2_SRC	46	49	PF00017	0.385
LIG_SH2_STAP1	365	369	PF00017	0.240
LIG_SH2_STAP1	448	452	PF00017	0.314
LIG_SH2_STAT5	118	121	PF00017	0.302
LIG_SH2_STAT5	149	152	PF00017	0.266
LIG_SH2_STAT5	388	391	PF00017	0.432
LIG_SH2_STAT5	410	413	PF00017	0.433
LIG_SH2_STAT5	448	451	PF00017	0.310
LIG_SH3_2	437	442	PF14604	0.500
LIG_SH3_3	334	340	PF00018	0.240
LIG_SH3_3	368	374	PF00018	0.408
LIG_SH3_3	379	385	PF00018	0.512
LIG_SH3_3	418	424	PF00018	0.331
LIG_SH3_3	434	440	PF00018	0.485
LIG_SH3_3	80	86	PF00018	0.351
LIG_SUMO_SIM_anti_2	323	329	PF11976	0.231
LIG_SUMO_SIM_anti_2	80	85	PF11976	0.325
LIG_SUMO_SIM_par_1	124	129	PF11976	0.336
LIG_SUMO_SIM_par_1	325	331	PF11976	0.231
LIG_SUMO_SIM_par_1	367	372	PF11976	0.402
LIG_SUMO_SIM_par_1	99	104	PF11976	0.251
LIG_TRAF2_1	221	224	PF00917	0.319
LIG_TYR_ITIM	446	451	PF00017	0.377
LIG_UBA3_1	245	254	PF00899	0.386
LIG_UBA3_1	296	300	PF00899	0.240
MOD_CDK_SPK_2	82	87	PF00069	0.393
MOD_CDK_SPxxK_3	347	354	PF00069	0.240
MOD_CK1_1	145	151	PF00069	0.240
MOD_CK1_1	227	233	PF00069	0.328
MOD_CK1_1	240	246	PF00069	0.247
MOD_CK1_1	250	256	PF00069	0.302
MOD_CK1_1	272	278	PF00069	0.295
MOD_CK1_1	295	301	PF00069	0.240
MOD_CK1_1	310	316	PF00069	0.309
MOD_CK1_1	323	329	PF00069	0.226
MOD_CK1_1	356	362	PF00069	0.362
MOD_CK2_1	171	177	PF00069	0.240
MOD_CK2_1	210	216	PF00069	0.255
MOD_CK2_1	403	409	PF00069	0.393
MOD_Cter_Amidation	461	464	PF01082	0.464
MOD_GlcNHglycan	144	147	PF01048	0.240
MOD_GlcNHglycan	196	201	PF01048	0.288
MOD_GlcNHglycan	277	280	PF01048	0.260
MOD_GlcNHglycan	90	93	PF01048	0.506
MOD_GSK3_1	145	152	PF00069	0.270
MOD_GSK3_1	224	231	PF00069	0.247
MOD_GSK3_1	236	243	PF00069	0.302
MOD_GSK3_1	277	284	PF00069	0.312
MOD_GSK3_1	291	298	PF00069	0.268
MOD_GSK3_1	369	376	PF00069	0.458
MOD_GSK3_1	42	49	PF00069	0.364
MOD_GSK3_1	82	89	PF00069	0.377
MOD_N-GLC_1	21	26	PF02516	0.407
MOD_N-GLC_1	236	241	PF02516	0.360
MOD_N-GLC_1	292	297	PF02516	0.240
MOD_N-GLC_1	386	391	PF02516	0.511
MOD_N-GLC_1	403	408	PF02516	0.480
MOD_N-GLC_1	67	72	PF02516	0.519
MOD_NEK2_1	21	26	PF00069	0.443
MOD_NEK2_1	210	215	PF00069	0.401
MOD_NEK2_1	291	296	PF00069	0.288
MOD_NEK2_1	308	313	PF00069	0.255
MOD_NEK2_1	353	358	PF00069	0.334
MOD_NEK2_1	369	374	PF00069	0.484
MOD_NEK2_1	446	451	PF00069	0.464
MOD_PIKK_1	111	117	PF00454	0.163
MOD_PIKK_1	224	230	PF00454	0.275
MOD_PIKK_1	310	316	PF00454	0.405
MOD_PIKK_1	398	404	PF00454	0.422
MOD_PKA_1	338	344	PF00069	0.240
MOD_PKA_2	228	234	PF00069	0.240
MOD_PKA_2	247	253	PF00069	0.240
MOD_PKA_2	338	344	PF00069	0.247
MOD_PKA_2	353	359	PF00069	0.240
MOD_Plk_1	292	298	PF00069	0.240
MOD_Plk_1	67	73	PF00069	0.514
MOD_Plk_1	92	98	PF00069	0.478
MOD_Plk_2-3	42	48	PF00069	0.440
MOD_Plk_4	171	177	PF00069	0.286
MOD_Plk_4	292	298	PF00069	0.240
MOD_Plk_4	323	329	PF00069	0.266
MOD_Plk_4	340	346	PF00069	0.382
MOD_Plk_4	364	370	PF00069	0.240
MOD_Plk_4	373	379	PF00069	0.425
MOD_ProDKin_1	160	166	PF00069	0.163
MOD_ProDKin_1	320	326	PF00069	0.271
MOD_ProDKin_1	347	353	PF00069	0.288
MOD_ProDKin_1	82	88	PF00069	0.399
MOD_SUMO_rev_2	196	205	PF00179	0.255
MOD_SUMO_rev_2	250	259	PF00179	0.386
MOD_SUMO_rev_2	282	292	PF00179	0.240
TRG_DiLeu_BaEn_1	77	82	PF01217	0.363
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.240
TRG_ENDOCYTIC_2	365	368	PF00928	0.240
TRG_ENDOCYTIC_2	448	451	PF00928	0.358
TRG_ER_diArg_1	303	306	PF00400	0.266
TRG_ER_diArg_1	320	322	PF00400	0.240
TRG_ER_diArg_1	337	339	PF00400	0.159
TRG_ER_diArg_1	429	431	PF00400	0.339
TRG_ER_diArg_1	53	56	PF00400	0.288
TRG_NES_CRM1_1	193	208	PF08389	0.239
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P6	Leptomonas seymouri	33%	72%
A0A0N0P959	Leptomonas seymouri	85%	100%
A0A0S4IYI8	Bodo saltans	33%	78%
A0A0S4J1I2	Bodo saltans	26%	73%
A0A0S4J971	Bodo saltans	61%	87%
A0A0S4JLC6	Bodo saltans	25%	86%
A0A0S4JMJ1	Bodo saltans	25%	79%
A0A0S4JRN9	Bodo saltans	30%	73%
A0A1X0NIJ1	Trypanosomatidae	30%	82%
A0A1X0NL76	Trypanosomatidae	35%	67%
A0A1X0NNY0	Trypanosomatidae	34%	73%
A0A1X0NQX5	Trypanosomatidae	28%	69%
A0A1X0P2B6	Trypanosomatidae	28%	78%
A0A1X0P2U1	Trypanosomatidae	32%	68%
A0A1X0P537	Trypanosomatidae	70%	100%
A0A1X0P5Y8	Trypanosomatidae	27%	71%
A0A1X0P9T0	Trypanosomatidae	28%	100%
A0A3Q8IAZ2	Leishmania donovani	26%	73%
A0A3Q8IHG6	Leishmania donovani	30%	81%
A0A3S5H4S8	Leishmania donovani	34%	71%
A0A3S5IRH3	Trypanosoma rangeli	27%	79%
A0A3S5ISI5	Trypanosoma rangeli	69%	100%
A0A3S7WS99	Leishmania donovani	31%	66%
A0A3S7WY84	Leishmania donovani	30%	83%
A0A3S7X9Y1	Leishmania donovani	93%	100%
A0A422MZ05	Trypanosoma rangeli	25%	71%
A0A422NBP2	Trypanosoma rangeli	33%	75%
A0A422NY45	Trypanosoma rangeli	34%	69%
A0A422NYZ6	Trypanosoma rangeli	30%	72%
A0A422P4C5	Trypanosoma rangeli	34%	66%
A4H337	Leishmania braziliensis	34%	72%
A4HCT2	Leishmania braziliensis	26%	67%
A4HDC2	Leishmania braziliensis	30%	83%
A4HHY2	Leishmania braziliensis	26%	79%
A4HRC5	Leishmania infantum	34%	71%
A4HSA6	Leishmania infantum	24%	99%
A4HVE9	Leishmania infantum	31%	66%
A4I0A6	Leishmania infantum	26%	73%
A4I0Q2	Leishmania infantum	30%	83%
A4I4V2	Leishmania infantum	30%	81%
A4IC09	Leishmania infantum	93%	100%
B9EY52	Oryza sativa subsp. japonica	33%	68%
B9G2X9	Oryza sativa subsp. japonica	28%	79%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	81%
C9ZL09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	83%
C9ZYJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
C9ZZN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	70%
D0A6E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	67%
D0A6W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	70%
D0A729	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	85%
D0A898	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	72%
E9ABZ2	Leishmania major	33%	72%
E9AFU7	Leishmania major	93%	100%
E9AJ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	71%
E9AP47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	66%
E9API5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	66%
E9AW71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	73%
E9AWQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	83%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	79%
E9B687	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	69%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
F4ICA0	Arabidopsis thaliana	33%	66%
F9W301	Oryza sativa subsp. japonica	26%	100%
P20480	Drosophila melanogaster	29%	69%
P45962	Caenorhabditis elegans	28%	80%
P46872	Strongylocentrotus purpuratus	32%	69%
P46873	Caenorhabditis elegans	32%	69%
P46874	Bombyx mori	28%	100%
P70096	Cricetulus griseus	31%	67%
P79955	Xenopus laevis	29%	75%
Q39493	Cylindrotheca fusiformis	38%	77%
Q4QAR9	Leishmania major	30%	83%
Q5XI63	Rattus norvegicus	27%	69%
Q60443	Cricetulus griseus	27%	77%
Q7Y1C8	Oryza sativa subsp. japonica	28%	66%
Q7ZYL5	Xenopus laevis	26%	74%
Q8GW44	Arabidopsis thaliana	30%	100%
Q8W0Y9	Arabidopsis thaliana	28%	77%
Q965T6	Caenorhabditis elegans	29%	74%
Q9BW19	Homo sapiens	27%	71%
Q9NF78	Leishmania major	26%	73%
Q9W1U4	Drosophila melanogaster	33%	77%
V5B8M1	Trypanosoma cruzi	27%	78%
V5B8X9	Trypanosoma cruzi	26%	68%
V5BHI2	Trypanosoma cruzi	33%	66%
V5D7H9	Trypanosoma cruzi	71%	100%
V5DMS2	Trypanosoma cruzi	30%	90%