Parkin coregulated gene protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PACRGB

Species:

Leishmania braziliensis

UniProt:

A4HND5_LEIBR

TriTrypDb:

LbrM.34.4660 , LBRM2903_340057200

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 21
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HND5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HND5

Function

Biological processes
Term	Name	Level	Count
GO:0010941	regulation of cell death	4	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0060548	negative regulation of cell death	5	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030544	Hsp70 protein binding	4	2
GO:0031072	heat shock protein binding	3	2
GO:0051087	protein-folding chaperone binding	3	2
GO:0051879	Hsp90 protein binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.545
CLV_NRD_NRD_1	224	226	PF00675	0.402
CLV_NRD_NRD_1	274	276	PF00675	0.281
CLV_PCSK_KEX2_1	274	276	PF00082	0.224
CLV_PCSK_SKI1_1	151	155	PF00082	0.308
CLV_PCSK_SKI1_1	19	23	PF00082	0.495
CLV_PCSK_SKI1_1	213	217	PF00082	0.272
CLV_PCSK_SKI1_1	225	229	PF00082	0.269
CLV_PCSK_SKI1_1	250	254	PF00082	0.299
DEG_APCC_DBOX_1	150	158	PF00400	0.308
DEG_APCC_DBOX_1	18	26	PF00400	0.508
DOC_CDC14_PxL_1	202	210	PF14671	0.278
DOC_CYCLIN_RxL_1	147	158	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.278
DOC_MAPK_DCC_7	200	210	PF00069	0.278
DOC_MAPK_MEF2A_6	138	145	PF00069	0.278
DOC_MAPK_NFAT4_5	138	146	PF00069	0.234
DOC_PP1_RVXF_1	149	156	PF00149	0.279
DOC_PP2B_LxvP_1	208	211	PF13499	0.278
DOC_PP4_FxxP_1	110	113	PF00568	0.511
DOC_USP7_MATH_1	101	105	PF00917	0.556
DOC_USP7_MATH_1	149	153	PF00917	0.313
DOC_USP7_MATH_1	215	219	PF00917	0.266
DOC_USP7_MATH_1	44	48	PF00917	0.678
DOC_USP7_UBL2_3	260	264	PF12436	0.313
DOC_WW_Pin1_4	125	130	PF00397	0.290
LIG_14-3-3_CanoR_1	262	267	PF00244	0.288
LIG_Actin_WH2_2	209	227	PF00022	0.402
LIG_APCC_ABBA_1	168	173	PF00400	0.278
LIG_BRCT_BRCA1_1	3	7	PF00533	0.406
LIG_EH1_1	228	236	PF00400	0.266
LIG_FHA_1	285	291	PF00498	0.273
LIG_Integrin_isoDGR_2	107	109	PF01839	0.522
LIG_LIR_Apic_2	292	297	PF02991	0.402
LIG_LIR_Gen_1	179	187	PF02991	0.320
LIG_LIR_Gen_1	298	308	PF02991	0.280
LIG_LIR_Nem_3	163	167	PF02991	0.285
LIG_LIR_Nem_3	179	185	PF02991	0.168
LIG_LIR_Nem_3	27	33	PF02991	0.476
LIG_LIR_Nem_3	298	303	PF02991	0.277
LIG_Pex14_2	33	37	PF04695	0.636
LIG_PTB_Apo_2	104	111	PF02174	0.663
LIG_PTB_Apo_2	299	306	PF02174	0.278
LIG_PTB_Phospho_1	299	305	PF10480	0.278
LIG_SH2_CRK	249	253	PF00017	0.286
LIG_SH2_CRK	305	309	PF00017	0.278
LIG_SH2_GRB2like	300	303	PF00017	0.294
LIG_SH2_PTP2	300	303	PF00017	0.294
LIG_SH2_SRC	167	170	PF00017	0.313
LIG_SH2_SRC	300	303	PF00017	0.294
LIG_SH2_STAP1	310	314	PF00017	0.303
LIG_SH2_STAT3	122	125	PF00017	0.563
LIG_SH2_STAT3	248	251	PF00017	0.284
LIG_SH2_STAT5	167	170	PF00017	0.304
LIG_SH2_STAT5	289	292	PF00017	0.421
LIG_SH2_STAT5	300	303	PF00017	0.294
LIG_SH3_1	200	206	PF00018	0.278
LIG_SH3_1	61	67	PF00018	0.449
LIG_SH3_2	113	118	PF14604	0.518
LIG_SH3_3	110	116	PF00018	0.491
LIG_SH3_3	200	206	PF00018	0.278
LIG_SH3_3	26	32	PF00018	0.509
LIG_SH3_3	61	67	PF00018	0.676
LIG_UBA3_1	208	213	PF00899	0.278
LIG_WRC_WIRS_1	92	97	PF05994	0.535
MOD_CK1_1	183	189	PF00069	0.375
MOD_CK1_1	47	53	PF00069	0.708
MOD_CK2_1	5	11	PF00069	0.538
MOD_Cter_Amidation	272	275	PF01082	0.140
MOD_GlcNHglycan	236	239	PF01048	0.188
MOD_GlcNHglycan	279	283	PF01048	0.140
MOD_GSK3_1	1	8	PF00069	0.531
MOD_GSK3_1	183	190	PF00069	0.399
MOD_GSK3_1	211	218	PF00069	0.294
MOD_GSK3_1	274	281	PF00069	0.402
MOD_GSK3_1	44	51	PF00069	0.626
MOD_GSK3_1	84	91	PF00069	0.522
MOD_N-GLC_1	101	106	PF02516	0.440
MOD_N-GLC_1	136	141	PF02516	0.140
MOD_N-GLC_1	149	154	PF02516	0.321
MOD_N-GLC_1	260	265	PF02516	0.390
MOD_N-GLC_1	284	289	PF02516	0.339
MOD_NEK2_1	90	95	PF00069	0.510
MOD_PIKK_1	274	280	PF00454	0.171
MOD_PIKK_1	5	11	PF00454	0.645
MOD_PKA_1	274	280	PF00069	0.416
MOD_PKA_2	274	280	PF00069	0.413
MOD_Plk_1	101	107	PF00069	0.591
MOD_Plk_1	149	155	PF00069	0.418
MOD_Plk_1	284	290	PF00069	0.281
MOD_Plk_4	284	290	PF00069	0.360
MOD_ProDKin_1	125	131	PF00069	0.290
TRG_DiLeu_BaEn_3	179	185	PF01217	0.286
TRG_ENDOCYTIC_2	167	170	PF00928	0.283
TRG_ENDOCYTIC_2	249	252	PF00928	0.278
TRG_ENDOCYTIC_2	300	303	PF00928	0.294
TRG_NES_CRM1_1	278	292	PF08389	0.264
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N4	Leptomonas seymouri	53%	100%
A0A0N0P9H6	Leptomonas seymouri	76%	99%
A0A0S4IYX0	Bodo saltans	51%	100%
A0A0S4J0U8	Bodo saltans	54%	100%
A0A1X0NY39	Trypanosomatidae	52%	100%
A0A1X0P4X2	Trypanosomatidae	60%	100%
A0A3S7WZF1	Leishmania donovani	57%	100%
A0A3S7XA05	Leishmania donovani	90%	100%
A0A422P182	Trypanosoma rangeli	58%	100%
A0A422P4M1	Trypanosoma rangeli	50%	100%
A4HEC4	Leishmania braziliensis	56%	77%
A4I1R9	Leishmania infantum	57%	100%
A4IC08	Leishmania infantum	90%	100%
C9ZKC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZYJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AFU6	Leishmania major	89%	100%
E9AXV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9B6Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9L7	Leishmania major	50%	100%
Q96M98	Homo sapiens	44%	100%
V5B824	Trypanosoma cruzi	50%	100%
V5BXN2	Trypanosoma cruzi	58%	98%