Putative katanin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative katanin

Gene product:

katanin, putative

Species:

Leishmania braziliensis

UniProt:

A4HND4_LEIBR

TriTrypDb:

LbrM.34.4650 , LBRM2903_340057000

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0005856	cytoskeleton	5	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	8
GO:0005875	microtubule associated complex	2	1
GO:0008352	katanin complex	3	1
GO:0032991	protein-containing complex	1	3
GO:0005840	ribosome	5	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

A4HND4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HND4

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007019	microtubule depolymerization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0031109	microtubule polymerization or depolymerization	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0051261	protein depolymerization	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004609	phosphatidylserine decarboxylase activity	5	5
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0008017	microtubule binding	5	9
GO:0008092	cytoskeletal protein binding	3	9
GO:0015631	tubulin binding	4	9
GO:0016829	lyase activity	2	5
GO:0016830	carbon-carbon lyase activity	3	5
GO:0016831	carboxy-lyase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.355
CLV_C14_Caspase3-7	362	366	PF00656	0.515
CLV_NRD_NRD_1	126	128	PF00675	0.262
CLV_NRD_NRD_1	453	455	PF00675	0.234
CLV_NRD_NRD_1	528	530	PF00675	0.229
CLV_PCSK_KEX2_1	453	455	PF00082	0.231
CLV_PCSK_KEX2_1	528	530	PF00082	0.229
CLV_PCSK_SKI1_1	136	140	PF00082	0.355
CLV_PCSK_SKI1_1	385	389	PF00082	0.743
CLV_PCSK_SKI1_1	480	484	PF00082	0.273
CLV_PCSK_SKI1_1	576	580	PF00082	0.270
CLV_PCSK_SKI1_1	90	94	PF00082	0.461
CLV_Separin_Metazoa	87	91	PF03568	0.454
DEG_Nend_Nbox_1	1	3	PF02207	0.482
DOC_CKS1_1	222	227	PF01111	0.361
DOC_CKS1_1	396	401	PF01111	0.488
DOC_CYCLIN_yCln2_LP_2	260	266	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.419
DOC_MAPK_gen_1	22	29	PF00069	0.446
DOC_MAPK_HePTP_8	495	507	PF00069	0.473
DOC_MAPK_MEF2A_6	22	29	PF00069	0.446
DOC_MAPK_MEF2A_6	498	507	PF00069	0.473
DOC_PP2B_LxvP_1	260	263	PF13499	0.456
DOC_PP4_MxPP_1	582	585	PF00568	0.485
DOC_USP7_MATH_1	113	117	PF00917	0.283
DOC_USP7_MATH_1	183	187	PF00917	0.262
DOC_USP7_MATH_1	20	24	PF00917	0.469
DOC_USP7_MATH_1	391	395	PF00917	0.611
DOC_USP7_MATH_1	401	405	PF00917	0.526
DOC_USP7_MATH_1	530	534	PF00917	0.531
DOC_WW_Pin1_4	145	150	PF00397	0.262
DOC_WW_Pin1_4	221	226	PF00397	0.365
DOC_WW_Pin1_4	350	355	PF00397	0.684
DOC_WW_Pin1_4	395	400	PF00397	0.639
LIG_14-3-3_CanoR_1	127	135	PF00244	0.269
LIG_14-3-3_CanoR_1	216	226	PF00244	0.423
LIG_14-3-3_CanoR_1	235	244	PF00244	0.208
LIG_14-3-3_CanoR_1	255	261	PF00244	0.241
LIG_14-3-3_CanoR_1	385	395	PF00244	0.627
LIG_14-3-3_CanoR_1	430	435	PF00244	0.461
LIG_14-3-3_CanoR_1	529	538	PF00244	0.494
LIG_14-3-3_CanoR_1	94	103	PF00244	0.548
LIG_Actin_WH2_2	420	437	PF00022	0.406
LIG_Actin_WH2_2	500	515	PF00022	0.494
LIG_BRCT_BRCA1_1	107	111	PF00533	0.438
LIG_BRCT_BRCA1_1	185	189	PF00533	0.262
LIG_eIF4E_1	501	507	PF01652	0.494
LIG_EVH1_1	395	399	PF00568	0.493
LIG_FHA_1	115	121	PF00498	0.357
LIG_FHA_1	137	143	PF00498	0.355
LIG_FHA_1	160	166	PF00498	0.458
LIG_FHA_1	202	208	PF00498	0.354
LIG_FHA_1	232	238	PF00498	0.403
LIG_FHA_1	45	51	PF00498	0.366
LIG_FHA_1	481	487	PF00498	0.578
LIG_FHA_1	52	58	PF00498	0.330
LIG_FHA_1	65	71	PF00498	0.298
LIG_FHA_2	222	228	PF00498	0.356
LIG_FHA_2	360	366	PF00498	0.659
LIG_FHA_2	497	503	PF00498	0.444
LIG_FHA_2	99	105	PF00498	0.316
LIG_Integrin_isoDGR_2	150	152	PF01839	0.355
LIG_LIR_Apic_2	535	541	PF02991	0.473
LIG_LIR_Gen_1	12	20	PF02991	0.434
LIG_LIR_Gen_1	192	202	PF02991	0.339
LIG_LIR_Gen_1	261	272	PF02991	0.368
LIG_LIR_Nem_3	12	18	PF02991	0.429
LIG_LIR_Nem_3	192	198	PF02991	0.333
LIG_LIR_Nem_3	461	465	PF02991	0.494
LIG_LIR_Nem_3	499	504	PF02991	0.462
LIG_LYPXL_S_1	38	42	PF13949	0.382
LIG_LYPXL_yS_3	39	42	PF13949	0.391
LIG_MYND_1	320	324	PF01753	0.475
LIG_Pex14_2	213	217	PF04695	0.359
LIG_Pex14_2	462	466	PF04695	0.494
LIG_SH2_CRK	15	19	PF00017	0.413
LIG_SH2_CRK	166	170	PF00017	0.379
LIG_SH2_NCK_1	15	19	PF00017	0.413
LIG_SH2_NCK_1	166	170	PF00017	0.304
LIG_SH2_STAP1	166	170	PF00017	0.355
LIG_SH2_STAP1	44	48	PF00017	0.348
LIG_SH2_STAT5	195	198	PF00017	0.352
LIG_SH2_STAT5	44	47	PF00017	0.415
LIG_SH3_3	317	323	PF00018	0.694
LIG_SH3_3	390	396	PF00018	0.754
LIG_SH3_3	577	583	PF00018	0.522
LIG_Sin3_3	575	582	PF02671	0.473
LIG_SUMO_SIM_anti_2	406	414	PF11976	0.414
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.473
LIG_SUMO_SIM_anti_2	488	494	PF11976	0.442
LIG_SUMO_SIM_anti_2	502	508	PF11976	0.396
LIG_SUMO_SIM_par_1	202	209	PF11976	0.359
LIG_SUMO_SIM_par_1	488	494	PF11976	0.372
LIG_TRAF2_1	302	305	PF00917	0.605
LIG_TYR_ITIM	193	198	PF00017	0.396
LIG_WRC_WIRS_1	210	215	PF05994	0.456
LIG_WW_3	584	588	PF00397	0.612
MOD_CDC14_SPxK_1	357	360	PF00782	0.649
MOD_CDK_SPxK_1	354	360	PF00069	0.676
MOD_CDK_SPxxK_3	145	152	PF00069	0.262
MOD_CK1_1	212	218	PF00069	0.419
MOD_CK1_1	221	227	PF00069	0.417
MOD_CK1_1	250	256	PF00069	0.418
MOD_CK1_1	350	356	PF00069	0.605
MOD_CK1_1	376	382	PF00069	0.795
MOD_CK1_1	485	491	PF00069	0.473
MOD_CK1_1	514	520	PF00069	0.427
MOD_CK1_1	533	539	PF00069	0.427
MOD_CK1_1	98	104	PF00069	0.305
MOD_CK2_1	401	407	PF00069	0.466
MOD_CK2_1	496	502	PF00069	0.494
MOD_GlcNHglycan	107	110	PF01048	0.446
MOD_GlcNHglycan	129	132	PF01048	0.318
MOD_GlcNHglycan	180	183	PF01048	0.250
MOD_GlcNHglycan	199	202	PF01048	0.359
MOD_GlcNHglycan	231	234	PF01048	0.431
MOD_GlcNHglycan	315	318	PF01048	0.636
MOD_GlcNHglycan	335	338	PF01048	0.437
MOD_GlcNHglycan	374	378	PF01048	0.782
MOD_GlcNHglycan	403	406	PF01048	0.526
MOD_GlcNHglycan	423	426	PF01048	0.172
MOD_GSK3_1	127	134	PF00069	0.291
MOD_GSK3_1	178	185	PF00069	0.293
MOD_GSK3_1	197	204	PF00069	0.190
MOD_GSK3_1	212	219	PF00069	0.360
MOD_GSK3_1	281	288	PF00069	0.460
MOD_GSK3_1	350	357	PF00069	0.645
MOD_GSK3_1	372	379	PF00069	0.656
MOD_GSK3_1	387	394	PF00069	0.483
MOD_GSK3_1	401	408	PF00069	0.587
MOD_GSK3_1	419	426	PF00069	0.446
MOD_GSK3_1	439	446	PF00069	0.402
MOD_GSK3_1	51	58	PF00069	0.391
MOD_N-GLC_1	250	255	PF02516	0.503
MOD_N-GLC_1	347	352	PF02516	0.614
MOD_N-GLC_1	443	448	PF02516	0.172
MOD_NEK2_1	111	116	PF00069	0.353
MOD_NEK2_1	217	222	PF00069	0.415
MOD_NEK2_1	231	236	PF00069	0.285
MOD_NEK2_1	247	252	PF00069	0.304
MOD_NEK2_1	281	286	PF00069	0.399
MOD_NEK2_1	42	47	PF00069	0.424
MOD_NEK2_1	482	487	PF00069	0.454
MOD_NEK2_2	159	164	PF00069	0.184
MOD_NEK2_2	183	188	PF00069	0.327
MOD_NEK2_2	292	297	PF00069	0.582
MOD_NEK2_2	367	372	PF00069	0.606
MOD_NEK2_2	508	513	PF00069	0.494
MOD_PIKK_1	218	224	PF00454	0.460
MOD_PIKK_1	439	445	PF00454	0.372
MOD_PIKK_1	530	536	PF00454	0.494
MOD_PK_1	32	38	PF00069	0.402
MOD_PKA_1	127	133	PF00069	0.262
MOD_PKA_2	126	132	PF00069	0.340
MOD_PKA_2	159	165	PF00069	0.220
MOD_PKA_2	333	339	PF00069	0.586
MOD_PKA_2	530	536	PF00069	0.576
MOD_Plk_1	253	259	PF00069	0.461
MOD_Plk_1	32	38	PF00069	0.368
MOD_Plk_1	367	373	PF00069	0.516
MOD_Plk_1	64	70	PF00069	0.439
MOD_Plk_2-3	209	215	PF00069	0.451
MOD_Plk_2-3	82	88	PF00069	0.445
MOD_Plk_4	203	209	PF00069	0.293
MOD_Plk_4	467	473	PF00069	0.557
MOD_Plk_4	485	491	PF00069	0.372
MOD_Plk_4	65	71	PF00069	0.394
MOD_ProDKin_1	145	151	PF00069	0.262
MOD_ProDKin_1	221	227	PF00069	0.362
MOD_ProDKin_1	350	356	PF00069	0.685
MOD_ProDKin_1	395	401	PF00069	0.639
MOD_SUMO_rev_2	569	578	PF00179	0.428
TRG_DiLeu_BaEn_1	502	507	PF01217	0.455
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.410
TRG_DiLeu_BaLyEn_6	500	505	PF01217	0.473
TRG_ENDOCYTIC_2	15	18	PF00928	0.415
TRG_ENDOCYTIC_2	166	169	PF00928	0.379
TRG_ENDOCYTIC_2	194	197	PF00928	0.341
TRG_ENDOCYTIC_2	39	42	PF00928	0.443
TRG_ENDOCYTIC_2	501	504	PF00928	0.494
TRG_ER_diArg_1	452	454	PF00400	0.434
TRG_ER_diArg_1	519	522	PF00400	0.465
TRG_ER_diArg_1	528	531	PF00400	0.433
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	438	443	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P963	Leptomonas seymouri	65%	100%
A0A1X0P573	Trypanosomatidae	38%	100%
A0A3S7XA71	Leishmania donovani	86%	100%
A4IC06	Leishmania infantum	86%	100%
C9ZYJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AFU4	Leishmania major	85%	100%
E9B6Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4V7Y7	Xenopus laevis	25%	90%
Q6NVM2	Xenopus tropicalis	25%	90%
Q7ZUV2	Danio rerio	28%	85%
Q8BHD1	Mus musculus	21%	100%
Q9BVA0	Homo sapiens	23%	90%