Protein-serine/threonine phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HND2_LEIBR

TriTrypDb:

LbrM.34.4630 , LBRM2903_340056800

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HND2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HND2

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0009966	regulation of signal transduction	4	1
GO:0009968	negative regulation of signal transduction	5	1
GO:0010646	regulation of cell communication	4	1
GO:0010648	negative regulation of cell communication	5	1
GO:0023051	regulation of signaling	3	1
GO:0023057	negative regulation of signaling	4	1
GO:0043408	regulation of MAPK cascade	6	1
GO:0043409	negative regulation of MAPK cascade	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048585	negative regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:1902532	negative regulation of intracellular signal transduction	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.711
CLV_NRD_NRD_1	88	90	PF00675	0.664
CLV_PCSK_KEX2_1	200	202	PF00082	0.711
CLV_PCSK_KEX2_1	88	90	PF00082	0.664
CLV_PCSK_SKI1_1	88	92	PF00082	0.658
DEG_APCC_DBOX_1	316	324	PF00400	0.402
DEG_Nend_UBRbox_3	1	3	PF02207	0.565
DEG_SPOP_SBC_1	129	133	PF00917	0.793
DOC_CKS1_1	153	158	PF01111	0.706
DOC_CKS1_1	165	170	PF01111	0.650
DOC_CKS1_1	175	180	PF01111	0.546
DOC_CYCLIN_yClb5_NLxxxL_5	188	195	PF00134	0.378
DOC_MAPK_gen_1	88	96	PF00069	0.655
DOC_MAPK_MEF2A_6	89	98	PF00069	0.758
DOC_PP2B_LxvP_1	126	129	PF13499	0.558
DOC_USP7_MATH_1	116	120	PF00917	0.705
DOC_USP7_MATH_1	49	53	PF00917	0.688
DOC_USP7_MATH_1	99	103	PF00917	0.597
DOC_WW_Pin1_4	152	157	PF00397	0.704
DOC_WW_Pin1_4	164	169	PF00397	0.662
DOC_WW_Pin1_4	174	179	PF00397	0.554
DOC_WW_Pin1_4	4	9	PF00397	0.707
DOC_WW_Pin1_4	76	81	PF00397	0.720
DOC_WW_Pin1_4	83	88	PF00397	0.705
LIG_14-3-3_CanoR_1	106	110	PF00244	0.550
LIG_14-3-3_CanoR_1	160	166	PF00244	0.565
LIG_14-3-3_CanoR_1	317	321	PF00244	0.465
LIG_14-3-3_CanoR_1	55	61	PF00244	0.628
LIG_APCC_ABBA_1	272	277	PF00400	0.411
LIG_BRCT_BRCA1_1	49	53	PF00533	0.688
LIG_CSL_BTD_1	126	129	PF09270	0.588
LIG_CtBP_PxDLS_1	8	12	PF00389	0.542
LIG_EVH1_1	77	81	PF00568	0.568
LIG_FHA_1	121	127	PF00498	0.570
LIG_FHA_1	153	159	PF00498	0.742
LIG_FHA_1	165	171	PF00498	0.550
LIG_FHA_1	175	181	PF00498	0.654
LIG_FHA_1	209	215	PF00498	0.470
LIG_FHA_1	333	339	PF00498	0.261
LIG_FHA_2	248	254	PF00498	0.411
LIG_FHA_2	285	291	PF00498	0.513
LIG_FHA_2	71	77	PF00498	0.784
LIG_Integrin_isoDGR_2	332	334	PF01839	0.411
LIG_LIR_Gen_1	21	28	PF02991	0.529
LIG_LIR_Gen_1	268	278	PF02991	0.416
LIG_LIR_Nem_3	125	130	PF02991	0.564
LIG_LIR_Nem_3	21	27	PF02991	0.528
LIG_LIR_Nem_3	268	274	PF02991	0.416
LIG_LIR_Nem_3	277	281	PF02991	0.404
LIG_LIR_Nem_3	50	56	PF02991	0.801
LIG_PTB_Apo_2	213	220	PF02174	0.450
LIG_PTB_Apo_2	337	344	PF02174	0.411
LIG_PTB_Phospho_1	213	219	PF10480	0.527
LIG_RPA_C_Fungi	300	312	PF08784	0.513
LIG_SH2_STAP1	278	282	PF00017	0.411
LIG_SH2_STAT3	176	179	PF00017	0.601
LIG_SH2_STAT5	176	179	PF00017	0.601
LIG_SH2_STAT5	219	222	PF00017	0.513
LIG_SH2_STAT5	271	274	PF00017	0.383
LIG_SH2_STAT5	313	316	PF00017	0.323
LIG_SH2_STAT5	351	354	PF00017	0.487
LIG_SH3_2	84	89	PF14604	0.730
LIG_SH3_3	162	168	PF00018	0.741
LIG_SH3_3	175	181	PF00018	0.496
LIG_SH3_3	72	78	PF00018	0.709
LIG_SH3_3	81	87	PF00018	0.683
LIG_TRAF2_1	28	31	PF00917	0.543
LIG_TRAF2_1	61	64	PF00917	0.809
LIG_Vh1_VBS_1	296	314	PF01044	0.358
LIG_WRC_WIRS_1	263	268	PF05994	0.290
LIG_WW_3	79	83	PF00397	0.547
MOD_CDC14_SPxK_1	79	82	PF00782	0.748
MOD_CDC14_SPxK_1	86	89	PF00782	0.653
MOD_CDK_SPK_2	83	88	PF00069	0.734
MOD_CDK_SPxK_1	76	82	PF00069	0.720
MOD_CDK_SPxK_1	83	89	PF00069	0.704
MOD_CK1_1	138	144	PF00069	0.725
MOD_CK1_1	265	271	PF00069	0.513
MOD_CK1_1	59	65	PF00069	0.721
MOD_CK2_1	247	253	PF00069	0.411
MOD_CK2_1	284	290	PF00069	0.513
MOD_CK2_1	58	64	PF00069	0.659
MOD_CK2_1	70	76	PF00069	0.777
MOD_GlcNHglycan	137	140	PF01048	0.718
MOD_GlcNHglycan	358	361	PF01048	0.397
MOD_GlcNHglycan	67	70	PF01048	0.649
MOD_GSK3_1	100	107	PF00069	0.732
MOD_GSK3_1	116	123	PF00069	0.621
MOD_GSK3_1	131	138	PF00069	0.676
MOD_GSK3_1	148	155	PF00069	0.536
MOD_GSK3_1	223	230	PF00069	0.261
MOD_GSK3_1	328	335	PF00069	0.261
MOD_GSK3_1	36	43	PF00069	0.742
MOD_N-GLC_1	120	125	PF02516	0.592
MOD_N-GLC_1	161	166	PF02516	0.542
MOD_N-GLC_1	303	308	PF02516	0.411
MOD_N-GLC_2	242	244	PF02516	0.411
MOD_NEK2_1	104	109	PF00069	0.788
MOD_NEK2_1	130	135	PF00069	0.607
MOD_NEK2_1	18	23	PF00069	0.653
MOD_NEK2_1	284	289	PF00069	0.513
MOD_NEK2_1	41	46	PF00069	0.721
MOD_NEK2_1	56	61	PF00069	0.714
MOD_NEK2_1	70	75	PF00069	0.594
MOD_PIKK_1	131	137	PF00454	0.643
MOD_PIKK_1	223	229	PF00454	0.524
MOD_PKA_2	105	111	PF00069	0.545
MOD_PKA_2	316	322	PF00069	0.402
MOD_PKA_2	47	53	PF00069	0.693
MOD_Plk_1	100	106	PF00069	0.524
MOD_Plk_1	161	167	PF00069	0.538
MOD_Plk_1	303	309	PF00069	0.411
MOD_Plk_1	36	42	PF00069	0.749
MOD_Plk_2-3	247	253	PF00069	0.261
MOD_Plk_4	122	128	PF00069	0.560
MOD_Plk_4	284	290	PF00069	0.513
MOD_ProDKin_1	152	158	PF00069	0.705
MOD_ProDKin_1	164	170	PF00069	0.655
MOD_ProDKin_1	174	180	PF00069	0.542
MOD_ProDKin_1	4	10	PF00069	0.706
MOD_ProDKin_1	76	82	PF00069	0.721
MOD_ProDKin_1	83	89	PF00069	0.702
TRG_DiLeu_BaEn_4	269	275	PF01217	0.513
TRG_ENDOCYTIC_2	24	27	PF00928	0.531
TRG_ENDOCYTIC_2	271	274	PF00928	0.411
TRG_ENDOCYTIC_2	278	281	PF00928	0.411
TRG_ER_diArg_1	200	202	PF00400	0.474
TRG_ER_diArg_1	334	337	PF00400	0.411
TRG_ER_diArg_1	87	89	PF00400	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PES2	Leptomonas seymouri	53%	100%
A0A3Q8IJV8	Leishmania donovani	78%	100%
A4IC04	Leishmania infantum	78%	100%
E9AFU2	Leishmania major	75%	100%
E9B6Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%