Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HNC9_LEIBR

TriTrypDb:

LbrM.34.4600 , LBRM2903_340056500

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNC9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0106310	protein serine kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.589
CLV_NRD_NRD_1	136	138	PF00675	0.309
CLV_NRD_NRD_1	21	23	PF00675	0.654
CLV_PCSK_KEX2_1	136	138	PF00082	0.309
CLV_PCSK_KEX2_1	21	23	PF00082	0.589
CLV_PCSK_SKI1_1	235	239	PF00082	0.388
CLV_Separin_Metazoa	167	171	PF03568	0.336
DEG_APCC_DBOX_1	191	199	PF00400	0.165
DEG_APCC_DBOX_1	234	242	PF00400	0.388
DEG_SPOP_SBC_1	2	6	PF00917	0.594
DOC_ANK_TNKS_1	111	118	PF00023	0.165
DOC_CYCLIN_RxL_1	229	240	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.286
DOC_MAPK_JIP1_4	235	241	PF00069	0.307
DOC_PP4_FxxP_1	223	226	PF00568	0.388
DOC_USP7_MATH_1	3	7	PF00917	0.653
DOC_WW_Pin1_4	207	212	PF00397	0.270
DOC_WW_Pin1_4	214	219	PF00397	0.227
DOC_WW_Pin1_4	61	66	PF00397	0.427
LIG_14-3-3_CanoR_1	137	147	PF00244	0.410
LIG_14-3-3_CanoR_1	22	30	PF00244	0.634
LIG_BIR_II_1	1	5	PF00653	0.453
LIG_FHA_1	18	24	PF00498	0.522
LIG_FHA_1	198	204	PF00498	0.277
LIG_FHA_1	57	63	PF00498	0.559
LIG_FHA_2	139	145	PF00498	0.285
LIG_Integrin_RGD_1	170	172	PF01839	0.307
LIG_LIR_Apic_2	222	226	PF02991	0.391
LIG_LIR_Gen_1	64	75	PF02991	0.430
LIG_LIR_Nem_3	64	70	PF02991	0.478
LIG_NRBOX	182	188	PF00104	0.336
LIG_PAM2_1	214	226	PF00658	0.271
LIG_SH2_STAT5	174	177	PF00017	0.423
LIG_SH2_STAT5	67	70	PF00017	0.390
LIG_SH3_3	191	197	PF00018	0.316
LIG_SH3_3	59	65	PF00018	0.453
LIG_SUMO_SIM_par_1	235	240	PF11976	0.242
MOD_CK1_1	17	23	PF00069	0.670
MOD_CK1_1	214	220	PF00069	0.249
MOD_CK1_1	263	269	PF00069	0.650
MOD_CK1_1	4	10	PF00069	0.695
MOD_CK2_1	138	144	PF00069	0.285
MOD_CK2_1	264	270	PF00069	0.617
MOD_GlcNHglycan	147	150	PF01048	0.209
MOD_GlcNHglycan	213	216	PF01048	0.343
MOD_GlcNHglycan	229	232	PF01048	0.325
MOD_GlcNHglycan	90	93	PF01048	0.307
MOD_GSK3_1	203	210	PF00069	0.279
MOD_GSK3_1	260	267	PF00069	0.709
MOD_GSK3_1	274	281	PF00069	0.694
MOD_GSK3_1	4	11	PF00069	0.602
MOD_NEK2_1	274	279	PF00069	0.462
MOD_PIKK_1	56	62	PF00454	0.526
MOD_PKA_2	23	29	PF00069	0.600
MOD_Plk_2-3	260	266	PF00069	0.605
MOD_Plk_4	219	225	PF00069	0.271
MOD_Plk_4	245	251	PF00069	0.307
MOD_ProDKin_1	207	213	PF00069	0.270
MOD_ProDKin_1	214	220	PF00069	0.227
MOD_ProDKin_1	61	67	PF00069	0.432
TRG_DiLeu_BaEn_1	204	209	PF01217	0.295
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.357
TRG_ENDOCYTIC_2	67	70	PF00928	0.471
TRG_ER_diArg_1	136	138	PF00400	0.316
TRG_ER_diArg_1	21	24	PF00400	0.582
TRG_ER_diArg_1	43	46	PF00400	0.405
TRG_NES_CRM1_1	240	256	PF08389	0.334
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAR1	Leptomonas seymouri	59%	95%
A0A1X0P5S2	Trypanosomatidae	33%	100%
A0A3Q8IFJ8	Leishmania donovani	77%	98%
A0A3R7MHW5	Trypanosoma rangeli	30%	71%
A0A422P1C1	Trypanosoma rangeli	32%	100%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	67%
C9ZYK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AFT9	Leishmania major	79%	100%
E9AHW8	Leishmania infantum	77%	98%
E9B6Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
O00506	Homo sapiens	24%	66%
O70150	Rattus norvegicus	28%	82%
Q14012	Homo sapiens	26%	76%
Q3SWY6	Bos taurus	24%	66%
Q63450	Rattus norvegicus	26%	75%
Q6P2M8	Homo sapiens	28%	82%
Q8BW96	Mus musculus	24%	73%
Q8IU85	Homo sapiens	24%	73%
Q91YS8	Mus musculus	26%	75%
Q9QYK9	Mus musculus	28%	82%
Q9Z2W1	Mus musculus	24%	66%
W0LYS5	Macrobrachium nipponense	23%	82%