Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNC8_LEIBR

TriTrypDb:

LbrM.34.4590 , LBRM2903_340056400

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.408
CLV_NRD_NRD_1	199	201	PF00675	0.502
CLV_PCSK_KEX2_1	199	201	PF00082	0.500
CLV_PCSK_SKI1_1	194	198	PF00082	0.514
CLV_PCSK_SKI1_1	82	86	PF00082	0.414
CLV_Separin_Metazoa	217	221	PF03568	0.533
DOC_CYCLIN_RxL_1	79	87	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.415
DOC_MAPK_gen_1	99	108	PF00069	0.412
DOC_MAPK_JIP1_4	102	108	PF00069	0.392
DOC_MAPK_MEF2A_6	102	110	PF00069	0.293
DOC_PP4_FxxP_1	226	229	PF00568	0.528
DOC_USP7_MATH_1	256	260	PF00917	0.520
DOC_USP7_UBL2_3	15	19	PF12436	0.539
DOC_USP7_UBL2_3	7	11	PF12436	0.581
DOC_USP7_UBL2_3	82	86	PF12436	0.407
DOC_WW_Pin1_4	142	147	PF00397	0.600
DOC_WW_Pin1_4	2	7	PF00397	0.638
DOC_WW_Pin1_4	254	259	PF00397	0.546
DOC_WW_Pin1_4	44	49	PF00397	0.537
LIG_14-3-3_CanoR_1	41	45	PF00244	0.438
LIG_14-3-3_CanoR_1	65	70	PF00244	0.407
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_Clathr_ClatBox_1	30	34	PF01394	0.513
LIG_deltaCOP1_diTrp_1	162	167	PF00928	0.506
LIG_EVH1_2	50	54	PF00568	0.499
LIG_FHA_1	245	251	PF00498	0.394
LIG_FHA_1	265	271	PF00498	0.279
LIG_FHA_1	33	39	PF00498	0.396
LIG_FHA_1	41	47	PF00498	0.432
LIG_FHA_2	274	280	PF00498	0.531
LIG_FHA_2	50	56	PF00498	0.488
LIG_HCF-1_HBM_1	176	179	PF13415	0.491
LIG_LIR_Gen_1	71	80	PF02991	0.501
LIG_LIR_Gen_1	87	95	PF02991	0.368
LIG_LIR_Nem_3	109	113	PF02991	0.473
LIG_LIR_Nem_3	162	167	PF02991	0.450
LIG_LIR_Nem_3	176	182	PF02991	0.374
LIG_LIR_Nem_3	231	236	PF02991	0.455
LIG_LIR_Nem_3	243	248	PF02991	0.391
LIG_LIR_Nem_3	71	75	PF02991	0.510
LIG_LIR_Nem_3	78	83	PF02991	0.386
LIG_LIR_Nem_3	87	92	PF02991	0.358
LIG_MYND_1	142	146	PF01753	0.494
LIG_PCNA_PIPBox_1	216	225	PF02747	0.436
LIG_PTB_Apo_2	61	68	PF02174	0.384
LIG_PTB_Phospho_1	61	67	PF10480	0.381
LIG_REV1ctd_RIR_1	282	287	PF16727	0.471
LIG_SH2_CRK	67	71	PF00017	0.411
LIG_SH2_NCK_1	67	71	PF00017	0.430
LIG_SH2_STAP1	180	184	PF00017	0.455
LIG_SH2_STAT3	261	264	PF00017	0.473
LIG_SH2_STAT5	107	110	PF00017	0.440
LIG_SH2_STAT5	261	264	PF00017	0.473
LIG_SH2_STAT5	67	70	PF00017	0.413
LIG_SH3_1	3	9	PF00018	0.394
LIG_SH3_2	48	53	PF14604	0.546
LIG_SH3_2	6	11	PF14604	0.546
LIG_SH3_3	3	9	PF00018	0.575
LIG_SH3_3	45	51	PF00018	0.549
LIG_SUMO_SIM_anti_2	28	35	PF11976	0.426
LIG_SUMO_SIM_par_1	28	35	PF11976	0.426
LIG_TRAF2_1	277	280	PF00917	0.375
LIG_UBA3_1	151	158	PF00899	0.302
LIG_WRC_WIRS_1	241	246	PF05994	0.314
MOD_CDC14_SPxK_1	257	260	PF00782	0.553
MOD_CDK_SPK_2	2	7	PF00069	0.541
MOD_CDK_SPxK_1	254	260	PF00069	0.550
MOD_CK1_1	2	8	PF00069	0.640
MOD_CK1_1	78	84	PF00069	0.385
MOD_CK2_1	209	215	PF00069	0.541
MOD_CK2_1	273	279	PF00069	0.504
MOD_CK2_1	49	55	PF00069	0.558
MOD_GlcNHglycan	167	170	PF01048	0.416
MOD_GSK3_1	236	243	PF00069	0.379
MOD_GSK3_1	40	47	PF00069	0.440
MOD_N-GLC_1	236	241	PF02516	0.382
MOD_NEK2_1	10	15	PF00069	0.443
MOD_NEK2_1	151	156	PF00069	0.447
MOD_NEK2_1	165	170	PF00069	0.398
MOD_NEK2_1	240	245	PF00069	0.385
MOD_NEK2_1	266	271	PF00069	0.557
MOD_NEK2_1	273	278	PF00069	0.488
MOD_NEK2_1	84	89	PF00069	0.425
MOD_PKA_1	199	205	PF00069	0.517
MOD_PKA_2	199	205	PF00069	0.517
MOD_PKA_2	40	46	PF00069	0.441
MOD_Plk_4	236	242	PF00069	0.366
MOD_Plk_4	25	31	PF00069	0.487
MOD_Plk_4	75	81	PF00069	0.382
MOD_ProDKin_1	142	148	PF00069	0.598
MOD_ProDKin_1	2	8	PF00069	0.629
MOD_ProDKin_1	254	260	PF00069	0.550
MOD_ProDKin_1	44	50	PF00069	0.536
TRG_ENDOCYTIC_2	107	110	PF00928	0.420
TRG_ENDOCYTIC_2	179	182	PF00928	0.415
TRG_ENDOCYTIC_2	248	251	PF00928	0.515
TRG_ENDOCYTIC_2	77	80	PF00928	0.385
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I461	Leptomonas seymouri	79%	100%
A0A0S4JTE6	Bodo saltans	43%	93%
A0A1X0P4X8	Trypanosomatidae	56%	100%
A0A3Q8IVK6	Leishmania donovani	90%	100%
A4IC01	Leishmania infantum	89%	100%
C9ZYK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	91%
E9AFT8	Leishmania major	89%	100%
E9B6Z0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BXR3	Trypanosoma cruzi	55%	100%