Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNC7_LEIBR

TriTrypDb:

LbrM.34.4580 , LBRM2903_340056300

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.636
CLV_NRD_NRD_1	168	170	PF00675	0.713
CLV_NRD_NRD_1	182	184	PF00675	0.448
CLV_NRD_NRD_1	436	438	PF00675	0.697
CLV_NRD_NRD_1	472	474	PF00675	0.576
CLV_NRD_NRD_1	483	485	PF00675	0.545
CLV_PCSK_FUR_1	480	484	PF00082	0.387
CLV_PCSK_KEX2_1	137	139	PF00082	0.687
CLV_PCSK_KEX2_1	168	170	PF00082	0.713
CLV_PCSK_KEX2_1	181	183	PF00082	0.484
CLV_PCSK_KEX2_1	23	25	PF00082	0.504
CLV_PCSK_KEX2_1	471	473	PF00082	0.600
CLV_PCSK_KEX2_1	482	484	PF00082	0.465
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.715
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.504
CLV_PCSK_SKI1_1	110	114	PF00082	0.700
CLV_PCSK_SKI1_1	18	22	PF00082	0.499
CLV_PCSK_SKI1_1	274	278	PF00082	0.603
CLV_PCSK_SKI1_1	472	476	PF00082	0.635
CLV_PCSK_SKI1_1	498	502	PF00082	0.482
CLV_PCSK_SKI1_1	75	79	PF00082	0.588
DEG_SCF_FBW7_1	350	356	PF00400	0.518
DOC_CKS1_1	350	355	PF01111	0.518
DOC_CYCLIN_RxL_1	15	25	PF00134	0.431
DOC_MAPK_gen_1	181	187	PF00069	0.570
DOC_MAPK_gen_1	9	17	PF00069	0.604
DOC_MAPK_MEF2A_6	11	19	PF00069	0.400
DOC_MAPK_MEF2A_6	494	503	PF00069	0.359
DOC_PP2B_LxvP_1	412	415	PF13499	0.735
DOC_PP2B_LxvP_1	515	518	PF13499	0.476
DOC_USP7_MATH_1	105	109	PF00917	0.659
DOC_USP7_MATH_1	173	177	PF00917	0.605
DOC_USP7_MATH_1	266	270	PF00917	0.671
DOC_USP7_MATH_1	303	307	PF00917	0.711
DOC_USP7_MATH_1	516	520	PF00917	0.692
DOC_USP7_UBL2_3	382	386	PF12436	0.595
DOC_WW_Pin1_4	293	298	PF00397	0.614
DOC_WW_Pin1_4	346	351	PF00397	0.673
DOC_WW_Pin1_4	354	359	PF00397	0.635
DOC_WW_Pin1_4	413	418	PF00397	0.693
LIG_14-3-3_CanoR_1	121	130	PF00244	0.471
LIG_14-3-3_CanoR_1	142	150	PF00244	0.616
LIG_14-3-3_CanoR_1	259	264	PF00244	0.697
LIG_14-3-3_CanoR_1	409	413	PF00244	0.533
LIG_APCC_ABBA_1	71	76	PF00400	0.615
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_eIF4E_1	26	32	PF01652	0.600
LIG_EVH1_1	414	418	PF00568	0.527
LIG_FHA_1	124	130	PF00498	0.559
LIG_FHA_1	207	213	PF00498	0.554
LIG_FHA_1	258	264	PF00498	0.449
LIG_FHA_1	357	363	PF00498	0.618
LIG_FHA_2	173	179	PF00498	0.552
LIG_FHA_2	2	8	PF00498	0.462
LIG_FHA_2	260	266	PF00498	0.433
LIG_FHA_2	365	371	PF00498	0.665
LIG_FHA_2	382	388	PF00498	0.431
LIG_FHA_2	447	453	PF00498	0.547
LIG_Integrin_RGD_1	89	91	PF01839	0.477
LIG_LIR_Gen_1	497	506	PF02991	0.361
LIG_LIR_Nem_3	101	106	PF02991	0.613
LIG_LIR_Nem_3	41	46	PF02991	0.561
LIG_LIR_Nem_3	497	503	PF02991	0.361
LIG_NRBOX	112	118	PF00104	0.657
LIG_NRBOX	16	22	PF00104	0.580
LIG_NRBOX	197	203	PF00104	0.556
LIG_PCNA_yPIPBox_3	195	206	PF02747	0.506
LIG_PCNA_yPIPBox_3	486	500	PF02747	0.366
LIG_SH2_CRK	43	47	PF00017	0.662
LIG_SH2_STAT3	320	323	PF00017	0.595
LIG_SH2_STAT3	37	40	PF00017	0.406
LIG_SH3_3	297	303	PF00018	0.767
LIG_SH3_3	347	353	PF00018	0.716
LIG_SH3_3	412	418	PF00018	0.718
LIG_SH3_3	74	80	PF00018	0.560
LIG_SH3_3	92	98	PF00018	0.575
LIG_SUMO_SIM_par_1	513	519	PF11976	0.474
LIG_TRAF2_1	262	265	PF00917	0.646
LIG_TRAF2_1	38	41	PF00917	0.613
LIG_TRAF2_1	45	48	PF00917	0.627
LIG_UBA3_1	201	210	PF00899	0.604
MOD_CK1_1	123	129	PF00069	0.447
MOD_CK1_1	2	8	PF00069	0.568
MOD_CK1_1	257	263	PF00069	0.661
MOD_CK1_1	349	355	PF00069	0.621
MOD_CK1_1	357	363	PF00069	0.710
MOD_CK1_1	431	437	PF00069	0.660
MOD_CK1_1	507	513	PF00069	0.672
MOD_CK2_1	143	149	PF00069	0.641
MOD_CK2_1	259	265	PF00069	0.437
MOD_CK2_1	303	309	PF00069	0.691
MOD_CK2_1	337	343	PF00069	0.674
MOD_CK2_1	381	387	PF00069	0.422
MOD_CK2_1	48	54	PF00069	0.607
MOD_GlcNHglycan	145	148	PF01048	0.765
MOD_GlcNHglycan	353	356	PF01048	0.773
MOD_GlcNHglycan	405	408	PF01048	0.481
MOD_GlcNHglycan	430	433	PF01048	0.621
MOD_GlcNHglycan	84	87	PF01048	0.709
MOD_GSK3_1	101	108	PF00069	0.748
MOD_GSK3_1	349	356	PF00069	0.647
MOD_GSK3_1	403	410	PF00069	0.691
MOD_GSK3_1	427	434	PF00069	0.743
MOD_GSK3_1	442	449	PF00069	0.665
MOD_GSK3_1	462	469	PF00069	0.314
MOD_GSK3_1	504	511	PF00069	0.589
MOD_N-GLC_1	152	157	PF02516	0.750
MOD_N-GLC_1	257	262	PF02516	0.440
MOD_N-GLC_1	407	412	PF02516	0.520
MOD_NEK2_1	1	6	PF00069	0.590
MOD_NEK2_1	143	148	PF00069	0.698
MOD_NEK2_1	187	192	PF00069	0.632
MOD_NEK2_1	201	206	PF00069	0.513
MOD_NEK2_1	231	236	PF00069	0.608
MOD_NEK2_1	442	447	PF00069	0.489
MOD_NEK2_1	82	87	PF00069	0.579
MOD_NEK2_2	69	74	PF00069	0.573
MOD_PIKK_1	337	343	PF00454	0.613
MOD_PIKK_1	504	510	PF00454	0.418
MOD_PKA_2	120	126	PF00069	0.572
MOD_PKA_2	141	147	PF00069	0.731
MOD_PKA_2	231	237	PF00069	0.664
MOD_PKA_2	408	414	PF00069	0.529
MOD_Plk_1	101	107	PF00069	0.726
MOD_Plk_1	152	158	PF00069	0.614
MOD_Plk_1	173	179	PF00069	0.633
MOD_Plk_1	232	238	PF00069	0.651
MOD_Plk_1	303	309	PF00069	0.726
MOD_Plk_1	407	413	PF00069	0.761
MOD_Plk_1	442	448	PF00069	0.485
MOD_Plk_1	47	53	PF00069	0.413
MOD_Plk_2-3	48	54	PF00069	0.517
MOD_Plk_4	153	159	PF00069	0.734
MOD_Plk_4	187	193	PF00069	0.596
MOD_ProDKin_1	293	299	PF00069	0.617
MOD_ProDKin_1	346	352	PF00069	0.677
MOD_ProDKin_1	354	360	PF00069	0.515
MOD_ProDKin_1	413	419	PF00069	0.697
MOD_SUMO_for_1	314	317	PF00179	0.519
MOD_SUMO_for_1	392	395	PF00179	0.413
MOD_SUMO_rev_2	119	129	PF00179	0.639
MOD_SUMO_rev_2	430	439	PF00179	0.711
TRG_DiLeu_BaEn_1	125	130	PF01217	0.659
TRG_DiLeu_BaEn_1	197	202	PF01217	0.485
TRG_DiLeu_BaEn_4	309	315	PF01217	0.616
TRG_DiLeu_BaEn_4	387	393	PF01217	0.407
TRG_ENDOCYTIC_2	43	46	PF00928	0.651
TRG_ER_diArg_1	168	170	PF00400	0.515
TRG_ER_diArg_1	181	183	PF00400	0.410
TRG_ER_diArg_1	471	473	PF00400	0.571
TRG_ER_diArg_1	482	484	PF00400	0.523
TRG_NES_CRM1_1	452	466	PF08389	0.621
TRG_NES_CRM1_1	61	76	PF08389	0.403
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P962	Leptomonas seymouri	44%	93%
A0A1X0P582	Trypanosomatidae	26%	100%
A0A3R7P212	Trypanosoma rangeli	26%	100%
A0A3S7X9X8	Leishmania donovani	67%	100%
A4IC00	Leishmania infantum	67%	100%
E9AFT7	Leishmania major	68%	98%
E9B6Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
V5C2K9	Trypanosoma cruzi	27%	100%