Phosphatidylserine decarboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylserine decarboxylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HNC6_LEIBR

TriTrypDb:

LbrM.34.4570 , LBRM2903_340056200

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	5
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

A4HNC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNC6

Function

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Biological processes
Term	Name	Level	Count
GO:0006575	cellular modified amino acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006646	phosphatidylethanolamine biosynthetic process	6	11
GO:0006650	glycerophospholipid metabolic process	5	11
GO:0006658	phosphatidylserine metabolic process	4	1
GO:0006660	phosphatidylserine catabolic process	5	1
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004609	phosphatidylserine decarboxylase activity	5	12
GO:0016829	lyase activity	2	12
GO:0016830	carbon-carbon lyase activity	3	12
GO:0016831	carboxy-lyase activity	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.496
CLV_NRD_NRD_1	26	28	PF00675	0.392
CLV_NRD_NRD_1	57	59	PF00675	0.473
CLV_PCSK_KEX2_1	195	197	PF00082	0.467
CLV_PCSK_KEX2_1	26	28	PF00082	0.392
CLV_PCSK_KEX2_1	284	286	PF00082	0.560
CLV_PCSK_KEX2_1	337	339	PF00082	0.560
CLV_PCSK_KEX2_1	57	59	PF00082	0.473
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.560
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.560

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9I0	Leptomonas seymouri	64%	100%
A0A0S4JVQ1	Bodo saltans	31%	94%
A0A1X0P613	Trypanosomatidae	44%	93%
A0A3S7X9Y9	Leishmania donovani	85%	100%
A0A422P1A9	Trypanosoma rangeli	48%	93%
A0KSQ8	Shewanella sp. (strain ANA-3)	26%	100%
A0Q562	Francisella tularensis subsp. novicida (strain U112)	23%	100%
A1JIQ6	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	27%	100%
A1KBF9	Azoarcus sp. (strain BH72)	28%	100%
A1RFQ8	Shewanella sp. (strain W3-18-1)	26%	100%

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