Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60Kd inner membrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNC5_LEIBR

TriTrypDb:

LbrM.34.4560 , LBRM2903_340056100

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HNC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNC5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007006	mitochondrial membrane organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0032978	protein insertion into membrane from inner side	6	1
GO:0032979	protein insertion into mitochondrial inner membrane from matrix	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051205	protein insertion into membrane	5	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061024	membrane organization	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0090151	establishment of protein localization to mitochondrial membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0032977	membrane insertase activity	3	11
GO:0140104	molecular carrier activity	1	11
GO:0140597	protein carrier chaperone	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	542	546	PF00656	0.658
CLV_NRD_NRD_1	184	186	PF00675	0.313
CLV_NRD_NRD_1	320	322	PF00675	0.367
CLV_PCSK_KEX2_1	184	186	PF00082	0.310
CLV_PCSK_KEX2_1	320	322	PF00082	0.362
CLV_PCSK_KEX2_1	512	514	PF00082	0.568
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.568
CLV_PCSK_SKI1_1	146	150	PF00082	0.351
CLV_PCSK_SKI1_1	185	189	PF00082	0.295
CLV_PCSK_SKI1_1	264	268	PF00082	0.351
CLV_PCSK_SKI1_1	350	354	PF00082	0.443
DEG_APCC_DBOX_1	145	153	PF00400	0.604
DEG_Nend_Nbox_1	1	3	PF02207	0.509
DOC_CDC14_PxL_1	243	251	PF14671	0.335
DOC_CKS1_1	28	33	PF01111	0.400
DOC_CYCLIN_RxL_1	315	329	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.292
DOC_CYCLIN_yCln2_LP_2	308	314	PF00134	0.306
DOC_MAPK_MEF2A_6	140	149	PF00069	0.587
DOC_MAPK_MEF2A_6	293	300	PF00069	0.236
DOC_MAPK_MEF2A_6	386	393	PF00069	0.549
DOC_PP1_RVXF_1	159	165	PF00149	0.553
DOC_PP1_RVXF_1	270	277	PF00149	0.472
DOC_PP1_RVXF_1	319	326	PF00149	0.590
DOC_PP2B_LxvP_1	147	150	PF13499	0.536
DOC_PP2B_LxvP_1	237	240	PF13499	0.315
DOC_PP2B_LxvP_1	244	247	PF13499	0.314
DOC_PP4_FxxP_1	325	328	PF00568	0.488
DOC_USP7_MATH_1	287	291	PF00917	0.193
DOC_USP7_MATH_1	336	340	PF00917	0.705
DOC_USP7_MATH_1	346	350	PF00917	0.698
DOC_USP7_MATH_1	476	480	PF00917	0.731
DOC_USP7_MATH_1	57	61	PF00917	0.413
DOC_USP7_MATH_1	96	100	PF00917	0.442
DOC_USP7_UBL2_3	413	417	PF12436	0.755
DOC_USP7_UBL2_3	512	516	PF12436	0.798
DOC_WW_Pin1_4	10	15	PF00397	0.556
DOC_WW_Pin1_4	21	26	PF00397	0.449
DOC_WW_Pin1_4	27	32	PF00397	0.416
DOC_WW_Pin1_4	313	318	PF00397	0.285
DOC_WW_Pin1_4	324	329	PF00397	0.650
DOC_WW_Pin1_4	332	337	PF00397	0.680
DOC_WW_Pin1_4	427	432	PF00397	0.681
DOC_WW_Pin1_4	466	471	PF00397	0.754
DOC_WW_Pin1_4	479	484	PF00397	0.697
DOC_WW_Pin1_4	499	504	PF00397	0.728
DOC_WW_Pin1_4	537	542	PF00397	0.767
DOC_WW_Pin1_4	550	555	PF00397	0.738
LIG_14-3-3_CanoR_1	128	133	PF00244	0.271
LIG_14-3-3_CanoR_1	184	188	PF00244	0.519
LIG_14-3-3_CanoR_1	3	11	PF00244	0.410
LIG_14-3-3_CanoR_1	350	355	PF00244	0.644
LIG_14-3-3_CanoR_1	518	523	PF00244	0.634
LIG_APCC_ABBA_1	134	139	PF00400	0.330
LIG_BRCT_BRCA1_1	74	78	PF00533	0.376
LIG_Clathr_ClatBox_1	255	259	PF01394	0.338
LIG_deltaCOP1_diTrp_1	70	78	PF00928	0.336
LIG_FHA_1	116	122	PF00498	0.356
LIG_FHA_1	13	19	PF00498	0.454
LIG_FHA_1	191	197	PF00498	0.568
LIG_FHA_1	248	254	PF00498	0.335
LIG_FHA_1	28	34	PF00498	0.451
LIG_FHA_1	42	48	PF00498	0.479
LIG_FHA_1	460	466	PF00498	0.669
LIG_FHA_2	236	242	PF00498	0.295
LIG_FHA_2	351	357	PF00498	0.640
LIG_FHA_2	62	68	PF00498	0.377
LIG_LIR_Gen_1	157	167	PF02991	0.517
LIG_LIR_Gen_1	341	352	PF02991	0.560
LIG_LIR_Gen_1	99	106	PF02991	0.293
LIG_LIR_Nem_3	131	137	PF02991	0.290
LIG_LIR_Nem_3	157	162	PF02991	0.517
LIG_LIR_Nem_3	186	191	PF02991	0.527
LIG_LIR_Nem_3	341	347	PF02991	0.565
LIG_LIR_Nem_3	390	396	PF02991	0.624
LIG_LIR_Nem_3	62	68	PF02991	0.366
LIG_LIR_Nem_3	75	81	PF02991	0.382
LIG_LIR_Nem_3	99	104	PF02991	0.268
LIG_NRBOX	251	257	PF00104	0.193
LIG_NRBOX	395	401	PF00104	0.657
LIG_Pex14_2	101	105	PF04695	0.298
LIG_SH2_GRB2like	163	166	PF00017	0.618
LIG_SH2_SRC	299	302	PF00017	0.215
LIG_SH2_STAT5	163	166	PF00017	0.569
LIG_SH2_STAT5	231	234	PF00017	0.398
LIG_SH2_STAT5	299	302	PF00017	0.271
LIG_SH2_STAT5	395	398	PF00017	0.605
LIG_SH2_STAT5	441	444	PF00017	0.799
LIG_SH2_STAT5	65	68	PF00017	0.354
LIG_SH3_3	538	544	PF00018	0.774
LIG_SH3_3	545	551	PF00018	0.774
LIG_SH3_3	8	14	PF00018	0.386
LIG_SUMO_SIM_anti_2	118	123	PF11976	0.325
LIG_SUMO_SIM_anti_2	241	248	PF11976	0.181
LIG_SUMO_SIM_par_1	117	123	PF11976	0.299
LIG_SUMO_SIM_par_1	205	210	PF11976	0.193
LIG_SUMO_SIM_par_1	241	248	PF11976	0.201
LIG_SUMO_SIM_par_1	310	316	PF11976	0.289
LIG_WRC_WIRS_1	289	294	PF05994	0.381
MOD_CDK_SPxxK_3	313	320	PF00069	0.274
MOD_CDK_SPxxK_3	466	473	PF00069	0.772
MOD_CK1_1	20	26	PF00069	0.459
MOD_CK1_1	235	241	PF00069	0.230
MOD_CK1_1	291	297	PF00069	0.307
MOD_CK1_1	479	485	PF00069	0.708
MOD_CK1_1	490	496	PF00069	0.671
MOD_CK1_1	549	555	PF00069	0.723
MOD_CK1_1	99	105	PF00069	0.395
MOD_CK2_1	166	172	PF00069	0.604
MOD_CK2_1	350	356	PF00069	0.642
MOD_CK2_1	479	485	PF00069	0.728
MOD_CK2_1	530	536	PF00069	0.651
MOD_CK2_1	61	67	PF00069	0.388
MOD_GlcNHglycan	168	171	PF01048	0.328
MOD_GlcNHglycan	215	218	PF01048	0.537
MOD_GlcNHglycan	234	237	PF01048	0.547
MOD_GlcNHglycan	293	296	PF01048	0.510
MOD_GlcNHglycan	489	492	PF01048	0.566
MOD_GlcNHglycan	49	52	PF01048	0.684
MOD_GlcNHglycan	506	509	PF01048	0.420
MOD_GlcNHglycan	524	527	PF01048	0.578
MOD_GlcNHglycan	528	531	PF01048	0.483
MOD_GlcNHglycan	59	62	PF01048	0.537
MOD_GlcNHglycan	94	97	PF01048	0.561
MOD_GSK3_1	120	127	PF00069	0.279
MOD_GSK3_1	128	135	PF00069	0.262
MOD_GSK3_1	17	24	PF00069	0.475
MOD_GSK3_1	175	182	PF00069	0.564
MOD_GSK3_1	247	254	PF00069	0.424
MOD_GSK3_1	287	294	PF00069	0.391
MOD_GSK3_1	332	339	PF00069	0.649
MOD_GSK3_1	342	349	PF00069	0.673
MOD_GSK3_1	37	44	PF00069	0.443
MOD_GSK3_1	475	482	PF00069	0.692
MOD_GSK3_1	517	524	PF00069	0.724
MOD_GSK3_1	526	533	PF00069	0.720
MOD_GSK3_1	546	553	PF00069	0.587
MOD_GSK3_1	55	62	PF00069	0.420
MOD_GSK3_1	77	84	PF00069	0.413
MOD_GSK3_1	92	99	PF00069	0.431
MOD_N-GLC_1	47	52	PF02516	0.684
MOD_NEK2_1	120	125	PF00069	0.367
MOD_NEK2_1	132	137	PF00069	0.288
MOD_NEK2_1	175	180	PF00069	0.455
MOD_NEK2_1	232	237	PF00069	0.318
MOD_NEK2_1	337	342	PF00069	0.566
MOD_NEK2_1	385	390	PF00069	0.688
MOD_NEK2_1	49	54	PF00069	0.453
MOD_NEK2_1	517	522	PF00069	0.715
MOD_NEK2_1	72	77	PF00069	0.378
MOD_PIKK_1	553	559	PF00454	0.686
MOD_PIKK_1	59	65	PF00454	0.331
MOD_PIKK_1	99	105	PF00454	0.430
MOD_PKA_2	183	189	PF00069	0.449
MOD_PKA_2	459	465	PF00069	0.663
MOD_PKA_2	487	493	PF00069	0.706
MOD_PKA_2	517	523	PF00069	0.664
MOD_PKB_1	348	356	PF00069	0.740
MOD_Plk_4	115	121	PF00069	0.331
MOD_Plk_4	128	134	PF00069	0.314
MOD_Plk_4	175	181	PF00069	0.595
MOD_Plk_4	227	233	PF00069	0.336
MOD_Plk_4	61	67	PF00069	0.374
MOD_Plk_4	96	102	PF00069	0.414
MOD_ProDKin_1	10	16	PF00069	0.557
MOD_ProDKin_1	21	27	PF00069	0.446
MOD_ProDKin_1	313	319	PF00069	0.284
MOD_ProDKin_1	324	330	PF00069	0.654
MOD_ProDKin_1	332	338	PF00069	0.686
MOD_ProDKin_1	427	433	PF00069	0.679
MOD_ProDKin_1	466	472	PF00069	0.756
MOD_ProDKin_1	479	485	PF00069	0.697
MOD_ProDKin_1	499	505	PF00069	0.728
MOD_ProDKin_1	537	543	PF00069	0.769
MOD_ProDKin_1	550	556	PF00069	0.737
MOD_SUMO_rev_2	259	268	PF00179	0.550
TRG_DiLeu_BaEn_1	115	120	PF01217	0.300
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.238
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.322
TRG_ER_diArg_1	144	147	PF00400	0.526
TRG_ER_diArg_1	319	321	PF00400	0.548
TRG_ER_diArg_1	347	350	PF00400	0.554
TRG_ER_diArg_1	423	426	PF00400	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFR8	Leptomonas seymouri	54%	100%
A0A1X0P4X1	Trypanosomatidae	40%	100%
A0A3S7XA08	Leishmania donovani	76%	100%
A0A422P166	Trypanosoma rangeli	38%	100%
A4IBZ8	Leishmania infantum	76%	100%
C9ZYK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AFT5	Leishmania major	76%	100%
E9B6Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
V5BT14	Trypanosoma cruzi	39%	100%