DUF962 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF962), putative

Species:

Leishmania braziliensis

UniProt:

A4HNB9_LEIBR

TriTrypDb:

LbrM.34.4500 , LBRM2903_340055500

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HNB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNB9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0030149	sphingolipid catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046466	membrane lipid catabolic process	5	1
GO:0046519	sphingoid metabolic process	5	1
GO:0046521	sphingoid catabolic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.531
CLV_PCSK_SKI1_1	162	166	PF00082	0.343
DEG_Nend_Nbox_1	1	3	PF02207	0.422
DOC_PP2B_LxvP_1	79	82	PF13499	0.331
DOC_PP2B_PxIxI_1	180	186	PF00149	0.525
DOC_USP7_UBL2_3	184	188	PF12436	0.709
LIG_14-3-3_CanoR_1	12	16	PF00244	0.369
LIG_BRCT_BRCA1_1	13	17	PF00533	0.297
LIG_LIR_Gen_1	66	76	PF02991	0.332
LIG_LIR_Nem_3	14	18	PF02991	0.297
LIG_LIR_Nem_3	6	11	PF02991	0.340
LIG_LIR_Nem_3	88	92	PF02991	0.410
LIG_SH2_CRK	80	84	PF00017	0.246
LIG_SH2_SRC	4	7	PF00017	0.263
LIG_SH2_SRC	80	83	PF00017	0.406
LIG_SH2_STAP1	65	69	PF00017	0.328
LIG_SH2_STAT3	21	24	PF00017	0.269
LIG_SH2_STAT5	4	7	PF00017	0.333
LIG_SH2_STAT5	65	68	PF00017	0.379
LIG_SH2_STAT5	8	11	PF00017	0.248
LIG_SH2_STAT5	89	92	PF00017	0.310
MOD_GSK3_1	37	44	PF00069	0.337
MOD_NEK2_1	11	16	PF00069	0.297
MOD_PKA_2	11	17	PF00069	0.369
MOD_Plk_4	11	17	PF00069	0.280
MOD_Plk_4	4	10	PF00069	0.331
MOD_Plk_4	41	47	PF00069	0.377
MOD_SUMO_for_1	156	159	PF00179	0.567
MOD_SUMO_for_1	70	73	PF00179	0.328
TRG_DiLeu_BaEn_1	159	164	PF01217	0.431
TRG_DiLeu_BaEn_2	144	150	PF01217	0.410
TRG_ENDOCYTIC_2	8	11	PF00928	0.297
TRG_ENDOCYTIC_2	80	83	PF00928	0.324
TRG_ENDOCYTIC_2	89	92	PF00928	0.328
TRG_ER_diLys_1	188	192	PF00400	0.644
TRG_NES_CRM1_1	133	145	PF08389	0.410
TRG_NES_CRM1_1	159	169	PF08389	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGQ0	Leptomonas seymouri	64%	99%
A0A0S4JU62	Bodo saltans	55%	100%
A0A1X0P4Z2	Trypanosomatidae	50%	96%
A0A3S7X9Y4	Leishmania donovani	78%	100%
A4IBZ2	Leishmania infantum	75%	88%
E9AFS9	Leishmania major	77%	100%
E9B6Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
O13737	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	86%
P25338	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%