Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNB8_LEIBR

TriTrypDb:

LbrM.34.4490 , LBRM2903_340055400

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HNB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.475
CLV_NRD_NRD_1	2	4	PF00675	0.434
CLV_NRD_NRD_1	80	82	PF00675	0.393
CLV_PCSK_KEX2_1	2	4	PF00082	0.415
CLV_PCSK_KEX2_1	80	82	PF00082	0.351
CLV_PCSK_SKI1_1	213	217	PF00082	0.502
DEG_APCC_DBOX_1	80	88	PF00400	0.381
DEG_Nend_UBRbox_1	1	4	PF02207	0.698
DEG_SPOP_SBC_1	37	41	PF00917	0.586
DOC_MAPK_DCC_7	132	140	PF00069	0.360
DOC_MAPK_MEF2A_6	132	140	PF00069	0.435
DOC_PP4_FxxP_1	139	142	PF00568	0.354
DOC_PP4_FxxP_1	56	59	PF00568	0.653
DOC_USP7_MATH_1	14	18	PF00917	0.596
DOC_USP7_MATH_1	51	55	PF00917	0.558
DOC_USP7_UBL2_3	151	155	PF12436	0.377
DOC_WW_Pin1_4	22	27	PF00397	0.663
LIG_14-3-3_CanoR_1	132	136	PF00244	0.378
LIG_14-3-3_CanoR_1	66	71	PF00244	0.694
LIG_Actin_WH2_2	171	189	PF00022	0.385
LIG_APCC_ABBAyCdc20_2	167	173	PF00400	0.444
LIG_eIF4E_1	218	224	PF01652	0.435
LIG_FHA_1	196	202	PF00498	0.319
LIG_FHA_1	84	90	PF00498	0.376
LIG_FHA_2	142	148	PF00498	0.378
LIG_FHA_2	37	43	PF00498	0.718
LIG_LIR_Apic_2	54	59	PF02991	0.650
LIG_LIR_Apic_2	69	73	PF02991	0.517
LIG_LIR_Gen_1	143	153	PF02991	0.331
LIG_LIR_Gen_1	219	229	PF02991	0.389
LIG_LIR_Nem_3	143	148	PF02991	0.332
LIG_LIR_Nem_3	219	224	PF02991	0.351
LIG_LIR_Nem_3	40	46	PF02991	0.678
LIG_PDZ_Class_2	226	231	PF00595	0.425
LIG_SH2_NCK_1	221	225	PF00017	0.404
LIG_SH2_PTP2	70	73	PF00017	0.613
LIG_SH2_SRC	70	73	PF00017	0.632
LIG_SH2_STAP1	145	149	PF00017	0.425
LIG_SH2_STAT5	100	103	PF00017	0.273
LIG_SH2_STAT5	70	73	PF00017	0.652
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.412
LIG_SUMO_SIM_anti_2	95	100	PF11976	0.439
LIG_SUMO_SIM_par_1	222	227	PF11976	0.301
LIG_TYR_ITIM	98	103	PF00017	0.349
LIG_TYR_ITSM	39	46	PF00017	0.680
MOD_CK1_1	27	33	PF00069	0.726
MOD_CK2_1	141	147	PF00069	0.336
MOD_CK2_1	216	222	PF00069	0.421
MOD_CK2_1	36	42	PF00069	0.707
MOD_CK2_1	66	72	PF00069	0.638
MOD_GlcNHglycan	218	221	PF01048	0.656
MOD_GlcNHglycan	26	29	PF01048	0.507
MOD_GlcNHglycan	33	36	PF01048	0.586
MOD_GSK3_1	16	23	PF00069	0.728
MOD_GSK3_1	161	168	PF00069	0.443
MOD_GSK3_1	27	34	PF00069	0.673
MOD_N-GLC_2	183	185	PF02516	0.531
MOD_NEK2_1	101	106	PF00069	0.359
MOD_NEK2_1	216	221	PF00069	0.377
MOD_NEK2_1	85	90	PF00069	0.278
MOD_NEK2_2	166	171	PF00069	0.403
MOD_NEK2_2	75	80	PF00069	0.597
MOD_PIKK_1	158	164	PF00454	0.402
MOD_PIKK_1	51	57	PF00454	0.703
MOD_PKA_2	131	137	PF00069	0.461
MOD_Plk_1	155	161	PF00069	0.352
MOD_Plk_4	171	177	PF00069	0.359
MOD_Plk_4	66	72	PF00069	0.677
MOD_ProDKin_1	22	28	PF00069	0.663
MOD_SUMO_rev_2	69	76	PF00179	0.641
TRG_DiLeu_BaEn_2	71	77	PF01217	0.572
TRG_ENDOCYTIC_2	100	103	PF00928	0.271
TRG_ENDOCYTIC_2	145	148	PF00928	0.425
TRG_ENDOCYTIC_2	149	152	PF00928	0.427
TRG_ENDOCYTIC_2	221	224	PF00928	0.361
TRG_ENDOCYTIC_2	43	46	PF00928	0.680
TRG_ER_diArg_1	1	3	PF00400	0.638
TRG_ER_diArg_1	107	110	PF00400	0.462
TRG_ER_diArg_1	124	127	PF00400	0.317
TRG_ER_diArg_1	79	81	PF00400	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMV6	Leptomonas seymouri	62%	97%
A0A0S4JR13	Bodo saltans	32%	97%
A0A1X0P4Y8	Trypanosomatidae	43%	100%
A0A3S7XA10	Leishmania donovani	84%	100%
A0A422P1A7	Trypanosoma rangeli	44%	100%
A4IBZ1	Leishmania infantum	84%	100%
C9ZYL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AFS8	Leishmania major	83%	100%
E9B6Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%