ARL2_Bind_BART domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNB6_LEIBR

TriTrypDb:

LbrM.34.4460 , LBRM2903_340054700

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A4HNB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	124	128	PF00082	0.253
DEG_Nend_UBRbox_3	1	3	PF02207	0.600
DEG_SCF_TRCP1_1	148	154	PF00400	0.467
DOC_USP7_MATH_1	46	50	PF00917	0.533
DOC_USP7_MATH_1	86	90	PF00917	0.506
DOC_WW_Pin1_4	101	106	PF00397	0.536
LIG_14-3-3_CanoR_1	110	118	PF00244	0.457
LIG_CSL_BTD_1	4	7	PF09270	0.422
LIG_FHA_1	112	118	PF00498	0.414
LIG_FHA_1	26	32	PF00498	0.435
LIG_FHA_1	39	45	PF00498	0.496
LIG_FHA_1	93	99	PF00498	0.384
LIG_FHA_2	51	57	PF00498	0.496
LIG_LIR_Apic_2	100	105	PF02991	0.521
LIG_LIR_Apic_2	163	169	PF02991	0.454
LIG_LIR_Gen_1	125	134	PF02991	0.470
LIG_LIR_Gen_1	39	50	PF02991	0.487
LIG_LIR_Nem_3	120	126	PF02991	0.499
LIG_LIR_Nem_3	137	142	PF02991	0.467
LIG_LIR_Nem_3	39	45	PF02991	0.487
LIG_SH2_CRK	109	113	PF00017	0.518
LIG_SH2_CRK	139	143	PF00017	0.602
LIG_SH2_CRK	68	72	PF00017	0.386
LIG_SH2_STAT5	116	119	PF00017	0.437
LIG_TRAF2_1	97	100	PF00917	0.444
MOD_CK1_1	23	29	PF00069	0.534
MOD_CK1_1	93	99	PF00069	0.521
MOD_CK2_1	50	56	PF00069	0.475
MOD_CK2_1	67	73	PF00069	0.432
MOD_GlcNHglycan	11	14	PF01048	0.329
MOD_GlcNHglycan	145	151	PF01048	0.553
MOD_GlcNHglycan	163	166	PF01048	0.444
MOD_GlcNHglycan	48	51	PF01048	0.253
MOD_GlcNHglycan	95	98	PF01048	0.396
MOD_GSK3_1	20	27	PF00069	0.563
MOD_GSK3_1	46	53	PF00069	0.540
MOD_GSK3_1	86	93	PF00069	0.574
MOD_PIKK_1	20	26	PF00454	0.453
MOD_Plk_1	38	44	PF00069	0.530
MOD_Plk_1	55	61	PF00069	0.418
MOD_Plk_1	86	92	PF00069	0.496
MOD_Plk_4	1	7	PF00069	0.648
MOD_Plk_4	112	118	PF00069	0.485
MOD_Plk_4	67	73	PF00069	0.430
MOD_Plk_4	86	92	PF00069	0.530
MOD_ProDKin_1	101	107	PF00069	0.536
MOD_SUMO_rev_2	120	126	PF00179	0.453
MOD_SUMO_rev_2	96	105	PF00179	0.401
TRG_DiLeu_BaEn_2	124	130	PF01217	0.384
TRG_ENDOCYTIC_2	109	112	PF00928	0.515
TRG_ENDOCYTIC_2	123	126	PF00928	0.562
TRG_ENDOCYTIC_2	139	142	PF00928	0.598
TRG_ENDOCYTIC_2	62	65	PF00928	0.446
TRG_ENDOCYTIC_2	68	71	PF00928	0.437
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICH3	Leptomonas seymouri	46%	88%
A0A0S4JM98	Bodo saltans	30%	100%
A0A1X0P624	Trypanosomatidae	29%	100%
A0A3Q8IQ44	Leishmania donovani	71%	89%
A0A422P1B2	Trypanosoma rangeli	35%	100%
A4IBY8	Leishmania infantum	71%	89%
C9ZYL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AFS5	Leishmania major	63%	100%
E9B6X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	89%