CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Co-chaperone protein P23

Species:

Leishmania braziliensis

UniProt:

A4HNB5_LEIBR

TriTrypDb:

LbrM.34.4450 , LBRM2903_340054600

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNB5

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0051131	chaperone-mediated protein complex assembly	6	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0031072	heat shock protein binding	3	8
GO:0051879	Hsp90 protein binding	4	8
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.631
CLV_NRD_NRD_1	10	12	PF00675	0.321
DOC_MAPK_gen_1	11	19	PF00069	0.479
DOC_MAPK_MEF2A_6	11	19	PF00069	0.479
DOC_MAPK_MEF2A_6	71	79	PF00069	0.479
DOC_USP7_MATH_1	122	126	PF00917	0.635
DOC_USP7_MATH_1	45	49	PF00917	0.521
DOC_USP7_MATH_1	65	69	PF00917	0.392
LIG_14-3-3_CanoR_1	14	20	PF00244	0.525
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_deltaCOP1_diTrp_1	107	111	PF00928	0.450
LIG_FHA_1	33	39	PF00498	0.611
LIG_FHA_1	67	73	PF00498	0.525
LIG_FHA_2	21	27	PF00498	0.547
LIG_FHA_2	28	34	PF00498	0.494
LIG_LIR_Gen_1	13	24	PF02991	0.503
LIG_LIR_Nem_3	125	130	PF02991	0.681
LIG_LIR_Nem_3	13	19	PF02991	0.503
LIG_LIR_Nem_3	67	73	PF02991	0.523
LIG_PDZ_Class_2	196	201	PF00595	0.674
LIG_SH2_GRB2like	88	91	PF00017	0.495
LIG_SH3_3	90	96	PF00018	0.398
LIG_SUMO_SIM_par_1	33	39	PF11976	0.525
LIG_TRAF2_1	30	33	PF00917	0.439
LIG_UBA3_1	156	162	PF00899	0.629
MOD_CK1_1	102	108	PF00069	0.481
MOD_CK2_1	165	171	PF00069	0.645
MOD_CK2_1	173	179	PF00069	0.675
MOD_CK2_1	27	33	PF00069	0.439
MOD_CMANNOS	108	111	PF00535	0.467
MOD_GlcNHglycan	104	107	PF01048	0.473
MOD_GlcNHglycan	38	41	PF01048	0.315
MOD_GSK3_1	152	159	PF00069	0.616
MOD_GSK3_1	32	39	PF00069	0.453
MOD_GSK3_1	41	48	PF00069	0.479
MOD_NEK2_1	156	161	PF00069	0.644
MOD_NEK2_1	73	78	PF00069	0.422
MOD_NEK2_1	99	104	PF00069	0.346
MOD_PK_1	34	40	PF00069	0.525
MOD_Plk_1	32	38	PF00069	0.487
MOD_Plk_1	65	71	PF00069	0.562
MOD_Plk_4	137	143	PF00069	0.610
MOD_Plk_4	152	158	PF00069	0.456
MOD_Plk_4	99	105	PF00069	0.485
MOD_SUMO_for_1	53	56	PF00179	0.521
TRG_DiLeu_BaEn_4	94	100	PF01217	0.362
TRG_ENDOCYTIC_2	130	133	PF00928	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I2	Leptomonas seymouri	28%	96%
A0A0S4JQC8	Bodo saltans	28%	100%
A0A0S4JTH1	Bodo saltans	45%	100%
A0A3Q8II57	Leishmania donovani	28%	96%
A0A3S5H807	Leishmania donovani	82%	100%
A4I9J1	Leishmania infantum	28%	96%
A4IBY7	Leishmania infantum	82%	100%
C9ZYL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AFS4	Leishmania major	81%	99%
E9B4I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	96%
E9B6X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
G1TGF1	Oryctolagus cuniculus	36%	100%
P0C8Z0	Oryza sativa subsp. indica	29%	96%
P83868	Rattus norvegicus	36%	100%
Q11118	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q15185	Homo sapiens	36%	100%
Q3ZBF7	Bos taurus	36%	100%
Q4Q3I7	Leishmania major	27%	96%
Q5NVM4	Pongo abelii	36%	100%
Q6PWL5	Macaca fascicularis	36%	100%
Q6YYB0	Oryza sativa subsp. japonica	29%	94%
Q90955	Gallus gallus	34%	100%
Q9FR62	Brassica napus	31%	100%
Q9R0Q7	Mus musculus	36%	100%
Q9VH95	Drosophila melanogaster	30%	100%
V5B2A2	Trypanosoma cruzi	28%	100%