C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNB3_LEIBR

TriTrypDb:

LbrM.34.4430 , LBRM2903_340054400

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNB3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.558
CLV_PCSK_KEX2_1	196	198	PF00082	0.558
DEG_Nend_UBRbox_2	1	3	PF02207	0.559
DEG_SCF_FBW7_1	236	242	PF00400	0.756
DEG_SCF_FBW7_1	243	249	PF00400	0.629
DOC_CDC14_PxL_1	237	245	PF14671	0.515
DOC_CKS1_1	210	215	PF01111	0.636
DOC_CKS1_1	236	241	PF01111	0.739
DOC_CKS1_1	243	248	PF01111	0.609
DOC_CKS1_1	5	10	PF01111	0.713
DOC_PP4_FxxP_1	201	204	PF00568	0.472
DOC_PP4_FxxP_1	251	254	PF00568	0.732
DOC_USP7_MATH_1	109	113	PF00917	0.506
DOC_USP7_MATH_1	162	166	PF00917	0.615
DOC_USP7_MATH_1	239	243	PF00917	0.627
DOC_USP7_MATH_1	255	259	PF00917	0.675
DOC_USP7_MATH_1	85	89	PF00917	0.680
DOC_WW_Pin1_4	12	17	PF00397	0.606
DOC_WW_Pin1_4	123	128	PF00397	0.608
DOC_WW_Pin1_4	140	145	PF00397	0.677
DOC_WW_Pin1_4	174	179	PF00397	0.535
DOC_WW_Pin1_4	205	210	PF00397	0.721
DOC_WW_Pin1_4	23	28	PF00397	0.399
DOC_WW_Pin1_4	232	237	PF00397	0.698
DOC_WW_Pin1_4	242	247	PF00397	0.595
DOC_WW_Pin1_4	4	9	PF00397	0.763
LIG_AP2alpha_2	172	174	PF02296	0.506
LIG_BRCT_BRCA1_1	125	129	PF00533	0.628
LIG_FHA_1	13	19	PF00498	0.679
LIG_FHA_1	151	157	PF00498	0.732
LIG_FHA_1	210	216	PF00498	0.612
LIG_FHA_1	243	249	PF00498	0.644
LIG_FHA_1	95	101	PF00498	0.734
LIG_FHA_2	255	261	PF00498	0.725
LIG_FHA_2	87	93	PF00498	0.509
LIG_Integrin_isoDGR_2	191	193	PF01839	0.529
LIG_LIR_Apic_2	152	158	PF02991	0.526
LIG_LIR_Apic_2	249	254	PF02991	0.726
LIG_LIR_Nem_3	238	243	PF02991	0.667
LIG_LYPXL_yS_3	240	243	PF13949	0.517
LIG_SH2_GRB2like	189	192	PF00017	0.516
LIG_SH2_PTP2	155	158	PF00017	0.526
LIG_SH2_PTP2	217	220	PF00017	0.495
LIG_SH2_SRC	189	192	PF00017	0.482
LIG_SH2_STAP1	76	80	PF00017	0.522
LIG_SH2_STAT5	155	158	PF00017	0.526
LIG_SH2_STAT5	189	192	PF00017	0.472
LIG_SH2_STAT5	19	22	PF00017	0.583
LIG_SH2_STAT5	217	220	PF00017	0.557
LIG_SH3_3	2	8	PF00018	0.768
LIG_SH3_3	233	239	PF00018	0.685
LIG_SH3_3	63	69	PF00018	0.669
MOD_CK1_1	121	127	PF00069	0.694
MOD_CK1_1	128	134	PF00069	0.665
MOD_CK1_1	224	230	PF00069	0.550
MOD_CK1_1	235	241	PF00069	0.671
MOD_CK1_1	242	248	PF00069	0.707
MOD_CK1_1	258	264	PF00069	0.562
MOD_CK1_1	94	100	PF00069	0.562
MOD_CK2_1	178	184	PF00069	0.564
MOD_CK2_1	254	260	PF00069	0.726
MOD_CK2_1	86	92	PF00069	0.514
MOD_GlcNHglycan	168	171	PF01048	0.663
MOD_GlcNHglycan	248	251	PF01048	0.664
MOD_GSK3_1	103	110	PF00069	0.575
MOD_GSK3_1	121	128	PF00069	0.685
MOD_GSK3_1	162	169	PF00069	0.635
MOD_GSK3_1	174	181	PF00069	0.496
MOD_GSK3_1	205	212	PF00069	0.608
MOD_GSK3_1	235	242	PF00069	0.674
MOD_GSK3_1	254	261	PF00069	0.604
MOD_N-GLC_1	227	232	PF02516	0.524
MOD_NEK2_1	118	123	PF00069	0.627
MOD_NEK2_1	166	171	PF00069	0.655
MOD_NEK2_2	86	91	PF00069	0.515
MOD_PIKK_1	109	115	PF00454	0.511
MOD_PIKK_1	134	140	PF00454	0.776
MOD_PIKK_1	164	170	PF00454	0.681
MOD_PIKK_1	20	26	PF00454	0.725
MOD_Plk_1	131	137	PF00069	0.545
MOD_Plk_1	227	233	PF00069	0.524
MOD_Plk_4	113	119	PF00069	0.560
MOD_Plk_4	221	227	PF00069	0.521
MOD_Plk_4	48	54	PF00069	0.643
MOD_Plk_4	67	73	PF00069	0.553
MOD_Plk_4	96	102	PF00069	0.652
MOD_ProDKin_1	12	18	PF00069	0.605
MOD_ProDKin_1	123	129	PF00069	0.611
MOD_ProDKin_1	140	146	PF00069	0.678
MOD_ProDKin_1	174	180	PF00069	0.530
MOD_ProDKin_1	205	211	PF00069	0.723
MOD_ProDKin_1	23	29	PF00069	0.398
MOD_ProDKin_1	232	238	PF00069	0.697
MOD_ProDKin_1	242	248	PF00069	0.595
MOD_ProDKin_1	4	10	PF00069	0.761
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.495
TRG_ENDOCYTIC_2	240	243	PF00928	0.700
TRG_NLS_MonoExtN_4	196	201	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I468	Leptomonas seymouri	33%	100%
A0A3S7X9W1	Leishmania donovani	64%	100%
A4IBY5	Leishmania infantum	64%	100%
E9AFS2	Leishmania major	63%	100%
E9B6X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%