Putative mitochondrial phosphate transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial phosphate transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HNB1_LEIBR

TriTrypDb:

LbrM.34.4400 , LBRM2903_340054100

Length:

307

Annotations

LeishMANIAdb annotations

Forms a well-defined channel with 6 helices. Some paralogs tend to have an additional hydrophobic segment that might be a transit or signal peptide. It is unclear if the N-peptide is a signal or transit peptide. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	14
GO:0016020	membrane	2	14
GO:0019866	organelle inner membrane	4	14
GO:0031090	organelle membrane	3	14
GO:0031966	mitochondrial membrane	4	14
GO:0110165	cellular anatomical entity	1	16
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HNB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNB1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0006811	monoatomic ion transport	4	16
GO:0006817	phosphate ion transport	7	16
GO:0006820	monoatomic anion transport	5	16
GO:0009987	cellular process	1	16
GO:0015698	inorganic anion transport	6	16
GO:0034220	monoatomic ion transmembrane transport	3	16
GO:0035435	phosphate ion transmembrane transport	6	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0055085	transmembrane transport	2	16
GO:0098656	monoatomic anion transmembrane transport	4	16
GO:0098660	inorganic ion transmembrane transport	4	16
GO:0098661	inorganic anion transmembrane transport	5	16
GO:1990542	mitochondrial transmembrane transport	3	16
GO:1990547	mitochondrial phosphate ion transmembrane transport	4	16

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	16
GO:0005315	inorganic phosphate transmembrane transporter activity	4	16
GO:0015291	secondary active transmembrane transporter activity	4	16
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	16
GO:0022804	active transmembrane transporter activity	3	16
GO:0022857	transmembrane transporter activity	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	295	297	PF00082	0.392
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.392
CLV_PCSK_SKI1_1	173	177	PF00082	0.377
CLV_PCSK_SKI1_1	292	296	PF00082	0.622
DEG_Nend_UBRbox_1	1	4	PF02207	0.291
DOC_AGCK_PIF_2	75	80	PF00069	0.439
DOC_MAPK_gen_1	295	303	PF00069	0.381
DOC_MAPK_gen_1	95	103	PF00069	0.517
DOC_MAPK_MEF2A_6	198	206	PF00069	0.386
DOC_PP4_FxxP_1	189	192	PF00568	0.430
DOC_USP7_MATH_1	141	145	PF00917	0.436
DOC_USP7_MATH_1	148	152	PF00917	0.368
DOC_USP7_MATH_1	155	159	PF00917	0.168
DOC_USP7_MATH_1	217	221	PF00917	0.374
DOC_USP7_MATH_1	236	240	PF00917	0.578
DOC_WW_Pin1_4	127	132	PF00397	0.308
LIG_14-3-3_CanoR_1	34	39	PF00244	0.460
LIG_APCC_ABBA_1	181	186	PF00400	0.204
LIG_BRCT_BRCA1_1	107	111	PF00533	0.334
LIG_BRCT_BRCA1_1	150	154	PF00533	0.410
LIG_BRCT_BRCA1_1	202	206	PF00533	0.389
LIG_DLG_GKlike_1	34	42	PF00625	0.460
LIG_FHA_1	135	141	PF00498	0.437
LIG_FHA_1	252	258	PF00498	0.394
LIG_GBD_Chelix_1	38	46	PF00786	0.204
LIG_LIR_Apic_2	186	192	PF02991	0.336
LIG_LIR_Gen_1	110	120	PF02991	0.318
LIG_LIR_Gen_1	246	257	PF02991	0.434
LIG_LIR_Gen_1	83	89	PF02991	0.334
LIG_LIR_Nem_3	239	243	PF02991	0.454
LIG_LIR_Nem_3	246	252	PF02991	0.391
LIG_LIR_Nem_3	33	38	PF02991	0.307
LIG_LIR_Nem_3	79	84	PF02991	0.332
LIG_PCNA_yPIPBox_3	47	61	PF02747	0.392
LIG_REV1ctd_RIR_1	173	183	PF16727	0.321
LIG_SH2_CRK	156	160	PF00017	0.448
LIG_SH2_CRK	240	244	PF00017	0.419
LIG_SH2_CRK	249	253	PF00017	0.414
LIG_SH2_GRB2like	249	252	PF00017	0.456
LIG_SH2_GRB2like	85	88	PF00017	0.334
LIG_SH2_NCK_1	196	200	PF00017	0.465
LIG_SH2_SRC	185	188	PF00017	0.493
LIG_SH2_STAP1	185	189	PF00017	0.296
LIG_SH2_STAP1	85	89	PF00017	0.334
LIG_SH2_STAT3	67	70	PF00017	0.318
LIG_SH2_STAT5	169	172	PF00017	0.304
LIG_SH2_STAT5	187	190	PF00017	0.412
LIG_SH2_STAT5	210	213	PF00017	0.361
LIG_SH2_STAT5	80	83	PF00017	0.450
LIG_SH3_3	216	222	PF00018	0.368
LIG_SH3_4	191	198	PF00018	0.543
LIG_SUMO_SIM_par_1	259	266	PF11976	0.387
MOD_CDK_SPK_2	127	132	PF00069	0.401
MOD_CK1_1	287	293	PF00069	0.399
MOD_CK2_1	287	293	PF00069	0.494
MOD_GlcNHglycan	105	108	PF01048	0.311
MOD_GlcNHglycan	143	146	PF01048	0.357
MOD_GlcNHglycan	151	154	PF01048	0.454
MOD_GlcNHglycan	207	210	PF01048	0.343
MOD_GlcNHglycan	227	230	PF01048	0.446
MOD_GlcNHglycan	286	289	PF01048	0.416
MOD_GlcNHglycan	67	70	PF01048	0.468
MOD_GSK3_1	127	134	PF00069	0.330
MOD_GSK3_1	274	281	PF00069	0.282
MOD_GSK3_1	283	290	PF00069	0.344
MOD_N-GLC_2	251	253	PF02516	0.437
MOD_NEK2_1	103	108	PF00069	0.306
MOD_NEK2_1	202	207	PF00069	0.458
MOD_NEK2_1	263	268	PF00069	0.384
MOD_NEK2_1	284	289	PF00069	0.436
MOD_PIKK_1	197	203	PF00454	0.405
MOD_Plk_4	222	228	PF00069	0.427
MOD_ProDKin_1	127	133	PF00069	0.308
MOD_SUMO_for_1	46	49	PF00179	0.419
MOD_SUMO_rev_2	287	297	PF00179	0.355
TRG_ENDOCYTIC_2	156	159	PF00928	0.460
TRG_ENDOCYTIC_2	185	188	PF00928	0.405
TRG_ENDOCYTIC_2	240	243	PF00928	0.433
TRG_ENDOCYTIC_2	249	252	PF00928	0.410
TRG_ENDOCYTIC_2	78	81	PF00928	0.308
TRG_ENDOCYTIC_2	85	88	PF00928	0.299
TRG_ENDOCYTIC_2	97	100	PF00928	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I993	Leptomonas seymouri	85%	97%
A0A0S4JBC4	Bodo saltans	40%	79%
A0A0S4JNX4	Bodo saltans	72%	91%
A0A0S4KJX8	Bodo saltans	27%	88%
A0A1D6N272	Zea mays	23%	91%
A0A1X0P0K9	Trypanosomatidae	39%	100%
A0A1X0P561	Trypanosomatidae	74%	96%
A0A3R7KY11	Trypanosoma rangeli	38%	100%
A0A3S5IRV4	Trypanosoma rangeli	77%	97%
A0A3S7X9V4	Leishmania donovani	94%	97%
A0A3S7X9Y0	Leishmania donovani	94%	97%
A4HNB2	Leishmania braziliensis	100%	97%
A4IBY2	Leishmania infantum	89%	97%
A4IBY3	Leishmania infantum	94%	97%
B0G143	Dictyostelium discoideum	24%	100%
B4FIJ0	Zea mays	23%	91%
C9ZYM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	97%
D0A4I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	81%
E9AFR9	Leishmania major	94%	100%
E9AFS0	Leishmania major	94%	100%
E9B6X2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	97%
O61703	Choristoneura fumiferana	52%	88%
P12234	Bos taurus	53%	85%
P16036	Rattus norvegicus	51%	86%
P23641	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	99%
P40035	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P40614	Caenorhabditis elegans	55%	90%
Q00325	Homo sapiens	52%	85%
Q54BF6	Dictyostelium discoideum	41%	100%
Q5R7W2	Pongo abelii	52%	85%
Q7DNC3	Arabidopsis thaliana	41%	99%
Q8VEM8	Mus musculus	51%	86%
Q9FMU6	Arabidopsis thaliana	52%	82%
Q9LJX5	Arabidopsis thaliana	23%	88%
Q9M2Z8	Arabidopsis thaliana	50%	85%
Q9P7V8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	99%
V5BT68	Trypanosoma cruzi	76%	97%