Putative amino acid permease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease, putative

Species:

Leishmania braziliensis

UniProt:

A4HNB0_LEIBR

TriTrypDb:

LbrM.34.4390 , LBRM2903_340054000

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24
GO:0000323	lytic vacuole	6	1
GO:0005764	lysosome	7	1
GO:0005773	vacuole	5	1
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HNB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNB0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005215	transporter activity	1	24
GO:0015203	polyamine transmembrane transporter activity	3	24
GO:0016787	hydrolase activity	2	6
GO:0022857	transmembrane transporter activity	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	502	506	PF00656	0.486
CLV_NRD_NRD_1	12	14	PF00675	0.370
CLV_PCSK_FUR_1	10	14	PF00082	0.304
CLV_PCSK_KEX2_1	12	14	PF00082	0.372
CLV_PCSK_SKI1_1	153	157	PF00082	0.328
CLV_PCSK_SKI1_1	32	36	PF00082	0.234
DEG_Nend_UBRbox_3	1	3	PF02207	0.587
DEG_SCF_FBW7_1	1	8	PF00400	0.588
DOC_CKS1_1	2	7	PF01111	0.591
DOC_CKS1_1	347	352	PF01111	0.418
DOC_CYCLIN_yCln2_LP_2	402	408	PF00134	0.426
DOC_MAPK_gen_1	10	20	PF00069	0.468
DOC_MAPK_MEF2A_6	12	20	PF00069	0.557
DOC_MAPK_MEF2A_6	60	68	PF00069	0.206
DOC_PP1_RVXF_1	151	157	PF00149	0.283
DOC_PP1_RVXF_1	194	201	PF00149	0.514
DOC_PP1_RVXF_1	392	398	PF00149	0.327
DOC_PP2B_LxvP_1	192	195	PF13499	0.322
DOC_PP2B_PxIxI_1	184	190	PF00149	0.150
DOC_PP4_FxxP_1	20	23	PF00568	0.534
DOC_PP4_FxxP_1	397	400	PF00568	0.431
DOC_USP7_MATH_1	106	110	PF00917	0.272
DOC_USP7_MATH_1	264	268	PF00917	0.340
DOC_USP7_MATH_1	317	321	PF00917	0.449
DOC_USP7_MATH_1	331	335	PF00917	0.422
DOC_USP7_MATH_1	452	456	PF00917	0.367
DOC_USP7_MATH_1	478	482	PF00917	0.658
DOC_USP7_MATH_1	92	96	PF00917	0.430
DOC_USP7_UBL2_3	338	342	PF12436	0.406
DOC_WW_Pin1_4	1	6	PF00397	0.650
DOC_WW_Pin1_4	12	17	PF00397	0.516
DOC_WW_Pin1_4	19	24	PF00397	0.419
DOC_WW_Pin1_4	291	296	PF00397	0.323
DOC_WW_Pin1_4	346	351	PF00397	0.418
LIG_14-3-3_CanoR_1	202	206	PF00244	0.475
LIG_14-3-3_CanoR_1	396	400	PF00244	0.523
LIG_14-3-3_CanoR_1	480	484	PF00244	0.646
LIG_14-3-3_CanoR_1	500	504	PF00244	0.570
LIG_Actin_WH2_2	137	155	PF00022	0.292
LIG_Actin_WH2_2	369	386	PF00022	0.258
LIG_BRCT_BRCA1_1	366	370	PF00533	0.167
LIG_BRCT_BRCA1_1	442	446	PF00533	0.150
LIG_BRCT_BRCA1_1	463	467	PF00533	0.483
LIG_BRCT_BRCA1_1	66	70	PF00533	0.238
LIG_Clathr_ClatBox_1	373	377	PF01394	0.314
LIG_Clathr_ClatBox_1	486	490	PF01394	0.472
LIG_deltaCOP1_diTrp_1	277	284	PF00928	0.203
LIG_deltaCOP1_diTrp_1	493	496	PF00928	0.447
LIG_EH1_1	173	181	PF00400	0.292
LIG_eIF4E_1	442	448	PF01652	0.403
LIG_eIF4E_1	456	462	PF01652	0.494
LIG_FHA_1	117	123	PF00498	0.237
LIG_FHA_1	157	163	PF00498	0.282
LIG_FHA_1	2	8	PF00498	0.629
LIG_FHA_1	306	312	PF00498	0.252
LIG_FHA_1	35	41	PF00498	0.300
LIG_FHA_1	359	365	PF00498	0.239
LIG_FHA_1	396	402	PF00498	0.506
LIG_FHA_1	411	417	PF00498	0.497
LIG_FHA_1	422	428	PF00498	0.245
LIG_FHA_1	44	50	PF00498	0.327
LIG_FHA_1	449	455	PF00498	0.334
LIG_FHA_1	456	462	PF00498	0.424
LIG_FHA_2	483	489	PF00498	0.585
LIG_LIR_Apic_2	257	261	PF02991	0.279
LIG_LIR_Apic_2	344	350	PF02991	0.471
LIG_LIR_Apic_2	403	409	PF02991	0.423
LIG_LIR_Gen_1	109	117	PF02991	0.261
LIG_LIR_Gen_1	119	129	PF02991	0.280
LIG_LIR_Gen_1	281	291	PF02991	0.271
LIG_LIR_Gen_1	367	376	PF02991	0.332
LIG_LIR_Gen_1	390	400	PF02991	0.328
LIG_LIR_Gen_1	424	433	PF02991	0.295
LIG_LIR_Gen_1	455	462	PF02991	0.388
LIG_LIR_Gen_1	67	77	PF02991	0.200
LIG_LIR_Nem_3	109	113	PF02991	0.260
LIG_LIR_Nem_3	115	121	PF02991	0.272
LIG_LIR_Nem_3	128	133	PF02991	0.236
LIG_LIR_Nem_3	281	287	PF02991	0.259
LIG_LIR_Nem_3	367	373	PF02991	0.256
LIG_LIR_Nem_3	390	395	PF02991	0.346
LIG_LIR_Nem_3	424	428	PF02991	0.303
LIG_LIR_Nem_3	455	459	PF02991	0.276
LIG_LIR_Nem_3	481	486	PF02991	0.612
LIG_LIR_Nem_3	492	497	PF02991	0.564
LIG_LIR_Nem_3	67	73	PF02991	0.190
LIG_LYPXL_S_1	129	133	PF13949	0.450
LIG_LYPXL_yS_3	130	133	PF13949	0.242
LIG_NRBOX	187	193	PF00104	0.340
LIG_PDZ_Class_2	512	517	PF00595	0.582
LIG_Pex14_1	279	283	PF04695	0.230
LIG_Pex14_1	339	343	PF04695	0.449
LIG_Pex14_2	142	146	PF04695	0.403
LIG_Pex14_2	186	190	PF04695	0.257
LIG_Pex14_2	332	336	PF04695	0.493
LIG_PTB_Apo_2	124	131	PF02174	0.230
LIG_PTB_Apo_2	237	244	PF02174	0.465
LIG_PTB_Apo_2	270	277	PF02174	0.244
LIG_PTB_Phospho_1	124	130	PF10480	0.242
LIG_REV1ctd_RIR_1	333	342	PF16727	0.517
LIG_SH2_CRK	347	351	PF00017	0.448
LIG_SH2_CRK	442	446	PF00017	0.394
LIG_SH2_CRK	483	487	PF00017	0.591
LIG_SH2_GRB2like	209	212	PF00017	0.450
LIG_SH2_NCK_1	442	446	PF00017	0.150
LIG_SH2_NCK_1	475	479	PF00017	0.628
LIG_SH2_PTP2	258	261	PF00017	0.289
LIG_SH2_PTP2	456	459	PF00017	0.403
LIG_SH2_SRC	258	261	PF00017	0.279
LIG_SH2_SRC	475	478	PF00017	0.602
LIG_SH2_STAP1	343	347	PF00017	0.504
LIG_SH2_STAP1	381	385	PF00017	0.286
LIG_SH2_STAP1	442	446	PF00017	0.416
LIG_SH2_STAP1	45	49	PF00017	0.301
LIG_SH2_STAT5	137	140	PF00017	0.237
LIG_SH2_STAT5	205	208	PF00017	0.431
LIG_SH2_STAT5	209	212	PF00017	0.449
LIG_SH2_STAT5	258	261	PF00017	0.270
LIG_SH2_STAT5	45	48	PF00017	0.280
LIG_SH2_STAT5	456	459	PF00017	0.279
LIG_SH3_3	233	239	PF00018	0.423
LIG_SH3_3	25	31	PF00018	0.700
LIG_SUMO_SIM_anti_2	175	180	PF11976	0.180
LIG_SUMO_SIM_anti_2	36	42	PF11976	0.250
LIG_SUMO_SIM_par_1	361	367	PF11976	0.295
LIG_SUMO_SIM_par_1	384	391	PF11976	0.386
LIG_TRAF2_1	267	270	PF00917	0.142
LIG_TYR_ITIM	440	445	PF00017	0.364
LIG_TYR_ITIM	454	459	PF00017	0.218
LIG_UBA3_1	187	196	PF00899	0.301
LIG_UBA3_1	385	394	PF00899	0.307
LIG_WRC_WIRS_1	332	337	PF05994	0.505
LIG_WRC_WIRS_1	389	394	PF05994	0.370
MOD_CDK_SPK_2	19	24	PF00069	0.600
MOD_CDK_SPxxK_3	12	19	PF00069	0.558
MOD_CK1_1	109	115	PF00069	0.392
MOD_CK1_1	334	340	PF00069	0.476
MOD_CK1_1	455	461	PF00069	0.333
MOD_CK2_1	264	270	PF00069	0.236
MOD_CK2_1	467	473	PF00069	0.559
MOD_CK2_1	482	488	PF00069	0.560
MOD_GlcNHglycan	148	151	PF01048	0.293
MOD_GlcNHglycan	223	226	PF01048	0.260
MOD_GlcNHglycan	227	230	PF01048	0.260
MOD_GlcNHglycan	323	326	PF01048	0.278
MOD_GlcNHglycan	49	52	PF01048	0.291
MOD_GSK3_1	1	8	PF00069	0.648
MOD_GSK3_1	112	119	PF00069	0.265
MOD_GSK3_1	221	228	PF00069	0.419
MOD_GSK3_1	311	318	PF00069	0.271
MOD_GSK3_1	321	328	PF00069	0.424
MOD_GSK3_1	356	363	PF00069	0.292
MOD_GSK3_1	43	50	PF00069	0.269
MOD_GSK3_1	448	455	PF00069	0.357
MOD_GSK3_1	478	485	PF00069	0.638
MOD_N-GLC_1	198	203	PF02516	0.183
MOD_N-GLC_1	221	226	PF02516	0.252
MOD_N-GLC_1	356	361	PF02516	0.266
MOD_NEK2_1	117	122	PF00069	0.345
MOD_NEK2_1	156	161	PF00069	0.185
MOD_NEK2_1	174	179	PF00069	0.250
MOD_NEK2_1	198	203	PF00069	0.400
MOD_NEK2_1	311	316	PF00069	0.245
MOD_NEK2_1	355	360	PF00069	0.314
MOD_NEK2_1	364	369	PF00069	0.307
MOD_NEK2_1	395	400	PF00069	0.479
MOD_NEK2_1	432	437	PF00069	0.339
MOD_NEK2_1	441	446	PF00069	0.295
MOD_NEK2_1	467	472	PF00069	0.570
MOD_NEK2_1	55	60	PF00069	0.226
MOD_NEK2_2	137	142	PF00069	0.403
MOD_OFUCOSY	85	91	PF10250	0.234
MOD_PIKK_1	395	401	PF00454	0.523
MOD_PKA_2	201	207	PF00069	0.489
MOD_PKA_2	395	401	PF00069	0.493
MOD_PKA_2	479	485	PF00069	0.519
MOD_PKA_2	499	505	PF00069	0.587
MOD_Plk_1	125	131	PF00069	0.217
MOD_Plk_1	198	204	PF00069	0.405
MOD_Plk_1	356	362	PF00069	0.274
MOD_Plk_1	478	484	PF00069	0.548
MOD_Plk_1	510	516	PF00069	0.510
MOD_Plk_1	55	61	PF00069	0.195
MOD_Plk_4	106	112	PF00069	0.279
MOD_Plk_4	117	123	PF00069	0.261
MOD_Plk_4	125	131	PF00069	0.206
MOD_Plk_4	137	143	PF00069	0.289
MOD_Plk_4	174	180	PF00069	0.293
MOD_Plk_4	239	245	PF00069	0.426
MOD_Plk_4	24	30	PF00069	0.579
MOD_Plk_4	254	260	PF00069	0.216
MOD_Plk_4	311	317	PF00069	0.241
MOD_Plk_4	331	337	PF00069	0.395
MOD_Plk_4	36	42	PF00069	0.250
MOD_Plk_4	369	375	PF00069	0.265
MOD_Plk_4	388	394	PF00069	0.162
MOD_Plk_4	441	447	PF00069	0.296
MOD_Plk_4	452	458	PF00069	0.270
MOD_Plk_4	467	473	PF00069	0.497
MOD_Plk_4	482	488	PF00069	0.571
MOD_Plk_4	499	505	PF00069	0.635
MOD_Plk_4	64	70	PF00069	0.272
MOD_ProDKin_1	1	7	PF00069	0.650
MOD_ProDKin_1	12	18	PF00069	0.504
MOD_ProDKin_1	19	25	PF00069	0.423
MOD_ProDKin_1	291	297	PF00069	0.323
MOD_ProDKin_1	346	352	PF00069	0.418
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.628
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.322
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.465
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.244
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.267
TRG_ENDOCYTIC_2	130	133	PF00928	0.236
TRG_ENDOCYTIC_2	442	445	PF00928	0.350
TRG_ENDOCYTIC_2	456	459	PF00928	0.271
TRG_ENDOCYTIC_2	483	486	PF00928	0.572
TRG_ER_diArg_1	12	14	PF00400	0.593
TRG_ER_FFAT_1	470	481	PF00635	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2T0	Leptomonas seymouri	39%	89%
A0A0N1PGN1	Leptomonas seymouri	80%	99%
A0A0S4IJF6	Bodo saltans	28%	89%
A0A0S4ISA5	Bodo saltans	26%	89%
A0A0S4JBT0	Bodo saltans	25%	100%
A0A1X0NNQ0	Trypanosomatidae	33%	82%
A0A1X0NV66	Trypanosomatidae	35%	99%
A0A1X0P501	Trypanosomatidae	68%	95%
A0A3R7M6P3	Trypanosoma rangeli	32%	84%
A0A3R7N0T9	Trypanosoma rangeli	37%	100%
A0A3S5IRV3	Trypanosoma rangeli	65%	100%
A0A3S7WRN2	Leishmania donovani	36%	100%
A0A3S7XA01	Leishmania donovani	83%	100%
A2X8M8	Oryza sativa subsp. indica	30%	97%
A4H6H7	Leishmania braziliensis	36%	100%
A4H7J1	Leishmania braziliensis	35%	69%
A4HUW5	Leishmania infantum	36%	100%
A4IBY1	Leishmania infantum	83%	100%
C9ZYM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
D0A7J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AFR8	Leishmania major	83%	100%
E9ANJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B6X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
P37034	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)	25%	100%
Q4QH28	Leishmania major	36%	100%
Q6Z8D0	Oryza sativa subsp. japonica	30%	97%
Q9C6S4	Arabidopsis thaliana	29%	100%
Q9C6S5	Arabidopsis thaliana	31%	100%
Q9FFL1	Arabidopsis thaliana	29%	100%
Q9LH39	Arabidopsis thaliana	29%	100%
Q9LHN7	Arabidopsis thaliana	28%	100%
V5BCQ1	Trypanosoma cruzi	71%	100%
V5DDZ5	Trypanosoma cruzi	32%	82%