Charged multivesicular body protein 1b

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Snf7, putative

Species:

Leishmania braziliensis

UniProt:

A4HNA9_LEIBR

TriTrypDb:

LbrM.34.4380 , LBRM2903_340053900

Length:

205

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000815	ESCRT III complex	3	1
GO:0005737	cytoplasm	2	1
GO:0005768	endosome	7	1
GO:0005770	late endosome	8	1
GO:0005771	multivesicular body	9	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0036452	ESCRT complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNA9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007034	vacuolar transport	4	11
GO:0009987	cellular process	1	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.358
CLV_PCSK_SKI1_1	18	22	PF00082	0.453
CLV_PCSK_SKI1_1	88	92	PF00082	0.431
DEG_SCF_FBW7_2	144	150	PF00400	0.503
DOC_CKS1_1	144	149	PF01111	0.503
DOC_USP7_MATH_1	54	58	PF00917	0.362
DOC_USP7_MATH_1	76	80	PF00917	0.289
DOC_USP7_UBL2_3	14	18	PF12436	0.377
DOC_USP7_UBL2_3	88	92	PF12436	0.404
DOC_USP7_UBL2_3	99	103	PF12436	0.336
DOC_WW_Pin1_4	143	148	PF00397	0.431
LIG_14-3-3_CanoR_1	69	77	PF00244	0.494
LIG_Actin_WH2_2	6	24	PF00022	0.503
LIG_BIR_II_1	1	5	PF00653	0.494
LIG_CaM_IQ_9	6	21	PF13499	0.401
LIG_FHA_1	108	114	PF00498	0.413
LIG_FHA_1	124	130	PF00498	0.340
LIG_FHA_2	143	149	PF00498	0.432
LIG_LIR_Gen_1	121	132	PF02991	0.342
LIG_LIR_Nem_3	196	202	PF02991	0.572
LIG_NRP_CendR_1	203	205	PF00754	0.654
LIG_Pex14_2	11	15	PF04695	0.401
LIG_Pex14_2	120	124	PF04695	0.342
LIG_Rb_pABgroove_1	1	9	PF01858	0.605
LIG_SH2_STAP1	7	11	PF00017	0.553
LIG_SH2_STAT3	7	10	PF00017	0.548
LIG_SH3_3	141	147	PF00018	0.503
LIG_WRC_WIRS_1	117	122	PF05994	0.431
MOD_CK1_1	107	113	PF00069	0.250
MOD_CK2_1	142	148	PF00069	0.377
MOD_CK2_1	180	186	PF00069	0.705
MOD_CK2_1	22	28	PF00069	0.377
MOD_GlcNHglycan	130	133	PF01048	0.470
MOD_GlcNHglycan	135	138	PF01048	0.470
MOD_GlcNHglycan	70	73	PF01048	0.503
MOD_GSK3_1	104	111	PF00069	0.450
MOD_GSK3_1	123	130	PF00069	0.350
MOD_GSK3_1	138	145	PF00069	0.317
MOD_GSK3_1	76	83	PF00069	0.289
MOD_N-GLC_1	179	184	PF02516	0.775
MOD_N-GLC_1	22	27	PF02516	0.377
MOD_N-GLC_2	36	38	PF02516	0.470
MOD_NEK2_1	108	113	PF00069	0.511
MOD_NEK2_1	127	132	PF00069	0.457
MOD_NEK2_1	13	18	PF00069	0.441
MOD_NEK2_1	68	73	PF00069	0.499
MOD_NEK2_2	54	59	PF00069	0.377
MOD_PIKK_1	180	186	PF00454	0.666
MOD_PKA_2	68	74	PF00069	0.503
MOD_ProDKin_1	143	149	PF00069	0.431
MOD_SUMO_rev_2	183	190	PF00179	0.738
MOD_SUMO_rev_2	191	200	PF00179	0.671
TRG_DiLeu_BaEn_1	150	155	PF01217	0.401
TRG_ER_diArg_1	202	205	PF00400	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G2	Leptomonas seymouri	81%	100%
A0A0N1IMC7	Leptomonas seymouri	48%	100%
A0A0S4IQI9	Bodo saltans	49%	97%
A0A0S4JPB9	Bodo saltans	68%	100%
A0A1X0P5A2	Trypanosomatidae	75%	100%
A0A3Q8IGX6	Leishmania donovani	46%	100%
A0A3R7NNK8	Trypanosoma rangeli	70%	99%
A0A3S7X9V9	Leishmania donovani	94%	100%
A0A422N603	Trypanosoma rangeli	45%	98%
A4HLQ2	Leishmania braziliensis	47%	100%
A4I952	Leishmania infantum	46%	100%
A4IBY0	Leishmania infantum	94%	100%
C9ZYM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
D0A6C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	83%
E9AFR7	Leishmania major	93%	100%
E9B427	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B6X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O60074	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
O96552	Dictyostelium discoideum	53%	100%
P69771	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
Q4Q3Z7	Leishmania major	46%	100%
Q5E994	Bos taurus	46%	100%
Q5R605	Pongo abelii	45%	100%
Q5ZKX1	Gallus gallus	47%	100%
Q6DF27	Xenopus tropicalis	47%	100%
Q6NUD8	Xenopus laevis	45%	100%
Q6PHF0	Danio rerio	44%	100%
Q7LBR1	Homo sapiens	46%	100%
Q7SZB5	Xenopus laevis	47%	100%
Q7ZVB1	Danio rerio	47%	100%
Q84VG1	Oryza sativa subsp. japonica	47%	100%
Q8LE58	Arabidopsis thaliana	47%	100%
Q921W0	Mus musculus	45%	100%
Q941D5	Arabidopsis thaliana	27%	98%
Q99LU0	Mus musculus	46%	100%
Q9CQD4	Mus musculus	47%	100%
Q9HD42	Homo sapiens	45%	100%
Q9SKI2	Arabidopsis thaliana	28%	91%
Q9SSM4	Arabidopsis thaliana	47%	100%