TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TAX-1

Species:

Leishmania braziliensis

UniProt:

A4HNA8_LEIBR

TriTrypDb:

LbrM.34.4370 , LBRM2903_340053800

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNA8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004427	inorganic diphosphate phosphatase activity	6	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	259	261	PF00675	0.482
CLV_PCSK_KEX2_1	144	146	PF00082	0.513
CLV_PCSK_KEX2_1	22	24	PF00082	0.679
CLV_PCSK_KEX2_1	259	261	PF00082	0.446
CLV_PCSK_KEX2_1	310	312	PF00082	0.556
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.513
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.765
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.556
CLV_PCSK_PC7_1	306	312	PF00082	0.540
CLV_PCSK_SKI1_1	210	214	PF00082	0.499
CLV_PCSK_SKI1_1	5	9	PF00082	0.493
CLV_PCSK_SKI1_1	96	100	PF00082	0.399
DOC_CKS1_1	60	65	PF01111	0.562
DOC_MAPK_gen_1	120	129	PF00069	0.493
DOC_MAPK_HePTP_8	159	171	PF00069	0.504
DOC_MAPK_MEF2A_6	109	117	PF00069	0.479
DOC_MAPK_MEF2A_6	162	171	PF00069	0.469
DOC_MAPK_MEF2A_6	321	330	PF00069	0.339
DOC_PP4_FxxP_1	353	356	PF00568	0.539
DOC_USP7_MATH_1	184	188	PF00917	0.500
DOC_USP7_MATH_1	227	231	PF00917	0.441
DOC_USP7_MATH_1	24	28	PF00917	0.689
DOC_USP7_MATH_1	288	292	PF00917	0.427
DOC_USP7_MATH_1	295	299	PF00917	0.403
DOC_USP7_MATH_1	402	406	PF00917	0.776
DOC_USP7_UBL2_3	18	22	PF12436	0.549
DOC_WW_Pin1_4	315	320	PF00397	0.366
DOC_WW_Pin1_4	59	64	PF00397	0.545
LIG_14-3-3_CanoR_1	138	146	PF00244	0.484
LIG_14-3-3_CanoR_1	210	219	PF00244	0.332
LIG_14-3-3_CanoR_1	23	29	PF00244	0.625
LIG_Actin_WH2_2	148	164	PF00022	0.266
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BRCT_BRCA1_1	349	353	PF00533	0.435
LIG_deltaCOP1_diTrp_1	365	371	PF00928	0.380
LIG_FHA_1	138	144	PF00498	0.273
LIG_FHA_1	162	168	PF00498	0.454
LIG_FHA_1	252	258	PF00498	0.337
LIG_FHA_1	268	274	PF00498	0.401
LIG_FHA_1	62	68	PF00498	0.367
LIG_FHA_2	331	337	PF00498	0.482
LIG_FHA_2	375	381	PF00498	0.587
LIG_LIR_Apic_2	350	356	PF02991	0.540
LIG_LIR_Gen_1	2	7	PF02991	0.490
LIG_LIR_Gen_1	214	224	PF02991	0.364
LIG_LIR_Gen_1	243	253	PF02991	0.455
LIG_LIR_Gen_1	50	60	PF02991	0.380
LIG_LIR_Nem_3	2	6	PF02991	0.748
LIG_LIR_Nem_3	214	219	PF02991	0.362
LIG_LIR_Nem_3	243	249	PF02991	0.452
LIG_LIR_Nem_3	45	49	PF02991	0.416
LIG_LIR_Nem_3	50	56	PF02991	0.350
LIG_Pex14_1	367	371	PF04695	0.379
LIG_SH2_CRK	238	242	PF00017	0.329
LIG_SH2_CRK	3	7	PF00017	0.492
LIG_SH2_PTP2	158	161	PF00017	0.488
LIG_SH2_STAP1	246	250	PF00017	0.519
LIG_SH2_STAP1	269	273	PF00017	0.393
LIG_SH2_STAP1	3	7	PF00017	0.592
LIG_SH2_STAT5	133	136	PF00017	0.340
LIG_SH2_STAT5	158	161	PF00017	0.479
LIG_SH2_STAT5	202	205	PF00017	0.350
LIG_SH2_STAT5	218	221	PF00017	0.330
LIG_SH2_STAT5	269	272	PF00017	0.436
LIG_SH3_3	353	359	PF00018	0.568
LIG_SUMO_SIM_anti_2	54	62	PF11976	0.518
LIG_SUMO_SIM_par_1	54	62	PF11976	0.512
LIG_TRAF2_1	274	277	PF00917	0.616
LIG_TYR_ITIM	200	205	PF00017	0.263
LIG_TYR_ITIM	244	249	PF00017	0.422
LIG_WRC_WIRS_1	213	218	PF05994	0.342
MOD_CDC14_SPxK_1	318	321	PF00782	0.379
MOD_CDK_SPxK_1	315	321	PF00069	0.410
MOD_CK1_1	27	33	PF00069	0.644
MOD_CK2_1	184	190	PF00069	0.488
MOD_CK2_1	330	336	PF00069	0.463
MOD_CK2_1	366	372	PF00069	0.403
MOD_GlcNHglycan	400	403	PF01048	0.514
MOD_GlcNHglycan	81	84	PF01048	0.479
MOD_GSK3_1	1	8	PF00069	0.722
MOD_GSK3_1	14	21	PF00069	0.622
MOD_GSK3_1	161	168	PF00069	0.470
MOD_GSK3_1	30	37	PF00069	0.476
MOD_GSK3_1	330	337	PF00069	0.408
MOD_GSK3_1	398	405	PF00069	0.727
MOD_N-GLC_1	334	339	PF02516	0.278
MOD_N-GLC_1	42	47	PF02516	0.546
MOD_NEK2_1	1	6	PF00069	0.702
MOD_NEK2_1	136	141	PF00069	0.326
MOD_NEK2_1	7	12	PF00069	0.668
MOD_NEK2_1	70	75	PF00069	0.351
MOD_PIKK_1	137	143	PF00454	0.276
MOD_PIKK_1	34	40	PF00454	0.569
MOD_PIKK_1	347	353	PF00454	0.413
MOD_PKA_2	137	143	PF00069	0.471
MOD_PKB_1	77	85	PF00069	0.507
MOD_Plk_1	165	171	PF00069	0.441
MOD_Plk_1	34	40	PF00069	0.587
MOD_Plk_1	42	48	PF00069	0.428
MOD_ProDKin_1	315	321	PF00069	0.361
MOD_ProDKin_1	59	65	PF00069	0.554
MOD_SUMO_for_1	383	386	PF00179	0.564
TRG_DiLeu_BaEn_1	55	60	PF01217	0.383
TRG_DiLeu_BaEn_1	94	99	PF01217	0.415
TRG_ENDOCYTIC_2	133	136	PF00928	0.340
TRG_ENDOCYTIC_2	158	161	PF00928	0.488
TRG_ENDOCYTIC_2	202	205	PF00928	0.350
TRG_ENDOCYTIC_2	218	221	PF00928	0.330
TRG_ENDOCYTIC_2	238	241	PF00928	0.227
TRG_ENDOCYTIC_2	246	249	PF00928	0.355
TRG_ENDOCYTIC_2	3	6	PF00928	0.575
TRG_ER_diArg_1	115	118	PF00400	0.460
TRG_ER_diArg_1	77	80	PF00400	0.518
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P968	Leptomonas seymouri	75%	100%
A0A0S4JSR6	Bodo saltans	44%	70%
A0A1X0P6F9	Trypanosomatidae	54%	100%
A0A3R7KSW5	Trypanosoma rangeli	53%	100%
A0A3S7X9V3	Leishmania donovani	81%	99%
A4IBX9	Leishmania infantum	82%	99%
C9ZYM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AFR6	Leishmania major	80%	100%
E9B6W9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
V5BXU3	Trypanosoma cruzi	53%	100%