LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNA7_LEIBR

TriTrypDb:

LbrM.34.4360 , LBRM2903_340053700

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.585
CLV_C14_Caspase3-7	179	183	PF00656	0.598
CLV_C14_Caspase3-7	299	303	PF00656	0.587
CLV_C14_Caspase3-7	340	344	PF00656	0.579
CLV_NRD_NRD_1	102	104	PF00675	0.724
CLV_NRD_NRD_1	157	159	PF00675	0.633
CLV_NRD_NRD_1	187	189	PF00675	0.743
CLV_NRD_NRD_1	217	219	PF00675	0.711
CLV_NRD_NRD_1	247	249	PF00675	0.737
CLV_NRD_NRD_1	277	279	PF00675	0.701
CLV_NRD_NRD_1	332	334	PF00675	0.588
CLV_NRD_NRD_1	41	43	PF00675	0.646
CLV_NRD_NRD_1	72	74	PF00675	0.695
CLV_PCSK_KEX2_1	141	143	PF00082	0.651
CLV_PCSK_KEX2_1	316	318	PF00082	0.608
CLV_PCSK_KEX2_1	353	355	PF00082	0.726
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.651
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.608
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.726
CLV_PCSK_SKI1_1	142	146	PF00082	0.725
CLV_PCSK_SKI1_1	317	321	PF00082	0.671
CLV_PCSK_SKI1_1	36	40	PF00082	0.555
CLV_Separin_Metazoa	100	104	PF03568	0.688
CLV_Separin_Metazoa	155	159	PF03568	0.628
CLV_Separin_Metazoa	185	189	PF03568	0.700
CLV_Separin_Metazoa	215	219	PF03568	0.664
CLV_Separin_Metazoa	245	249	PF03568	0.724
CLV_Separin_Metazoa	275	279	PF03568	0.659
CLV_Separin_Metazoa	330	334	PF03568	0.574
CLV_Separin_Metazoa	70	74	PF03568	0.733
DEG_SPOP_SBC_1	337	341	PF00917	0.584
DOC_CKS1_1	506	511	PF01111	0.792
DOC_PP2B_LxvP_1	3	6	PF13499	0.603
DOC_USP7_MATH_1	510	514	PF00917	0.594
DOC_USP7_MATH_1	59	63	PF00917	0.799
DOC_USP7_UBL2_3	104	108	PF12436	0.729
DOC_USP7_UBL2_3	109	113	PF12436	0.691
DOC_USP7_UBL2_3	159	163	PF12436	0.750
DOC_USP7_UBL2_3	164	168	PF12436	0.678
DOC_USP7_UBL2_3	189	193	PF12436	0.734
DOC_USP7_UBL2_3	194	198	PF12436	0.705
DOC_USP7_UBL2_3	219	223	PF12436	0.657
DOC_USP7_UBL2_3	224	228	PF12436	0.716
DOC_USP7_UBL2_3	249	253	PF12436	0.753
DOC_USP7_UBL2_3	254	258	PF12436	0.711
DOC_USP7_UBL2_3	279	283	PF12436	0.636
DOC_USP7_UBL2_3	284	288	PF12436	0.682
DOC_USP7_UBL2_3	74	78	PF12436	0.710
DOC_USP7_UBL2_3	79	83	PF12436	0.661
DOC_WW_Pin1_4	108	113	PF00397	0.676
DOC_WW_Pin1_4	163	168	PF00397	0.714
DOC_WW_Pin1_4	193	198	PF00397	0.681
DOC_WW_Pin1_4	223	228	PF00397	0.625
DOC_WW_Pin1_4	253	258	PF00397	0.706
DOC_WW_Pin1_4	283	288	PF00397	0.619
DOC_WW_Pin1_4	505	510	PF00397	0.698
DOC_WW_Pin1_4	78	83	PF00397	0.741
LIG_14-3-3_CanoR_1	42	47	PF00244	0.410
LIG_14-3-3_CanoR_1	498	506	PF00244	0.590
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_FHA_1	506	512	PF00498	0.795
LIG_FHA_2	338	344	PF00498	0.582
LIG_LIR_Gen_1	343	351	PF02991	0.584
LIG_LIR_Nem_3	343	349	PF02991	0.585
LIG_RPA_C_Fungi	37	49	PF08784	0.394
LIG_SH2_GRB2like	23	26	PF00017	0.389
LIG_SH2_NCK_1	23	27	PF00017	0.621
LIG_SH2_NCK_1	346	350	PF00017	0.590
LIG_SH2_SRC	346	349	PF00017	0.588
LIG_SH2_STAP1	23	27	PF00017	0.621
LIG_SH2_STAP1	40	44	PF00017	0.361
LIG_SH2_STAT5	15	18	PF00017	0.489
LIG_SH2_STAT5	23	26	PF00017	0.523
LIG_SH3_3	131	137	PF00018	0.808
LIG_SH3_3	154	160	PF00018	0.826
LIG_SH3_3	184	190	PF00018	0.821
LIG_SH3_3	214	220	PF00018	0.800
LIG_SH3_3	244	250	PF00018	0.821
LIG_SH3_3	274	280	PF00018	0.799
LIG_SH3_3	306	312	PF00018	0.820
LIG_SH3_3	329	335	PF00018	0.762
LIG_SH3_3	69	75	PF00018	0.677
LIG_SH3_3	99	105	PF00018	0.807
LIG_SH3_4	104	111	PF00018	0.772
LIG_SH3_4	159	166	PF00018	0.783
LIG_SH3_4	189	196	PF00018	0.775
LIG_SH3_4	219	226	PF00018	0.614
LIG_SH3_4	249	256	PF00018	0.833
LIG_SH3_4	279	286	PF00018	0.603
LIG_SH3_4	74	81	PF00018	0.833
LIG_TRAF2_1	29	32	PF00917	0.545
MOD_CDK_SPK_2	108	113	PF00069	0.676
MOD_CDK_SPK_2	163	168	PF00069	0.714
MOD_CDK_SPK_2	193	198	PF00069	0.681
MOD_CDK_SPK_2	223	228	PF00069	0.625
MOD_CDK_SPK_2	253	258	PF00069	0.706
MOD_CDK_SPK_2	283	288	PF00069	0.619
MOD_CDK_SPK_2	78	83	PF00069	0.741
MOD_CK1_1	47	53	PF00069	0.620
MOD_GlcNHglycan	46	49	PF01048	0.545
MOD_GlcNHglycan	55	58	PF01048	0.622
MOD_GSK3_1	121	128	PF00069	0.592
MOD_GSK3_1	142	149	PF00069	0.615
MOD_GSK3_1	176	183	PF00069	0.614
MOD_GSK3_1	296	303	PF00069	0.603
MOD_GSK3_1	317	324	PF00069	0.619
MOD_GSK3_1	337	344	PF00069	0.582
MOD_GSK3_1	370	377	PF00069	0.831
MOD_GSK3_1	38	45	PF00069	0.398
MOD_GSK3_1	510	517	PF00069	0.796
MOD_GSK3_1	59	66	PF00069	0.798
MOD_N-GLC_1	145	150	PF02516	0.589
MOD_N-GLC_1	320	325	PF02516	0.587
MOD_N-GLC_1	341	346	PF02516	0.582
MOD_N-GLC_1	370	375	PF02516	0.737
MOD_N-GLC_1	514	519	PF02516	0.710
MOD_NEK2_1	514	519	PF00069	0.560
MOD_PIKK_1	499	505	PF00454	0.555
MOD_PIKK_1	50	56	PF00454	0.427
MOD_PK_1	42	48	PF00069	0.411
MOD_PKA_1	42	48	PF00069	0.411
MOD_Plk_1	514	520	PF00069	0.711
MOD_Plk_2-3	123	129	PF00069	0.681
MOD_Plk_2-3	178	184	PF00069	0.742
MOD_Plk_2-3	208	214	PF00069	0.713
MOD_Plk_2-3	238	244	PF00069	0.727
MOD_Plk_2-3	268	274	PF00069	0.692
MOD_Plk_2-3	298	304	PF00069	0.737
MOD_Plk_2-3	63	69	PF00069	0.621
MOD_Plk_2-3	93	99	PF00069	0.731
MOD_ProDKin_1	108	114	PF00069	0.677
MOD_ProDKin_1	163	169	PF00069	0.716
MOD_ProDKin_1	193	199	PF00069	0.684
MOD_ProDKin_1	223	229	PF00069	0.627
MOD_ProDKin_1	253	259	PF00069	0.707
MOD_ProDKin_1	283	289	PF00069	0.622
MOD_ProDKin_1	505	511	PF00069	0.696
MOD_ProDKin_1	78	84	PF00069	0.743
MOD_SUMO_for_1	6	9	PF00179	0.537
TRG_ENDOCYTIC_2	15	18	PF00928	0.481
TRG_ENDOCYTIC_2	346	349	PF00928	0.588
TRG_ER_diArg_1	495	498	PF00400	0.572
TRG_NLS_MonoCore_2	352	357	PF00514	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X9Y7	Leishmania donovani	58%	82%
A4IBX8	Leishmania infantum	52%	93%
C9ZYM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	94%
E9AFR5	Leishmania major	57%	100%
E9B6W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	95%