Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNA3_LEIBR

TriTrypDb:

LbrM.34.4320 , LBRM2903_340053300

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HNA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.539
CLV_NRD_NRD_1	171	173	PF00675	0.542
CLV_NRD_NRD_1	185	187	PF00675	0.525
CLV_NRD_NRD_1	3	5	PF00675	0.642
CLV_NRD_NRD_1	42	44	PF00675	0.636
CLV_NRD_NRD_1	65	67	PF00675	0.588
CLV_NRD_NRD_1	96	98	PF00675	0.624
CLV_PCSK_KEX2_1	136	138	PF00082	0.539
CLV_PCSK_KEX2_1	171	173	PF00082	0.533
CLV_PCSK_KEX2_1	185	187	PF00082	0.507
CLV_PCSK_KEX2_1	3	5	PF00082	0.642
CLV_PCSK_KEX2_1	95	97	PF00082	0.660
CLV_PCSK_SKI1_1	164	168	PF00082	0.546
CLV_PCSK_SKI1_1	171	175	PF00082	0.499
CLV_PCSK_SKI1_1	230	234	PF00082	0.590
CLV_PCSK_SKI1_1	37	41	PF00082	0.597
DEG_Nend_Nbox_1	1	3	PF02207	0.492
DEG_SCF_FBW7_2	190	196	PF00400	0.268
DOC_CDC14_PxL_1	46	54	PF14671	0.422
DOC_CKS1_1	190	195	PF01111	0.264
DOC_CYCLIN_RxL_1	93	102	PF00134	0.442
DOC_MAPK_RevD_3	28	44	PF00069	0.268
DOC_USP7_MATH_1	324	328	PF00917	0.578
DOC_USP7_UBL2_3	326	330	PF12436	0.653
DOC_WW_Pin1_4	153	158	PF00397	0.419
DOC_WW_Pin1_4	189	194	PF00397	0.255
LIG_14-3-3_CanoR_1	112	117	PF00244	0.397
LIG_14-3-3_CanoR_1	3	10	PF00244	0.456
LIG_14-3-3_CanoR_1	66	75	PF00244	0.276
LIG_Clathr_ClatBox_1	166	170	PF01394	0.301
LIG_FHA_1	140	146	PF00498	0.398
LIG_FHA_1	229	235	PF00498	0.406
LIG_FHA_1	258	264	PF00498	0.401
LIG_FHA_1	315	321	PF00498	0.602
LIG_FHA_1	70	76	PF00498	0.375
LIG_FHA_2	115	121	PF00498	0.452
LIG_FHA_2	153	159	PF00498	0.408
LIG_FHA_2	197	203	PF00498	0.344
LIG_FHA_2	217	223	PF00498	0.411
LIG_FHA_2	241	247	PF00498	0.422
LIG_FHA_2	257	263	PF00498	0.344
LIG_IRF3_LxIS_1	203	210	PF10401	0.260
LIG_LIR_Gen_1	243	251	PF02991	0.375
LIG_LIR_Gen_1	273	283	PF02991	0.367
LIG_LIR_Gen_1	5	15	PF02991	0.292
LIG_LIR_Nem_3	243	247	PF02991	0.397
LIG_LIR_Nem_3	273	278	PF02991	0.376
LIG_LIR_Nem_3	295	299	PF02991	0.373
LIG_LIR_Nem_3	48	52	PF02991	0.403
LIG_LIR_Nem_3	5	10	PF02991	0.397
LIG_LYPXL_yS_3	49	52	PF13949	0.441
LIG_NRBOX	162	168	PF00104	0.342
LIG_Pex14_1	286	290	PF04695	0.346
LIG_Pex14_1	293	297	PF04695	0.312
LIG_SH2_STAP1	110	114	PF00017	0.400
LIG_SH2_STAT5	126	129	PF00017	0.370
LIG_SH2_STAT5	332	335	PF00017	0.644
LIG_SH2_STAT5	46	49	PF00017	0.357
LIG_SH3_3	19	25	PF00018	0.384
LIG_SH3_3	262	268	PF00018	0.382
LIG_SH3_5	45	49	PF00018	0.277
LIG_SUMO_SIM_anti_2	165	170	PF11976	0.347
LIG_SUMO_SIM_anti_2	300	308	PF11976	0.388
LIG_SUMO_SIM_par_1	111	117	PF11976	0.428
LIG_SUMO_SIM_par_1	165	170	PF11976	0.364
LIG_TRAF2_1	199	202	PF00917	0.325
LIG_TRAF2_1	236	239	PF00917	0.427
LIG_TRAF2_1	39	42	PF00917	0.457
LIG_TYR_ITIM	283	288	PF00017	0.282
LIG_TYR_ITIM	47	52	PF00017	0.264
LIG_UBA3_1	12	21	PF00899	0.400
LIG_UBA3_1	206	213	PF00899	0.388
LIG_UBA3_1	309	313	PF00899	0.462
MOD_CK1_1	69	75	PF00069	0.383
MOD_CK2_1	114	120	PF00069	0.472
MOD_CK2_1	152	158	PF00069	0.423
MOD_CK2_1	196	202	PF00069	0.411
MOD_CK2_1	216	222	PF00069	0.432
MOD_CK2_1	240	246	PF00069	0.370
MOD_CK2_1	256	262	PF00069	0.324
MOD_CMANNOS	286	289	PF00535	0.335
MOD_Cter_Amidation	183	186	PF01082	0.602
MOD_GlcNHglycan	13	16	PF01048	0.617
MOD_GlcNHglycan	224	227	PF01048	0.507
MOD_GlcNHglycan	326	329	PF01048	0.388
MOD_GSK3_1	147	154	PF00069	0.410
MOD_GSK3_1	192	199	PF00069	0.427
MOD_GSK3_1	207	214	PF00069	0.330
MOD_GSK3_1	333	340	PF00069	0.634
MOD_GSK3_1	69	76	PF00069	0.297
MOD_N-GLC_1	216	221	PF02516	0.639
MOD_N-GLC_1	240	245	PF02516	0.575
MOD_NEK2_1	2	7	PF00069	0.473
MOD_NEK2_1	207	212	PF00069	0.437
MOD_NEK2_1	228	233	PF00069	0.427
MOD_NEK2_1	278	283	PF00069	0.406
MOD_NEK2_2	292	297	PF00069	0.480
MOD_PIKK_1	114	120	PF00454	0.448
MOD_PIKK_1	139	145	PF00454	0.270
MOD_PIKK_1	177	183	PF00454	0.418
MOD_PK_1	112	118	PF00069	0.415
MOD_PKA_1	136	142	PF00069	0.350
MOD_PKA_1	171	177	PF00069	0.430
MOD_PKA_1	66	72	PF00069	0.396
MOD_PKA_1	73	79	PF00069	0.421
MOD_PKA_2	136	142	PF00069	0.355
MOD_PKA_2	171	177	PF00069	0.402
MOD_PKA_2	2	8	PF00069	0.470
MOD_PKA_2	254	260	PF00069	0.433
MOD_PKA_2	278	284	PF00069	0.435
MOD_PKA_2	314	320	PF00069	0.510
MOD_Plk_1	216	222	PF00069	0.443
MOD_Plk_1	240	246	PF00069	0.344
MOD_Plk_1	257	263	PF00069	0.286
MOD_Plk_2-3	196	202	PF00069	0.351
MOD_Plk_4	136	142	PF00069	0.364
MOD_Plk_4	278	284	PF00069	0.352
MOD_Plk_4	292	298	PF00069	0.298
MOD_ProDKin_1	153	159	PF00069	0.409
MOD_ProDKin_1	189	195	PF00069	0.261
MOD_SUMO_for_1	197	200	PF00179	0.359
MOD_SUMO_rev_2	195	199	PF00179	0.361
MOD_SUMO_rev_2	41	45	PF00179	0.444
TRG_DiLeu_BaEn_1	158	163	PF01217	0.383
TRG_DiLeu_BaEn_1	202	207	PF01217	0.383
TRG_DiLeu_BaEn_1	302	307	PF01217	0.480
TRG_DiLeu_LyEn_5	202	207	PF01217	0.411
TRG_ENDOCYTIC_2	110	113	PF00928	0.402
TRG_ENDOCYTIC_2	285	288	PF00928	0.335
TRG_ENDOCYTIC_2	49	52	PF00928	0.423
TRG_ER_diArg_1	135	137	PF00400	0.337
TRG_ER_diArg_1	171	173	PF00400	0.338
TRG_ER_diArg_1	185	187	PF00400	0.307
TRG_ER_diArg_1	2	4	PF00400	0.452
TRG_ER_diArg_1	94	97	PF00400	0.432
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4W7	Leptomonas seymouri	73%	100%
A0A0S4JN93	Bodo saltans	46%	100%
A0A1X0P510	Trypanosomatidae	54%	99%
A0A3Q8IVJ8	Leishmania donovani	88%	100%
A4IBX4	Leishmania infantum	88%	100%
C9ZYN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	84%
E9AFR1	Leishmania major	87%	100%
E9B6W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BXU8	Trypanosoma cruzi	52%	99%