Pre-RNA processing PIH1/Nop17 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17, putative

Species:

Leishmania braziliensis

UniProt:

A4HNA2_LEIBR

TriTrypDb:

LbrM.34.4310 , LBRM2903_340053200

Length:

632

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.521
CLV_C14_Caspase3-7	523	527	PF00656	0.466
CLV_NRD_NRD_1	178	180	PF00675	0.362
CLV_NRD_NRD_1	346	348	PF00675	0.364
CLV_NRD_NRD_1	408	410	PF00675	0.282
CLV_NRD_NRD_1	477	479	PF00675	0.458
CLV_NRD_NRD_1	519	521	PF00675	0.531
CLV_PCSK_KEX2_1	178	180	PF00082	0.381
CLV_PCSK_KEX2_1	308	310	PF00082	0.638
CLV_PCSK_KEX2_1	346	348	PF00082	0.335
CLV_PCSK_KEX2_1	47	49	PF00082	0.557
CLV_PCSK_KEX2_1	477	479	PF00082	0.640
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.647
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.626
CLV_PCSK_PC7_1	342	348	PF00082	0.362
CLV_PCSK_SKI1_1	294	298	PF00082	0.563
CLV_PCSK_SKI1_1	435	439	PF00082	0.647
CLV_PCSK_SKI1_1	626	630	PF00082	0.551
CLV_PCSK_SKI1_1	65	69	PF00082	0.334
DEG_APCC_DBOX_1	504	512	PF00400	0.537
DEG_APCC_KENBOX_2	122	126	PF00400	0.405
DEG_APCC_KENBOX_2	316	320	PF00400	0.480
DEG_Nend_UBRbox_3	1	3	PF02207	0.645
DOC_CYCLIN_RxL_1	623	632	PF00134	0.551
DOC_MAPK_gen_1	406	416	PF00069	0.511
DOC_MAPK_HePTP_8	378	394	PF00069	0.405
DOC_MAPK_MEF2A_6	409	418	PF00069	0.495
DOC_MAPK_RevD_3	331	347	PF00069	0.562
DOC_PP1_RVXF_1	201	208	PF00149	0.562
DOC_PP2B_LxvP_1	328	331	PF13499	0.534
DOC_PP4_FxxP_1	84	87	PF00568	0.558
DOC_USP7_MATH_1	239	243	PF00917	0.736
DOC_USP7_MATH_1	270	274	PF00917	0.719
DOC_USP7_MATH_1	292	296	PF00917	0.516
DOC_USP7_MATH_1	366	370	PF00917	0.558
DOC_USP7_MATH_1	41	45	PF00917	0.429
DOC_USP7_MATH_1	567	571	PF00917	0.732
DOC_USP7_UBL2_3	38	42	PF12436	0.431
DOC_USP7_UBL2_3	406	410	PF12436	0.482
DOC_USP7_UBL2_3	561	565	PF12436	0.699
DOC_USP7_UBL2_3	65	69	PF12436	0.492
DOC_WW_Pin1_4	268	273	PF00397	0.725
DOC_WW_Pin1_4	278	283	PF00397	0.692
DOC_WW_Pin1_4	384	389	PF00397	0.562
DOC_WW_Pin1_4	565	570	PF00397	0.761
DOC_WW_Pin1_4	576	581	PF00397	0.737
DOC_WW_Pin1_4	596	601	PF00397	0.541
LIG_14-3-3_CanoR_1	137	147	PF00244	0.562
LIG_14-3-3_CanoR_1	409	414	PF00244	0.496
LIG_14-3-3_CanoR_1	477	481	PF00244	0.501
LIG_14-3-3_CanoR_1	553	558	PF00244	0.488
LIG_Clathr_ClatBox_1	628	632	PF01394	0.563
LIG_CtBP_PxDLS_1	580	584	PF00389	0.509
LIG_DLG_GKlike_1	409	416	PF00625	0.586
LIG_FHA_1	282	288	PF00498	0.698
LIG_FHA_1	409	415	PF00498	0.562
LIG_FHA_2	333	339	PF00498	0.513
LIG_FHA_2	429	435	PF00498	0.644
LIG_FHA_2	436	442	PF00498	0.591
LIG_FHA_2	61	67	PF00498	0.492
LIG_IBAR_NPY_1	313	315	PF08397	0.495
LIG_KLC1_Yacidic_2	349	354	PF13176	0.513
LIG_LIR_Apic_2	133	139	PF02991	0.482
LIG_LIR_Gen_1	14	24	PF02991	0.606
LIG_LIR_Gen_1	387	397	PF02991	0.564
LIG_LIR_Nem_3	14	19	PF02991	0.611
LIG_LIR_Nem_3	174	180	PF02991	0.482
LIG_LIR_Nem_3	200	205	PF02991	0.544
LIG_LIR_Nem_3	387	392	PF02991	0.564
LIG_Pex14_2	16	20	PF04695	0.454
LIG_Pex14_2	619	623	PF04695	0.421
LIG_PTB_Apo_2	10	17	PF02174	0.476
LIG_PTB_Apo_2	201	208	PF02174	0.496
LIG_PTB_Apo_2	310	317	PF02174	0.523
LIG_SH2_CRK	136	140	PF00017	0.562
LIG_SH2_CRK	159	163	PF00017	0.482
LIG_SH2_STAP1	159	163	PF00017	0.482
LIG_SH2_STAT5	315	318	PF00017	0.496
LIG_SH2_STAT5	352	355	PF00017	0.482
LIG_SH2_STAT5	407	410	PF00017	0.562
LIG_SH2_STAT5	480	483	PF00017	0.497
LIG_SH2_STAT5	543	546	PF00017	0.479
LIG_SH2_STAT5	627	630	PF00017	0.551
LIG_SH3_2	118	123	PF14604	0.405
LIG_SH3_3	115	121	PF00018	0.538
LIG_SH3_3	259	265	PF00018	0.703
LIG_SH3_3	417	423	PF00018	0.482
LIG_SUMO_SIM_par_1	579	584	PF11976	0.513
LIG_TRAF2_1	126	129	PF00917	0.448
LIG_TRAF2_1	605	608	PF00917	0.524
LIG_UBA3_1	36	42	PF00899	0.558
LIG_UBA3_1	413	417	PF00899	0.378
LIG_UBA3_1	540	547	PF00899	0.545
MOD_CK1_1	193	199	PF00069	0.408
MOD_CK1_1	384	390	PF00069	0.354
MOD_CK1_1	579	585	PF00069	0.634
MOD_CK1_1	599	605	PF00069	0.652
MOD_CK2_1	332	338	PF00069	0.335
MOD_CK2_1	428	434	PF00069	0.656
MOD_CK2_1	435	441	PF00069	0.626
MOD_CK2_1	476	482	PF00069	0.519
MOD_CK2_1	60	66	PF00069	0.303
MOD_GlcNHglycan	129	133	PF01048	0.329
MOD_GlcNHglycan	220	223	PF01048	0.227
MOD_GlcNHglycan	241	244	PF01048	0.701
MOD_GlcNHglycan	272	275	PF01048	0.782
MOD_GlcNHglycan	29	32	PF01048	0.679
MOD_GlcNHglycan	368	371	PF01048	0.468
MOD_GlcNHglycan	383	386	PF01048	0.222
MOD_GlcNHglycan	488	491	PF01048	0.630
MOD_GlcNHglycan	576	579	PF01048	0.611
MOD_GlcNHglycan	583	586	PF01048	0.648
MOD_GSK3_1	235	242	PF00069	0.664
MOD_GSK3_1	264	271	PF00069	0.648
MOD_GSK3_1	272	279	PF00069	0.663
MOD_GSK3_1	377	384	PF00069	0.452
MOD_GSK3_1	482	489	PF00069	0.634
MOD_GSK3_1	565	572	PF00069	0.755
MOD_LATS_1	307	313	PF00433	0.663
MOD_N-GLC_1	265	270	PF02516	0.536
MOD_N-GLC_1	3	8	PF02516	0.428
MOD_N-GLC_1	302	307	PF02516	0.392
MOD_N-GLC_1	482	487	PF02516	0.611
MOD_N-GLC_1	609	614	PF02516	0.569
MOD_N-GLC_2	106	108	PF02516	0.335
MOD_NEK2_1	36	41	PF00069	0.655
MOD_NEK2_1	609	614	PF00069	0.645
MOD_NEK2_2	302	307	PF00069	0.392
MOD_NEK2_2	332	337	PF00069	0.480
MOD_PIKK_1	244	250	PF00454	0.736
MOD_PIKK_1	423	429	PF00454	0.680
MOD_PIKK_1	599	605	PF00454	0.747
MOD_PK_1	521	527	PF00069	0.534
MOD_PKA_1	381	387	PF00069	0.227
MOD_PKA_1	409	415	PF00069	0.480
MOD_PKA_2	218	224	PF00069	0.335
MOD_PKA_2	408	414	PF00069	0.335
MOD_PKA_2	476	482	PF00069	0.504
MOD_Plk_1	302	308	PF00069	0.399
MOD_Plk_1	482	488	PF00069	0.618
MOD_Plk_2-3	476	482	PF00069	0.523
MOD_Plk_2-3	546	552	PF00069	0.662
MOD_Plk_4	374	380	PF00069	0.227
MOD_Plk_4	409	415	PF00069	0.480
MOD_Plk_4	482	488	PF00069	0.417
MOD_ProDKin_1	268	274	PF00069	0.726
MOD_ProDKin_1	278	284	PF00069	0.690
MOD_ProDKin_1	384	390	PF00069	0.447
MOD_ProDKin_1	565	571	PF00069	0.761
MOD_ProDKin_1	576	582	PF00069	0.735
MOD_ProDKin_1	596	602	PF00069	0.540
MOD_SUMO_for_1	287	290	PF00179	0.739
MOD_SUMO_for_1	46	49	PF00179	0.630
MOD_SUMO_rev_2	399	408	PF00179	0.408
TRG_DiLeu_BaEn_2	175	181	PF01217	0.378
TRG_ENDOCYTIC_2	159	162	PF00928	0.335
TRG_ER_diArg_1	177	179	PF00400	0.447
TRG_ER_diArg_1	217	220	PF00400	0.335
TRG_ER_diArg_1	346	348	PF00400	0.475
TRG_ER_diArg_1	552	555	PF00400	0.712
TRG_NES_CRM1_1	538	551	PF08389	0.427
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6F3	Leptomonas seymouri	65%	100%
A0A1X0P509	Trypanosomatidae	48%	100%
A0A3Q8IIQ5	Leishmania donovani	80%	100%
A0A422NU93	Trypanosoma rangeli	49%	100%
A4IBX3	Leishmania infantum	80%	100%
C9ZYN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AFR0	Leishmania major	80%	100%
E9B6W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5BT79	Trypanosoma cruzi	47%	100%