HAD-superfamily hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HAD hydrolase, TIGR01456 family/HAD hydrolase, family IIA, putative

Species:

Leishmania braziliensis

UniProt:

A4HNA1_LEIBR

TriTrypDb:

LbrM.34.4300 , LBRM2903_340053100

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNA1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.463
CLV_NRD_NRD_1	20	22	PF00675	0.558
CLV_NRD_NRD_1	290	292	PF00675	0.481
CLV_NRD_NRD_1	482	484	PF00675	0.308
CLV_NRD_NRD_1	50	52	PF00675	0.575
CLV_NRD_NRD_1	76	78	PF00675	0.587
CLV_NRD_NRD_1	92	94	PF00675	0.366
CLV_PCSK_KEX2_1	20	22	PF00082	0.545
CLV_PCSK_KEX2_1	290	292	PF00082	0.438
CLV_PCSK_KEX2_1	315	317	PF00082	0.509
CLV_PCSK_KEX2_1	482	484	PF00082	0.308
CLV_PCSK_KEX2_1	76	78	PF00082	0.704
CLV_PCSK_KEX2_1	92	94	PF00082	0.366
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.551
CLV_PCSK_SKI1_1	118	122	PF00082	0.423
CLV_PCSK_SKI1_1	166	170	PF00082	0.381
CLV_PCSK_SKI1_1	251	255	PF00082	0.179
CLV_PCSK_SKI1_1	393	397	PF00082	0.371
CLV_PCSK_SKI1_1	443	447	PF00082	0.269
CLV_PCSK_SKI1_1	515	519	PF00082	0.330
CLV_PCSK_SKI1_1	93	97	PF00082	0.537
DEG_APCC_DBOX_1	392	400	PF00400	0.375
DEG_Nend_UBRbox_1	1	4	PF02207	0.632
DOC_CKS1_1	177	182	PF01111	0.418
DOC_CKS1_1	365	370	PF01111	0.469
DOC_CYCLIN_RxL_1	512	522	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.437
DOC_MAPK_MEF2A_6	214	222	PF00069	0.449
DOC_PP2B_LxvP_1	218	221	PF13499	0.437
DOC_PP2B_LxvP_1	262	265	PF13499	0.448
DOC_PP2B_LxvP_1	350	353	PF13499	0.404
DOC_PP4_FxxP_1	22	25	PF00568	0.508
DOC_USP7_MATH_1	127	131	PF00917	0.560
DOC_USP7_MATH_1	134	138	PF00917	0.637
DOC_USP7_MATH_1	323	327	PF00917	0.375
DOC_USP7_UBL2_3	156	160	PF12436	0.523
DOC_WW_Pin1_4	173	178	PF00397	0.661
DOC_WW_Pin1_4	255	260	PF00397	0.442
DOC_WW_Pin1_4	274	279	PF00397	0.437
DOC_WW_Pin1_4	364	369	PF00397	0.441
DOC_WW_Pin1_4	499	504	PF00397	0.365
DOC_WW_Pin1_4	527	532	PF00397	0.578
DOC_WW_Pin1_4	98	103	PF00397	0.601
LIG_14-3-3_CanoR_1	171	177	PF00244	0.444
LIG_14-3-3_CanoR_1	2	7	PF00244	0.666
LIG_14-3-3_CanoR_1	214	219	PF00244	0.540
LIG_14-3-3_CanoR_1	290	296	PF00244	0.429
LIG_14-3-3_CanoR_1	482	488	PF00244	0.462
LIG_Actin_WH2_2	428	445	PF00022	0.221
LIG_BRCT_BRCA1_1	18	22	PF00533	0.721
LIG_EH1_1	511	519	PF00400	0.418
LIG_eIF4E_1	199	205	PF01652	0.480
LIG_FHA_1	123	129	PF00498	0.426
LIG_FHA_1	215	221	PF00498	0.539
LIG_FHA_1	482	488	PF00498	0.528
LIG_FHA_2	30	36	PF00498	0.591
LIG_FHA_2	343	349	PF00498	0.369
LIG_LIR_Apic_2	162	167	PF02991	0.465
LIG_LIR_Apic_2	19	25	PF02991	0.615
LIG_LIR_Apic_2	502	508	PF02991	0.350
LIG_LIR_Apic_2	65	71	PF02991	0.443
LIG_LIR_Gen_1	337	347	PF02991	0.378
LIG_LIR_Gen_1	398	408	PF02991	0.399
LIG_LIR_LC3C_4	270	275	PF02991	0.491
LIG_LIR_Nem_3	321	327	PF02991	0.369
LIG_LIR_Nem_3	337	343	PF02991	0.312
LIG_LIR_Nem_3	34	40	PF02991	0.502
LIG_LIR_Nem_3	398	403	PF02991	0.396
LIG_LYPXL_SIV_4	368	376	PF13949	0.468
LIG_LYPXL_SIV_4	420	428	PF13949	0.368
LIG_NRBOX	239	245	PF00104	0.539
LIG_NRBOX	346	352	PF00104	0.367
LIG_Pex14_2	22	26	PF04695	0.507
LIG_SH2_CRK	413	417	PF00017	0.289
LIG_SH2_CRK	68	72	PF00017	0.431
LIG_SH2_NCK_1	400	404	PF00017	0.518
LIG_SH2_NCK_1	68	72	PF00017	0.431
LIG_SH2_PTP2	164	167	PF00017	0.481
LIG_SH2_PTP2	505	508	PF00017	0.343
LIG_SH2_STAP1	141	145	PF00017	0.486
LIG_SH2_STAP1	161	165	PF00017	0.441
LIG_SH2_STAP1	490	494	PF00017	0.344
LIG_SH2_STAT5	105	108	PF00017	0.439
LIG_SH2_STAT5	164	167	PF00017	0.481
LIG_SH2_STAT5	360	363	PF00017	0.432
LIG_SH2_STAT5	369	372	PF00017	0.284
LIG_SH2_STAT5	505	508	PF00017	0.343
LIG_SH3_3	174	180	PF00018	0.613
LIG_SH3_3	272	278	PF00018	0.462
LIG_SH3_3	319	325	PF00018	0.392
LIG_SUMO_SIM_anti_2	269	277	PF11976	0.542
LIG_SUMO_SIM_anti_2	345	351	PF11976	0.369
LIG_SUMO_SIM_par_1	269	277	PF11976	0.423
LIG_SUMO_SIM_par_1	483	489	PF11976	0.486
LIG_TRFH_1	68	72	PF08558	0.431
LIG_UBA3_1	149	156	PF00899	0.344
MOD_CDC14_SPxK_1	258	261	PF00782	0.539
MOD_CDK_SPK_2	176	181	PF00069	0.433
MOD_CDK_SPK_2	98	103	PF00069	0.487
MOD_CDK_SPxK_1	255	261	PF00069	0.504
MOD_CDK_SPxK_1	98	104	PF00069	0.598
MOD_CK1_1	137	143	PF00069	0.609
MOD_CK1_1	172	178	PF00069	0.672
MOD_CK1_1	497	503	PF00069	0.375
MOD_CK2_1	172	178	PF00069	0.525
MOD_CK2_1	29	35	PF00069	0.516
MOD_CK2_1	331	337	PF00069	0.477
MOD_CK2_1	395	401	PF00069	0.496
MOD_GlcNHglycan	238	243	PF01048	0.230
MOD_GlcNHglycan	327	330	PF01048	0.444
MOD_GlcNHglycan	361	364	PF01048	0.502
MOD_GlcNHglycan	42	45	PF01048	0.479
MOD_GlcNHglycan	430	434	PF01048	0.370
MOD_GlcNHglycan	472	475	PF01048	0.274
MOD_GSK3_1	12	19	PF00069	0.647
MOD_GSK3_1	137	144	PF00069	0.608
MOD_GSK3_1	166	173	PF00069	0.638
MOD_GSK3_1	359	366	PF00069	0.418
MOD_GSK3_1	395	402	PF00069	0.503
MOD_N-GLC_1	137	142	PF02516	0.584
MOD_N-GLC_1	527	532	PF02516	0.398
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NEK2_1	12	17	PF00069	0.603
MOD_NEK2_1	121	126	PF00069	0.529
MOD_NEK2_1	170	175	PF00069	0.560
MOD_NEK2_1	184	189	PF00069	0.347
MOD_NEK2_1	359	364	PF00069	0.617
MOD_NEK2_1	395	400	PF00069	0.451
MOD_NEK2_1	465	470	PF00069	0.368
MOD_PK_1	291	297	PF00069	0.393
MOD_PK_1	483	489	PF00069	0.612
MOD_PKA_2	1	7	PF00069	0.589
MOD_PKA_2	170	176	PF00069	0.440
MOD_PKA_2	213	219	PF00069	0.379
MOD_PKA_2	481	487	PF00069	0.490
MOD_Plk_1	137	143	PF00069	0.636
MOD_Plk_1	238	244	PF00069	0.480
MOD_Plk_1	429	435	PF00069	0.193
MOD_Plk_2-3	342	348	PF00069	0.383
MOD_Plk_2-3	62	68	PF00069	0.563
MOD_Plk_4	2	8	PF00069	0.641
MOD_Plk_4	342	348	PF00069	0.376
MOD_Plk_4	395	401	PF00069	0.496
MOD_ProDKin_1	173	179	PF00069	0.660
MOD_ProDKin_1	255	261	PF00069	0.442
MOD_ProDKin_1	274	280	PF00069	0.437
MOD_ProDKin_1	364	370	PF00069	0.436
MOD_ProDKin_1	499	505	PF00069	0.362
MOD_ProDKin_1	527	533	PF00069	0.581
MOD_ProDKin_1	98	104	PF00069	0.598
MOD_SUMO_rev_2	110	120	PF00179	0.337
MOD_SUMO_rev_2	152	158	PF00179	0.565
MOD_SUMO_rev_2	27	33	PF00179	0.487
TRG_DiLeu_BaEn_1	239	244	PF01217	0.462
TRG_DiLeu_BaEn_1	269	274	PF01217	0.491
TRG_DiLeu_BaEn_1	430	435	PF01217	0.193
TRG_DiLeu_BaEn_3	90	96	PF01217	0.573
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.569
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.539
TRG_ENDOCYTIC_2	400	403	PF00928	0.521
TRG_ER_diArg_1	20	22	PF00400	0.535
TRG_ER_diArg_1	289	291	PF00400	0.487
TRG_ER_diArg_1	76	78	PF00400	0.587
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I3	Leptomonas seymouri	72%	100%
A0A0S4JPF8	Bodo saltans	53%	100%
A0A1X0P5B2	Trypanosomatidae	59%	100%
A0A3Q8IMX2	Leishmania donovani	84%	100%
A0A3R7L7A5	Trypanosoma rangeli	60%	100%
A4IBX2	Leishmania infantum	84%	100%
C9ZYN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AFQ9	Leishmania major	84%	100%
E9B6W2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BCR1	Trypanosoma cruzi	60%	100%