Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN99_LEIBR

TriTrypDb:

LbrM.34.4280 , LBRM2903_340052900

Length:

247

Annotations

LeishMANIAdb annotations

A very conserved protein restricted to Kinetoplastids, protentially involved in coiled-coil interactions

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.361
CLV_NRD_NRD_1	179	181	PF00675	0.329
CLV_NRD_NRD_1	25	27	PF00675	0.690
CLV_NRD_NRD_1	54	56	PF00675	0.612
CLV_NRD_NRD_1	74	76	PF00675	0.606
CLV_PCSK_KEX2_1	178	180	PF00082	0.331
CLV_PCSK_KEX2_1	2	4	PF00082	0.634
CLV_PCSK_KEX2_1	244	246	PF00082	0.338
CLV_PCSK_KEX2_1	25	27	PF00082	0.690
CLV_PCSK_KEX2_1	53	55	PF00082	0.609
CLV_PCSK_KEX2_1	73	75	PF00082	0.601
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.355
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.708
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.338
CLV_PCSK_SKI1_1	148	152	PF00082	0.323
CLV_PCSK_SKI1_1	179	183	PF00082	0.394
CLV_PCSK_SKI1_1	26	30	PF00082	0.559
CLV_Separin_Metazoa	155	159	PF03568	0.560
DEG_APCC_DBOX_1	147	155	PF00400	0.525
DEG_Nend_UBRbox_1	1	4	PF02207	0.456
DOC_MAPK_gen_1	158	165	PF00069	0.549
DOC_MAPK_gen_1	178	184	PF00069	0.552
DOC_MAPK_gen_1	73	80	PF00069	0.415
LIG_14-3-3_CanoR_1	228	234	PF00244	0.549
LIG_14-3-3_CanoR_1	25	31	PF00244	0.389
LIG_14-3-3_CanoR_1	3	8	PF00244	0.426
LIG_DLG_GKlike_1	3	11	PF00625	0.345
LIG_FHA_1	117	123	PF00498	0.390
LIG_FHA_1	145	151	PF00498	0.542
LIG_FHA_1	209	215	PF00498	0.624
LIG_FHA_1	82	88	PF00498	0.431
LIG_FHA_1	90	96	PF00498	0.367
LIG_LIR_Nem_3	97	102	PF02991	0.346
LIG_Pex14_2	101	105	PF04695	0.328
LIG_SH2_CRK	27	31	PF00017	0.362
LIG_SH2_STAP1	27	31	PF00017	0.507
LIG_SH2_STAT3	172	175	PF00017	0.536
LIG_SH2_STAT5	233	236	PF00017	0.513
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.554
LIG_SUMO_SIM_par_1	76	81	PF11976	0.457
LIG_TRAF2_1	67	70	PF00917	0.475
LIG_UBA3_1	150	159	PF00899	0.628
MOD_CK1_1	17	23	PF00069	0.477
MOD_CK1_1	6	12	PF00069	0.402
MOD_CK1_1	81	87	PF00069	0.431
MOD_CK2_1	149	155	PF00069	0.544
MOD_GlcNHglycan	16	19	PF01048	0.691
MOD_GlcNHglycan	8	11	PF01048	0.632
MOD_GSK3_1	125	132	PF00069	0.624
MOD_GSK3_1	2	9	PF00069	0.355
MOD_N-GLC_1	81	86	PF02516	0.621
MOD_NEK2_1	116	121	PF00069	0.290
MOD_NEK2_1	80	85	PF00069	0.416
MOD_NEK2_2	111	116	PF00069	0.201
MOD_PIKK_1	116	122	PF00454	0.286
MOD_PIKK_1	131	137	PF00454	0.681
MOD_PIKK_1	227	233	PF00454	0.546
MOD_PKA_1	2	8	PF00069	0.424
MOD_PKA_1	53	59	PF00069	0.406
MOD_PKA_2	125	131	PF00069	0.623
MOD_PKA_2	2	8	PF00069	0.431
MOD_PKA_2	205	211	PF00069	0.609
MOD_PKA_2	227	233	PF00069	0.558
MOD_PKA_2	53	59	PF00069	0.406
MOD_Plk_2-3	149	155	PF00069	0.539
MOD_Plk_2-3	45	51	PF00069	0.421
MOD_Plk_4	26	32	PF00069	0.361
MOD_Plk_4	3	9	PF00069	0.499
MOD_Plk_4	94	100	PF00069	0.350
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.540
TRG_ENDOCYTIC_2	27	30	PF00928	0.358
TRG_ENDOCYTIC_2	99	102	PF00928	0.363
TRG_ER_diArg_1	24	26	PF00400	0.433
TRG_ER_diArg_1	53	55	PF00400	0.607
TRG_ER_diArg_1	72	75	PF00400	0.504
TRG_ER_diLys_1	242	247	PF00400	0.540
TRG_Pf-PMV_PEXEL_1	148	153	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X4	Leptomonas seymouri	74%	97%
A0A0S4KGJ1	Bodo saltans	71%	100%
A0A1X0P6H7	Trypanosomatidae	80%	94%
A0A3Q8IIE6	Leishmania donovani	83%	99%
A0A422NU86	Trypanosoma rangeli	74%	97%
A4IBX0	Leishmania infantum	84%	99%
C9ZYN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	98%
E9AFQ7	Leishmania major	84%	100%
E9B6W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
V5DUI0	Trypanosoma cruzi	78%	100%