DUF4408 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HN98_LEIBR

TriTrypDb:

LbrM.34.4270 , LBRM2903_340052700

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HN98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	220	226	PF00089	0.385
CLV_NRD_NRD_1	60	62	PF00675	0.395
CLV_PCSK_KEX2_1	129	131	PF00082	0.465
CLV_PCSK_KEX2_1	272	274	PF00082	0.404
CLV_PCSK_KEX2_1	284	286	PF00082	0.431
CLV_PCSK_KEX2_1	59	61	PF00082	0.395
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.465
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.387
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.371
CLV_PCSK_PC7_1	56	62	PF00082	0.359
CLV_PCSK_SKI1_1	111	115	PF00082	0.442
CLV_PCSK_SKI1_1	218	222	PF00082	0.386
CLV_PCSK_SKI1_1	284	288	PF00082	0.376
CLV_PCSK_SKI1_1	298	302	PF00082	0.438
DEG_SCF_FBW7_1	300	305	PF00400	0.575
DEG_SPOP_SBC_1	103	107	PF00917	0.709
DEG_SPOP_SBC_1	7	11	PF00917	0.349
DOC_CYCLIN_RxL_1	282	292	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	135	141	PF00134	0.685
DOC_MAPK_MEF2A_6	185	193	PF00069	0.733
DOC_PP1_RVXF_1	10	16	PF00149	0.347
DOC_PP2B_LxvP_1	139	142	PF13499	0.673
DOC_SPAK_OSR1_1	238	242	PF12202	0.661
DOC_USP7_MATH_1	103	107	PF00917	0.656
DOC_USP7_MATH_1	212	216	PF00917	0.689
DOC_USP7_MATH_1	294	298	PF00917	0.678
DOC_USP7_MATH_1	302	306	PF00917	0.716
DOC_USP7_MATH_1	46	50	PF00917	0.598
DOC_USP7_MATH_1	7	11	PF00917	0.447
DOC_USP7_MATH_1	95	99	PF00917	0.615
DOC_USP7_UBL2_3	316	320	PF12436	0.609
DOC_USP7_UBL2_3	47	51	PF12436	0.494
DOC_WW_Pin1_4	150	155	PF00397	0.702
DOC_WW_Pin1_4	298	303	PF00397	0.577
DOC_WW_Pin1_4	99	104	PF00397	0.778
LIG_14-3-3_CanoR_1	12	16	PF00244	0.348
LIG_14-3-3_CanoR_1	243	251	PF00244	0.643
LIG_14-3-3_CanoR_1	260	268	PF00244	0.617
LIG_14-3-3_CanoR_1	308	312	PF00244	0.616
LIG_FHA_1	174	180	PF00498	0.856
LIG_FHA_1	195	201	PF00498	0.610
LIG_FHA_1	215	221	PF00498	0.669
LIG_FHA_1	288	294	PF00498	0.664
LIG_FHA_1	319	325	PF00498	0.725
LIG_LIR_Gen_1	14	20	PF02991	0.401
LIG_LIR_Nem_3	14	18	PF02991	0.404
LIG_PCNA_yPIPBox_3	267	281	PF02747	0.629
LIG_SH2_CRK	140	144	PF00017	0.614
LIG_SH2_SRC	140	143	PF00017	0.615
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.324
LIG_TYR_ITIM	29	34	PF00017	0.381
MOD_CDK_SPK_2	150	155	PF00069	0.685
MOD_CDK_SPxxK_3	104	111	PF00069	0.643
MOD_CK1_1	106	112	PF00069	0.731
MOD_CK1_1	195	201	PF00069	0.667
MOD_CK1_1	204	210	PF00069	0.678
MOD_CK1_1	229	235	PF00069	0.634
MOD_CK1_1	245	251	PF00069	0.765
MOD_CK1_1	252	258	PF00069	0.641
MOD_CK1_1	304	310	PF00069	0.636
MOD_CK1_1	6	12	PF00069	0.464
MOD_CK1_1	81	87	PF00069	0.657
MOD_CK1_1	98	104	PF00069	0.789
MOD_CK2_1	106	112	PF00069	0.645
MOD_CK2_1	125	131	PF00069	0.723
MOD_CK2_1	165	171	PF00069	0.688
MOD_CK2_1	259	265	PF00069	0.600
MOD_GlcNHglycan	194	197	PF01048	0.519
MOD_GlcNHglycan	214	217	PF01048	0.498
MOD_GlcNHglycan	228	231	PF01048	0.447
MOD_GlcNHglycan	5	8	PF01048	0.651
MOD_GlcNHglycan	88	91	PF01048	0.421
MOD_GSK3_1	103	110	PF00069	0.685
MOD_GSK3_1	111	118	PF00069	0.668
MOD_GSK3_1	181	188	PF00069	0.688
MOD_GSK3_1	194	201	PF00069	0.668
MOD_GSK3_1	202	209	PF00069	0.795
MOD_GSK3_1	210	217	PF00069	0.726
MOD_GSK3_1	225	232	PF00069	0.619
MOD_GSK3_1	245	252	PF00069	0.678
MOD_GSK3_1	294	301	PF00069	0.601
MOD_GSK3_1	3	10	PF00069	0.473
MOD_GSK3_1	318	325	PF00069	0.767
MOD_GSK3_1	80	87	PF00069	0.708
MOD_GSK3_1	95	102	PF00069	0.715
MOD_N-GLC_1	120	125	PF02516	0.421
MOD_N-GLC_1	181	186	PF02516	0.526
MOD_N-GLC_1	245	250	PF02516	0.503
MOD_N-GLC_2	256	258	PF02516	0.483
MOD_NEK2_1	113	118	PF00069	0.677
MOD_NEK2_1	165	170	PF00069	0.652
MOD_NEK2_1	18	23	PF00069	0.407
MOD_NEK2_1	200	205	PF00069	0.661
MOD_NEK2_1	206	211	PF00069	0.669
MOD_NEK2_1	226	231	PF00069	0.623
MOD_NEK2_1	289	294	PF00069	0.658
MOD_NEK2_1	86	91	PF00069	0.610
MOD_NEK2_2	46	51	PF00069	0.492
MOD_NMyristoyl	1	7	PF02799	0.379
MOD_PIKK_1	229	235	PF00454	0.660
MOD_PKA_2	11	17	PF00069	0.347
MOD_PKA_2	242	248	PF00069	0.790
MOD_PKA_2	249	255	PF00069	0.728
MOD_PKA_2	259	265	PF00069	0.607
MOD_PKA_2	307	313	PF00069	0.610
MOD_PKA_2	81	87	PF00069	0.593
MOD_Plk_1	120	126	PF00069	0.639
MOD_Plk_1	198	204	PF00069	0.652
MOD_Plk_4	185	191	PF00069	0.720
MOD_ProDKin_1	150	156	PF00069	0.703
MOD_ProDKin_1	298	304	PF00069	0.578
MOD_ProDKin_1	99	105	PF00069	0.780
MOD_SUMO_for_1	319	322	PF00179	0.612
TRG_DiLeu_BaEn_1	25	30	PF01217	0.324
TRG_DiLeu_BaEn_4	25	31	PF01217	0.216
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.635
TRG_ENDOCYTIC_2	140	143	PF00928	0.615
TRG_ENDOCYTIC_2	31	34	PF00928	0.391
TRG_ER_diArg_1	59	61	PF00400	0.595
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK89	Leptomonas seymouri	38%	100%
A0A3S7X9U4	Leishmania donovani	63%	100%
A4IBW9	Leishmania infantum	63%	100%
E9AFQ6	Leishmania major	58%	100%
E9B6V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%