SAS-6_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spindle assembly abnormal protein 6 homolog

Species:

Leishmania braziliensis

UniProt:

A4HN97_LEIBR

TriTrypDb:

LbrM.34.4260 , LBRM2903_340052600

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0043226	organelle	2	10
GO:0043229	intracellular organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HN97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN97

PDB structure(s): 4ckm_A , 4ckm_B , 4ckm_C , 4ckn_A , 4ckn_B , 4ckn_C , 4ckn_D , 4ckp_A , 4ckp_B , 4ckp_C , 4ckp_D , 4ckp_E , 4ckp_F

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007099	centriole replication	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0031023	microtubule organizing center organization	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0098534	centriole assembly	4	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.506
CLV_C14_Caspase3-7	627	631	PF00656	0.476
CLV_NRD_NRD_1	318	320	PF00675	0.527
CLV_NRD_NRD_1	32	34	PF00675	0.761
CLV_NRD_NRD_1	547	549	PF00675	0.576
CLV_NRD_NRD_1	564	566	PF00675	0.554
CLV_NRD_NRD_1	71	73	PF00675	0.778
CLV_PCSK_KEX2_1	272	274	PF00082	0.430
CLV_PCSK_KEX2_1	31	33	PF00082	0.755
CLV_PCSK_KEX2_1	547	549	PF00082	0.576
CLV_PCSK_KEX2_1	71	73	PF00082	0.741
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.430
CLV_PCSK_PC7_1	27	33	PF00082	0.764
CLV_PCSK_SKI1_1	128	132	PF00082	0.393
CLV_PCSK_SKI1_1	167	171	PF00082	0.492
CLV_PCSK_SKI1_1	326	330	PF00082	0.390
CLV_PCSK_SKI1_1	519	523	PF00082	0.469
CLV_PCSK_SKI1_1	785	789	PF00082	0.612
CLV_Separin_Metazoa	562	566	PF03568	0.553
DEG_APCC_DBOX_1	110	118	PF00400	0.727
DEG_APCC_DBOX_1	127	135	PF00400	0.276
DEG_APCC_DBOX_1	166	174	PF00400	0.481
DEG_APCC_DBOX_1	241	249	PF00400	0.485
DEG_APCC_DBOX_1	570	578	PF00400	0.329
DEG_Nend_Nbox_1	1	3	PF02207	0.721
DOC_ANK_TNKS_1	216	223	PF00023	0.568
DOC_ANK_TNKS_1	70	77	PF00023	0.777
DOC_MAPK_gen_1	196	205	PF00069	0.377
DOC_MAPK_gen_1	301	309	PF00069	0.580
DOC_MAPK_gen_1	317	327	PF00069	0.556
DOC_MAPK_MEF2A_6	196	205	PF00069	0.467
DOC_MAPK_MEF2A_6	254	263	PF00069	0.467
DOC_MAPK_NFAT4_5	196	204	PF00069	0.467
DOC_PP2B_LxvP_1	651	654	PF13499	0.453
DOC_PP2B_LxvP_1	659	662	PF13499	0.433
DOC_PP4_FxxP_1	23	26	PF00568	0.757
DOC_USP7_MATH_1	120	124	PF00917	0.741
DOC_USP7_MATH_1	461	465	PF00917	0.603
DOC_USP7_MATH_1	615	619	PF00917	0.681
DOC_USP7_MATH_1	662	666	PF00917	0.507
DOC_USP7_MATH_1	715	719	PF00917	0.694
DOC_USP7_MATH_1	753	757	PF00917	0.686
DOC_USP7_MATH_1	761	765	PF00917	0.426
DOC_USP7_MATH_1	783	787	PF00917	0.677
DOC_USP7_MATH_1	804	808	PF00917	0.608
DOC_USP7_UBL2_3	502	506	PF12436	0.561
DOC_WD40_RPTOR_TOS_1	183	189	PF00400	0.485
DOC_WW_Pin1_4	100	105	PF00397	0.548
DOC_WW_Pin1_4	116	121	PF00397	0.719
DOC_WW_Pin1_4	403	408	PF00397	0.478
DOC_WW_Pin1_4	683	688	PF00397	0.645
DOC_WW_Pin1_4	709	714	PF00397	0.726
LIG_14-3-3_CanoR_1	108	117	PF00244	0.751
LIG_14-3-3_CanoR_1	172	176	PF00244	0.467
LIG_14-3-3_CanoR_1	287	294	PF00244	0.411
LIG_14-3-3_CanoR_1	317	327	PF00244	0.603
LIG_14-3-3_CanoR_1	388	396	PF00244	0.682
LIG_14-3-3_CanoR_1	42	50	PF00244	0.767
LIG_14-3-3_CanoR_1	565	574	PF00244	0.563
LIG_14-3-3_CanoR_1	664	668	PF00244	0.699
LIG_14-3-3_CanoR_1	776	780	PF00244	0.762
LIG_14-3-3_CanoR_1	796	805	PF00244	0.691
LIG_Actin_WH2_2	249	267	PF00022	0.485
LIG_Actin_WH2_2	362	379	PF00022	0.601
LIG_Actin_WH2_2	442	458	PF00022	0.525
LIG_AP2alpha_2	178	180	PF02296	0.467
LIG_BIR_III_4	384	388	PF00653	0.430
LIG_BRCT_BRCA1_1	176	180	PF00533	0.376
LIG_BRCT_BRCA1_1	19	23	PF00533	0.760
LIG_BRCT_BRCA1_1	636	640	PF00533	0.611
LIG_BRCT_BRCA1_1	806	810	PF00533	0.588
LIG_CaM_IQ_9	557	573	PF13499	0.594
LIG_Clathr_ClatBox_1	182	186	PF01394	0.485
LIG_CtBP_PxDLS_1	104	108	PF00389	0.481
LIG_FHA_1	164	170	PF00498	0.514
LIG_FHA_1	242	248	PF00498	0.467
LIG_FHA_1	295	301	PF00498	0.468
LIG_FHA_1	371	377	PF00498	0.599
LIG_FHA_1	555	561	PF00498	0.549
LIG_FHA_1	599	605	PF00498	0.640
LIG_FHA_1	674	680	PF00498	0.462
LIG_FHA_1	688	694	PF00498	0.437
LIG_FHA_1	726	732	PF00498	0.721
LIG_FHA_2	120	126	PF00498	0.568
LIG_FHA_2	319	325	PF00498	0.494
LIG_FHA_2	328	334	PF00498	0.538
LIG_FHA_2	377	383	PF00498	0.615
LIG_FHA_2	448	454	PF00498	0.568
LIG_FHA_2	696	702	PF00498	0.696
LIG_Integrin_isoDGR_2	605	607	PF01839	0.576
LIG_LIR_Apic_2	20	26	PF02991	0.733
LIG_LIR_Gen_1	189	199	PF02991	0.568
LIG_LIR_Gen_1	445	455	PF02991	0.527
LIG_LIR_Gen_1	480	487	PF02991	0.453
LIG_LIR_Nem_3	177	183	PF02991	0.469
LIG_LIR_Nem_3	189	195	PF02991	0.464
LIG_LIR_Nem_3	204	208	PF02991	0.467
LIG_LIR_Nem_3	250	256	PF02991	0.469
LIG_LIR_Nem_3	277	282	PF02991	0.413
LIG_LIR_Nem_3	445	451	PF02991	0.529
LIG_LIR_Nem_3	480	485	PF02991	0.454
LIG_LIR_Nem_3	777	782	PF02991	0.708
LIG_MLH1_MIPbox_1	806	810	PF16413	0.588
LIG_Pex14_2	640	644	PF04695	0.660
LIG_SH2_CRK	656	660	PF00017	0.589
LIG_SH2_PTP2	448	451	PF00017	0.527
LIG_SH2_PTP2	482	485	PF00017	0.459
LIG_SH2_STAP1	226	230	PF00017	0.508
LIG_SH2_STAP1	282	286	PF00017	0.456
LIG_SH2_STAT3	476	479	PF00017	0.441
LIG_SH2_STAT5	154	157	PF00017	0.484
LIG_SH2_STAT5	211	214	PF00017	0.464
LIG_SH2_STAT5	274	277	PF00017	0.388
LIG_SH2_STAT5	448	451	PF00017	0.527
LIG_SH2_STAT5	482	485	PF00017	0.459
LIG_SH3_1	140	146	PF00018	0.605
LIG_SH3_3	140	146	PF00018	0.533
LIG_SH3_3	173	179	PF00018	0.482
LIG_SH3_3	38	44	PF00018	0.704
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.476
LIG_SUMO_SIM_anti_2	184	191	PF11976	0.365
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.467
LIG_SUMO_SIM_par_1	132	139	PF11976	0.504
LIG_TRAF2_1	123	126	PF00917	0.720
LIG_TRAF2_1	321	324	PF00917	0.524
LIG_TRAF2_1	368	371	PF00917	0.573
LIG_TRAF2_1	464	467	PF00917	0.533
LIG_TRAF2_1	718	721	PF00917	0.721
LIG_TYR_ITIM	446	451	PF00017	0.528
LIG_WRC_WIRS_1	784	789	PF05994	0.713
MOD_CDK_SPK_2	116	121	PF00069	0.768
MOD_CK1_1	10	16	PF00069	0.722
MOD_CK1_1	103	109	PF00069	0.507
MOD_CK1_1	119	125	PF00069	0.440
MOD_CK1_1	18	24	PF00069	0.739
MOD_CK1_1	289	295	PF00069	0.500
MOD_CK1_1	534	540	PF00069	0.533
MOD_CK1_1	686	692	PF00069	0.503
MOD_CK1_1	725	731	PF00069	0.709
MOD_CK1_1	739	745	PF00069	0.620
MOD_CK2_1	119	125	PF00069	0.656
MOD_CK2_1	221	227	PF00069	0.511
MOD_CK2_1	318	324	PF00069	0.465
MOD_CK2_1	327	333	PF00069	0.533
MOD_CK2_1	376	382	PF00069	0.610
MOD_CK2_1	439	445	PF00069	0.427
MOD_CK2_1	447	453	PF00069	0.497
MOD_CK2_1	461	467	PF00069	0.440
MOD_CK2_1	695	701	PF00069	0.604
MOD_CK2_1	715	721	PF00069	0.718
MOD_CK2_1	741	747	PF00069	0.507
MOD_GlcNHglycan	122	125	PF01048	0.713
MOD_GlcNHglycan	189	195	PF01048	0.335
MOD_GlcNHglycan	223	226	PF01048	0.375
MOD_GlcNHglycan	613	616	PF01048	0.637
MOD_GlcNHglycan	681	684	PF01048	0.669
MOD_GlcNHglycan	724	727	PF01048	0.746
MOD_GlcNHglycan	749	752	PF01048	0.712
MOD_GlcNHglycan	755	758	PF01048	0.705
MOD_GlcNHglycan	763	766	PF01048	0.436
MOD_GlcNHglycan	806	809	PF01048	0.608
MOD_GSK3_1	1	8	PF00069	0.721
MOD_GSK3_1	11	18	PF00069	0.718
MOD_GSK3_1	116	123	PF00069	0.711
MOD_GSK3_1	237	244	PF00069	0.464
MOD_GSK3_1	248	255	PF00069	0.442
MOD_GSK3_1	282	289	PF00069	0.571
MOD_GSK3_1	435	442	PF00069	0.511
MOD_GSK3_1	457	464	PF00069	0.566
MOD_GSK3_1	50	57	PF00069	0.768
MOD_GSK3_1	611	618	PF00069	0.679
MOD_GSK3_1	621	628	PF00069	0.641
MOD_GSK3_1	663	670	PF00069	0.559
MOD_GSK3_1	679	686	PF00069	0.545
MOD_GSK3_1	697	704	PF00069	0.667
MOD_GSK3_1	705	712	PF00069	0.708
MOD_GSK3_1	725	732	PF00069	0.645
MOD_GSK3_1	739	746	PF00069	0.588
MOD_GSK3_1	749	756	PF00069	0.681
MOD_N-GLC_1	351	356	PF02516	0.350
MOD_NEK2_1	1	6	PF00069	0.716
MOD_NEK2_1	130	135	PF00069	0.572
MOD_NEK2_1	376	381	PF00069	0.590
MOD_NEK2_1	455	460	PF00069	0.523
MOD_NEK2_1	50	55	PF00069	0.759
MOD_NEK2_1	598	603	PF00069	0.517
MOD_NEK2_1	629	634	PF00069	0.567
MOD_NEK2_1	663	668	PF00069	0.582
MOD_NEK2_1	673	678	PF00069	0.540
MOD_NEK2_1	705	710	PF00069	0.600
MOD_NEK2_1	774	779	PF00069	0.524
MOD_NEK2_2	282	287	PF00069	0.528
MOD_PIKK_1	531	537	PF00454	0.449
MOD_PIKK_1	588	594	PF00454	0.497
MOD_PIKK_1	716	722	PF00454	0.707
MOD_PIKK_1	755	761	PF00454	0.483
MOD_PIKK_1	791	797	PF00454	0.760
MOD_PKA_1	565	571	PF00069	0.549
MOD_PKA_2	155	161	PF00069	0.461
MOD_PKA_2	171	177	PF00069	0.457
MOD_PKA_2	241	247	PF00069	0.481
MOD_PKA_2	286	292	PF00069	0.544
MOD_PKA_2	318	324	PF00069	0.504
MOD_PKA_2	354	360	PF00069	0.486
MOD_PKA_2	376	382	PF00069	0.642
MOD_PKA_2	387	393	PF00069	0.683
MOD_PKA_2	455	461	PF00069	0.561
MOD_PKA_2	663	669	PF00069	0.705
MOD_PKA_2	701	707	PF00069	0.741
MOD_PKA_2	736	742	PF00069	0.679
MOD_PKA_2	747	753	PF00069	0.718
MOD_PKA_2	775	781	PF00069	0.525
MOD_PKB_1	454	462	PF00069	0.521
MOD_Plk_1	190	196	PF00069	0.494
MOD_Plk_1	226	232	PF00069	0.527
MOD_Plk_1	282	288	PF00069	0.529
MOD_Plk_1	289	295	PF00069	0.534
MOD_Plk_2-3	252	258	PF00069	0.467
MOD_Plk_2-3	695	701	PF00069	0.482
MOD_Plk_4	130	136	PF00069	0.497
MOD_Plk_4	18	24	PF00069	0.777
MOD_Plk_4	226	232	PF00069	0.517
MOD_Plk_4	534	540	PF00069	0.551
MOD_Plk_4	663	669	PF00069	0.686
MOD_Plk_4	7	13	PF00069	0.740
MOD_Plk_4	701	707	PF00069	0.665
MOD_Plk_4	783	789	PF00069	0.633
MOD_ProDKin_1	100	106	PF00069	0.548
MOD_ProDKin_1	116	122	PF00069	0.716
MOD_ProDKin_1	403	409	PF00069	0.480
MOD_ProDKin_1	683	689	PF00069	0.645
MOD_ProDKin_1	709	715	PF00069	0.721
MOD_SUMO_for_1	433	436	PF00179	0.598
MOD_SUMO_rev_2	249	256	PF00179	0.538
MOD_SUMO_rev_2	356	362	PF00179	0.569
MOD_SUMO_rev_2	366	373	PF00179	0.577
MOD_SUMO_rev_2	464	470	PF00179	0.559
MOD_SUMO_rev_2	582	591	PF00179	0.500
TRG_DiLeu_BaEn_1	126	131	PF01217	0.512
TRG_DiLeu_BaEn_1	257	262	PF01217	0.467
TRG_DiLeu_BaEn_1	333	338	PF01217	0.602
TRG_DiLeu_BaEn_3	322	328	PF01217	0.569
TRG_ENDOCYTIC_2	192	195	PF00928	0.467
TRG_ENDOCYTIC_2	448	451	PF00928	0.527
TRG_ENDOCYTIC_2	482	485	PF00928	0.459
TRG_ENDOCYTIC_2	656	659	PF00928	0.713
TRG_ER_diArg_1	31	33	PF00400	0.755
TRG_ER_diArg_1	314	317	PF00400	0.402
TRG_ER_diArg_1	70	72	PF00400	0.503
TRG_NES_CRM1_1	299	312	PF08389	0.316
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	484	488	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWL2	Leptomonas seymouri	57%	96%
A0A1X0NEU3	Trypanosomatidae	43%	100%
A0A3S7X9W8	Leishmania donovani	79%	100%
A0A422NU91	Trypanosoma rangeli	39%	100%
A4IBW8	Leishmania infantum	79%	99%
C9ZYP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AFQ5	Leishmania major	79%	100%
E9B6V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q6NRG6	Xenopus laevis	23%	100%