LeishMANIAdb
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Bestrophin/UPF0187

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Bestrophin/UPF0187
Gene product:
Present in the outer mitochondrial membrane proteome 6
Species:
Leishmania braziliensis
UniProt:
A4HN96_LEIBR
TriTrypDb:
LbrM.34.4250 , LBRM2903_340052500 *
Length:
169

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0000331 contractile vacuole 6 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0005773 vacuole 5 1
GO:0016020 membrane 2 2
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4HN96
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN96

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 129 131 PF00675 0.547
CLV_NRD_NRD_1 161 163 PF00675 0.555
CLV_NRD_NRD_1 63 65 PF00675 0.500
CLV_PCSK_FUR_1 159 163 PF00082 0.648
CLV_PCSK_KEX2_1 129 131 PF00082 0.543
CLV_PCSK_KEX2_1 159 161 PF00082 0.543
CLV_PCSK_SKI1_1 130 134 PF00082 0.530
DEG_Nend_UBRbox_2 1 3 PF02207 0.544
DOC_CYCLIN_yCln2_LP_2 18 24 PF00134 0.630
DOC_MAPK_gen_1 78 86 PF00069 0.587
DOC_MAPK_MEF2A_6 30 38 PF00069 0.557
DOC_MAPK_RevD_3 145 161 PF00069 0.452
DOC_PP1_RVXF_1 127 134 PF00149 0.376
DOC_PP2B_LxvP_1 18 21 PF13499 0.568
DOC_USP7_MATH_1 102 106 PF00917 0.705
LIG_FHA_1 135 141 PF00498 0.594
LIG_FHA_1 70 76 PF00498 0.449
LIG_LIR_Apic_2 45 51 PF02991 0.508
LIG_PCNA_yPIPBox_3 78 89 PF02747 0.614
LIG_Pex14_2 62 66 PF04695 0.475
LIG_RPA_C_Fungi 124 136 PF08784 0.514
LIG_SH2_STAT3 107 110 PF00017 0.650
LIG_SH2_STAT5 107 110 PF00017 0.534
LIG_SH2_STAT5 28 31 PF00017 0.603
LIG_SH3_3 18 24 PF00018 0.580
LIG_SxIP_EBH_1 53 62 PF03271 0.378
LIG_TRAF2_1 98 101 PF00917 0.651
LIG_WRC_WIRS_1 8 13 PF05994 0.512
MOD_CK1_1 7 13 PF00069 0.422
MOD_GlcNHglycan 113 116 PF01048 0.566
MOD_GSK3_1 102 109 PF00069 0.608
MOD_NEK2_1 4 9 PF00069 0.406
MOD_PIKK_1 106 112 PF00454 0.672
MOD_PKA_2 110 116 PF00069 0.541
MOD_Plk_4 24 30 PF00069 0.536
MOD_Plk_4 57 63 PF00069 0.535
MOD_Plk_4 7 13 PF00069 0.435
TRG_ER_diArg_1 129 131 PF00400 0.375
TRG_ER_diArg_1 158 161 PF00400 0.536
TRG_Pf-PMV_PEXEL_1 161 165 PF00026 0.608

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD34 Leptomonas seymouri 80% 100%
A0A1X0P529 Trypanosomatidae 48% 100%
A0A3Q8IQ29 Leishmania donovani 91% 100%
A0A422NU90 Trypanosoma rangeli 46% 100%
A4IBW7 Leishmania infantum 91% 100%
C9ZYP2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AFQ4 Leishmania major 91% 100%
E9B6V7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS