Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN94_LEIBR

TriTrypDb:

LbrM.34.4220 , LBRM2903_340052000

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.535
CLV_NRD_NRD_1	274	276	PF00675	0.405
CLV_PCSK_KEX2_1	274	276	PF00082	0.405
CLV_PCSK_SKI1_1	133	137	PF00082	0.373
CLV_PCSK_SKI1_1	146	150	PF00082	0.551
CLV_PCSK_SKI1_1	177	181	PF00082	0.630
CLV_PCSK_SKI1_1	286	290	PF00082	0.462
CLV_Separin_Metazoa	245	249	PF03568	0.445
DEG_APCC_DBOX_1	132	140	PF00400	0.369
DEG_APCC_DBOX_1	230	238	PF00400	0.288
DEG_SCF_FBW7_2	238	245	PF00400	0.416
DEG_SPOP_SBC_1	172	176	PF00917	0.450
DEG_SPOP_SBC_1	6	10	PF00917	0.484
DOC_CKS1_1	239	244	PF01111	0.409
DOC_CYCLIN_RxL_1	283	292	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.297
DOC_MAPK_gen_1	231	239	PF00069	0.506
DOC_PP2B_LxvP_1	217	220	PF13499	0.375
DOC_USP7_MATH_1	208	212	PF00917	0.630
DOC_USP7_MATH_1	6	10	PF00917	0.628
DOC_WW_Pin1_4	238	243	PF00397	0.333
LIG_14-3-3_CanoR_1	146	155	PF00244	0.606
LIG_14-3-3_CanoR_1	231	239	PF00244	0.414
LIG_14-3-3_CanoR_1	36	40	PF00244	0.415
LIG_14-3-3_CanoR_1	7	16	PF00244	0.582
LIG_Actin_WH2_2	132	148	PF00022	0.329
LIG_APCC_ABBA_1	221	226	PF00400	0.242
LIG_BRCT_BRCA1_1	8	12	PF00533	0.427
LIG_deltaCOP1_diTrp_1	40	46	PF00928	0.436
LIG_FHA_1	149	155	PF00498	0.638
LIG_FHA_1	214	220	PF00498	0.388
LIG_FHA_1	73	79	PF00498	0.374
LIG_FHA_1	83	89	PF00498	0.383
LIG_FHA_2	247	253	PF00498	0.441
LIG_Integrin_RGD_1	110	112	PF01839	0.427
LIG_LIR_Gen_1	89	99	PF02991	0.302
LIG_LIR_Gen_1	9	20	PF02991	0.619
LIG_LIR_LC3C_4	216	219	PF02991	0.449
LIG_LIR_Nem_3	124	129	PF02991	0.472
LIG_LIR_Nem_3	19	23	PF02991	0.467
LIG_LIR_Nem_3	40	46	PF02991	0.430
LIG_LIR_Nem_3	89	95	PF02991	0.302
LIG_LIR_Nem_3	9	15	PF02991	0.619
LIG_LIR_Nem_3	97	102	PF02991	0.313
LIG_PCNA_yPIPBox_3	28	41	PF02747	0.290
LIG_Rb_LxCxE_1	249	265	PF01857	0.410
LIG_SH2_SRC	224	227	PF00017	0.478
LIG_SH2_STAT5	123	126	PF00017	0.385
LIG_SH2_STAT5	127	130	PF00017	0.315
LIG_SH2_STAT5	224	227	PF00017	0.478
LIG_SUMO_SIM_par_1	287	292	PF11976	0.495
LIG_TRAF2_1	256	259	PF00917	0.264
MOD_CK1_1	10	16	PF00069	0.620
MOD_CK1_1	141	147	PF00069	0.555
MOD_CK2_1	18	24	PF00069	0.533
MOD_CK2_1	246	252	PF00069	0.542
MOD_GlcNHglycan	177	180	PF01048	0.656
MOD_GlcNHglycan	299	302	PF01048	0.424
MOD_GlcNHglycan	9	12	PF01048	0.651
MOD_GlcNHglycan	96	99	PF01048	0.380
MOD_GSK3_1	102	109	PF00069	0.529
MOD_GSK3_1	159	166	PF00069	0.628
MOD_GSK3_1	171	178	PF00069	0.476
MOD_GSK3_1	209	216	PF00069	0.548
MOD_GSK3_1	6	13	PF00069	0.683
MOD_N-GLC_1	121	126	PF02516	0.478
MOD_N-GLC_1	208	213	PF02516	0.417
MOD_N-GLC_1	294	299	PF02516	0.527
MOD_NEK2_1	129	134	PF00069	0.358
MOD_NEK2_1	246	251	PF00069	0.503
MOD_NEK2_1	269	274	PF00069	0.374
MOD_NEK2_1	289	294	PF00069	0.485
MOD_NEK2_1	5	10	PF00069	0.638
MOD_NEK2_1	82	87	PF00069	0.464
MOD_NEK2_1	91	96	PF00069	0.324
MOD_OFUCOSY	69	76	PF10250	0.439
MOD_PIKK_1	24	30	PF00454	0.460
MOD_PIKK_1	44	50	PF00454	0.559
MOD_PKA_2	232	238	PF00069	0.442
MOD_PKA_2	35	41	PF00069	0.466
MOD_PKA_2	6	12	PF00069	0.539
MOD_Plk_1	163	169	PF00069	0.462
MOD_Plk_1	294	300	PF00069	0.409
MOD_Plk_4	149	155	PF00069	0.698
MOD_Plk_4	213	219	PF00069	0.476
MOD_Plk_4	284	290	PF00069	0.423
MOD_Plk_4	294	300	PF00069	0.462
MOD_Plk_4	91	97	PF00069	0.440
MOD_ProDKin_1	238	244	PF00069	0.333
MOD_SUMO_for_1	278	281	PF00179	0.509
TRG_ENDOCYTIC_2	126	129	PF00928	0.470
TRG_ENDOCYTIC_2	20	23	PF00928	0.536
TRG_ER_diArg_1	231	234	PF00400	0.579
TRG_ER_diArg_1	247	250	PF00400	0.408
TRG_ER_diArg_1	273	275	PF00400	0.388
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY73	Leptomonas seymouri	48%	100%
A0A0S4JF57	Bodo saltans	35%	100%
A0A1X0P581	Trypanosomatidae	34%	100%
A0A3R7NNI3	Trypanosoma rangeli	38%	100%
A0A3S7X9V8	Leishmania donovani	72%	100%
A4IBW4	Leishmania infantum	72%	100%
C9ZYP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AFQ1	Leishmania major	71%	98%
E9B6V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
V5BCR5	Trypanosoma cruzi	33%	100%