Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HN92_LEIBR

TriTrypDb:

LbrM.34.4200 , LBRM2903_340051800

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.508
CLV_NRD_NRD_1	144	146	PF00675	0.566
CLV_NRD_NRD_1	167	169	PF00675	0.580
CLV_NRD_NRD_1	36	38	PF00675	0.720
CLV_NRD_NRD_1	580	582	PF00675	0.734
CLV_NRD_NRD_1	593	595	PF00675	0.586
CLV_PCSK_FUR_1	86	90	PF00082	0.580
CLV_PCSK_KEX2_1	144	146	PF00082	0.566
CLV_PCSK_KEX2_1	167	169	PF00082	0.580
CLV_PCSK_KEX2_1	217	219	PF00082	0.725
CLV_PCSK_KEX2_1	36	38	PF00082	0.720
CLV_PCSK_KEX2_1	592	594	PF00082	0.700
CLV_PCSK_KEX2_1	88	90	PF00082	0.576
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.725
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.576
CLV_PCSK_PC7_1	589	595	PF00082	0.700
CLV_PCSK_SKI1_1	217	221	PF00082	0.725
CLV_PCSK_SKI1_1	27	31	PF00082	0.663
CLV_PCSK_SKI1_1	535	539	PF00082	0.596
CLV_PCSK_SKI1_1	98	102	PF00082	0.561
DEG_SCF_FBW7_1	169	176	PF00400	0.594
DEG_SPOP_SBC_1	134	138	PF00917	0.577
DEG_SPOP_SBC_1	436	440	PF00917	0.651
DOC_CKS1_1	121	126	PF01111	0.602
DOC_CYCLIN_yCln2_LP_2	251	257	PF00134	0.707
DOC_CYCLIN_yCln2_LP_2	274	280	PF00134	0.653
DOC_CYCLIN_yCln2_LP_2	545	551	PF00134	0.551
DOC_MAPK_MEF2A_6	221	229	PF00069	0.547
DOC_MAPK_MEF2A_6	458	465	PF00069	0.530
DOC_MAPK_MEF2A_6	48	57	PF00069	0.526
DOC_PIKK_1	561	568	PF02985	0.564
DOC_PP2B_LxvP_1	199	202	PF13499	0.566
DOC_PP2B_LxvP_1	251	254	PF13499	0.702
DOC_PP2B_LxvP_1	274	277	PF13499	0.558
DOC_PP2B_LxvP_1	545	548	PF13499	0.547
DOC_USP7_MATH_1	111	115	PF00917	0.719
DOC_USP7_MATH_1	188	192	PF00917	0.592
DOC_USP7_MATH_1	225	229	PF00917	0.552
DOC_USP7_MATH_1	255	259	PF00917	0.715
DOC_USP7_MATH_1	316	320	PF00917	0.694
DOC_USP7_MATH_1	322	326	PF00917	0.748
DOC_USP7_MATH_1	330	334	PF00917	0.704
DOC_USP7_MATH_1	344	348	PF00917	0.616
DOC_USP7_MATH_1	361	365	PF00917	0.623
DOC_USP7_MATH_1	376	380	PF00917	0.657
DOC_USP7_MATH_1	397	401	PF00917	0.727
DOC_USP7_MATH_1	448	452	PF00917	0.561
DOC_USP7_MATH_1	471	475	PF00917	0.580
DOC_USP7_MATH_1	490	494	PF00917	0.557
DOC_USP7_MATH_1	502	506	PF00917	0.602
DOC_USP7_MATH_1	508	512	PF00917	0.606
DOC_USP7_MATH_1	519	523	PF00917	0.573
DOC_USP7_UBL2_3	30	34	PF12436	0.653
DOC_USP7_UBL2_3	44	48	PF12436	0.547
DOC_WW_Pin1_4	120	125	PF00397	0.676
DOC_WW_Pin1_4	169	174	PF00397	0.592
DOC_WW_Pin1_4	179	184	PF00397	0.547
DOC_WW_Pin1_4	221	226	PF00397	0.545
DOC_WW_Pin1_4	279	284	PF00397	0.685
DOC_WW_Pin1_4	287	292	PF00397	0.621
DOC_WW_Pin1_4	304	309	PF00397	0.525
DOC_WW_Pin1_4	381	386	PF00397	0.656
DOC_WW_Pin1_4	47	52	PF00397	0.670
DOC_WW_Pin1_4	483	488	PF00397	0.546
DOC_WW_Pin1_4	77	82	PF00397	0.603
DOC_WW_Pin1_4	92	97	PF00397	0.685
LIG_14-3-3_CanoR_1	144	153	PF00244	0.582
LIG_14-3-3_CanoR_1	187	193	PF00244	0.576
LIG_14-3-3_CanoR_1	205	212	PF00244	0.573
LIG_14-3-3_CanoR_1	221	225	PF00244	0.666
LIG_14-3-3_CanoR_1	275	283	PF00244	0.686
LIG_14-3-3_CanoR_1	363	369	PF00244	0.711
LIG_14-3-3_CanoR_1	472	479	PF00244	0.535
LIG_14-3-3_CanoR_1	496	502	PF00244	0.583
LIG_14-3-3_CanoR_1	512	516	PF00244	0.657
LIG_14-3-3_CanoR_1	523	528	PF00244	0.638
LIG_14-3-3_CanoR_1	581	585	PF00244	0.594
LIG_BRCT_BRCA1_1	234	238	PF00533	0.546
LIG_FHA_1	121	127	PF00498	0.608
LIG_FHA_1	135	141	PF00498	0.579
LIG_FHA_1	309	315	PF00498	0.619
LIG_FHA_1	427	433	PF00498	0.665
LIG_FHA_1	484	490	PF00498	0.791
LIG_FHA_2	234	240	PF00498	0.692
LIG_FHA_2	307	313	PF00498	0.591
LIG_FHA_2	473	479	PF00498	0.534
LIG_FHA_2	594	600	PF00498	0.714
LIG_LIR_Gen_1	439	449	PF02991	0.682
LIG_LIR_Gen_1	459	468	PF02991	0.482
LIG_LIR_Gen_1	596	601	PF02991	0.715
LIG_LIR_Nem_3	405	409	PF02991	0.770
LIG_LIR_Nem_3	439	445	PF02991	0.679
LIG_LIR_Nem_3	459	465	PF02991	0.481
LIG_LIR_Nem_3	596	601	PF02991	0.715
LIG_MYND_1	47	51	PF01753	0.529
LIG_PDZ_Class_3	596	601	PF00595	0.715
LIG_PTAP_UEV_1	211	216	PF05743	0.573
LIG_SH2_CRK	442	446	PF00017	0.683
LIG_SH2_SRC	20	23	PF00017	0.664
LIG_SH2_STAP1	449	453	PF00017	0.610
LIG_SH2_STAT5	20	23	PF00017	0.664
LIG_SH2_STAT5	404	407	PF00017	0.642
LIG_SH2_STAT5	409	412	PF00017	0.598
LIG_SH3_2	212	217	PF14604	0.704
LIG_SH3_3	101	107	PF00018	0.662
LIG_SH3_3	177	183	PF00018	0.625
LIG_SH3_3	209	215	PF00018	0.709
LIG_SH3_3	219	225	PF00018	0.595
LIG_SH3_3	244	250	PF00018	0.539
LIG_SH3_3	350	356	PF00018	0.671
LIG_SH3_3	484	490	PF00018	0.678
LIG_SH3_3	57	63	PF00018	0.518
LIG_WRC_WIRS_1	229	234	PF05994	0.540
MOD_CDC14_SPxK_1	95	98	PF00782	0.565
MOD_CDK_SPK_2	49	54	PF00069	0.679
MOD_CDK_SPxK_1	304	310	PF00069	0.566
MOD_CDK_SPxK_1	92	98	PF00069	0.565
MOD_CDK_SPxxK_3	381	388	PF00069	0.557
MOD_CDK_SPxxK_3	47	54	PF00069	0.526
MOD_CK1_1	158	164	PF00069	0.628
MOD_CK1_1	182	188	PF00069	0.586
MOD_CK1_1	191	197	PF00069	0.685
MOD_CK1_1	228	234	PF00069	0.557
MOD_CK1_1	279	285	PF00069	0.694
MOD_CK1_1	306	312	PF00069	0.610
MOD_CK1_1	420	426	PF00069	0.615
MOD_CK1_1	435	441	PF00069	0.596
MOD_CK1_1	511	517	PF00069	0.692
MOD_CK1_1	540	546	PF00069	0.625
MOD_CK1_1	76	82	PF00069	0.607
MOD_CK2_1	233	239	PF00069	0.692
MOD_CK2_1	330	336	PF00069	0.567
MOD_CK2_1	375	381	PF00069	0.636
MOD_CK2_1	472	478	PF00069	0.534
MOD_CK2_1	5	11	PF00069	0.517
MOD_CK2_1	593	599	PF00069	0.571
MOD_Cter_Amidation	86	89	PF01082	0.581
MOD_DYRK1A_RPxSP_1	221	225	PF00069	0.548
MOD_GlcNHglycan	139	143	PF01048	0.608
MOD_GlcNHglycan	212	215	PF01048	0.611
MOD_GlcNHglycan	24	27	PF01048	0.501
MOD_GlcNHglycan	244	247	PF01048	0.566
MOD_GlcNHglycan	251	254	PF01048	0.663
MOD_GlcNHglycan	278	281	PF01048	0.713
MOD_GlcNHglycan	300	303	PF01048	0.734
MOD_GlcNHglycan	338	341	PF01048	0.625
MOD_GlcNHglycan	357	360	PF01048	0.514
MOD_GlcNHglycan	364	367	PF01048	0.664
MOD_GlcNHglycan	369	372	PF01048	0.672
MOD_GlcNHglycan	399	402	PF01048	0.683
MOD_GlcNHglycan	469	472	PF01048	0.723
MOD_GlcNHglycan	492	495	PF01048	0.701
MOD_GlcNHglycan	517	520	PF01048	0.607
MOD_GlcNHglycan	6	10	PF01048	0.662
MOD_GSK3_1	134	141	PF00069	0.590
MOD_GSK3_1	169	176	PF00069	0.634
MOD_GSK3_1	188	195	PF00069	0.620
MOD_GSK3_1	221	228	PF00069	0.689
MOD_GSK3_1	300	307	PF00069	0.708
MOD_GSK3_1	317	324	PF00069	0.585
MOD_GSK3_1	376	383	PF00069	0.680
MOD_GSK3_1	388	395	PF00069	0.590
MOD_GSK3_1	420	427	PF00069	0.711
MOD_GSK3_1	428	435	PF00069	0.690
MOD_GSK3_1	436	443	PF00069	0.550
MOD_GSK3_1	467	474	PF00069	0.640
MOD_GSK3_1	511	518	PF00069	0.679
MOD_GSK3_1	519	526	PF00069	0.689
MOD_GSK3_1	531	538	PF00069	0.643
MOD_GSK3_1	73	80	PF00069	0.614
MOD_N-GLC_1	158	163	PF02516	0.587
MOD_N-GLC_1	169	174	PF02516	0.570
MOD_N-GLC_1	317	322	PF02516	0.546
MOD_NEK2_1	220	225	PF00069	0.709
MOD_NEK2_1	232	237	PF00069	0.570
MOD_NEK2_1	362	367	PF00069	0.569
MOD_NEK2_1	424	429	PF00069	0.688
MOD_NEK2_1	550	555	PF00069	0.673
MOD_NEK2_2	188	193	PF00069	0.603
MOD_PIKK_1	424	430	PF00454	0.688
MOD_PIKK_1	521	527	PF00454	0.562
MOD_PK_1	105	111	PF00069	0.554
MOD_PKA_1	144	150	PF00069	0.567
MOD_PKA_1	593	599	PF00069	0.716
MOD_PKA_2	144	150	PF00069	0.700
MOD_PKA_2	163	169	PF00069	0.541
MOD_PKA_2	220	226	PF00069	0.706
MOD_PKA_2	303	309	PF00069	0.686
MOD_PKA_2	344	350	PF00069	0.704
MOD_PKA_2	362	368	PF00069	0.594
MOD_PKA_2	387	393	PF00069	0.731
MOD_PKA_2	471	477	PF00069	0.575
MOD_PKA_2	495	501	PF00069	0.595
MOD_PKA_2	508	514	PF00069	0.627
MOD_PKA_2	580	586	PF00069	0.639
MOD_PKA_2	593	599	PF00069	0.669
MOD_PKB_1	268	276	PF00069	0.643
MOD_Plk_1	255	261	PF00069	0.597
MOD_Plk_1	440	446	PF00069	0.693
MOD_Plk_1	73	79	PF00069	0.562
MOD_Plk_2-3	64	70	PF00069	0.525
MOD_Plk_4	330	336	PF00069	0.538
MOD_Plk_4	428	434	PF00069	0.584
MOD_Plk_4	440	446	PF00069	0.628
MOD_ProDKin_1	120	126	PF00069	0.678
MOD_ProDKin_1	169	175	PF00069	0.594
MOD_ProDKin_1	179	185	PF00069	0.547
MOD_ProDKin_1	221	227	PF00069	0.546
MOD_ProDKin_1	279	285	PF00069	0.685
MOD_ProDKin_1	287	293	PF00069	0.622
MOD_ProDKin_1	304	310	PF00069	0.525
MOD_ProDKin_1	381	387	PF00069	0.658
MOD_ProDKin_1	47	53	PF00069	0.668
MOD_ProDKin_1	483	489	PF00069	0.547
MOD_ProDKin_1	77	83	PF00069	0.602
MOD_ProDKin_1	92	98	PF00069	0.686
MOD_SUMO_for_1	393	396	PF00179	0.695
MOD_SUMO_for_1	559	562	PF00179	0.712
TRG_ENDOCYTIC_2	409	412	PF00928	0.755
TRG_ENDOCYTIC_2	442	445	PF00928	0.683
TRG_ER_diArg_1	129	132	PF00400	0.574
TRG_ER_diArg_1	167	169	PF00400	0.580
TRG_ER_diArg_1	267	270	PF00400	0.612
TRG_ER_diArg_1	35	37	PF00400	0.720
TRG_ER_diArg_1	591	594	PF00400	0.722

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJF9	Leishmania donovani	54%	100%
A4IBW2	Leishmania infantum	54%	100%
E9AFP9	Leishmania major	53%	100%
E9B6V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%