VMA21-like domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN91_LEIBR

TriTrypDb:

LbrM.34.4190 , LBRM2903_340051400

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	4
GO:0031982	vesicle	4	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0097708	intracellular vesicle	5	4

Expansion

Sequence features

A4HN91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN91

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	4
GO:0022607	cellular component assembly	4	4
GO:0043933	protein-containing complex organization	4	4
GO:0065003	protein-containing complex assembly	5	4
GO:0070070	proton-transporting V-type ATPase complex assembly	7	4
GO:0070071	proton-transporting two-sector ATPase complex assembly	6	4
GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	8	4
GO:0071840	cellular component organization or biogenesis	2	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.722
CLV_PCSK_KEX2_1	119	121	PF00082	0.425
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.425
CLV_PCSK_SKI1_1	116	120	PF00082	0.389
CLV_PCSK_SKI1_1	76	80	PF00082	0.397
DEG_SCF_FBW7_1	18	24	PF00400	0.735
DEG_SCF_FBW7_1	34	41	PF00400	0.631
DEG_SCF_TRCP1_1	59	64	PF00400	0.705
DEG_SPOP_SBC_1	2	6	PF00917	0.625
DOC_CKS1_1	18	23	PF01111	0.733
DOC_MAPK_gen_1	147	157	PF00069	0.470
DOC_MAPK_MEF2A_6	151	159	PF00069	0.467
DOC_MAPK_MEF2A_6	176	184	PF00069	0.401
DOC_PP2B_LxvP_1	177	180	PF13499	0.407
DOC_USP7_MATH_1	19	23	PF00917	0.748
DOC_USP7_MATH_1	2	6	PF00917	0.625
DOC_USP7_MATH_1	38	42	PF00917	0.779
DOC_USP7_MATH_1	48	52	PF00917	0.740
DOC_USP7_MATH_1	57	61	PF00917	0.699
DOC_USP7_UBL2_3	147	151	PF12436	0.562
DOC_WW_Pin1_4	17	22	PF00397	0.777
DOC_WW_Pin1_4	30	35	PF00397	0.649
DOC_WW_Pin1_4	40	45	PF00397	0.664
DOC_WW_Pin1_4	59	64	PF00397	0.616
LIG_BRCT_BRCA1_1	199	203	PF00533	0.215
LIG_FHA_1	136	142	PF00498	0.563
LIG_FHA_1	163	169	PF00498	0.292
LIG_FHA_1	70	76	PF00498	0.690
LIG_FHA_2	10	16	PF00498	0.697
LIG_FHA_2	105	111	PF00498	0.670
LIG_LIR_Gen_1	200	211	PF02991	0.215
LIG_LIR_Nem_3	200	206	PF02991	0.298
LIG_LIR_Nem_3	88	94	PF02991	0.593
LIG_NRP_CendR_1	227	230	PF00754	0.508
LIG_SH2_PTP2	154	157	PF00017	0.305
LIG_SH2_STAP1	87	91	PF00017	0.584
LIG_SH2_STAT5	154	157	PF00017	0.340
LIG_SH2_STAT5	205	208	PF00017	0.292
LIG_SH2_STAT5	85	88	PF00017	0.565
LIG_SUMO_SIM_anti_2	160	165	PF11976	0.241
LIG_TRAF2_1	12	15	PF00917	0.648
LIG_TYR_ITIM	152	157	PF00017	0.305
LIG_UBA3_1	171	176	PF00899	0.320
LIG_WRC_WIRS_1	141	146	PF05994	0.544
MOD_CDK_SPK_2	40	45	PF00069	0.721
MOD_CK1_1	123	129	PF00069	0.541
MOD_CK1_1	30	36	PF00069	0.812
MOD_CK2_1	219	225	PF00069	0.647
MOD_CK2_1	48	54	PF00069	0.775
MOD_CK2_1	9	15	PF00069	0.717
MOD_GlcNHglycan	21	24	PF01048	0.549
MOD_GlcNHglycan	54	58	PF01048	0.527
MOD_GlcNHglycan	59	62	PF01048	0.506
MOD_GSK3_1	104	111	PF00069	0.576
MOD_GSK3_1	17	24	PF00069	0.758
MOD_GSK3_1	197	204	PF00069	0.471
MOD_GSK3_1	219	226	PF00069	0.675
MOD_GSK3_1	30	37	PF00069	0.781
MOD_GSK3_1	40	47	PF00069	0.728
MOD_GSK3_1	53	60	PF00069	0.690
MOD_GSK3_1	86	93	PF00069	0.638
MOD_N-GLC_1	219	224	PF02516	0.461
MOD_N-GLC_1	57	62	PF02516	0.507
MOD_NEK2_1	140	145	PF00069	0.606
MOD_NEK2_1	162	167	PF00069	0.303
MOD_NEK2_1	201	206	PF00069	0.351
MOD_NEK2_1	3	8	PF00069	0.623
MOD_PIKK_1	142	148	PF00454	0.591
MOD_PKA_2	69	75	PF00069	0.678
MOD_Plk_1	104	110	PF00069	0.654
MOD_Plk_1	14	20	PF00069	0.634
MOD_Plk_2-3	104	110	PF00069	0.654
MOD_Plk_4	197	203	PF00069	0.346
MOD_Plk_4	86	92	PF00069	0.605
MOD_ProDKin_1	17	23	PF00069	0.777
MOD_ProDKin_1	30	36	PF00069	0.651
MOD_ProDKin_1	40	46	PF00069	0.664
MOD_ProDKin_1	59	65	PF00069	0.617
MOD_SUMO_for_1	118	121	PF00179	0.622
MOD_SUMO_for_1	78	81	PF00179	0.503
MOD_SUMO_rev_2	71	80	PF00179	0.545
TRG_ENDOCYTIC_2	154	157	PF00928	0.305
TRG_ENDOCYTIC_2	205	208	PF00928	0.355
TRG_ENDOCYTIC_2	87	90	PF00928	0.578
TRG_ENDOCYTIC_2	91	94	PF00928	0.596
TRG_ER_diLys_1	227	230	PF00400	0.663
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVK4	Leptomonas seymouri	50%	100%
A0A3Q8IFH5	Leishmania donovani	71%	100%
A4IBV9	Leishmania infantum	72%	100%
C9ZYQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AFP6	Leishmania major	70%	100%
E9B6U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%