Putative Bardet-Biedl syndrome 1 protein homolog (BBS1-like protein 1)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 1 protein

Species:

Leishmania braziliensis

UniProt:

A4HN90_LEIBR

TriTrypDb:

LbrM.34.4180 , LBRM2903_340051300

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0036064	ciliary basal body	3	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HN90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN90

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:1905515	non-motile cilium assembly	7	12
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006897	endocytosis	5	1
GO:0006907	pinocytosis	6	1
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0030001	metal ion transport	6	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0033572	transferrin transport	5	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0061512	protein localization to cilium	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0001664	G protein-coupled receptor binding	4	1
GO:0005102	signaling receptor binding	3	1
GO:0005113	patched binding	4	1
GO:0005119	smoothened binding	5	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.417
CLV_C14_Caspase3-7	256	260	PF00656	0.224
CLV_C14_Caspase3-7	84	88	PF00656	0.365
CLV_NRD_NRD_1	432	434	PF00675	0.420
CLV_NRD_NRD_1	8	10	PF00675	0.580
CLV_PCSK_KEX2_1	55	57	PF00082	0.314
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.349
CLV_PCSK_SKI1_1	206	210	PF00082	0.327
CLV_PCSK_SKI1_1	231	235	PF00082	0.394
CLV_PCSK_SKI1_1	517	521	PF00082	0.409
CLV_PCSK_SKI1_1	55	59	PF00082	0.251
DEG_APCC_DBOX_1	21	29	PF00400	0.266
DEG_SCF_TRCP1_1	151	157	PF00400	0.327
DOC_CDC14_PxL_1	534	542	PF14671	0.357
DOC_CKS1_1	166	171	PF01111	0.227
DOC_CKS1_1	235	240	PF01111	0.327
DOC_MAPK_DCC_7	113	121	PF00069	0.256
DOC_MAPK_DCC_7	178	187	PF00069	0.327
DOC_MAPK_gen_1	222	230	PF00069	0.332
DOC_MAPK_gen_1	306	315	PF00069	0.355
DOC_MAPK_gen_1	370	380	PF00069	0.320
DOC_MAPK_HePTP_8	220	232	PF00069	0.170
DOC_MAPK_MEF2A_6	113	121	PF00069	0.275
DOC_MAPK_MEF2A_6	178	187	PF00069	0.394
DOC_MAPK_MEF2A_6	223	232	PF00069	0.244
DOC_MAPK_MEF2A_6	373	382	PF00069	0.316
DOC_PP1_RVXF_1	515	521	PF00149	0.464
DOC_PP2B_PxIxI_1	91	97	PF00149	0.224
DOC_PP4_FxxP_1	114	117	PF00568	0.311
DOC_PP4_FxxP_1	535	538	PF00568	0.420
DOC_PP4_FxxP_1	72	75	PF00568	0.345
DOC_PP4_MxPP_1	115	118	PF00568	0.394
DOC_SPAK_OSR1_1	113	117	PF12202	0.311
DOC_USP7_MATH_1	197	201	PF00917	0.394
DOC_USP7_MATH_1	30	34	PF00917	0.284
DOC_USP7_MATH_1	426	430	PF00917	0.456
DOC_USP7_MATH_1	466	470	PF00917	0.633
DOC_USP7_MATH_1	51	55	PF00917	0.346
DOC_USP7_MATH_1	562	566	PF00917	0.578
DOC_USP7_MATH_1	579	583	PF00917	0.367
DOC_USP7_MATH_1	61	65	PF00917	0.328
DOC_USP7_MATH_1	77	81	PF00917	0.205
DOC_USP7_MATH_2	468	474	PF00917	0.384
DOC_WW_Pin1_4	165	170	PF00397	0.408
DOC_WW_Pin1_4	234	239	PF00397	0.353
DOC_WW_Pin1_4	575	580	PF00397	0.534
LIG_14-3-3_CanoR_1	252	262	PF00244	0.208
LIG_14-3-3_CanoR_1	451	459	PF00244	0.380
LIG_14-3-3_CanoR_1	487	495	PF00244	0.275
LIG_Actin_WH2_2	435	453	PF00022	0.429
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_BIR_III_2	278	282	PF00653	0.409
LIG_BRCT_BRCA1_1	421	425	PF00533	0.521
LIG_Clathr_ClatBox_1	163	167	PF01394	0.280
LIG_Clathr_ClatBox_1	184	188	PF01394	0.394
LIG_deltaCOP1_diTrp_1	14	21	PF00928	0.312
LIG_FHA_1	132	138	PF00498	0.326
LIG_FHA_1	158	164	PF00498	0.310
LIG_FHA_1	324	330	PF00498	0.316
LIG_FHA_1	35	41	PF00498	0.333
LIG_FHA_2	166	172	PF00498	0.391
LIG_FHA_2	197	203	PF00498	0.290
LIG_FHA_2	322	328	PF00498	0.333
LIG_FHA_2	552	558	PF00498	0.461
LIG_FHA_2	570	576	PF00498	0.405
LIG_FHA_2	581	587	PF00498	0.498
LIG_FHA_2	61	67	PF00498	0.170
LIG_LIR_Apic_2	525	531	PF02991	0.517
LIG_LIR_Gen_1	438	447	PF02991	0.443
LIG_LIR_Gen_1	45	51	PF02991	0.394
LIG_LIR_Gen_1	98	105	PF02991	0.394
LIG_LIR_LC3C_4	386	389	PF02991	0.304
LIG_LIR_LC3C_4	565	570	PF02991	0.284
LIG_LIR_Nem_3	14	19	PF02991	0.384
LIG_LIR_Nem_3	248	254	PF02991	0.256
LIG_LIR_Nem_3	299	305	PF02991	0.308
LIG_LIR_Nem_3	357	363	PF02991	0.354
LIG_LIR_Nem_3	438	443	PF02991	0.452
LIG_LIR_Nem_3	45	49	PF02991	0.272
LIG_MYND_1	538	542	PF01753	0.357
LIG_NRBOX	145	151	PF00104	0.394
LIG_NRBOX	160	166	PF00104	0.394
LIG_PCNA_yPIPBox_3	106	115	PF02747	0.327
LIG_PDZ_Class_3	591	596	PF00595	0.493
LIG_Pex14_1	17	21	PF04695	0.251
LIG_SH2_CRK	251	255	PF00017	0.251
LIG_SH2_CRK	360	364	PF00017	0.320
LIG_SH2_CRK	46	50	PF00017	0.266
LIG_SH2_CRK	528	532	PF00017	0.432
LIG_SH2_STAP1	247	251	PF00017	0.170
LIG_SH2_STAT5	101	104	PF00017	0.345
LIG_SH2_STAT5	219	222	PF00017	0.272
LIG_SH2_STAT5	314	317	PF00017	0.344
LIG_SH2_STAT5	348	351	PF00017	0.350
LIG_SH2_STAT5	458	461	PF00017	0.373
LIG_SH2_STAT5	521	524	PF00017	0.538
LIG_SH3_3	229	235	PF00018	0.274
LIG_SH3_3	271	277	PF00018	0.430
LIG_SH3_3	310	316	PF00018	0.345
LIG_SH3_3	411	417	PF00018	0.486
LIG_SH3_3	536	542	PF00018	0.477
LIG_SH3_3	582	588	PF00018	0.410
LIG_SUMO_SIM_anti_2	207	214	PF11976	0.303
LIG_SUMO_SIM_anti_2	565	572	PF11976	0.280
LIG_SUMO_SIM_anti_2	589	595	PF11976	0.458
LIG_SUMO_SIM_par_1	117	122	PF11976	0.236
LIG_SUMO_SIM_par_1	207	214	PF11976	0.303
LIG_SUMO_SIM_par_1	288	296	PF11976	0.302
LIG_SUMO_SIM_par_1	336	341	PF11976	0.376
LIG_SUMO_SIM_par_1	565	572	PF11976	0.533
LIG_SUMO_SIM_par_1	582	589	PF11976	0.304
LIG_SUMO_SIM_par_1	92	98	PF11976	0.345
LIG_TRAF2_1	200	203	PF00917	0.170
LIG_TYR_ITIM	249	254	PF00017	0.285
LIG_TYR_ITIM	300	305	PF00017	0.311
LIG_TYR_ITIM	358	363	PF00017	0.462
LIG_UBA3_1	217	223	PF00899	0.170
LIG_WRC_WIRS_1	78	83	PF05994	0.311
MOD_CDK_SPxxK_3	165	172	PF00069	0.324
MOD_CK1_1	157	163	PF00069	0.273
MOD_CK1_1	301	307	PF00069	0.294
MOD_CK1_1	323	329	PF00069	0.422
MOD_CK1_1	76	82	PF00069	0.297
MOD_CK2_1	165	171	PF00069	0.364
MOD_CK2_1	196	202	PF00069	0.398
MOD_CK2_1	30	36	PF00069	0.224
MOD_CK2_1	338	344	PF00069	0.378
MOD_CK2_1	426	432	PF00069	0.473
MOD_CK2_1	551	557	PF00069	0.468
MOD_CK2_1	569	575	PF00069	0.258
MOD_CK2_1	60	66	PF00069	0.170
MOD_Cter_Amidation	306	309	PF01082	0.372
MOD_GlcNHglycan	151	154	PF01048	0.427
MOD_GlcNHglycan	428	431	PF01048	0.350
MOD_GlcNHglycan	488	491	PF01048	0.261
MOD_GlcNHglycan	564	567	PF01048	0.431
MOD_GlcNHglycan	75	78	PF01048	0.273
MOD_GSK3_1	145	152	PF00069	0.361
MOD_GSK3_1	153	160	PF00069	0.304
MOD_GSK3_1	192	199	PF00069	0.200
MOD_GSK3_1	292	299	PF00069	0.304
MOD_GSK3_1	30	37	PF00069	0.280
MOD_GSK3_1	323	330	PF00069	0.364
MOD_GSK3_1	420	427	PF00069	0.551
MOD_GSK3_1	466	473	PF00069	0.395
MOD_GSK3_1	482	489	PF00069	0.323
MOD_GSK3_1	540	547	PF00069	0.412
MOD_GSK3_1	569	576	PF00069	0.384
MOD_GSK3_1	73	80	PF00069	0.287
MOD_N-GLC_1	383	388	PF02516	0.309
MOD_N-GLC_1	396	401	PF02516	0.401
MOD_NEK2_1	149	154	PF00069	0.415
MOD_NEK2_1	240	245	PF00069	0.449
MOD_NEK2_1	398	403	PF00069	0.540
MOD_NEK2_1	450	455	PF00069	0.380
MOD_NEK2_1	475	480	PF00069	0.515
MOD_NEK2_1	486	491	PF00069	0.278
MOD_NEK2_1	580	585	PF00069	0.459
MOD_NEK2_2	482	487	PF00069	0.516
MOD_NEK2_2	77	82	PF00069	0.311
MOD_PIKK_1	348	354	PF00454	0.399
MOD_PIKK_1	424	430	PF00454	0.501
MOD_PIKK_1	445	451	PF00454	0.472
MOD_PK_1	261	267	PF00069	0.345
MOD_PK_1	309	315	PF00069	0.422
MOD_PKA_1	9	15	PF00069	0.378
MOD_PKA_2	450	456	PF00069	0.430
MOD_PKA_2	486	492	PF00069	0.338
MOD_PKA_2	562	568	PF00069	0.315
MOD_Plk_1	445	451	PF00069	0.411
MOD_Plk_1	482	488	PF00069	0.422
MOD_Plk_4	145	151	PF00069	0.428
MOD_Plk_4	204	210	PF00069	0.340
MOD_Plk_4	298	304	PF00069	0.283
MOD_Plk_4	309	315	PF00069	0.338
MOD_Plk_4	383	389	PF00069	0.316
MOD_Plk_4	420	426	PF00069	0.417
MOD_Plk_4	470	476	PF00069	0.498
MOD_Plk_4	580	586	PF00069	0.415
MOD_Plk_4	77	83	PF00069	0.362
MOD_ProDKin_1	165	171	PF00069	0.408
MOD_ProDKin_1	234	240	PF00069	0.353
MOD_ProDKin_1	575	581	PF00069	0.524
MOD_SUMO_rev_2	473	481	PF00179	0.424
TRG_DiLeu_BaEn_1	332	337	PF01217	0.474
TRG_DiLeu_BaEn_2	170	176	PF01217	0.224
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.394
TRG_ENDOCYTIC_2	101	104	PF00928	0.281
TRG_ENDOCYTIC_2	112	115	PF00928	0.415
TRG_ENDOCYTIC_2	251	254	PF00928	0.251
TRG_ENDOCYTIC_2	302	305	PF00928	0.298
TRG_ENDOCYTIC_2	360	363	PF00928	0.323
TRG_ENDOCYTIC_2	440	443	PF00928	0.460
TRG_ENDOCYTIC_2	458	461	PF00928	0.266
TRG_ENDOCYTIC_2	46	49	PF00928	0.266

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJK5	Leptomonas seymouri	72%	100%
A0A0S4KEX6	Bodo saltans	40%	97%
A0A1X0P534	Trypanosomatidae	47%	97%
A0A3Q8IVI7	Leishmania donovani	85%	100%
A0A3R7KG84	Trypanosoma rangeli	47%	100%
A4IBV8	Leishmania infantum	85%	100%
C9ZYQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	98%
E9AFP5	Leishmania major	84%	99%
E9B6U8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q3V3N7	Mus musculus	32%	100%
Q8NFJ9	Homo sapiens	31%	100%
Q9NEZ7	Caenorhabditis elegans	23%	100%
V5DUI8	Trypanosoma cruzi	47%	100%