Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase III RPC4, putative

Species:

Leishmania braziliensis

UniProt:

A4HN89_LEIBR

TriTrypDb:

LbrM.34.4170 , LBRM2903_340051200

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	5
GO:0005666	RNA polymerase III complex	4	5
GO:0030880	RNA polymerase complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	5
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	5
GO:0140513	nuclear protein-containing complex	2	5
GO:0140535	intracellular protein-containing complex	2	5
GO:1902494	catalytic complex	2	5
GO:1990234	transferase complex	3	5

Expansion

Sequence features

A4HN89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN89

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006351	DNA-templated transcription	7	5
GO:0006383	transcription by RNA polymerase III	8	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009058	biosynthetic process	2	5
GO:0009059	macromolecule biosynthetic process	4	5
GO:0009987	cellular process	1	5
GO:0016070	RNA metabolic process	5	5
GO:0018130	heterocycle biosynthetic process	4	5
GO:0019438	aromatic compound biosynthetic process	4	5
GO:0032774	RNA biosynthetic process	5	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034654	nucleobase-containing compound biosynthetic process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044271	cellular nitrogen compound biosynthetic process	4	5
GO:0046483	heterocycle metabolic process	3	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:0097659	nucleic acid-templated transcription	6	5
GO:1901360	organic cyclic compound metabolic process	3	5
GO:1901362	organic cyclic compound biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003677	DNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	188	194	PF00089	0.530
CLV_NRD_NRD_1	110	112	PF00675	0.565
CLV_NRD_NRD_1	139	141	PF00675	0.661
CLV_PCSK_KEX2_1	110	112	PF00082	0.672
CLV_PCSK_KEX2_1	139	141	PF00082	0.625
CLV_PCSK_SKI1_1	13	17	PF00082	0.689
CLV_PCSK_SKI1_1	300	304	PF00082	0.438
CLV_Separin_Metazoa	247	251	PF03568	0.412
DOC_CKS1_1	358	363	PF01111	0.411
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.643
DOC_MAPK_gen_1	294	303	PF00069	0.424
DOC_MAPK_gen_1	9	16	PF00069	0.685
DOC_MAPK_MEF2A_6	297	305	PF00069	0.513
DOC_MAPK_MEF2A_6	9	16	PF00069	0.685
DOC_PP2B_LxvP_1	178	181	PF13499	0.638
DOC_PP4_FxxP_1	283	286	PF00568	0.513
DOC_USP7_MATH_1	155	159	PF00917	0.684
DOC_USP7_MATH_1	161	165	PF00917	0.682
DOC_USP7_MATH_1	27	31	PF00917	0.531
DOC_USP7_MATH_1	331	335	PF00917	0.428
DOC_USP7_MATH_1	336	340	PF00917	0.415
DOC_USP7_MATH_1	96	100	PF00917	0.671
DOC_USP7_UBL2_3	9	13	PF12436	0.685
DOC_WW_Pin1_4	210	215	PF00397	0.725
DOC_WW_Pin1_4	357	362	PF00397	0.411
DOC_WW_Pin1_4	87	92	PF00397	0.574
LIG_14-3-3_CanoR_1	24	34	PF00244	0.646
LIG_14-3-3_CanoR_1	250	256	PF00244	0.463
LIG_14-3-3_CanoR_1	64	68	PF00244	0.569
LIG_14-3-3_CanoR_1	97	104	PF00244	0.574
LIG_FHA_1	222	228	PF00498	0.589
LIG_FHA_1	29	35	PF00498	0.643
LIG_FHA_1	358	364	PF00498	0.411
LIG_FHA_2	88	94	PF00498	0.572
LIG_Integrin_RGD_1	197	199	PF01839	0.553
LIG_LIR_Apic_2	281	286	PF02991	0.513
LIG_LIR_Nem_3	176	182	PF02991	0.647
LIG_LIR_Nem_3	281	285	PF02991	0.424
LIG_SH2_NCK_1	317	321	PF00017	0.411
LIG_SH2_PTP2	179	182	PF00017	0.494
LIG_SH2_SRC	245	248	PF00017	0.551
LIG_SH2_SRC	317	320	PF00017	0.411
LIG_SH2_STAP1	245	249	PF00017	0.548
LIG_SH2_STAP1	310	314	PF00017	0.411
LIG_SH2_STAT5	179	182	PF00017	0.494
LIG_SH2_STAT5	46	49	PF00017	0.661
LIG_SH3_3	149	155	PF00018	0.676
LIG_SH3_3	177	183	PF00018	0.522
LIG_SH3_3	208	214	PF00018	0.561
LIG_SH3_3	335	341	PF00018	0.448
LIG_SH3_3	358	364	PF00018	0.492
LIG_SUMO_SIM_anti_2	30	38	PF11976	0.615
LIG_TRAF2_1	133	136	PF00917	0.634
LIG_TRAF2_1	193	196	PF00917	0.690
LIG_TRAF2_1	91	94	PF00917	0.674
LIG_TRFH_1	283	287	PF08558	0.513
LIG_WW_2	152	155	PF00397	0.678
MOD_CK1_1	165	171	PF00069	0.636
MOD_CK1_1	173	179	PF00069	0.667
MOD_CK1_1	25	31	PF00069	0.538
MOD_CK1_1	339	345	PF00069	0.393
MOD_CK1_1	69	75	PF00069	0.614
MOD_CK1_1	87	93	PF00069	0.782
MOD_CK2_1	190	196	PF00069	0.569
MOD_CK2_1	343	349	PF00069	0.411
MOD_CK2_1	87	93	PF00069	0.645
MOD_Cter_Amidation	108	111	PF01082	0.564
MOD_GlcNHglycan	128	131	PF01048	0.738
MOD_GlcNHglycan	165	168	PF01048	0.768
MOD_GlcNHglycan	170	173	PF01048	0.686
MOD_GlcNHglycan	175	178	PF01048	0.592
MOD_GlcNHglycan	192	195	PF01048	0.576
MOD_GlcNHglycan	201	204	PF01048	0.704
MOD_GlcNHglycan	214	217	PF01048	0.746
MOD_GlcNHglycan	257	260	PF01048	0.756
MOD_GlcNHglycan	297	300	PF01048	0.353
MOD_GlcNHglycan	334	337	PF01048	0.420
MOD_GlcNHglycan	52	55	PF01048	0.675
MOD_GlcNHglycan	60	63	PF01048	0.666
MOD_GlcNHglycan	71	74	PF01048	0.603
MOD_GSK3_1	110	117	PF00069	0.643
MOD_GSK3_1	161	168	PF00069	0.532
MOD_GSK3_1	18	25	PF00069	0.719
MOD_GSK3_1	251	258	PF00069	0.474
MOD_GSK3_1	28	35	PF00069	0.640
MOD_GSK3_1	325	332	PF00069	0.421
MOD_GSK3_1	336	343	PF00069	0.380
MOD_GSK3_1	52	59	PF00069	0.644
MOD_GSK3_1	63	70	PF00069	0.666
MOD_GSK3_1	82	89	PF00069	0.598
MOD_N-GLC_1	126	131	PF02516	0.735
MOD_NEK2_1	184	189	PF00069	0.705
MOD_NEK2_1	52	57	PF00069	0.544
MOD_NEK2_1	65	70	PF00069	0.518
MOD_PIKK_1	142	148	PF00454	0.736
MOD_PIKK_1	165	171	PF00454	0.535
MOD_PIKK_1	25	31	PF00454	0.791
MOD_PIKK_1	329	335	PF00454	0.411
MOD_PKA_1	110	116	PF00069	0.678
MOD_PKA_2	110	116	PF00069	0.647
MOD_PKA_2	190	196	PF00069	0.539
MOD_PKA_2	63	69	PF00069	0.569
MOD_PKA_2	96	102	PF00069	0.642
MOD_Plk_1	142	148	PF00069	0.736
MOD_Plk_1	184	190	PF00069	0.663
MOD_Plk_1	234	240	PF00069	0.463
MOD_Plk_1	32	38	PF00069	0.617
MOD_Plk_4	114	120	PF00069	0.826
MOD_Plk_4	251	257	PF00069	0.475
MOD_Plk_4	32	38	PF00069	0.617
MOD_ProDKin_1	210	216	PF00069	0.723
MOD_ProDKin_1	357	363	PF00069	0.411
MOD_ProDKin_1	87	93	PF00069	0.574
TRG_DiLeu_BaEn_4	195	201	PF01217	0.689
TRG_ENDOCYTIC_2	179	182	PF00928	0.644
TRG_ENDOCYTIC_2	245	248	PF00928	0.401
TRG_ENDOCYTIC_2	309	312	PF00928	0.375
TRG_NES_CRM1_1	304	318	PF08389	0.375
TRG_NES_CRM1_1	38	49	PF08389	0.619
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBD4	Leptomonas seymouri	55%	93%
A0A3S7XA21	Leishmania donovani	74%	100%
A4IBV7	Leishmania infantum	74%	100%
E9AFP4	Leishmania major	76%	100%
E9B6U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%