UPF0652 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

UPF0652 protein

Gene product:

Protein of unknown function (DUF2009), putative

Species:

Leishmania braziliensis

UniProt:

A4HN88_LEIBR

TriTrypDb:

LbrM.34.4160 , LBRM2903_340051100

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	237	241	PF00656	0.237
CLV_C14_Caspase3-7	278	282	PF00656	0.326
CLV_C14_Caspase3-7	443	447	PF00656	0.237
CLV_C14_Caspase3-7	453	457	PF00656	0.271
CLV_C14_Caspase3-7	62	66	PF00656	0.274
CLV_NRD_NRD_1	10	12	PF00675	0.550
CLV_NRD_NRD_1	123	125	PF00675	0.237
CLV_NRD_NRD_1	307	309	PF00675	0.305
CLV_NRD_NRD_1	44	46	PF00675	0.237
CLV_NRD_NRD_1	96	98	PF00675	0.394
CLV_PCSK_FUR_1	8	12	PF00082	0.622
CLV_PCSK_KEX2_1	10	12	PF00082	0.618
CLV_PCSK_KEX2_1	123	125	PF00082	0.237
CLV_PCSK_KEX2_1	428	430	PF00082	0.315
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.315
CLV_PCSK_SKI1_1	106	110	PF00082	0.196
CLV_PCSK_SKI1_1	154	158	PF00082	0.237
CLV_PCSK_SKI1_1	199	203	PF00082	0.296
CLV_PCSK_SKI1_1	215	219	PF00082	0.181
CLV_PCSK_SKI1_1	429	433	PF00082	0.258
CLV_PCSK_SKI1_1	75	79	PF00082	0.260
CLV_PCSK_SKI1_1	81	85	PF00082	0.220
DOC_CYCLIN_RxL_1	71	82	PF00134	0.302
DOC_MAPK_DCC_7	185	195	PF00069	0.256
DOC_MAPK_gen_1	204	213	PF00069	0.236
DOC_MAPK_gen_1	45	56	PF00069	0.399
DOC_MAPK_gen_1	470	479	PF00069	0.237
DOC_MAPK_gen_1	71	80	PF00069	0.237
DOC_PP2B_LxvP_1	26	29	PF13499	0.460
DOC_USP7_MATH_1	147	151	PF00917	0.302
DOC_USP7_MATH_1	270	274	PF00917	0.231
DOC_USP7_MATH_1	280	284	PF00917	0.280
DOC_WW_Pin1_4	188	193	PF00397	0.237
DOC_WW_Pin1_4	261	266	PF00397	0.256
DOC_WW_Pin1_4	320	325	PF00397	0.253
DOC_WW_Pin1_4	38	43	PF00397	0.344
LIG_14-3-3_CanoR_1	284	293	PF00244	0.315
LIG_14-3-3_CanoR_1	458	465	PF00244	0.237
LIG_CtBP_PxDLS_1	93	98	PF00389	0.302
LIG_EH1_1	174	182	PF00400	0.370
LIG_FHA_1	133	139	PF00498	0.279
LIG_FHA_1	292	298	PF00498	0.160
LIG_FHA_1	59	65	PF00498	0.237
LIG_FHA_1	82	88	PF00498	0.262
LIG_FHA_2	355	361	PF00498	0.237
LIG_GBD_Chelix_1	79	87	PF00786	0.256
LIG_LIR_Gen_1	135	144	PF02991	0.237
LIG_LIR_Gen_1	21	31	PF02991	0.399
LIG_LIR_Gen_1	481	490	PF02991	0.370
LIG_LIR_Nem_3	105	111	PF02991	0.237
LIG_LIR_Nem_3	135	140	PF02991	0.250
LIG_LIR_Nem_3	21	26	PF02991	0.481
LIG_LIR_Nem_3	385	390	PF02991	0.254
LIG_LIR_Nem_3	473	478	PF02991	0.357
LIG_LIR_Nem_3	481	486	PF02991	0.300
LIG_LYPXL_S_1	474	478	PF13949	0.237
LIG_NRBOX	254	260	PF00104	0.294
LIG_PCNA_yPIPBox_3	45	55	PF02747	0.283
LIG_Pex14_2	436	440	PF04695	0.237
LIG_Pex14_2	474	478	PF04695	0.237
LIG_REV1ctd_RIR_1	433	441	PF16727	0.237
LIG_SH2_CRK	293	297	PF00017	0.189
LIG_SH2_CRK	347	351	PF00017	0.176
LIG_SH2_CRK	387	391	PF00017	0.256
LIG_SH2_STAP1	293	297	PF00017	0.160
LIG_SH2_STAP1	328	332	PF00017	0.269
LIG_SH2_STAP1	60	64	PF00017	0.237
LIG_SH2_STAT3	142	145	PF00017	0.237
LIG_SH2_STAT5	137	140	PF00017	0.237
LIG_SH2_STAT5	171	174	PF00017	0.237
LIG_SH2_STAT5	293	296	PF00017	0.250
LIG_SH2_STAT5	311	314	PF00017	0.254
LIG_SH2_STAT5	416	419	PF00017	0.301
LIG_SH2_STAT5	60	63	PF00017	0.237
LIG_SH3_3	181	187	PF00018	0.160
LIG_SUMO_SIM_anti_2	228	235	PF11976	0.399
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.370
LIG_SUMO_SIM_par_1	76	82	PF11976	0.370
LIG_TRAF2_1	357	360	PF00917	0.315
LIG_TRAF2_1	41	44	PF00917	0.344
LIG_UBA3_1	255	260	PF00899	0.256
LIG_UBA3_1	90	98	PF00899	0.256
LIG_WRC_WIRS_1	483	488	PF05994	0.237
MOD_CDK_SPxxK_3	320	327	PF00069	0.160
MOD_CDK_SPxxK_3	38	45	PF00069	0.344
MOD_CK1_1	150	156	PF00069	0.160
MOD_CK1_1	266	272	PF00069	0.349
MOD_CK1_1	283	289	PF00069	0.252
MOD_CK1_1	481	487	PF00069	0.370
MOD_CK1_1	58	64	PF00069	0.237
MOD_CK2_1	312	318	PF00069	0.249
MOD_CK2_1	320	326	PF00069	0.237
MOD_CK2_1	354	360	PF00069	0.237
MOD_CK2_1	38	44	PF00069	0.344
MOD_GlcNHglycan	441	445	PF01048	0.237
MOD_GlcNHglycan	460	463	PF01048	0.237
MOD_GlcNHglycan	480	483	PF01048	0.370
MOD_GlcNHglycan	65	68	PF01048	0.390
MOD_GSK3_1	266	273	PF00069	0.377
MOD_GSK3_1	478	485	PF00069	0.370
MOD_GSK3_1	81	88	PF00069	0.288
MOD_N-GLC_2	203	205	PF02516	0.370
MOD_N-GLC_2	305	307	PF02516	0.237
MOD_N-GLC_2	464	466	PF02516	0.237
MOD_NEK2_1	285	290	PF00069	0.199
MOD_NEK2_1	291	296	PF00069	0.199
MOD_NEK2_1	330	335	PF00069	0.237
MOD_NEK2_1	440	445	PF00069	0.265
MOD_NEK2_1	478	483	PF00069	0.370
MOD_NEK2_1	56	61	PF00069	0.391
MOD_OFUCOSY	262	268	PF10250	0.160
MOD_PKA_2	283	289	PF00069	0.237
MOD_PKA_2	330	336	PF00069	0.281
MOD_PKA_2	457	463	PF00069	0.237
MOD_PKB_1	104	112	PF00069	0.250
MOD_Plk_1	106	112	PF00069	0.250
MOD_Plk_1	13	19	PF00069	0.480
MOD_Plk_4	291	297	PF00069	0.298
MOD_Plk_4	298	304	PF00069	0.276
MOD_ProDKin_1	188	194	PF00069	0.237
MOD_ProDKin_1	261	267	PF00069	0.256
MOD_ProDKin_1	320	326	PF00069	0.253
MOD_ProDKin_1	38	44	PF00069	0.344
MOD_SUMO_rev_2	41	47	PF00179	0.290
TRG_DiLeu_BaEn_4	21	27	PF01217	0.403
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.370
TRG_ENDOCYTIC_2	125	128	PF00928	0.237
TRG_ENDOCYTIC_2	137	140	PF00928	0.237
TRG_ENDOCYTIC_2	171	174	PF00928	0.299
TRG_ENDOCYTIC_2	23	26	PF00928	0.352
TRG_ENDOCYTIC_2	293	296	PF00928	0.273
TRG_ENDOCYTIC_2	347	350	PF00928	0.244
TRG_ENDOCYTIC_2	387	390	PF00928	0.254
TRG_ENDOCYTIC_2	475	478	PF00928	0.237
TRG_ER_diArg_1	123	125	PF00400	0.238
TRG_ER_diArg_1	8	11	PF00400	0.559
TRG_NES_CRM1_1	82	95	PF08389	0.315
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P579	Leptomonas seymouri	31%	100%
A0A0N1IK28	Leptomonas seymouri	83%	100%
A0A0S4JK69	Bodo saltans	33%	98%
A0A1X0P4E6	Trypanosomatidae	31%	100%
A0A1X0P522	Trypanosomatidae	66%	100%
A0A3R7KQ87	Trypanosoma rangeli	32%	100%
A0A3S7X9T8	Leishmania donovani	93%	100%
A0A3S7XBA3	Leishmania donovani	31%	100%
A0A422NK56	Trypanosoma rangeli	67%	100%
A4HPM5	Leishmania braziliensis	32%	100%
A4IBV6	Leishmania infantum	92%	100%
A4ID40	Leishmania infantum	31%	100%
C9ZYQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
D0A8J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AFP3	Leishmania major	92%	100%
E9ATD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B6U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q10301	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q4Q160	Leishmania major	32%	97%
Q54BM8	Dictyostelium discoideum	40%	73%
Q9USN2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
V5BS87	Trypanosoma cruzi	32%	98%
V5C2P9	Trypanosoma cruzi	66%	100%