Ion_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HN86_LEIBR

TriTrypDb:

LbrM.34.4140 , LBRM2903_340050900

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HN86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.611
CLV_C14_Caspase3-7	261	265	PF00656	0.697
CLV_NRD_NRD_1	133	135	PF00675	0.361
CLV_NRD_NRD_1	212	214	PF00675	0.498
CLV_NRD_NRD_1	291	293	PF00675	0.510
CLV_PCSK_KEX2_1	212	214	PF00082	0.444
CLV_PCSK_KEX2_1	291	293	PF00082	0.504
CLV_PCSK_SKI1_1	129	133	PF00082	0.329
CLV_PCSK_SKI1_1	212	216	PF00082	0.442
CLV_PCSK_SKI1_1	298	302	PF00082	0.390
CLV_PCSK_SKI1_1	89	93	PF00082	0.312
DEG_Nend_Nbox_1	1	3	PF02207	0.397
DEG_SPOP_SBC_1	257	261	PF00917	0.632
DOC_CDC14_PxL_1	96	104	PF14671	0.416
DOC_CYCLIN_RxL_1	168	176	PF00134	0.509
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.556
DOC_MAPK_DCC_7	178	188	PF00069	0.555
DOC_MAPK_DCC_7	54	64	PF00069	0.586
DOC_MAPK_gen_1	134	140	PF00069	0.545
DOC_MAPK_gen_1	209	217	PF00069	0.583
DOC_MAPK_gen_1	27	35	PF00069	0.569
DOC_MAPK_gen_1	49	59	PF00069	0.558
DOC_MAPK_MEF2A_6	142	151	PF00069	0.548
DOC_MAPK_MEF2A_6	52	59	PF00069	0.599
DOC_PP1_RVXF_1	169	176	PF00149	0.507
DOC_PP1_RVXF_1	87	93	PF00149	0.312
DOC_PP2B_LxvP_1	111	114	PF13499	0.462
DOC_PP2B_LxvP_1	97	100	PF13499	0.609
DOC_PP4_FxxP_1	98	101	PF00568	0.504
DOC_USP7_MATH_1	187	191	PF00917	0.675
DOC_USP7_MATH_1	199	203	PF00917	0.652
DOC_USP7_MATH_1	241	245	PF00917	0.716
DOC_USP7_MATH_1	248	252	PF00917	0.674
DOC_USP7_MATH_1	257	261	PF00917	0.621
DOC_USP7_MATH_1	36	40	PF00917	0.607
DOC_WW_Pin1_4	122	127	PF00397	0.649
DOC_WW_Pin1_4	253	258	PF00397	0.723
LIG_14-3-3_CanoR_1	157	162	PF00244	0.536
LIG_APCC_ABBA_1	82	87	PF00400	0.312
LIG_deltaCOP1_diTrp_1	80	85	PF00928	0.329
LIG_FHA_1	247	253	PF00498	0.687
LIG_FHA_1	285	291	PF00498	0.710
LIG_FHA_1	29	35	PF00498	0.679
LIG_FHA_2	259	265	PF00498	0.687
LIG_Integrin_RGD_1	262	264	PF01839	0.421
LIG_LIR_Apic_2	236	241	PF02991	0.602
LIG_LIR_Apic_2	95	101	PF02991	0.425
LIG_LIR_Gen_1	106	116	PF02991	0.561
LIG_LIR_Nem_3	106	111	PF02991	0.561
LIG_LIR_Nem_3	11	15	PF02991	0.284
LIG_LIR_Nem_3	80	85	PF02991	0.275
LIG_NRBOX	72	78	PF00104	0.219
LIG_Pex14_1	81	85	PF04695	0.388
LIG_Pex14_2	12	16	PF04695	0.231
LIG_REV1ctd_RIR_1	129	136	PF16727	0.522
LIG_SH2_CRK	108	112	PF00017	0.463
LIG_SH2_CRK	94	98	PF00017	0.312
LIG_SH2_PTP2	238	241	PF00017	0.603
LIG_SH2_SRC	238	241	PF00017	0.603
LIG_SH2_SRC	274	277	PF00017	0.614
LIG_SH2_STAP1	108	112	PF00017	0.463
LIG_SH2_STAP1	94	98	PF00017	0.330
LIG_SH2_STAT5	15	18	PF00017	0.312
LIG_SH2_STAT5	154	157	PF00017	0.578
LIG_SH2_STAT5	238	241	PF00017	0.603
LIG_SH2_STAT5	274	277	PF00017	0.614
LIG_SH2_STAT5	94	97	PF00017	0.312
LIG_SH3_3	120	126	PF00018	0.614
LIG_SH3_3	181	187	PF00018	0.567
LIG_SUMO_SIM_par_1	6	11	PF11976	0.388
LIG_SUMO_SIM_par_1	64	70	PF11976	0.312
LIG_TRAF2_1	103	106	PF00917	0.559
LIG_WRC_WIRS_1	9	14	PF05994	0.303
MOD_CDK_SPK_2	122	127	PF00069	0.537
MOD_CDK_SPxxK_3	122	129	PF00069	0.648
MOD_CK1_1	243	249	PF00069	0.655
MOD_CK1_1	251	257	PF00069	0.752
MOD_CK1_1	269	275	PF00069	0.790
MOD_CK1_1	282	288	PF00069	0.688
MOD_CK1_1	38	44	PF00069	0.726
MOD_CK2_1	274	280	PF00069	0.686
MOD_GlcNHglycan	197	200	PF01048	0.515
MOD_GlcNHglycan	201	205	PF01048	0.475
MOD_GlcNHglycan	276	279	PF01048	0.584
MOD_GlcNHglycan	280	284	PF01048	0.460
MOD_GSK3_1	118	125	PF00069	0.524
MOD_GSK3_1	187	194	PF00069	0.657
MOD_GSK3_1	195	202	PF00069	0.688
MOD_GSK3_1	246	253	PF00069	0.655
MOD_GSK3_1	265	272	PF00069	0.680
MOD_GSK3_1	35	42	PF00069	0.619
MOD_N-GLC_1	152	157	PF02516	0.369
MOD_NEK2_1	1	6	PF00069	0.410
MOD_NEK2_1	173	178	PF00069	0.523
MOD_NEK2_1	258	263	PF00069	0.682
MOD_NEK2_1	266	271	PF00069	0.715
MOD_NEK2_1	67	72	PF00069	0.439
MOD_NEK2_1	8	13	PF00069	0.279
MOD_NEK2_1	92	97	PF00069	0.312
MOD_PIKK_1	152	158	PF00454	0.502
MOD_PIKK_1	173	179	PF00454	0.589
MOD_PIKK_1	282	288	PF00454	0.626
MOD_PKA_2	199	205	PF00069	0.663
MOD_PKA_2	28	34	PF00069	0.609
MOD_Plk_1	241	247	PF00069	0.667
MOD_Plk_1	36	42	PF00069	0.560
MOD_Plk_2-3	284	290	PF00069	0.624
MOD_Plk_4	118	124	PF00069	0.547
MOD_Plk_4	39	45	PF00069	0.625
MOD_Plk_4	72	78	PF00069	0.439
MOD_Plk_4	8	14	PF00069	0.316
MOD_Plk_4	92	98	PF00069	0.326
MOD_ProDKin_1	122	128	PF00069	0.647
MOD_ProDKin_1	253	259	PF00069	0.723
MOD_SUMO_rev_2	201	211	PF00179	0.600
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.562
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.384
TRG_ENDOCYTIC_2	108	111	PF00928	0.469
TRG_ENDOCYTIC_2	15	18	PF00928	0.312
TRG_ENDOCYTIC_2	20	23	PF00928	0.312
TRG_ENDOCYTIC_2	94	97	PF00928	0.312
TRG_ER_diArg_1	211	213	PF00400	0.699
TRG_ER_diArg_1	290	292	PF00400	0.688
TRG_NES_CRM1_1	207	218	PF08389	0.585
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X0	Leptomonas seymouri	51%	99%
A0A3Q8IIP6	Leishmania donovani	62%	99%
A4IBV4	Leishmania infantum	62%	99%
E9AFP1	Leishmania major	63%	100%
E9B6U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%