Polyadenylate-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

polyadenylate-binding protein 2

Species:

Leishmania braziliensis

UniProt:

A4HN85_LEIBR

TriTrypDb:

LbrM.34.4130 , LBRM2903_340050800

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0000932	P-body	5	1
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0032991	protein-containing complex	1	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097165	nuclear stress granule	4	1
GO:0099080	supramolecular complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HN85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN85

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0005515	protein binding	2	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0031369	translation initiation factor binding	3	1
GO:0031370	eukaryotic initiation factor 4G binding	4	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	554	558	PF00656	0.563
CLV_NRD_NRD_1	277	279	PF00675	0.521
CLV_NRD_NRD_1	366	368	PF00675	0.490
CLV_NRD_NRD_1	371	373	PF00675	0.493
CLV_NRD_NRD_1	90	92	PF00675	0.515
CLV_PCSK_FUR_1	275	279	PF00082	0.514
CLV_PCSK_KEX2_1	277	279	PF00082	0.519
CLV_PCSK_KEX2_1	371	373	PF00082	0.500
CLV_PCSK_KEX2_1	89	91	PF00082	0.514
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.487
CLV_PCSK_PC7_1	273	279	PF00082	0.516
CLV_PCSK_PC7_1	367	373	PF00082	0.506
CLV_PCSK_PC7_1	85	91	PF00082	0.488
CLV_PCSK_SKI1_1	112	116	PF00082	0.265
CLV_PCSK_SKI1_1	180	184	PF00082	0.481
CLV_PCSK_SKI1_1	200	204	PF00082	0.300
CLV_PCSK_SKI1_1	358	362	PF00082	0.391
CLV_PCSK_SKI1_1	518	522	PF00082	0.255
CLV_PCSK_SKI1_1	79	83	PF00082	0.407
DOC_ANK_TNKS_1	119	126	PF00023	0.466
DOC_CYCLIN_RxL_1	109	116	PF00134	0.400
DOC_CYCLIN_RxL_1	355	363	PF00134	0.325
DOC_CYCLIN_yCln2_LP_2	556	562	PF00134	0.437
DOC_MAPK_gen_1	117	126	PF00069	0.488
DOC_MAPK_HePTP_8	307	319	PF00069	0.479
DOC_MAPK_MEF2A_6	310	319	PF00069	0.466
DOC_MAPK_MEF2A_6	539	547	PF00069	0.455
DOC_PP1_RVXF_1	137	143	PF00149	0.522
DOC_PP2B_PxIxI_1	7	13	PF00149	0.305
DOC_PP4_FxxP_1	3	6	PF00568	0.625
DOC_PP4_FxxP_1	354	357	PF00568	0.530
DOC_PP4_FxxP_1	402	405	PF00568	0.582
DOC_PP4_FxxP_1	415	418	PF00568	0.570
DOC_PP4_FxxP_1	56	59	PF00568	0.455
DOC_USP7_MATH_1	208	212	PF00917	0.445
DOC_USP7_MATH_1	33	37	PF00917	0.455
DOC_USP7_MATH_1	486	490	PF00917	0.691
DOC_USP7_MATH_1	6	10	PF00917	0.412
DOC_USP7_UBL2_3	100	104	PF12436	0.559
DOC_WW_Pin1_4	414	419	PF00397	0.629
DOC_WW_Pin1_4	555	560	PF00397	0.497
LIG_14-3-3_CanoR_1	120	126	PF00244	0.461
LIG_14-3-3_CanoR_1	139	143	PF00244	0.455
LIG_14-3-3_CanoR_1	524	529	PF00244	0.559
LIG_14-3-3_CterR_2	575	579	PF00244	0.606
LIG_BIR_II_1	1	5	PF00653	0.509
LIG_BRCT_BRCA1_1	327	331	PF00533	0.455
LIG_BRCT_BRCA1_1	378	382	PF00533	0.672
LIG_Clathr_ClatBox_1	544	548	PF01394	0.455
LIG_eIF4E_1	109	115	PF01652	0.400
LIG_EVH1_2	398	402	PF00568	0.699
LIG_FHA_1	106	112	PF00498	0.511
LIG_FHA_1	255	261	PF00498	0.331
LIG_FHA_1	312	318	PF00498	0.455
LIG_FHA_1	361	367	PF00498	0.431
LIG_FHA_1	539	545	PF00498	0.455
LIG_GBD_Chelix_1	536	544	PF00786	0.359
LIG_LIR_Apic_2	352	357	PF02991	0.621
LIG_LIR_Gen_1	113	123	PF02991	0.522
LIG_LIR_Gen_1	134	142	PF02991	0.466
LIG_LIR_Gen_1	26	34	PF02991	0.457
LIG_LIR_Gen_1	523	534	PF02991	0.455
LIG_LIR_Gen_1	75	83	PF02991	0.617
LIG_LIR_Nem_3	113	118	PF02991	0.455
LIG_LIR_Nem_3	134	140	PF02991	0.466
LIG_LIR_Nem_3	26	31	PF02991	0.457
LIG_LIR_Nem_3	285	290	PF02991	0.431
LIG_LIR_Nem_3	305	311	PF02991	0.369
LIG_LIR_Nem_3	328	334	PF02991	0.455
LIG_LIR_Nem_3	48	54	PF02991	0.455
LIG_LIR_Nem_3	523	529	PF02991	0.455
LIG_LIR_Nem_3	75	80	PF02991	0.535
LIG_LYPXL_yS_3	287	290	PF13949	0.401
LIG_REV1ctd_RIR_1	200	209	PF16727	0.553
LIG_SH2_CRK	137	141	PF00017	0.494
LIG_SH2_CRK	206	210	PF00017	0.400
LIG_SH2_CRK	51	55	PF00017	0.455
LIG_SH2_CRK	526	530	PF00017	0.479
LIG_SH2_GRB2like	53	56	PF00017	0.455
LIG_SH2_NCK_1	137	141	PF00017	0.466
LIG_SH2_STAP1	25	29	PF00017	0.455
LIG_SH2_STAP1	526	530	PF00017	0.559
LIG_SH2_STAT3	170	173	PF00017	0.628
LIG_SH2_STAT5	186	189	PF00017	0.471
LIG_SH2_STAT5	228	231	PF00017	0.489
LIG_SH2_STAT5	27	30	PF00017	0.550
LIG_SH2_STAT5	291	294	PF00017	0.455
LIG_SH2_STAT5	528	531	PF00017	0.479
LIG_SH2_STAT5	53	56	PF00017	0.455
LIG_SH2_STAT5	77	80	PF00017	0.571
LIG_SH3_1	479	485	PF00018	0.676
LIG_SH3_3	408	414	PF00018	0.631
LIG_SH3_3	415	421	PF00018	0.587
LIG_SH3_3	464	470	PF00018	0.600
LIG_SH3_3	479	485	PF00018	0.635
LIG_SH3_4	484	491	PF00018	0.773
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.479
LIG_SUMO_SIM_par_1	255	261	PF11976	0.554
LIG_SUMO_SIM_par_1	313	318	PF11976	0.479
LIG_SUMO_SIM_par_1	557	564	PF11976	0.400
LIG_TRAF2_1	240	243	PF00917	0.459
LIG_TRAF2_1	265	268	PF00917	0.544
LIG_TRAF2_1	345	348	PF00917	0.466
LIG_TYR_ITIM	49	54	PF00017	0.455
MOD_CDK_SPK_2	414	419	PF00069	0.478
MOD_CK1_1	532	538	PF00069	0.501
MOD_CK2_1	144	150	PF00069	0.409
MOD_CK2_1	262	268	PF00069	0.483
MOD_GlcNHglycan	145	149	PF01048	0.255
MOD_GlcNHglycan	210	213	PF01048	0.300
MOD_GlcNHglycan	3	6	PF01048	0.509
MOD_GlcNHglycan	42	45	PF01048	0.359
MOD_GlcNHglycan	91	94	PF01048	0.456
MOD_GSK3_1	254	261	PF00069	0.567
MOD_GSK3_1	311	318	PF00069	0.494
MOD_GSK3_1	471	478	PF00069	0.761
MOD_GSK3_1	547	554	PF00069	0.568
MOD_GSK3_1	68	75	PF00069	0.544
MOD_GSK3_1	85	92	PF00069	0.384
MOD_N-GLC_1	349	354	PF02516	0.359
MOD_NEK2_1	1	6	PF00069	0.637
MOD_NEK2_1	258	263	PF00069	0.423
MOD_NEK2_1	295	300	PF00069	0.462
MOD_NEK2_1	349	354	PF00069	0.455
MOD_NEK2_1	360	365	PF00069	0.386
MOD_NEK2_1	407	412	PF00069	0.638
MOD_NEK2_1	561	566	PF00069	0.522
MOD_NEK2_2	33	38	PF00069	0.455
MOD_NEK2_2	332	337	PF00069	0.455
MOD_PIKK_1	340	346	PF00454	0.501
MOD_PIKK_1	42	48	PF00454	0.466
MOD_PIKK_1	471	477	PF00454	0.727
MOD_PKA_1	89	95	PF00069	0.469
MOD_PKA_2	119	125	PF00069	0.461
MOD_PKA_2	138	144	PF00069	0.499
MOD_PKA_2	89	95	PF00069	0.454
MOD_Plk_1	144	150	PF00069	0.457
MOD_Plk_1	254	260	PF00069	0.565
MOD_Plk_1	295	301	PF00069	0.466
MOD_Plk_2-3	551	557	PF00069	0.563
MOD_Plk_4	315	321	PF00069	0.479
MOD_Plk_4	350	356	PF00069	0.479
MOD_Plk_4	486	492	PF00069	0.691
MOD_Plk_4	524	530	PF00069	0.501
MOD_Plk_4	551	557	PF00069	0.563
MOD_Plk_4	6	12	PF00069	0.403
MOD_ProDKin_1	414	420	PF00069	0.630
MOD_ProDKin_1	555	561	PF00069	0.497
MOD_SUMO_for_1	252	255	PF00179	0.363
MOD_SUMO_rev_2	191	199	PF00179	0.479
MOD_SUMO_rev_2	557	567	PF00179	0.455
TRG_ENDOCYTIC_2	137	140	PF00928	0.494
TRG_ENDOCYTIC_2	206	209	PF00928	0.528
TRG_ENDOCYTIC_2	228	231	PF00928	0.537
TRG_ENDOCYTIC_2	25	28	PF00928	0.455
TRG_ENDOCYTIC_2	287	290	PF00928	0.401
TRG_ENDOCYTIC_2	51	54	PF00928	0.455
TRG_ENDOCYTIC_2	526	529	PF00928	0.455
TRG_ENDOCYTIC_2	77	80	PF00928	0.571
TRG_ER_diArg_1	263	266	PF00400	0.480
TRG_ER_diArg_1	275	278	PF00400	0.503
TRG_ER_diArg_1	382	385	PF00400	0.563
TRG_ER_diArg_1	476	479	PF00400	0.638
TRG_NES_CRM1_1	176	191	PF08389	0.474
TRG_NLS_MonoExtN_4	87	93	PF00514	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A9	Leptomonas seymouri	89%	100%
A0A0N1I0F0	Leptomonas seymouri	35%	100%
A0A0S4IKZ4	Bodo saltans	57%	100%
A0A0S4JPT3	Bodo saltans	33%	100%
A0A1X0P4T3	Trypanosomatidae	37%	100%
A0A1X0P4V5	Trypanosomatidae	34%	100%
A0A1X0P525	Trypanosomatidae	68%	100%
A0A3Q8IF40	Leishmania donovani	36%	100%
A0A3Q8IMW2	Leishmania donovani	93%	99%
A0A3R7NAH9	Trypanosoma rangeli	37%	100%
A0A422NK82	Trypanosoma rangeli	67%	100%
A1CRM1	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	33%	77%
A1D4K4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	32%	77%
A2Q848	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	33%	79%
A3LXL0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	34%	92%
A4HDV5	Leishmania braziliensis	37%	100%
A4HNG6	Leishmania braziliensis	38%	100%
A4I150	Leishmania infantum	35%	100%
A4IBV3	Leishmania infantum	93%	99%
A4QUF0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	33%	76%
A5DM21	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	35%	92%
A5DW14	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	34%	88%
C9ZYQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AFP0	Leishmania major	91%	100%
E9AFX7	Leishmania major	38%	100%
E9AX84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B6U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	97%
F1QB54	Danio rerio	40%	91%
O22173	Arabidopsis thaliana	38%	87%
O64380	Arabidopsis thaliana	39%	88%
P04147	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P0CP46	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	37%	86%
P0CP47	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	37%	86%
P11940	Homo sapiens	37%	91%
P20965	Xenopus laevis	40%	91%
P29341	Mus musculus	37%	91%
P31209	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	89%
P42731	Arabidopsis thaliana	38%	92%
P61286	Bos taurus	37%	91%
Q05196	Arabidopsis thaliana	35%	85%
Q0CR95	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	33%	77%
Q0U1G2	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	32%	78%
Q1DXH0	Coccidioides immitis (strain RS)	33%	75%
Q1ZXC2	Dictyostelium discoideum	31%	71%
Q2GSX8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	32%	74%
Q2UK72	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	29%	76%
Q4P8R9	Ustilago maydis (strain 521 / FGSC 9021)	35%	89%
Q4QA88	Leishmania major	33%	92%
Q4VXU2	Homo sapiens	39%	94%
Q4WK03	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	32%	77%
Q54BM2	Dictyostelium discoideum	33%	100%
Q5AI15	Candida albicans (strain SC5314 / ATCC MYA-2876)	34%	92%
Q5B630	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	33%	79%
Q5R8F7	Pongo abelii	37%	91%
Q6BI95	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	35%	92%
Q6CDH3	Yarrowia lipolytica (strain CLIB 122 / E 150)	32%	92%
Q6CSV3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	34%	98%
Q6DEY7	Xenopus tropicalis	38%	92%
Q6FKG4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	34%	100%
Q6GR16	Xenopus laevis	37%	92%
Q6IP09	Xenopus laevis	40%	91%
Q74ZS6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	37%	99%
Q7S6N6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	34%	76%
Q8SR30	Encephalitozoon cuniculi (strain GB-M1)	26%	100%
Q98SP8	Xenopus laevis	37%	92%
Q9EPH8	Rattus norvegicus	39%	91%
Q9ZQA8	Arabidopsis thaliana	30%	95%
V5BYR2	Trypanosoma cruzi	36%	100%
V5DUJ1	Trypanosoma cruzi	67%	100%