Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN84_LEIBR

TriTrypDb:

LbrM.34.4120 , LBRM2903_340050700

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.692
CLV_NRD_NRD_1	203	205	PF00675	0.797
CLV_NRD_NRD_1	239	241	PF00675	0.805
CLV_NRD_NRD_1	427	429	PF00675	0.726
CLV_NRD_NRD_1	431	433	PF00675	0.710
CLV_NRD_NRD_1	485	487	PF00675	0.564
CLV_NRD_NRD_1	66	68	PF00675	0.723
CLV_NRD_NRD_1	69	71	PF00675	0.718
CLV_PCSK_KEX2_1	203	205	PF00082	0.797
CLV_PCSK_KEX2_1	239	241	PF00082	0.805
CLV_PCSK_KEX2_1	288	290	PF00082	0.674
CLV_PCSK_KEX2_1	485	487	PF00082	0.746
CLV_PCSK_KEX2_1	66	68	PF00082	0.723
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.730
CLV_PCSK_PC7_1	284	290	PF00082	0.580
CLV_PCSK_SKI1_1	193	197	PF00082	0.635
CLV_PCSK_SKI1_1	284	288	PF00082	0.570
CLV_PCSK_SKI1_1	428	432	PF00082	0.673
CLV_PCSK_SKI1_1	70	74	PF00082	0.698
DEG_Nend_UBRbox_3	1	3	PF02207	0.607
DEG_SPOP_SBC_1	29	33	PF00917	0.664
DOC_CKS1_1	139	144	PF01111	0.746
DOC_CKS1_1	346	351	PF01111	0.612
DOC_CKS1_1	532	537	PF01111	0.581
DOC_MAPK_gen_1	239	245	PF00069	0.546
DOC_MAPK_gen_1	35	43	PF00069	0.560
DOC_PP2B_LxvP_1	328	331	PF13499	0.719
DOC_PP4_FxxP_1	522	525	PF00568	0.683
DOC_PP4_MxPP_1	115	118	PF00568	0.536
DOC_USP7_MATH_1	140	144	PF00917	0.532
DOC_USP7_MATH_1	147	151	PF00917	0.731
DOC_USP7_MATH_1	213	217	PF00917	0.662
DOC_USP7_MATH_1	247	251	PF00917	0.787
DOC_USP7_MATH_1	424	428	PF00917	0.696
DOC_USP7_MATH_1	460	464	PF00917	0.535
DOC_USP7_MATH_1	471	475	PF00917	0.505
DOC_USP7_MATH_1	490	494	PF00917	0.686
DOC_USP7_MATH_1	499	503	PF00917	0.721
DOC_USP7_MATH_1	507	511	PF00917	0.585
DOC_USP7_UBL2_3	429	433	PF12436	0.809
DOC_WW_Pin1_4	138	143	PF00397	0.716
DOC_WW_Pin1_4	223	228	PF00397	0.675
DOC_WW_Pin1_4	234	239	PF00397	0.677
DOC_WW_Pin1_4	3	8	PF00397	0.584
DOC_WW_Pin1_4	301	306	PF00397	0.760
DOC_WW_Pin1_4	345	350	PF00397	0.733
DOC_WW_Pin1_4	422	427	PF00397	0.543
DOC_WW_Pin1_4	456	461	PF00397	0.697
DOC_WW_Pin1_4	479	484	PF00397	0.647
DOC_WW_Pin1_4	512	517	PF00397	0.768
DOC_WW_Pin1_4	531	536	PF00397	0.620
DOC_WW_Pin1_4	562	567	PF00397	0.674
LIG_14-3-3_CanoR_1	14	24	PF00244	0.706
LIG_14-3-3_CanoR_1	193	198	PF00244	0.656
LIG_14-3-3_CanoR_1	203	209	PF00244	0.800
LIG_14-3-3_CanoR_1	246	256	PF00244	0.748
LIG_14-3-3_CanoR_1	289	299	PF00244	0.677
LIG_14-3-3_CanoR_1	301	305	PF00244	0.609
LIG_14-3-3_CanoR_1	399	407	PF00244	0.703
LIG_14-3-3_CanoR_1	42	47	PF00244	0.712
LIG_14-3-3_CanoR_1	485	492	PF00244	0.808
LIG_14-3-3_CanoR_1	54	59	PF00244	0.697
LIG_14-3-3_CanoR_1	559	565	PF00244	0.706
LIG_14-3-3_CanoR_1	578	582	PF00244	0.766
LIG_14-3-3_CanoR_1	93	97	PF00244	0.607
LIG_EVH1_2	447	451	PF00568	0.758
LIG_FHA_1	139	145	PF00498	0.603
LIG_FHA_1	197	203	PF00498	0.580
LIG_FHA_1	207	213	PF00498	0.604
LIG_FHA_1	224	230	PF00498	0.567
LIG_FHA_1	301	307	PF00498	0.578
LIG_FHA_1	341	347	PF00498	0.749
LIG_FHA_1	36	42	PF00498	0.666
LIG_FHA_1	4	10	PF00498	0.567
LIG_FHA_1	429	435	PF00498	0.767
LIG_FHA_1	457	463	PF00498	0.622
LIG_FHA_1	57	63	PF00498	0.570
LIG_FHA_2	314	320	PF00498	0.565
LIG_FHA_2	566	572	PF00498	0.679
LIG_LIR_Apic_2	519	525	PF02991	0.682
LIG_LIR_Gen_1	568	575	PF02991	0.668
LIG_LIR_Nem_3	456	461	PF02991	0.537
LIG_LIR_Nem_3	463	467	PF02991	0.515
LIG_LIR_Nem_3	568	573	PF02991	0.703
LIG_PDZ_Class_2	578	583	PF00595	0.769
LIG_Pex14_2	522	526	PF04695	0.685
LIG_SH2_CRK	458	462	PF00017	0.534
LIG_SH2_NCK_1	248	252	PF00017	0.810
LIG_SH2_STAP1	248	252	PF00017	0.558
LIG_SH2_STAT5	248	251	PF00017	0.559
LIG_SH2_STAT5	458	461	PF00017	0.534
LIG_SH3_2	235	240	PF14604	0.705
LIG_SH3_2	480	485	PF14604	0.715
LIG_SH3_3	111	117	PF00018	0.772
LIG_SH3_3	136	142	PF00018	0.618
LIG_SH3_3	174	180	PF00018	0.697
LIG_SH3_3	229	235	PF00018	0.681
LIG_SH3_3	241	247	PF00018	0.619
LIG_SH3_3	302	308	PF00018	0.691
LIG_SH3_3	343	349	PF00018	0.670
LIG_SH3_3	442	448	PF00018	0.662
LIG_SH3_3	465	471	PF00018	0.676
LIG_SH3_3	474	480	PF00018	0.649
LIG_SH3_3	545	551	PF00018	0.728
LIG_SH3_4	73	80	PF00018	0.652
LIG_SUMO_SIM_par_1	59	65	PF11976	0.567
LIG_SUMO_SIM_par_1	94	102	PF11976	0.539
LIG_SxIP_EBH_1	204	218	PF03271	0.547
LIG_UBA3_1	100	107	PF00899	0.530
LIG_WRC_WIRS_1	461	466	PF05994	0.696
LIG_WW_3	330	334	PF00397	0.612
MOD_CDC14_SPxK_1	237	240	PF00782	0.805
MOD_CDC14_SPxK_1	425	428	PF00782	0.535
MOD_CDC14_SPxK_1	482	485	PF00782	0.710
MOD_CDK_SPK_2	234	239	PF00069	0.805
MOD_CDK_SPK_2	345	350	PF00069	0.826
MOD_CDK_SPK_2	562	567	PF00069	0.701
MOD_CDK_SPxK_1	234	240	PF00069	0.806
MOD_CDK_SPxK_1	422	428	PF00069	0.544
MOD_CDK_SPxK_1	479	485	PF00069	0.713
MOD_CDK_SPxxK_3	3	10	PF00069	0.585
MOD_CDK_SPxxK_3	422	429	PF00069	0.587
MOD_CDK_SPxxK_3	479	486	PF00069	0.713
MOD_CDK_SPxxK_3	531	538	PF00069	0.664
MOD_CK1_1	124	130	PF00069	0.800
MOD_CK1_1	15	21	PF00069	0.648
MOD_CK1_1	206	212	PF00069	0.592
MOD_CK1_1	258	264	PF00069	0.648
MOD_CK1_1	28	34	PF00069	0.629
MOD_CK1_1	290	296	PF00069	0.678
MOD_CK1_1	3	9	PF00069	0.692
MOD_CK1_1	366	372	PF00069	0.608
MOD_CK1_1	385	391	PF00069	0.495
MOD_CK1_1	394	400	PF00069	0.606
MOD_CK1_1	515	521	PF00069	0.540
MOD_CK1_1	530	536	PF00069	0.700
MOD_CK1_1	565	571	PF00069	0.685
MOD_CK1_1	60	66	PF00069	0.818
MOD_CK1_1	99	105	PF00069	0.683
MOD_CK2_1	225	231	PF00069	0.702
MOD_GlcNHglycan	118	121	PF01048	0.652
MOD_GlcNHglycan	134	137	PF01048	0.769
MOD_GlcNHglycan	149	152	PF01048	0.549
MOD_GlcNHglycan	193	196	PF01048	0.549
MOD_GlcNHglycan	2	5	PF01048	0.681
MOD_GlcNHglycan	215	218	PF01048	0.684
MOD_GlcNHglycan	249	252	PF01048	0.647
MOD_GlcNHglycan	292	295	PF01048	0.684
MOD_GlcNHglycan	324	327	PF01048	0.643
MOD_GlcNHglycan	350	353	PF01048	0.761
MOD_GlcNHglycan	378	381	PF01048	0.819
MOD_GlcNHglycan	385	388	PF01048	0.712
MOD_GlcNHglycan	396	399	PF01048	0.721
MOD_GlcNHglycan	416	419	PF01048	0.725
MOD_GlcNHglycan	422	425	PF01048	0.716
MOD_GlcNHglycan	437	440	PF01048	0.646
MOD_GlcNHglycan	44	47	PF01048	0.675
MOD_GlcNHglycan	473	476	PF01048	0.771
MOD_GlcNHglycan	492	495	PF01048	0.668
MOD_GlcNHglycan	501	504	PF01048	0.699
MOD_GlcNHglycan	575	578	PF01048	0.662
MOD_GlcNHglycan	94	97	PF01048	0.664
MOD_GSK3_1	12	19	PF00069	0.707
MOD_GSK3_1	149	156	PF00069	0.665
MOD_GSK3_1	198	205	PF00069	0.587
MOD_GSK3_1	207	214	PF00069	0.655
MOD_GSK3_1	217	224	PF00069	0.607
MOD_GSK3_1	247	254	PF00069	0.706
MOD_GSK3_1	25	32	PF00069	0.714
MOD_GSK3_1	289	296	PF00069	0.731
MOD_GSK3_1	297	304	PF00069	0.727
MOD_GSK3_1	340	347	PF00069	0.749
MOD_GSK3_1	348	355	PF00069	0.690
MOD_GSK3_1	363	370	PF00069	0.506
MOD_GSK3_1	37	44	PF00069	0.686
MOD_GSK3_1	383	390	PF00069	0.790
MOD_GSK3_1	420	427	PF00069	0.716
MOD_GSK3_1	433	440	PF00069	0.620
MOD_GSK3_1	456	463	PF00069	0.600
MOD_GSK3_1	486	493	PF00069	0.682
MOD_GSK3_1	527	534	PF00069	0.612
MOD_GSK3_1	53	60	PF00069	0.677
MOD_GSK3_1	542	549	PF00069	0.668
MOD_GSK3_1	558	565	PF00069	0.687
MOD_GSK3_1	573	580	PF00069	0.647
MOD_GSK3_1	85	92	PF00069	0.657
MOD_N-GLC_1	147	152	PF02516	0.761
MOD_N-GLC_1	16	21	PF02516	0.711
MOD_N-GLC_1	290	295	PF02516	0.670
MOD_NEK2_1	191	196	PF00069	0.756
MOD_NEK2_1	198	203	PF00069	0.791
MOD_NEK2_1	340	345	PF00069	0.727
MOD_NEK2_1	367	372	PF00069	0.616
MOD_NEK2_1	451	456	PF00069	0.699
MOD_NEK2_1	573	578	PF00069	0.663
MOD_NEK2_1	62	67	PF00069	0.775
MOD_PIKK_1	217	223	PF00454	0.802
MOD_PIKK_1	272	278	PF00454	0.565
MOD_PIKK_1	73	79	PF00454	0.716
MOD_PK_1	204	210	PF00069	0.546
MOD_PK_1	225	231	PF00069	0.585
MOD_PK_1	255	261	PF00069	0.699
MOD_PK_1	37	43	PF00069	0.561
MOD_PKA_1	203	209	PF00069	0.665
MOD_PKA_1	428	434	PF00069	0.810
MOD_PKA_1	485	491	PF00069	0.716
MOD_PKA_2	202	208	PF00069	0.755
MOD_PKA_2	300	306	PF00069	0.776
MOD_PKA_2	374	380	PF00069	0.623
MOD_PKA_2	41	47	PF00069	0.700
MOD_PKA_2	484	490	PF00069	0.809
MOD_PKA_2	507	513	PF00069	0.721
MOD_PKA_2	527	533	PF00069	0.662
MOD_PKA_2	53	59	PF00069	0.720
MOD_PKA_2	558	564	PF00069	0.707
MOD_PKA_2	577	583	PF00069	0.666
MOD_PKA_2	65	71	PF00069	0.781
MOD_PKA_2	92	98	PF00069	0.676
MOD_PKB_1	52	60	PF00069	0.707
MOD_Plk_1	355	361	PF00069	0.558
MOD_Plk_4	110	116	PF00069	0.586
MOD_Plk_4	140	146	PF00069	0.538
MOD_Plk_4	193	199	PF00069	0.548
MOD_Plk_4	207	213	PF00069	0.685
MOD_Plk_4	527	533	PF00069	0.613
MOD_Plk_4	57	63	PF00069	0.620
MOD_Plk_4	96	102	PF00069	0.645
MOD_ProDKin_1	138	144	PF00069	0.720
MOD_ProDKin_1	223	229	PF00069	0.675
MOD_ProDKin_1	234	240	PF00069	0.677
MOD_ProDKin_1	3	9	PF00069	0.584
MOD_ProDKin_1	301	307	PF00069	0.758
MOD_ProDKin_1	345	351	PF00069	0.733
MOD_ProDKin_1	422	428	PF00069	0.544
MOD_ProDKin_1	456	462	PF00069	0.697
MOD_ProDKin_1	479	485	PF00069	0.648
MOD_ProDKin_1	512	518	PF00069	0.765
MOD_ProDKin_1	531	537	PF00069	0.624
MOD_ProDKin_1	562	568	PF00069	0.672
TRG_ENDOCYTIC_2	458	461	PF00928	0.534
TRG_ER_diArg_1	161	164	PF00400	0.631
TRG_ER_diArg_1	202	204	PF00400	0.801
TRG_ER_diArg_1	238	240	PF00400	0.793
TRG_ER_diArg_1	359	362	PF00400	0.761
TRG_ER_diArg_1	36	39	PF00400	0.624
TRG_ER_diArg_1	484	486	PF00400	0.562
TRG_ER_diArg_1	51	54	PF00400	0.581
TRG_NLS_MonoExtC_3	69	74	PF00514	0.561
TRG_NLS_MonoExtN_4	67	74	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3V4	Leptomonas seymouri	36%	100%
A0A3S7X9W4	Leishmania donovani	64%	100%
A4IBV2	Leishmania infantum	64%	100%
E9AFN9	Leishmania major	62%	100%
E9B6U2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%