5'-deoxynucleotidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HD domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HN82_LEIBR

TriTrypDb:

LbrM.34.4100 , LBRM2903_340050500

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN82

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002953	5'-deoxynucleotidase activity	6	11
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.347
CLV_PCSK_KEX2_1	28	30	PF00082	0.347
CLV_PCSK_SKI1_1	122	126	PF00082	0.321
CLV_PCSK_SKI1_1	137	141	PF00082	0.282
CLV_PCSK_SKI1_1	179	183	PF00082	0.397
CLV_PCSK_SKI1_1	65	69	PF00082	0.253
CLV_PCSK_SKI1_1	91	95	PF00082	0.372
DEG_APCC_DBOX_1	47	55	PF00400	0.300
DOC_MAPK_gen_1	63	71	PF00069	0.241
DOC_USP7_MATH_1	101	105	PF00917	0.310
DOC_USP7_MATH_1	57	61	PF00917	0.319
DOC_USP7_UBL2_3	91	95	PF12436	0.372
DOC_WW_Pin1_4	109	114	PF00397	0.321
DOC_WW_Pin1_4	23	28	PF00397	0.266
DOC_WW_Pin1_4	81	86	PF00397	0.241
LIG_14-3-3_CanoR_1	48	52	PF00244	0.319
LIG_Actin_WH2_2	10	26	PF00022	0.471
LIG_BIR_II_1	1	5	PF00653	0.625
LIG_FHA_1	97	103	PF00498	0.254
LIG_FHA_2	114	120	PF00498	0.178
LIG_FHA_2	182	188	PF00498	0.610
LIG_HCF-1_HBM_1	44	47	PF13415	0.241
LIG_LIR_Gen_1	153	159	PF02991	0.377
LIG_LIR_Nem_3	123	128	PF02991	0.278
LIG_LIR_Nem_3	188	194	PF02991	0.615
LIG_REV1ctd_RIR_1	164	172	PF16727	0.583
LIG_SH2_STAT3	128	131	PF00017	0.241
LIG_SH2_STAT5	191	194	PF00017	0.626
LIG_UBA3_1	79	88	PF00899	0.284
LIG_WRC_WIRS_1	13	18	PF05994	0.634
LIG_WRC_WIRS_1	163	168	PF05994	0.548
MOD_CDK_SPK_2	23	28	PF00069	0.201
MOD_CDK_SPxK_1	23	29	PF00069	0.254
MOD_CDK_SPxxK_3	81	88	PF00069	0.319
MOD_CK1_1	112	118	PF00069	0.314
MOD_CK1_1	153	159	PF00069	0.317
MOD_CK2_1	113	119	PF00069	0.314
MOD_CK2_1	181	187	PF00069	0.610
MOD_GlcNHglycan	168	171	PF01048	0.509
MOD_GSK3_1	108	115	PF00069	0.371
MOD_GSK3_1	12	19	PF00069	0.635
MOD_GSK3_1	162	169	PF00069	0.547
MOD_GSK3_1	181	188	PF00069	0.361
MOD_N-GLC_1	113	118	PF02516	0.244
MOD_NEK2_1	1	6	PF00069	0.600
MOD_NEK2_1	108	113	PF00069	0.372
MOD_NEK2_1	16	21	PF00069	0.538
MOD_NEK2_1	166	171	PF00069	0.624
MOD_NEK2_1	185	190	PF00069	0.353
MOD_PIKK_1	96	102	PF00454	0.364
MOD_PK_1	38	44	PF00069	0.201
MOD_PKA_2	47	53	PF00069	0.319
MOD_PKA_2	96	102	PF00069	0.213
MOD_Plk_1	113	119	PF00069	0.340
MOD_Plk_1	57	63	PF00069	0.259
MOD_Plk_4	162	168	PF00069	0.547
MOD_Plk_4	181	187	PF00069	0.377
MOD_Plk_4	47	53	PF00069	0.319
MOD_Plk_4	75	81	PF00069	0.241
MOD_ProDKin_1	109	115	PF00069	0.321
MOD_ProDKin_1	23	29	PF00069	0.266
MOD_ProDKin_1	81	87	PF00069	0.241
TRG_ENDOCYTIC_2	154	157	PF00928	0.347
TRG_ER_diArg_1	27	29	PF00400	0.254
TRG_NES_CRM1_1	44	58	PF08389	0.319
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.223
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.488
TRG_PTS2	1	36	PF00400	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX92	Leptomonas seymouri	82%	100%
A0A0S4J0X2	Bodo saltans	61%	100%
A0A1X0P6J6	Trypanosomatidae	60%	100%
A0A3Q8IQ15	Leishmania donovani	88%	100%
A0A3R7MHB3	Trypanosoma rangeli	62%	100%
A4IBV0	Leishmania infantum	88%	100%
C9ZYR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AFN7	Leishmania major	87%	100%
E9B6U0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P38331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	87%
P53144	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	96%
P87242	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
Q0P565	Bos taurus	44%	100%
Q1LUI2	Danio rerio	41%	100%
Q3SXD3	Mus musculus	44%	100%
Q54FK1	Dictyostelium discoideum	39%	100%
Q66L17	Xenopus laevis	44%	100%
Q7Z4H3	Homo sapiens	44%	100%