SseB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN81_LEIBR

TriTrypDb:

LbrM.34.4090 , LBRM2903_340050400

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.593
CLV_C14_Caspase3-7	230	234	PF00656	0.642
CLV_NRD_NRD_1	218	220	PF00675	0.678
CLV_NRD_NRD_1	262	264	PF00675	0.412
CLV_NRD_NRD_1	311	313	PF00675	0.528
CLV_NRD_NRD_1	330	332	PF00675	0.556
CLV_PCSK_FUR_1	309	313	PF00082	0.575
CLV_PCSK_KEX2_1	109	111	PF00082	0.487
CLV_PCSK_KEX2_1	218	220	PF00082	0.640
CLV_PCSK_KEX2_1	262	264	PF00082	0.501
CLV_PCSK_KEX2_1	311	313	PF00082	0.509
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.560
CLV_PCSK_PC7_1	258	264	PF00082	0.376
CLV_PCSK_PC7_1	307	313	PF00082	0.504
CLV_PCSK_SKI1_1	201	205	PF00082	0.441
CLV_PCSK_SKI1_1	258	262	PF00082	0.435
CLV_PCSK_SKI1_1	311	315	PF00082	0.531
CLV_PCSK_SKI1_1	386	390	PF00082	0.488
CLV_PCSK_SKI1_1	53	57	PF00082	0.543
DEG_APCC_DBOX_1	257	265	PF00400	0.609
DEG_APCC_DBOX_1	52	60	PF00400	0.548
DEG_Nend_UBRbox_1	1	4	PF02207	0.697
DEG_SPOP_SBC_1	36	40	PF00917	0.562
DOC_CYCLIN_RxL_1	255	265	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.507
DOC_MAPK_gen_1	109	117	PF00069	0.535
DOC_MAPK_gen_1	218	226	PF00069	0.682
DOC_MAPK_gen_1	48	56	PF00069	0.636
DOC_MAPK_gen_1	95	105	PF00069	0.514
DOC_MAPK_MEF2A_6	109	116	PF00069	0.460
DOC_MAPK_MEF2A_6	48	56	PF00069	0.636
DOC_MAPK_MEF2A_6	68	76	PF00069	0.312
DOC_MAPK_MEF2A_6	95	103	PF00069	0.569
DOC_PP2B_LxvP_1	314	317	PF13499	0.396
DOC_PP4_FxxP_1	148	151	PF00568	0.507
DOC_PP4_FxxP_1	402	405	PF00568	0.625
DOC_USP7_MATH_1	232	236	PF00917	0.695
DOC_USP7_MATH_1	333	337	PF00917	0.613
DOC_WW_Pin1_4	228	233	PF00397	0.705
LIG_14-3-3_CanoR_1	386	392	PF00244	0.615
LIG_14-3-3_CanoR_1	417	422	PF00244	0.613
LIG_14-3-3_CanoR_1	77	85	PF00244	0.536
LIG_Actin_WH2_2	39	55	PF00022	0.648
LIG_APCC_ABBA_1	291	296	PF00400	0.595
LIG_BRCT_BRCA1_1	144	148	PF00533	0.533
LIG_BRCT_BRCA1_1	198	202	PF00533	0.488
LIG_BRCT_BRCA1_1	89	93	PF00533	0.656
LIG_BRCT_BRCA1_2	89	95	PF00533	0.695
LIG_deltaCOP1_diTrp_1	67	75	PF00928	0.524
LIG_FHA_1	168	174	PF00498	0.533
LIG_FHA_1	179	185	PF00498	0.409
LIG_FHA_1	254	260	PF00498	0.514
LIG_FHA_1	5	11	PF00498	0.643
LIG_FHA_1	81	87	PF00498	0.610
LIG_FHA_2	126	132	PF00498	0.605
LIG_FHA_2	153	159	PF00498	0.556
LIG_FHA_2	202	208	PF00498	0.452
LIG_FHA_2	228	234	PF00498	0.718
LIG_FHA_2	319	325	PF00498	0.442
LIG_FHA_2	393	399	PF00498	0.727
LIG_FHA_2	405	411	PF00498	0.647
LIG_LIR_Apic_2	145	151	PF02991	0.526
LIG_LIR_Gen_1	155	165	PF02991	0.502
LIG_LIR_Gen_1	369	380	PF02991	0.586
LIG_LIR_Gen_1	67	76	PF02991	0.529
LIG_LIR_Nem_3	144	150	PF02991	0.575
LIG_LIR_Nem_3	155	160	PF02991	0.500
LIG_LIR_Nem_3	199	205	PF02991	0.501
LIG_LIR_Nem_3	369	375	PF02991	0.599
LIG_LIR_Nem_3	416	421	PF02991	0.632
LIG_LIR_Nem_3	67	72	PF02991	0.505
LIG_LYPXL_S_1	293	297	PF13949	0.453
LIG_LYPXL_yS_3	205	208	PF13949	0.466
LIG_LYPXL_yS_3	294	297	PF13949	0.435
LIG_MAD2	258	266	PF02301	0.378
LIG_NRBOX	286	292	PF00104	0.484
LIG_PCNA_yPIPBox_3	29	37	PF02747	0.556
LIG_PDZ_Class_1	417	422	PF00595	0.676
LIG_Pex14_1	69	73	PF04695	0.501
LIG_Pex14_2	346	350	PF04695	0.542
LIG_SH2_GRB2like	376	379	PF00017	0.604
LIG_SH2_STAP1	143	147	PF00017	0.644
LIG_SH2_STAP1	376	380	PF00017	0.584
LIG_SH2_STAP1	415	419	PF00017	0.617
LIG_SH2_STAT5	136	139	PF00017	0.509
LIG_SH2_STAT5	23	26	PF00017	0.578
LIG_SH2_STAT5	301	304	PF00017	0.517
LIG_SH2_STAT5	418	421	PF00017	0.660
LIG_SH2_STAT5	73	76	PF00017	0.519
LIG_SH3_3	119	125	PF00018	0.494
LIG_SH3_3	274	280	PF00018	0.527
LIG_SH3_3	302	308	PF00018	0.478
LIG_SH3_3	323	329	PF00018	0.556
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.433
LIG_SUMO_SIM_par_1	207	212	PF11976	0.596
LIG_TRAF2_1	128	131	PF00917	0.470
LIG_TRAF2_1	363	366	PF00917	0.651
LIG_WRC_WIRS_1	251	256	PF05994	0.571
LIG_WRC_WIRS_1	388	393	PF05994	0.640
LIG_WRC_WIRS_1	5	10	PF05994	0.677
MOD_CK1_1	135	141	PF00069	0.630
MOD_CK2_1	125	131	PF00069	0.454
MOD_CK2_1	13	19	PF00069	0.693
MOD_CK2_1	152	158	PF00069	0.512
MOD_CK2_1	201	207	PF00069	0.449
MOD_CK2_1	333	339	PF00069	0.501
MOD_CK2_1	404	410	PF00069	0.610
MOD_Cter_Amidation	95	98	PF01082	0.631
MOD_GlcNHglycan	15	18	PF01048	0.720
MOD_GlcNHglycan	152	155	PF01048	0.669
MOD_GlcNHglycan	233	237	PF01048	0.686
MOD_GSK3_1	174	181	PF00069	0.507
MOD_GSK3_1	197	204	PF00069	0.446
MOD_GSK3_1	224	231	PF00069	0.721
MOD_GSK3_1	250	257	PF00069	0.487
MOD_GSK3_1	76	83	PF00069	0.592
MOD_N-GLC_1	13	18	PF02516	0.602
MOD_N-GLC_1	87	92	PF02516	0.701
MOD_NEK2_1	1	6	PF00069	0.452
MOD_NEK2_1	137	142	PF00069	0.662
MOD_NEK2_1	197	202	PF00069	0.571
MOD_NEK2_1	224	229	PF00069	0.588
MOD_NEK2_1	245	250	PF00069	0.455
MOD_NEK2_1	254	259	PF00069	0.357
MOD_NEK2_1	37	42	PF00069	0.665
MOD_NEK2_2	387	392	PF00069	0.700
MOD_PIKK_1	152	158	PF00454	0.585
MOD_PIKK_1	209	215	PF00454	0.584
MOD_PIKK_1	224	230	PF00454	0.670
MOD_PIKK_1	318	324	PF00454	0.474
MOD_PIKK_1	37	43	PF00454	0.666
MOD_PKA_2	197	203	PF00069	0.458
MOD_PKA_2	76	82	PF00069	0.512
MOD_Plk_1	254	260	PF00069	0.434
MOD_Plk_1	333	339	PF00069	0.614
MOD_Plk_2-3	404	410	PF00069	0.585
MOD_Plk_4	132	138	PF00069	0.621
MOD_Plk_4	296	302	PF00069	0.368
MOD_Plk_4	333	339	PF00069	0.599
MOD_ProDKin_1	228	234	PF00069	0.706
MOD_SUMO_rev_2	102	111	PF00179	0.586
MOD_SUMO_rev_2	377	385	PF00179	0.545
TRG_DiLeu_BaEn_1	286	291	PF01217	0.528
TRG_DiLeu_BaEn_2	70	76	PF01217	0.521
TRG_DiLeu_BaEn_4	158	164	PF01217	0.510
TRG_ENDOCYTIC_2	205	208	PF00928	0.466
TRG_ENDOCYTIC_2	294	297	PF00928	0.426
TRG_ENDOCYTIC_2	73	76	PF00928	0.519
TRG_ER_diArg_1	261	263	PF00400	0.412
TRG_ER_diArg_1	29	32	PF00400	0.689
TRG_ER_diArg_1	307	310	PF00400	0.522
TRG_ER_diArg_1	311	313	PF00400	0.537
TRG_ER_diArg_1	51	54	PF00400	0.646
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR9	Leptomonas seymouri	68%	90%
A0A0S4J059	Bodo saltans	43%	94%
A0A1X0P5E2	Trypanosomatidae	52%	93%
A0A3S7X9S4	Leishmania donovani	86%	100%
A4IBU9	Leishmania infantum	86%	100%
C9ZYR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	92%
E9AFN6	Leishmania major	86%	100%
E9B6T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BCS7	Trypanosoma cruzi	52%	93%