RIIa domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulatory subunit of type II PKA R-subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HN77_LEIBR

TriTrypDb:

LbrM.34.4050 , LBRM2903_340050000

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HN77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN77

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005509	calcium ion binding	5	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.498
CLV_NRD_NRD_1	109	111	PF00675	0.543
CLV_PCSK_KEX2_1	109	111	PF00082	0.534
CLV_PCSK_SKI1_1	109	113	PF00082	0.392
CLV_PCSK_SKI1_1	208	212	PF00082	0.506
CLV_PCSK_SKI1_1	263	267	PF00082	0.393
CLV_PCSK_SKI1_1	34	38	PF00082	0.341
CLV_PCSK_SKI1_1	54	58	PF00082	0.281
CLV_PCSK_SKI1_1	81	85	PF00082	0.462
CLV_PCSK_SKI1_1	87	91	PF00082	0.437
CLV_Separin_Metazoa	35	39	PF03568	0.328
DOC_CYCLIN_RxL_1	205	213	PF00134	0.515
DOC_CYCLIN_RxL_1	259	268	PF00134	0.521
DOC_CYCLIN_RxL_1	50	60	PF00134	0.344
DOC_MAPK_gen_1	87	97	PF00069	0.535
DOC_PP2B_LxvP_1	127	130	PF13499	0.468
DOC_WW_Pin1_4	70	75	PF00397	0.691
LIG_14-3-3_CanoR_1	109	118	PF00244	0.519
LIG_14-3-3_CanoR_1	9	17	PF00244	0.704
LIG_APCC_ABBA_1	270	275	PF00400	0.447
LIG_BIR_II_1	1	5	PF00653	0.673
LIG_deltaCOP1_diTrp_1	46	52	PF00928	0.449
LIG_FHA_1	130	136	PF00498	0.518
LIG_FHA_1	204	210	PF00498	0.440
LIG_FHA_1	57	63	PF00498	0.545
LIG_FHA_1	71	77	PF00498	0.691
LIG_FHA_1	92	98	PF00498	0.544
LIG_FHA_2	131	137	PF00498	0.559
LIG_FHA_2	224	230	PF00498	0.398
LIG_FHA_2	3	9	PF00498	0.593
LIG_LIR_Gen_1	128	135	PF02991	0.488
LIG_LIR_Gen_1	148	157	PF02991	0.211
LIG_LIR_Gen_1	191	201	PF02991	0.402
LIG_LIR_Gen_1	268	276	PF02991	0.457
LIG_LIR_Nem_3	128	134	PF02991	0.481
LIG_LIR_Nem_3	148	152	PF02991	0.223
LIG_LIR_Nem_3	191	197	PF02991	0.392
LIG_LIR_Nem_3	268	273	PF02991	0.400
LIG_LIR_Nem_3	70	75	PF02991	0.671
LIG_MYND_3	103	107	PF01753	0.295
LIG_Pex14_1	47	51	PF04695	0.328
LIG_Pex14_2	194	198	PF04695	0.427
LIG_PTB_Apo_2	217	224	PF02174	0.454
LIG_PTB_Phospho_1	217	223	PF10480	0.446
LIG_SH2_CRK	72	76	PF00017	0.733
LIG_SH2_STAP1	253	257	PF00017	0.421
LIG_SH2_STAP1	32	36	PF00017	0.328
LIG_SH2_STAT3	162	165	PF00017	0.521
LIG_SH2_STAT5	125	128	PF00017	0.340
LIG_SH2_STAT5	149	152	PF00017	0.459
LIG_SH2_STAT5	162	165	PF00017	0.462
LIG_SH2_STAT5	51	54	PF00017	0.343
LIG_SH2_STAT5	72	75	PF00017	0.702
LIG_SH3_3	73	79	PF00018	0.640
MOD_CK1_1	140	146	PF00069	0.618
MOD_CK1_1	2	8	PF00069	0.699
MOD_CK2_1	130	136	PF00069	0.551
MOD_CK2_1	2	8	PF00069	0.613
MOD_CK2_1	268	274	PF00069	0.424
MOD_GlcNHglycan	136	142	PF01048	0.599
MOD_GlcNHglycan	154	157	PF01048	0.353
MOD_GlcNHglycan	46	50	PF01048	0.332
MOD_GlcNHglycan	96	100	PF01048	0.460
MOD_GSK3_1	125	132	PF00069	0.488
MOD_GSK3_1	152	159	PF00069	0.437
MOD_GSK3_1	173	180	PF00069	0.585
MOD_GSK3_1	91	98	PF00069	0.486
MOD_N-GLC_1	178	183	PF02516	0.414
MOD_N-GLC_1	23	28	PF02516	0.449
MOD_NEK2_1	118	123	PF00069	0.451
MOD_NEK2_1	152	157	PF00069	0.355
MOD_NEK2_1	45	50	PF00069	0.363
MOD_NEK2_1	95	100	PF00069	0.446
MOD_NEK2_2	178	183	PF00069	0.475
MOD_PIKK_1	10	16	PF00454	0.704
MOD_PIKK_1	118	124	PF00454	0.402
MOD_Plk_1	147	153	PF00069	0.373
MOD_Plk_1	178	184	PF00069	0.413
MOD_Plk_1	7	13	PF00069	0.615
MOD_Plk_2-3	268	274	PF00069	0.424
MOD_Plk_4	130	136	PF00069	0.568
MOD_Plk_4	147	153	PF00069	0.260
MOD_ProDKin_1	70	76	PF00069	0.687
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.521
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.522
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.399
TRG_ENDOCYTIC_2	149	152	PF00928	0.413
TRG_ENDOCYTIC_2	72	75	PF00928	0.702
TRG_ER_diArg_1	108	110	PF00400	0.533
TRG_NES_CRM1_1	189	203	PF08389	0.533
TRG_NES_CRM1_1	256	268	PF08389	0.396
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJL0	Leptomonas seymouri	70%	98%
A0A0S4IX78	Bodo saltans	46%	100%
A0A1X0P532	Trypanosomatidae	55%	100%
A0A3Q8IJR7	Leishmania donovani	89%	100%
A0A422NK65	Trypanosoma rangeli	50%	100%
A4IBU5	Leishmania infantum	89%	100%
C9ZYR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AFN2	Leishmania major	88%	100%
E9B6T5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5C2Q7	Trypanosoma cruzi	53%	100%