LeishMANIAdb
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DUF3475 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF3475 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HN75_LEIBR
TriTrypDb:
LbrM.34.4030 , LBRM2903_340049800
Length:
115

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN75
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN75

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 78 80 PF00675 0.438
CLV_PCSK_KEX2_1 77 79 PF00082 0.518
CLV_PCSK_SKI1_1 64 68 PF00082 0.342
DEG_SPOP_SBC_1 5 9 PF00917 0.551
DEG_SPOP_SBC_1 71 75 PF00917 0.294
DOC_USP7_MATH_1 106 110 PF00917 0.379
DOC_USP7_MATH_1 6 10 PF00917 0.540
DOC_USP7_MATH_1 69 73 PF00917 0.414
LIG_BIR_II_1 1 5 PF00653 0.577
LIG_BRCT_BRCA1_1 108 112 PF00533 0.585
LIG_BRCT_BRCA1_1 72 76 PF00533 0.522
LIG_FHA_1 39 45 PF00498 0.356
LIG_FHA_1 49 55 PF00498 0.483
LIG_FHA_1 97 103 PF00498 0.349
LIG_FHA_2 15 21 PF00498 0.522
LIG_FHA_2 95 101 PF00498 0.400
LIG_LIR_Gen_1 99 108 PF02991 0.384
LIG_LIR_Nem_3 99 104 PF02991 0.387
LIG_SH2_STAT5 38 41 PF00017 0.463
LIG_SH2_STAT5 88 91 PF00017 0.365
MOD_CK1_1 4 10 PF00069 0.627
MOD_CK1_1 72 78 PF00069 0.446
MOD_CK1_1 82 88 PF00069 0.405
MOD_GlcNHglycan 3 6 PF01048 0.564
MOD_GlcNHglycan 8 11 PF01048 0.559
MOD_GlcNHglycan 81 84 PF01048 0.442
MOD_GSK3_1 1 8 PF00069 0.596
MOD_GSK3_1 108 115 PF00069 0.547
MOD_GSK3_1 90 97 PF00069 0.414
MOD_N-GLC_2 27 29 PF02516 0.350
MOD_NEK2_1 1 6 PF00069 0.527
MOD_NEK2_1 39 44 PF00069 0.347
MOD_PKB_1 77 85 PF00069 0.364
MOD_Plk_4 50 56 PF00069 0.393
MOD_SUMO_rev_2 42 52 PF00179 0.375
TRG_ER_diArg_1 76 79 PF00400 0.455

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5B2 Leptomonas seymouri 66% 100%
A0A1X0P535 Trypanosomatidae 50% 94%
A0A3Q8IVH8 Leishmania donovani 83% 100%
A0A3R7MNW4 Trypanosoma rangeli 53% 100%
A4IBU3 Leishmania infantum 83% 100%
C9ZYR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9AFN0 Leishmania major 82% 100%
E9B6T3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS