J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DNAJ, putatative

Species:

Leishmania braziliensis

UniProt:

A4HN74_LEIBR

TriTrypDb:

LbrM.34.4020 , LBRM2903_340049700

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.583
CLV_NRD_NRD_1	101	103	PF00675	0.477
CLV_NRD_NRD_1	123	125	PF00675	0.534
CLV_NRD_NRD_1	21	23	PF00675	0.492
CLV_NRD_NRD_1	230	232	PF00675	0.684
CLV_NRD_NRD_1	283	285	PF00675	0.590
CLV_NRD_NRD_1	302	304	PF00675	0.655
CLV_PCSK_FUR_1	281	285	PF00082	0.682
CLV_PCSK_KEX2_1	101	103	PF00082	0.477
CLV_PCSK_KEX2_1	125	127	PF00082	0.596
CLV_PCSK_KEX2_1	21	23	PF00082	0.449
CLV_PCSK_KEX2_1	225	227	PF00082	0.708
CLV_PCSK_KEX2_1	229	231	PF00082	0.682
CLV_PCSK_KEX2_1	25	27	PF00082	0.384
CLV_PCSK_KEX2_1	283	285	PF00082	0.725
CLV_PCSK_KEX2_1	302	304	PF00082	0.520
CLV_PCSK_KEX2_1	58	60	PF00082	0.652
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.603
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.572
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.575
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.421
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.652
CLV_PCSK_PC7_1	21	27	PF00082	0.385
CLV_PCSK_PC7_1	226	232	PF00082	0.579
CLV_PCSK_SKI1_1	21	25	PF00082	0.431
CLV_PCSK_SKI1_1	26	30	PF00082	0.401
CLV_PCSK_SKI1_1	315	319	PF00082	0.647
CLV_PCSK_SKI1_1	388	392	PF00082	0.569
CLV_PCSK_SKI1_1	84	88	PF00082	0.505
CLV_Separin_Fungi	270	276	PF03568	0.550
DEG_APCC_DBOX_1	100	108	PF00400	0.481
DEG_Nend_Nbox_1	1	3	PF02207	0.503
DEG_SPOP_SBC_1	325	329	PF00917	0.644
DOC_MAPK_DCC_7	315	325	PF00069	0.512
DOC_MAPK_gen_1	21	31	PF00069	0.385
DOC_MAPK_MEF2A_6	22	31	PF00069	0.392
DOC_PP1_RVXF_1	386	392	PF00149	0.558
DOC_PP4_FxxP_1	264	267	PF00568	0.678
DOC_USP7_MATH_1	13	17	PF00917	0.385
DOC_USP7_MATH_1	255	259	PF00917	0.564
DOC_USP7_MATH_1	267	271	PF00917	0.530
DOC_USP7_MATH_1	346	350	PF00917	0.656
DOC_USP7_MATH_1	65	69	PF00917	0.630
DOC_USP7_UBL2_3	225	229	PF12436	0.578
DOC_WW_Pin1_4	189	194	PF00397	0.666
LIG_14-3-3_CanoR_1	185	191	PF00244	0.569
LIG_14-3-3_CanoR_1	315	321	PF00244	0.556
LIG_14-3-3_CanoR_1	358	362	PF00244	0.825
LIG_BRCT_BRCA1_1	328	332	PF00533	0.640
LIG_BRCT_BRCA1_1	82	86	PF00533	0.639
LIG_CaM_IQ_9	76	92	PF13499	0.413
LIG_FHA_1	384	390	PF00498	0.545
LIG_FHA_1	43	49	PF00498	0.685
LIG_FHA_1	64	70	PF00498	0.522
LIG_FHA_2	178	184	PF00498	0.518
LIG_FHA_2	249	255	PF00498	0.555
LIG_LIR_Gen_1	106	115	PF02991	0.621
LIG_LIR_Gen_1	4	13	PF02991	0.385
LIG_LIR_Gen_1	76	86	PF02991	0.551
LIG_LIR_Gen_1	91	100	PF02991	0.382
LIG_LIR_Nem_3	106	112	PF02991	0.613
LIG_LIR_Nem_3	4	9	PF02991	0.385
LIG_LIR_Nem_3	76	82	PF02991	0.674
LIG_LIR_Nem_3	83	89	PF02991	0.628
LIG_LIR_Nem_3	91	96	PF02991	0.461
LIG_MYND_1	53	57	PF01753	0.544
LIG_SH2_STAP1	105	109	PF00017	0.504
LIG_SH2_STAT3	377	380	PF00017	0.554
LIG_SH2_STAT5	103	106	PF00017	0.533
LIG_SH2_STAT5	262	265	PF00017	0.551
LIG_SH2_STAT5	311	314	PF00017	0.623
LIG_SH3_3	187	193	PF00018	0.623
LIG_SH3_3	208	214	PF00018	0.625
LIG_SH3_3	342	348	PF00018	0.674
LIG_SH3_3	368	374	PF00018	0.626
LIG_SH3_3	54	60	PF00018	0.540
LIG_TRAF2_1	16	19	PF00917	0.385
MOD_CK1_1	171	177	PF00069	0.532
MOD_CK1_1	189	195	PF00069	0.539
MOD_CK1_1	212	218	PF00069	0.677
MOD_CK1_1	297	303	PF00069	0.663
MOD_CK1_1	349	355	PF00069	0.517
MOD_CK1_1	51	57	PF00069	0.635
MOD_CK1_1	68	74	PF00069	0.488
MOD_CK1_1	75	81	PF00069	0.492
MOD_CK2_1	13	19	PF00069	0.385
MOD_CK2_1	170	176	PF00069	0.616
MOD_CK2_1	330	336	PF00069	0.606
MOD_CK2_1	341	347	PF00069	0.617
MOD_GlcNHglycan	15	18	PF01048	0.485
MOD_GlcNHglycan	211	214	PF01048	0.660
MOD_GlcNHglycan	250	254	PF01048	0.613
MOD_GlcNHglycan	304	307	PF01048	0.564
MOD_GlcNHglycan	351	354	PF01048	0.632
MOD_GSK3_1	166	173	PF00069	0.645
MOD_GSK3_1	209	216	PF00069	0.636
MOD_GSK3_1	293	300	PF00069	0.678
MOD_GSK3_1	302	309	PF00069	0.593
MOD_GSK3_1	326	333	PF00069	0.635
MOD_GSK3_1	334	341	PF00069	0.600
MOD_GSK3_1	35	42	PF00069	0.605
MOD_GSK3_1	379	386	PF00069	0.533
MOD_GSK3_1	43	50	PF00069	0.626
MOD_GSK3_1	65	72	PF00069	0.592
MOD_GSK3_1	80	87	PF00069	0.451
MOD_LATS_1	228	234	PF00433	0.582
MOD_N-GLC_1	169	174	PF02516	0.531
MOD_N-GLC_1	186	191	PF02516	0.515
MOD_N-GLC_1	240	245	PF02516	0.581
MOD_N-GLC_1	72	77	PF02516	0.533
MOD_NEK2_1	316	321	PF00069	0.630
MOD_NEK2_1	324	329	PF00069	0.596
MOD_NEK2_2	44	49	PF00069	0.537
MOD_PIKK_1	255	261	PF00454	0.687
MOD_PIKK_1	297	303	PF00454	0.677
MOD_PKA_1	230	236	PF00069	0.582
MOD_PKA_1	302	308	PF00069	0.686
MOD_PKA_2	13	19	PF00069	0.426
MOD_PKA_2	230	236	PF00069	0.645
MOD_PKA_2	274	280	PF00069	0.556
MOD_PKA_2	293	299	PF00069	0.651
MOD_PKA_2	302	308	PF00069	0.572
MOD_PKA_2	349	355	PF00069	0.626
MOD_PKA_2	357	363	PF00069	0.669
MOD_PKB_1	313	321	PF00069	0.516
MOD_Plk_1	186	192	PF00069	0.588
MOD_Plk_1	240	246	PF00069	0.695
MOD_Plk_1	383	389	PF00069	0.537
MOD_Plk_4	65	71	PF00069	0.512
MOD_ProDKin_1	189	195	PF00069	0.670
MOD_SUMO_rev_2	122	127	PF00179	0.407
MOD_SUMO_rev_2	305	312	PF00179	0.655
TRG_ENDOCYTIC_2	109	112	PF00928	0.622
TRG_ENDOCYTIC_2	5	8	PF00928	0.385
TRG_ENDOCYTIC_2	93	96	PF00928	0.457
TRG_ER_diArg_1	101	103	PF00400	0.477
TRG_ER_diArg_1	124	127	PF00400	0.467
TRG_ER_diArg_1	20	22	PF00400	0.414
TRG_ER_diArg_1	281	284	PF00400	0.675
TRG_ER_diArg_1	302	304	PF00400	0.690
TRG_ER_diArg_1	313	316	PF00400	0.566
TRG_NES_CRM1_1	18	30	PF08389	0.385
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIN7	Leishmania donovani	64%	100%
A4IBU2	Leishmania infantum	64%	100%
E9AFM9	Leishmania major	64%	98%
E9B6T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%