Putative ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HN73_LEIBR

TriTrypDb:

LbrM.34.4010 , LBRM2903_340049600

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HN73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN73

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.512
CLV_C14_Caspase3-7	409	413	PF00656	0.433
CLV_NRD_NRD_1	202	204	PF00675	0.254
CLV_NRD_NRD_1	427	429	PF00675	0.527
CLV_NRD_NRD_1	453	455	PF00675	0.546
CLV_NRD_NRD_1	456	458	PF00675	0.547
CLV_NRD_NRD_1	495	497	PF00675	0.417
CLV_NRD_NRD_1	653	655	PF00675	0.690
CLV_NRD_NRD_1	680	682	PF00675	0.587
CLV_NRD_NRD_1	687	689	PF00675	0.586
CLV_PCSK_FUR_1	454	458	PF00082	0.663
CLV_PCSK_FUR_1	579	583	PF00082	0.574
CLV_PCSK_KEX2_1	196	198	PF00082	0.251
CLV_PCSK_KEX2_1	202	204	PF00082	0.251
CLV_PCSK_KEX2_1	320	322	PF00082	0.262
CLV_PCSK_KEX2_1	330	332	PF00082	0.262
CLV_PCSK_KEX2_1	427	429	PF00082	0.495
CLV_PCSK_KEX2_1	453	455	PF00082	0.538
CLV_PCSK_KEX2_1	456	458	PF00082	0.513
CLV_PCSK_KEX2_1	495	497	PF00082	0.379
CLV_PCSK_KEX2_1	554	556	PF00082	0.591
CLV_PCSK_KEX2_1	581	583	PF00082	0.524
CLV_PCSK_KEX2_1	607	609	PF00082	0.637
CLV_PCSK_KEX2_1	653	655	PF00082	0.635
CLV_PCSK_KEX2_1	98	100	PF00082	0.335
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.262
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.262
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.262
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.591
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.563
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.637
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.335
CLV_PCSK_PC7_1	326	332	PF00082	0.309
CLV_PCSK_SKI1_1	2	6	PF00082	0.480
CLV_PCSK_SKI1_1	326	330	PF00082	0.262
CLV_PCSK_SKI1_1	333	337	PF00082	0.262
CLV_PCSK_SKI1_1	428	432	PF00082	0.574
CLV_PCSK_SKI1_1	525	529	PF00082	0.303
CLV_PCSK_SKI1_1	621	625	PF00082	0.605
CLV_PCSK_SKI1_1	98	102	PF00082	0.262
DEG_APCC_DBOX_1	187	195	PF00400	0.537
DEG_Nend_UBRbox_1	1	4	PF02207	0.593
DOC_CKS1_1	147	152	PF01111	0.451
DOC_CYCLIN_RxL_1	422	433	PF00134	0.591
DOC_CYCLIN_RxL_1	96	105	PF00134	0.492
DOC_MAPK_DCC_7	344	353	PF00069	0.462
DOC_MAPK_gen_1	330	337	PF00069	0.472
DOC_MAPK_gen_1	375	385	PF00069	0.522
DOC_MAPK_gen_1	554	563	PF00069	0.499
DOC_MAPK_gen_1	613	622	PF00069	0.575
DOC_MAPK_HePTP_8	341	353	PF00069	0.462
DOC_MAPK_MEF2A_6	224	233	PF00069	0.416
DOC_MAPK_MEF2A_6	344	353	PF00069	0.462
DOC_MAPK_MEF2A_6	554	563	PF00069	0.441
DOC_PP1_RVXF_1	179	186	PF00149	0.451
DOC_PP1_RVXF_1	265	272	PF00149	0.462
DOC_PP1_RVXF_1	97	104	PF00149	0.472
DOC_PP2B_LxvP_1	346	349	PF13499	0.451
DOC_PP2B_LxvP_1	559	562	PF13499	0.412
DOC_PP2B_LxvP_1	82	85	PF13499	0.556
DOC_PP4_FxxP_1	385	388	PF00568	0.338
DOC_PP4_FxxP_1	545	548	PF00568	0.303
DOC_USP7_MATH_1	420	424	PF00917	0.349
DOC_USP7_MATH_1	511	515	PF00917	0.315
DOC_USP7_UBL2_3	196	200	PF12436	0.440
DOC_USP7_UBL2_3	434	438	PF12436	0.640
DOC_WW_Pin1_4	109	114	PF00397	0.556
DOC_WW_Pin1_4	146	151	PF00397	0.451
DOC_WW_Pin1_4	485	490	PF00397	0.404
LIG_14-3-3_CanoR_1	224	230	PF00244	0.413
LIG_14-3-3_CanoR_1	232	237	PF00244	0.515
LIG_14-3-3_CanoR_1	427	431	PF00244	0.534
LIG_14-3-3_CanoR_1	510	516	PF00244	0.303
LIG_14-3-3_CanoR_1	608	617	PF00244	0.600
LIG_BRCT_BRCA1_1	381	385	PF00533	0.375
LIG_Clathr_ClatBox_1	173	177	PF01394	0.462
LIG_FHA_1	210	216	PF00498	0.462
LIG_FHA_1	228	234	PF00498	0.477
LIG_FHA_1	28	34	PF00498	0.451
LIG_FHA_2	3	9	PF00498	0.313
LIG_FHA_2	34	40	PF00498	0.537
LIG_LIR_Apic_2	382	388	PF02991	0.343
LIG_LIR_Apic_2	51	57	PF02991	0.451
LIG_LIR_Gen_1	121	126	PF02991	0.488
LIG_LIR_Gen_1	159	168	PF02991	0.434
LIG_LIR_Gen_1	169	179	PF02991	0.452
LIG_LIR_Gen_1	291	301	PF02991	0.492
LIG_LIR_Gen_1	36	45	PF02991	0.537
LIG_LIR_Gen_1	390	399	PF02991	0.389
LIG_LIR_Gen_1	645	652	PF02991	0.678
LIG_LIR_Nem_3	121	125	PF02991	0.516
LIG_LIR_Nem_3	159	165	PF02991	0.434
LIG_LIR_Nem_3	169	174	PF02991	0.452
LIG_LIR_Nem_3	253	258	PF02991	0.475
LIG_LIR_Nem_3	291	297	PF02991	0.492
LIG_LIR_Nem_3	36	41	PF02991	0.537
LIG_LIR_Nem_3	390	396	PF02991	0.360
LIG_LIR_Nem_3	539	545	PF02991	0.305
LIG_LIR_Nem_3	565	570	PF02991	0.502
LIG_NRBOX	152	158	PF00104	0.462
LIG_NRBOX	58	64	PF00104	0.512
LIG_NRBOX	638	644	PF00104	0.657
LIG_NRP_CendR_1	688	691	PF00754	0.643
LIG_PCNA_yPIPBox_3	630	643	PF02747	0.549
LIG_Rb_LxCxE_1	51	73	PF01857	0.476
LIG_SH2_CRK	162	166	PF00017	0.435
LIG_SH2_CRK	357	361	PF00017	0.462
LIG_SH2_CRK	38	42	PF00017	0.516
LIG_SH2_SRC	357	360	PF00017	0.451
LIG_SH2_SRC	54	57	PF00017	0.511
LIG_SH2_STAP1	154	158	PF00017	0.451
LIG_SH2_STAP1	162	166	PF00017	0.451
LIG_SH2_STAP1	294	298	PF00017	0.396
LIG_SH2_STAP1	38	42	PF00017	0.474
LIG_SH2_STAT3	120	123	PF00017	0.451
LIG_SH2_STAT3	526	529	PF00017	0.319
LIG_SH2_STAT5	393	396	PF00017	0.360
LIG_SH2_STAT5	526	529	PF00017	0.319
LIG_SH2_STAT5	54	57	PF00017	0.450
LIG_SH2_STAT5	648	651	PF00017	0.530
LIG_SH3_1	357	363	PF00018	0.462
LIG_SH3_2	246	251	PF14604	0.326
LIG_SH3_3	144	150	PF00018	0.512
LIG_SH3_3	243	249	PF00018	0.455
LIG_SH3_3	357	363	PF00018	0.462
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.462
LIG_SUMO_SIM_par_1	172	178	PF11976	0.462
LIG_SUMO_SIM_par_1	225	230	PF11976	0.445
LIG_SUMO_SIM_par_1	531	537	PF11976	0.319
LIG_SUMO_SIM_par_1	80	86	PF11976	0.473
LIG_TRAF2_1	562	565	PF00917	0.437
LIG_TRAF2_1	585	588	PF00917	0.629
LIG_TYR_ITSM	34	41	PF00017	0.537
LIG_UBA3_1	173	181	PF00899	0.476
LIG_UBA3_1	194	200	PF00899	0.429
LIG_UBA3_1	622	627	PF00899	0.681
LIG_WRC_WIRS_1	393	398	PF05994	0.264
LIG_WRC_WIRS_1	512	517	PF05994	0.303
MOD_CDK_SPxK_1	146	152	PF00069	0.451
MOD_CK1_1	235	241	PF00069	0.512
MOD_CK1_1	379	385	PF00069	0.494
MOD_CK1_1	433	439	PF00069	0.493
MOD_CK1_1	48	54	PF00069	0.445
MOD_CK1_1	628	634	PF00069	0.673
MOD_CK1_1	674	680	PF00069	0.633
MOD_CK1_1	7	13	PF00069	0.434
MOD_CK2_1	166	172	PF00069	0.476
MOD_CK2_1	2	8	PF00069	0.426
MOD_CK2_1	449	455	PF00069	0.591
MOD_CK2_1	623	629	PF00069	0.532
MOD_CK2_1	674	680	PF00069	0.527
MOD_GlcNHglycan	207	210	PF01048	0.251
MOD_GlcNHglycan	237	240	PF01048	0.527
MOD_GlcNHglycan	378	381	PF01048	0.542
MOD_GlcNHglycan	47	50	PF01048	0.243
MOD_GlcNHglycan	590	593	PF01048	0.633
MOD_GSK3_1	157	164	PF00069	0.368
MOD_GSK3_1	201	208	PF00069	0.451
MOD_GSK3_1	336	343	PF00069	0.509
MOD_GSK3_1	426	433	PF00069	0.481
MOD_GSK3_1	583	590	PF00069	0.673
MOD_GSK3_1	671	678	PF00069	0.538
MOD_N-GLC_1	109	114	PF02516	0.327
MOD_N-GLC_1	166	171	PF02516	0.190
MOD_NEK2_1	156	161	PF00069	0.451
MOD_NEK2_1	166	171	PF00069	0.451
MOD_NEK2_1	18	23	PF00069	0.502
MOD_NEK2_1	207	212	PF00069	0.451
MOD_NEK2_1	271	276	PF00069	0.441
MOD_NEK2_1	33	38	PF00069	0.512
MOD_NEK2_1	430	435	PF00069	0.399
MOD_NEK2_1	623	628	PF00069	0.605
MOD_NEK2_1	643	648	PF00069	0.352
MOD_PIKK_1	166	172	PF00454	0.556
MOD_PIKK_1	207	213	PF00454	0.451
MOD_PIKK_1	256	262	PF00454	0.335
MOD_PKA_2	201	207	PF00069	0.451
MOD_PKA_2	250	256	PF00069	0.431
MOD_PKA_2	410	416	PF00069	0.468
MOD_PKA_2	426	432	PF00069	0.472
MOD_PKA_2	473	479	PF00069	0.578
MOD_PKA_2	583	589	PF00069	0.550
MOD_Plk_1	166	172	PF00069	0.395
MOD_Plk_1	671	677	PF00069	0.620
MOD_Plk_2-3	410	416	PF00069	0.518
MOD_Plk_4	161	167	PF00069	0.373
MOD_Plk_4	296	302	PF00069	0.472
MOD_Plk_4	362	368	PF00069	0.451
MOD_Plk_4	379	385	PF00069	0.374
MOD_Plk_4	487	493	PF00069	0.409
MOD_Plk_4	511	517	PF00069	0.303
MOD_Plk_4	643	649	PF00069	0.550
MOD_Plk_4	671	677	PF00069	0.601
MOD_ProDKin_1	109	115	PF00069	0.556
MOD_ProDKin_1	146	152	PF00069	0.451
MOD_ProDKin_1	485	491	PF00069	0.397
MOD_SUMO_for_1	316	319	PF00179	0.462
MOD_SUMO_for_1	649	652	PF00179	0.530
MOD_SUMO_rev_2	274	281	PF00179	0.455
MOD_SUMO_rev_2	674	684	PF00179	0.557
MOD_SUMO_rev_2	69	77	PF00179	0.465
TRG_DiLeu_BaEn_1	178	183	PF01217	0.451
TRG_DiLeu_BaEn_1	618	623	PF01217	0.651
TRG_DiLeu_BaEn_1	638	643	PF01217	0.350
TRG_DiLeu_BaEn_2	380	386	PF01217	0.318
TRG_DiLeu_BaEn_2	391	397	PF01217	0.403
TRG_DiLeu_BaEn_3	565	571	PF01217	0.440
TRG_ENDOCYTIC_2	122	125	PF00928	0.562
TRG_ENDOCYTIC_2	154	157	PF00928	0.451
TRG_ENDOCYTIC_2	162	165	PF00928	0.451
TRG_ENDOCYTIC_2	294	297	PF00928	0.482
TRG_ENDOCYTIC_2	38	41	PF00928	0.488
TRG_ENDOCYTIC_2	393	396	PF00928	0.360
TRG_ENDOCYTIC_2	648	651	PF00928	0.676
TRG_ER_diArg_1	494	496	PF00400	0.434
TRG_ER_diArg_1	555	558	PF00400	0.616
TRG_ER_diArg_1	63	66	PF00400	0.537
TRG_NES_CRM1_1	390	400	PF08389	0.391
TRG_NES_CRM1_1	552	565	PF08389	0.432
TRG_NES_CRM1_1	615	629	PF08389	0.681
TRG_NLS_Bipartite_1	320	334	PF00514	0.479
TRG_NLS_MonoExtC_3	606	612	PF00514	0.588
TRG_NLS_MonoExtN_4	604	611	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.260
TRG_Pf-PMV_PEXEL_1	525	529	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.251

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X4	Leptomonas seymouri	83%	99%
A0A0S4IX79	Bodo saltans	56%	95%
A0A0S4JPF4	Bodo saltans	23%	100%
A0A1X0P5E1	Trypanosomatidae	66%	97%
A0A3Q8ID91	Leishmania donovani	33%	100%
A0A3Q8IE53	Leishmania donovani	29%	88%
A0A3S5H6T7	Leishmania donovani	27%	100%
A0A3S7WQ33	Leishmania donovani	30%	100%
A0A3S7X5R1	Leishmania donovani	31%	89%
A0A3S7X9W0	Leishmania donovani	91%	100%
A0A3S7XAT8	Leishmania donovani	35%	100%
A0A422NKE3	Trypanosoma rangeli	65%	95%
A1A4H6	Bos taurus	29%	90%
A4H7Y3	Leishmania braziliensis	27%	100%
A4HGR1	Leishmania braziliensis	33%	100%
A4HP49	Leishmania braziliensis	34%	100%
A4HT33	Leishmania infantum	30%	100%
A4HWB0	Leishmania infantum	27%	100%
A4HZF8	Leishmania infantum	27%	100%
A4I2K1	Leishmania infantum	29%	88%
A4I3T6	Leishmania infantum	33%	100%
A4I846	Leishmania infantum	31%	89%
A4IBU1	Leishmania infantum	91%	100%
A4IDF6	Leishmania infantum	35%	100%
A4QYM6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	28%	87%
A4R8G3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	29%	100%
A5DAR2	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	93%
A6R918	Ajellomyces capsulatus (strain NAm1 / WU24)	35%	100%
C9ZYS3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	90%
E9AFM8	Leishmania major	89%	100%
E9ASV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B028	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B6T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O60173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	97%
P0CR08	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	31%	92%
P0CR09	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	31%	92%
Q09903	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	92%
Q0DLB9	Oryza sativa subsp. japonica	28%	100%
Q4Q1K8	Leishmania major	30%	100%
Q4Q1N9	Leishmania major	35%	100%
Q4Q858	Leishmania major	33%	100%
Q59S50	Candida albicans (strain SC5314 / ATCC MYA-2876)	27%	95%
Q6CK32	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	93%
Q6FIL3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	100%
Q6NZQ2	Mus musculus	29%	100%
Q750Q4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	100%
Q86B47	Drosophila melanogaster	30%	71%
Q9H8H2	Homo sapiens	28%	81%
V5BG99	Trypanosoma cruzi	27%	84%
V5DUK0	Trypanosoma cruzi	64%	90%