LeishMANIAdb
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Bem46-like serine peptidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Bem46-like serine peptidase
Gene product:
Serine peptidase, Clan SC, Family S09X
Species:
Leishmania braziliensis
UniProt:
A4HN72_LEIBR
TriTrypDb:
LbrM.34.4000 , LBRM2903_340049500
Length:
394

Annotations

LeishMANIAdb annotations

A signal-anchored protein probably with an extra re-entrant loop. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4HN72
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN72

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0008474 palmitoyl-(protein) hydrolase activity 3 1
GO:0016787 hydrolase activity 2 2
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016790 thiolester hydrolase activity 4 1
GO:0098599 palmitoyl hydrolase activity 3 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 125 129 PF00656 0.618
CLV_C14_Caspase3-7 97 101 PF00656 0.634
CLV_NRD_NRD_1 248 250 PF00675 0.272
CLV_NRD_NRD_1 355 357 PF00675 0.283
CLV_PCSK_KEX2_1 248 250 PF00082 0.252
CLV_PCSK_KEX2_1 355 357 PF00082 0.295
CLV_PCSK_PC7_1 244 250 PF00082 0.245
CLV_PCSK_SKI1_1 271 275 PF00082 0.307
CLV_PCSK_SKI1_1 336 340 PF00082 0.388
CLV_PCSK_SKI1_1 348 352 PF00082 0.313
CLV_PCSK_SKI1_1 355 359 PF00082 0.313
DEG_APCC_DBOX_1 270 278 PF00400 0.530
DOC_ANK_TNKS_1 116 123 PF00023 0.704
DOC_CYCLIN_RxL_1 291 301 PF00134 0.509
DOC_CYCLIN_RxL_1 353 362 PF00134 0.521
DOC_MAPK_DCC_7 310 318 PF00069 0.540
DOC_MAPK_gen_1 219 227 PF00069 0.524
DOC_MAPK_gen_1 248 255 PF00069 0.443
DOC_MAPK_gen_1 307 317 PF00069 0.521
DOC_MAPK_JIP1_4 294 300 PF00069 0.475
DOC_MAPK_MEF2A_6 307 315 PF00069 0.496
DOC_PP1_RVXF_1 297 303 PF00149 0.537
DOC_PP1_RVXF_1 354 361 PF00149 0.520
DOC_PP2B_LxvP_1 350 353 PF13499 0.631
DOC_PP2B_LxvP_1 59 62 PF13499 0.604
DOC_USP7_MATH_1 84 88 PF00917 0.672
DOC_USP7_UBL2_3 336 340 PF12436 0.565
DOC_WW_Pin1_4 103 108 PF00397 0.572
DOC_WW_Pin1_4 95 100 PF00397 0.736
LIG_14-3-3_CanoR_1 141 146 PF00244 0.723
LIG_14-3-3_CanoR_1 299 303 PF00244 0.506
LIG_14-3-3_CanoR_1 31 40 PF00244 0.604
LIG_14-3-3_CanoR_1 66 75 PF00244 0.538
LIG_Actin_WH2_2 286 301 PF00022 0.509
LIG_Actin_WH2_2 327 345 PF00022 0.600
LIG_BIR_II_1 1 5 PF00653 0.348
LIG_BIR_III_4 100 104 PF00653 0.589
LIG_DLG_GKlike_1 141 149 PF00625 0.532
LIG_DLG_GKlike_1 280 288 PF00625 0.373
LIG_FHA_1 125 131 PF00498 0.578
LIG_FHA_1 200 206 PF00498 0.463
LIG_FHA_1 337 343 PF00498 0.619
LIG_FHA_1 349 355 PF00498 0.635
LIG_FHA_2 68 74 PF00498 0.548
LIG_Integrin_isoDGR_2 346 348 PF01839 0.303
LIG_IRF3_LxIS_1 295 301 PF10401 0.507
LIG_LIR_Apic_2 212 218 PF02991 0.491
LIG_LIR_Apic_2 290 295 PF02991 0.536
LIG_LIR_Gen_1 151 157 PF02991 0.477
LIG_LIR_Gen_1 22 32 PF02991 0.336
LIG_LIR_Gen_1 256 266 PF02991 0.425
LIG_LIR_Nem_3 151 155 PF02991 0.498
LIG_LIR_Nem_3 186 190 PF02991 0.435
LIG_LIR_Nem_3 2 6 PF02991 0.371
LIG_LIR_Nem_3 22 27 PF02991 0.145
LIG_LIR_Nem_3 256 262 PF02991 0.441
LIG_LYPXL_yS_3 42 45 PF13949 0.641
LIG_NRBOX 11 17 PF00104 0.255
LIG_PAM2_1 280 292 PF00658 0.427
LIG_PCNA_PIPBox_1 375 384 PF02747 0.491
LIG_Pex14_2 20 24 PF04695 0.356
LIG_Pex14_2 211 215 PF04695 0.534
LIG_SH2_PTP2 292 295 PF00017 0.510
LIG_SH2_STAP1 246 250 PF00017 0.470
LIG_SH2_STAP1 63 67 PF00017 0.579
LIG_SH2_STAT3 32 35 PF00017 0.532
LIG_SH2_STAT3 41 44 PF00017 0.507
LIG_SH2_STAT5 13 16 PF00017 0.356
LIG_SH2_STAT5 156 159 PF00017 0.428
LIG_SH2_STAT5 213 216 PF00017 0.461
LIG_SH2_STAT5 292 295 PF00017 0.527
LIG_SH3_3 215 221 PF00018 0.475
LIG_SH3_3 308 314 PF00018 0.503
LIG_SH3_3 366 372 PF00018 0.572
LIG_SH3_3 40 46 PF00018 0.521
LIG_SUMO_SIM_anti_2 223 231 PF11976 0.530
LIG_SUMO_SIM_par_1 201 206 PF11976 0.463
LIG_TRAF2_1 377 380 PF00917 0.418
LIG_TRFH_1 80 84 PF08558 0.554
LIG_TYR_ITIM 40 45 PF00017 0.558
LIG_WRC_WIRS_1 149 154 PF05994 0.509
LIG_WRC_WIRS_1 27 32 PF05994 0.347
MOD_CK1_1 131 137 PF00069 0.684
MOD_CK1_1 144 150 PF00069 0.628
MOD_CK1_1 258 264 PF00069 0.499
MOD_CK1_1 267 273 PF00069 0.479
MOD_CK1_1 301 307 PF00069 0.492
MOD_CK1_1 94 100 PF00069 0.662
MOD_CK2_1 85 91 PF00069 0.655
MOD_GlcNHglycan 130 133 PF01048 0.513
MOD_GlcNHglycan 146 149 PF01048 0.427
MOD_GlcNHglycan 266 269 PF01048 0.330
MOD_GlcNHglycan 303 306 PF01048 0.294
MOD_GlcNHglycan 318 321 PF01048 0.241
MOD_GlcNHglycan 375 378 PF01048 0.387
MOD_GlcNHglycan 387 390 PF01048 0.316
MOD_GlcNHglycan 8 11 PF01048 0.382
MOD_GSK3_1 124 131 PF00069 0.714
MOD_GSK3_1 132 139 PF00069 0.695
MOD_GSK3_1 144 151 PF00069 0.635
MOD_GSK3_1 272 279 PF00069 0.493
MOD_GSK3_1 91 98 PF00069 0.795
MOD_N-GLC_1 141 146 PF02516 0.479
MOD_N-GLC_1 94 99 PF02516 0.596
MOD_NEK2_1 136 141 PF00069 0.633
MOD_NEK2_1 19 24 PF00069 0.224
MOD_NEK2_1 228 233 PF00069 0.439
MOD_NEK2_1 298 303 PF00069 0.504
MOD_NEK2_1 316 321 PF00069 0.438
MOD_NEK2_1 6 11 PF00069 0.350
MOD_NEK2_2 234 239 PF00069 0.463
MOD_PIKK_1 196 202 PF00454 0.491
MOD_PIKK_1 31 37 PF00454 0.558
MOD_PKA_2 298 304 PF00069 0.500
MOD_PKA_2 385 391 PF00069 0.469
MOD_Plk_1 141 147 PF00069 0.606
MOD_Plk_1 255 261 PF00069 0.425
MOD_Plk_4 148 154 PF00069 0.555
MOD_Plk_4 19 25 PF00069 0.342
MOD_ProDKin_1 103 109 PF00069 0.572
MOD_ProDKin_1 95 101 PF00069 0.734
TRG_DiLeu_BaLyEn_6 35 40 PF01217 0.582
TRG_ENDOCYTIC_2 13 16 PF00928 0.404
TRG_ENDOCYTIC_2 187 190 PF00928 0.450
TRG_ENDOCYTIC_2 42 45 PF00928 0.641
TRG_ER_diArg_1 248 250 PF00400 0.472
TRG_ER_diArg_1 354 356 PF00400 0.503
TRG_Pf-PMV_PEXEL_1 356 361 PF00026 0.316

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK32 Leptomonas seymouri 61% 96%
A0A0S4J610 Bodo saltans 38% 100%
A0A1X0P675 Trypanosomatidae 42% 100%
A0A3Q8IMT8 Leishmania donovani 83% 100%
A0A3R7NFR6 Trypanosoma rangeli 43% 100%
A4IBU0 Leishmania infantum 83% 100%
C9ZYS4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AFM7 Leishmania major 83% 100%
E9B6T0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
V5BXX8 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS