HTH myb-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

4E-interacting protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HN68_LEIBR

TriTrypDb:

LbrM.34.3960 , LBRM2903_340049000

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HN68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN68

PDB structure(s): 5wb5_B

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0045182	translation regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.647
CLV_NRD_NRD_1	118	120	PF00675	0.716
CLV_NRD_NRD_1	185	187	PF00675	0.596
CLV_NRD_NRD_1	30	32	PF00675	0.614
CLV_NRD_NRD_1	47	49	PF00675	0.713
CLV_NRD_NRD_1	726	728	PF00675	0.659
CLV_PCSK_KEX2_1	118	120	PF00082	0.716
CLV_PCSK_KEX2_1	175	177	PF00082	0.579
CLV_PCSK_KEX2_1	46	48	PF00082	0.713
CLV_PCSK_KEX2_1	535	537	PF00082	0.506
CLV_PCSK_KEX2_1	726	728	PF00082	0.674
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.579
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.713
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.506
CLV_PCSK_SKI1_1	192	196	PF00082	0.579
CLV_Separin_Metazoa	12	16	PF03568	0.571
CLV_Separin_Metazoa	28	32	PF03568	0.606
DEG_APCC_DBOX_1	9	17	PF00400	0.575
DEG_COP1_1	474	484	PF00400	0.706
DEG_SCF_FBW7_1	289	296	PF00400	0.704
DEG_SCF_TRCP1_1	128	133	PF00400	0.549
DEG_SPOP_SBC_1	376	380	PF00917	0.595
DEG_SPOP_SBC_1	385	389	PF00917	0.536
DEG_SPOP_SBC_1	68	72	PF00917	0.565
DOC_CKS1_1	290	295	PF01111	0.704
DOC_CKS1_1	449	454	PF01111	0.684
DOC_CKS1_1	608	613	PF01111	0.579
DOC_CYCLIN_yClb3_PxF_3	552	558	PF00134	0.712
DOC_CYCLIN_yCln2_LP_2	694	700	PF00134	0.643
DOC_MAPK_gen_1	31	38	PF00069	0.656
DOC_MAPK_gen_1	46	54	PF00069	0.558
DOC_PP2B_LxvP_1	258	261	PF13499	0.547
DOC_PP2B_LxvP_1	404	407	PF13499	0.565
DOC_PP2B_LxvP_1	591	594	PF13499	0.565
DOC_PP2B_LxvP_1	615	618	PF13499	0.682
DOC_PP2B_LxvP_1	694	697	PF13499	0.648
DOC_PP4_FxxP_1	142	145	PF00568	0.640
DOC_PP4_FxxP_1	558	561	PF00568	0.717
DOC_PP4_FxxP_1	571	574	PF00568	0.725
DOC_PP4_FxxP_1	725	728	PF00568	0.512
DOC_USP7_MATH_1	274	278	PF00917	0.617
DOC_USP7_MATH_1	285	289	PF00917	0.711
DOC_USP7_MATH_1	293	297	PF00917	0.624
DOC_USP7_MATH_1	305	309	PF00917	0.556
DOC_USP7_MATH_1	367	371	PF00917	0.685
DOC_USP7_MATH_1	376	380	PF00917	0.588
DOC_USP7_MATH_1	385	389	PF00917	0.580
DOC_USP7_MATH_1	400	404	PF00917	0.607
DOC_USP7_MATH_1	408	412	PF00917	0.701
DOC_USP7_MATH_1	457	461	PF00917	0.626
DOC_USP7_MATH_1	499	503	PF00917	0.548
DOC_USP7_MATH_1	506	510	PF00917	0.544
DOC_USP7_MATH_1	581	585	PF00917	0.647
DOC_USP7_MATH_1	621	625	PF00917	0.689
DOC_USP7_MATH_1	635	639	PF00917	0.614
DOC_USP7_MATH_1	74	78	PF00917	0.574
DOC_USP7_MATH_1	84	88	PF00917	0.547
DOC_WW_Pin1_4	101	106	PF00397	0.716
DOC_WW_Pin1_4	289	294	PF00397	0.681
DOC_WW_Pin1_4	295	300	PF00397	0.617
DOC_WW_Pin1_4	332	337	PF00397	0.676
DOC_WW_Pin1_4	445	450	PF00397	0.706
DOC_WW_Pin1_4	551	556	PF00397	0.843
DOC_WW_Pin1_4	574	579	PF00397	0.713
DOC_WW_Pin1_4	607	612	PF00397	0.619
DOC_WW_Pin1_4	643	648	PF00397	0.639
DOC_WW_Pin1_4	665	670	PF00397	0.828
LIG_14-3-3_CanoR_1	15	20	PF00244	0.619
LIG_14-3-3_CanoR_1	238	246	PF00244	0.815
LIG_14-3-3_CanoR_1	360	365	PF00244	0.581
LIG_BRCT_BRCA1_1	130	134	PF00533	0.574
LIG_BRCT_BRCA1_1	236	240	PF00533	0.684
LIG_BRCT_BRCA1_1	390	394	PF00533	0.563
LIG_BRCT_BRCA1_1	567	571	PF00533	0.596
LIG_DLG_GKlike_1	15	23	PF00625	0.456
LIG_EH_1	755	759	PF12763	0.677
LIG_eIF4E_1	8	14	PF01652	0.573
LIG_EVH1_1	258	262	PF00568	0.546
LIG_EVH1_1	404	408	PF00568	0.564
LIG_EVH1_1	615	619	PF00568	0.680
LIG_FHA_1	212	218	PF00498	0.609
LIG_FHA_1	279	285	PF00498	0.577
LIG_FHA_1	378	384	PF00498	0.651
LIG_FHA_1	519	525	PF00498	0.681
LIG_FHA_1	671	677	PF00498	0.724
LIG_FHA_2	156	162	PF00498	0.599
LIG_FHA_2	223	229	PF00498	0.633
LIG_FHA_2	523	529	PF00498	0.636
LIG_FHA_2	7	13	PF00498	0.615
LIG_HP1_1	647	651	PF01393	0.576
LIG_LIR_Apic_2	140	145	PF02991	0.645
LIG_LIR_Apic_2	568	574	PF02991	0.597
LIG_LIR_Gen_1	137	145	PF02991	0.652
LIG_LIR_Gen_1	303	312	PF02991	0.537
LIG_LIR_Gen_1	646	655	PF02991	0.627
LIG_LIR_Nem_3	137	142	PF02991	0.660
LIG_MLH1_MIPbox_1	236	240	PF16413	0.657
LIG_MYND_1	674	678	PF01753	0.722
LIG_NRBOX	489	495	PF00104	0.617
LIG_NRBOX	528	534	PF00104	0.465
LIG_NRP_CendR_1	771	772	PF00754	0.681
LIG_SH2_STAP1	139	143	PF00017	0.647
LIG_SH2_STAT5	706	709	PF00017	0.615
LIG_SH2_STAT5	8	11	PF00017	0.578
LIG_SH3_3	254	260	PF00018	0.706
LIG_SH3_3	330	336	PF00018	0.620
LIG_SH3_3	35	41	PF00018	0.681
LIG_SH3_3	355	361	PF00018	0.633
LIG_SH3_3	393	399	PF00018	0.731
LIG_SH3_3	402	408	PF00018	0.714
LIG_SH3_3	438	444	PF00018	0.705
LIG_SH3_3	446	452	PF00018	0.662
LIG_SH3_3	502	508	PF00018	0.705
LIG_SH3_3	549	555	PF00018	0.709
LIG_SH3_3	558	564	PF00018	0.623
LIG_SH3_3	575	581	PF00018	0.710
LIG_SH3_3	608	614	PF00018	0.706
LIG_SH3_3	615	621	PF00018	0.558
LIG_SH3_3	624	630	PF00018	0.710
LIG_SH3_3	646	652	PF00018	0.820
LIG_SH3_3	672	678	PF00018	0.858
LIG_SH3_3	745	751	PF00018	0.672
LIG_SUMO_SIM_par_1	34	40	PF11976	0.678
LIG_TRAF2_1	158	161	PF00917	0.601
LIG_TRAF2_1	9	12	PF00917	0.608
MOD_CDK_SPK_2	607	612	PF00069	0.579
MOD_CDK_SPxK_1	289	295	PF00069	0.558
MOD_CK1_1	100	106	PF00069	0.686
MOD_CK1_1	150	156	PF00069	0.490
MOD_CK1_1	18	24	PF00069	0.559
MOD_CK1_1	269	275	PF00069	0.652
MOD_CK1_1	308	314	PF00069	0.749
MOD_CK1_1	321	327	PF00069	0.667
MOD_CK1_1	370	376	PF00069	0.587
MOD_CK1_1	379	385	PF00069	0.666
MOD_CK1_1	388	394	PF00069	0.572
MOD_CK1_1	417	423	PF00069	0.611
MOD_CK1_1	448	454	PF00069	0.587
MOD_CK1_1	474	480	PF00069	0.614
MOD_CK1_1	514	520	PF00069	0.647
MOD_CK1_1	541	547	PF00069	0.572
MOD_CK1_1	57	63	PF00069	0.678
MOD_CK1_1	64	70	PF00069	0.635
MOD_CK1_1	661	667	PF00069	0.631
MOD_CK1_1	77	83	PF00069	0.571
MOD_CK2_1	155	161	PF00069	0.695
MOD_CK2_1	483	489	PF00069	0.493
MOD_CK2_1	522	528	PF00069	0.646
MOD_CK2_1	6	12	PF00069	0.621
MOD_GlcNHglycan	107	110	PF01048	0.680
MOD_GlcNHglycan	127	131	PF01048	0.676
MOD_GlcNHglycan	136	139	PF01048	0.649
MOD_GlcNHglycan	169	172	PF01048	0.543
MOD_GlcNHglycan	20	23	PF01048	0.616
MOD_GlcNHglycan	240	243	PF01048	0.728
MOD_GlcNHglycan	248	251	PF01048	0.689
MOD_GlcNHglycan	276	279	PF01048	0.553
MOD_GlcNHglycan	295	298	PF01048	0.836
MOD_GlcNHglycan	323	326	PF01048	0.769
MOD_GlcNHglycan	383	386	PF01048	0.749
MOD_GlcNHglycan	388	391	PF01048	0.664
MOD_GlcNHglycan	414	417	PF01048	0.704
MOD_GlcNHglycan	436	439	PF01048	0.719
MOD_GlcNHglycan	473	476	PF01048	0.727
MOD_GlcNHglycan	485	488	PF01048	0.519
MOD_GlcNHglycan	502	505	PF01048	0.543
MOD_GlcNHglycan	513	516	PF01048	0.618
MOD_GlcNHglycan	540	543	PF01048	0.596
MOD_GlcNHglycan	663	666	PF01048	0.587
MOD_GlcNHglycan	709	712	PF01048	0.469
MOD_GlcNHglycan	76	79	PF01048	0.678
MOD_GlcNHglycan	87	90	PF01048	0.580
MOD_GSK3_1	101	108	PF00069	0.727
MOD_GSK3_1	126	133	PF00069	0.774
MOD_GSK3_1	230	237	PF00069	0.757
MOD_GSK3_1	266	273	PF00069	0.615
MOD_GSK3_1	274	281	PF00069	0.596
MOD_GSK3_1	285	292	PF00069	0.699
MOD_GSK3_1	300	307	PF00069	0.535
MOD_GSK3_1	310	317	PF00069	0.758
MOD_GSK3_1	332	339	PF00069	0.599
MOD_GSK3_1	352	359	PF00069	0.696
MOD_GSK3_1	375	382	PF00069	0.773
MOD_GSK3_1	384	391	PF00069	0.681
MOD_GSK3_1	408	415	PF00069	0.716
MOD_GSK3_1	444	451	PF00069	0.790
MOD_GSK3_1	471	478	PF00069	0.724
MOD_GSK3_1	479	486	PF00069	0.600
MOD_GSK3_1	495	502	PF00069	0.516
MOD_GSK3_1	507	514	PF00069	0.609
MOD_GSK3_1	518	525	PF00069	0.594
MOD_GSK3_1	53	60	PF00069	0.658
MOD_GSK3_1	543	550	PF00069	0.639
MOD_GSK3_1	621	628	PF00069	0.672
MOD_GSK3_1	63	70	PF00069	0.633
MOD_GSK3_1	661	668	PF00069	0.587
MOD_GSK3_1	92	99	PF00069	0.722
MOD_N-GLC_1	61	66	PF02516	0.663
MOD_N-GLC_1	665	670	PF02516	0.727
MOD_N-GLC_1	74	79	PF02516	0.574
MOD_N-GLC_1	84	89	PF02516	0.577
MOD_N-GLC_1	96	101	PF02516	0.605
MOD_NEK2_1	134	139	PF00069	0.579
MOD_NEK2_1	167	172	PF00069	0.548
MOD_NEK2_1	270	275	PF00069	0.567
MOD_NEK2_1	315	320	PF00069	0.814
MOD_NEK2_1	326	331	PF00069	0.649
MOD_NEK2_1	352	357	PF00069	0.595
MOD_NEK2_1	54	59	PF00069	0.690
MOD_NEK2_1	63	68	PF00069	0.610
MOD_NEK2_1	707	712	PF00069	0.481
MOD_NEK2_1	733	738	PF00069	0.532
MOD_NEK2_2	130	135	PF00069	0.544
MOD_NEK2_2	3	8	PF00069	0.711
MOD_NEK2_2	305	310	PF00069	0.682
MOD_NEK2_2	728	733	PF00069	0.650
MOD_PIKK_1	344	350	PF00454	0.694
MOD_PIKK_1	352	358	PF00454	0.694
MOD_PIKK_1	518	524	PF00454	0.695
MOD_PIKK_1	621	627	PF00454	0.694
MOD_PIKK_1	635	641	PF00454	0.610
MOD_PIKK_1	658	664	PF00454	0.582
MOD_PIKK_1	733	739	PF00454	0.534
MOD_PKA_1	47	53	PF00069	0.558
MOD_PKA_1	495	501	PF00069	0.518
MOD_PKA_2	147	153	PF00069	0.526
MOD_PKA_2	167	173	PF00069	0.552
MOD_PKA_2	211	217	PF00069	0.492
MOD_PKA_2	47	53	PF00069	0.666
MOD_PKB_1	236	244	PF00069	0.673
MOD_PKB_1	536	544	PF00069	0.549
MOD_Plk_2-3	211	217	PF00069	0.616
MOD_Plk_4	230	236	PF00069	0.529
MOD_Plk_4	285	291	PF00069	0.711
MOD_Plk_4	408	414	PF00069	0.777
MOD_Plk_4	528	534	PF00069	0.612
MOD_Plk_4	54	60	PF00069	0.687
MOD_Plk_4	565	571	PF00069	0.617
MOD_Plk_4	597	603	PF00069	0.561
MOD_Plk_4	685	691	PF00069	0.528
MOD_Plk_4	728	734	PF00069	0.651
MOD_ProDKin_1	101	107	PF00069	0.716
MOD_ProDKin_1	289	295	PF00069	0.682
MOD_ProDKin_1	332	338	PF00069	0.679
MOD_ProDKin_1	445	451	PF00069	0.709
MOD_ProDKin_1	551	557	PF00069	0.846
MOD_ProDKin_1	574	580	PF00069	0.715
MOD_ProDKin_1	607	613	PF00069	0.620
MOD_ProDKin_1	643	649	PF00069	0.639
MOD_ProDKin_1	665	671	PF00069	0.829
MOD_SUMO_for_1	198	201	PF00179	0.618
TRG_DiLeu_BaEn_1	216	221	PF01217	0.591
TRG_DiLeu_BaEn_1	489	494	PF01217	0.466
TRG_DiLeu_BaEn_1	528	533	PF01217	0.465
TRG_DiLeu_LyEn_5	216	221	PF01217	0.591
TRG_ENDOCYTIC_2	139	142	PF00928	0.657
TRG_ER_diArg_1	235	238	PF00400	0.658
TRG_ER_diArg_1	725	727	PF00400	0.628
TRG_NES_CRM1_1	24	37	PF08389	0.624
TRG_NLS_MonoExtC_3	173	179	PF00514	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X9R7	Leishmania donovani	73%	98%
A4IBT6	Leishmania infantum	73%	98%
E9AFM3	Leishmania major	72%	100%
E9B6S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%