Sperm-tail_PG-rich_repeat

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN63_LEIBR

TriTrypDb:

LbrM.34.3910 , LBRM2903_340048500

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HN63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	416	420	PF00656	0.473
CLV_NRD_NRD_1	111	113	PF00675	0.333
CLV_NRD_NRD_1	150	152	PF00675	0.335
CLV_NRD_NRD_1	267	269	PF00675	0.594
CLV_NRD_NRD_1	304	306	PF00675	0.318
CLV_NRD_NRD_1	307	309	PF00675	0.670
CLV_NRD_NRD_1	353	355	PF00675	0.597
CLV_NRD_NRD_1	425	427	PF00675	0.689
CLV_PCSK_FUR_1	305	309	PF00082	0.736
CLV_PCSK_KEX2_1	150	152	PF00082	0.335
CLV_PCSK_KEX2_1	201	203	PF00082	0.650
CLV_PCSK_KEX2_1	267	269	PF00082	0.592
CLV_PCSK_KEX2_1	304	306	PF00082	0.354
CLV_PCSK_KEX2_1	307	309	PF00082	0.687
CLV_PCSK_KEX2_1	31	33	PF00082	0.362
CLV_PCSK_KEX2_1	353	355	PF00082	0.596
CLV_PCSK_KEX2_1	425	427	PF00082	0.718
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.650
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.362
CLV_PCSK_SKI1_1	31	35	PF00082	0.173
CLV_Separin_Metazoa	165	169	PF03568	0.595
DEG_Nend_UBRbox_2	1	3	PF02207	0.721
DOC_CDC14_PxL_1	1	9	PF14671	0.693
DOC_MAPK_gen_1	434	443	PF00069	0.569
DOC_PP1_RVXF_1	432	439	PF00149	0.659
DOC_PP2B_LxvP_1	167	170	PF13499	0.467
DOC_PP4_FxxP_1	120	123	PF00568	0.699
DOC_PP4_FxxP_1	312	315	PF00568	0.741
DOC_USP7_MATH_1	127	131	PF00917	0.634
DOC_USP7_MATH_1	190	194	PF00917	0.490
DOC_USP7_MATH_1	238	242	PF00917	0.579
DOC_USP7_MATH_1	279	283	PF00917	0.629
DOC_USP7_MATH_1	303	307	PF00917	0.502
DOC_USP7_MATH_1	317	321	PF00917	0.549
DOC_USP7_MATH_1	41	45	PF00917	0.474
DOC_USP7_MATH_1	442	446	PF00917	0.602
DOC_USP7_MATH_1	68	72	PF00917	0.471
DOC_USP7_MATH_1	81	85	PF00917	0.585
DOC_USP7_MATH_1	92	96	PF00917	0.535
DOC_USP7_MATH_2	232	238	PF00917	0.698
DOC_WW_Pin1_4	210	215	PF00397	0.607
DOC_WW_Pin1_4	292	297	PF00397	0.682
DOC_WW_Pin1_4	444	449	PF00397	0.584
LIG_14-3-3_CanoR_1	286	292	PF00244	0.602
LIG_14-3-3_CanoR_1	437	443	PF00244	0.612
LIG_BIR_III_2	419	423	PF00653	0.472
LIG_BRCT_BRCA1_1	116	120	PF00533	0.755
LIG_BRCT_BRCA1_1	192	196	PF00533	0.490
LIG_BRCT_BRCA1_1	242	246	PF00533	0.662
LIG_BRCT_BRCA1_1	276	280	PF00533	0.629
LIG_BRCT_BRCA1_1	78	82	PF00533	0.606
LIG_BRCT_BRCA1_1	85	89	PF00533	0.667
LIG_FHA_1	131	137	PF00498	0.582
LIG_FHA_1	259	265	PF00498	0.563
LIG_FHA_1	403	409	PF00498	0.729
LIG_FHA_1	470	476	PF00498	0.636
LIG_FHA_1	61	67	PF00498	0.428
LIG_Integrin_isoDGR_2	346	348	PF01839	0.576
LIG_LIR_Apic_2	117	123	PF02991	0.699
LIG_LIR_Apic_2	311	315	PF02991	0.741
LIG_LIR_Apic_2	378	384	PF02991	0.554
LIG_LIR_Apic_2	63	67	PF02991	0.482
LIG_LIR_Gen_1	282	292	PF02991	0.649
LIG_LIR_Gen_1	413	422	PF02991	0.726
LIG_LIR_Gen_1	435	443	PF02991	0.647
LIG_LIR_Nem_3	234	239	PF02991	0.630
LIG_LIR_Nem_3	282	287	PF02991	0.649
LIG_LIR_Nem_3	413	417	PF02991	0.732
LIG_LIR_Nem_3	435	441	PF02991	0.653
LIG_Pex14_2	325	329	PF04695	0.681
LIG_PTB_Apo_2	139	146	PF02174	0.510
LIG_PTB_Apo_2	388	395	PF02174	0.678
LIG_PTB_Phospho_1	139	145	PF10480	0.510
LIG_SH2_CRK	360	364	PF00017	0.440
LIG_SH2_CRK	64	68	PF00017	0.510
LIG_SH2_NCK_1	103	107	PF00017	0.533
LIG_SH2_NCK_1	145	149	PF00017	0.535
LIG_SH2_NCK_1	64	68	PF00017	0.427
LIG_SH2_STAP1	132	136	PF00017	0.605
LIG_SH2_STAP1	377	381	PF00017	0.570
LIG_SH2_STAT5	132	135	PF00017	0.620
LIG_SH2_STAT5	260	263	PF00017	0.566
LIG_SH2_STAT5	414	417	PF00017	0.651
LIG_SH3_2	370	375	PF14604	0.433
LIG_SH3_3	163	169	PF00018	0.669
LIG_SH3_3	367	373	PF00018	0.531
LIG_SH3_3	405	411	PF00018	0.650
LIG_SH3_3	44	50	PF00018	0.557
LIG_WW_2	370	373	PF00397	0.415
MOD_CK1_1	107	113	PF00069	0.479
MOD_CK1_1	130	136	PF00069	0.460
MOD_CK1_1	241	247	PF00069	0.690
MOD_CK1_1	444	450	PF00069	0.578
MOD_CK2_1	159	165	PF00069	0.571
MOD_CK2_1	410	416	PF00069	0.680
MOD_Cter_Amidation	423	426	PF01082	0.606
MOD_GlcNHglycan	120	123	PF01048	0.699
MOD_GlcNHglycan	236	239	PF01048	0.574
MOD_GlcNHglycan	276	279	PF01048	0.577
MOD_GlcNHglycan	281	284	PF01048	0.538
MOD_GlcNHglycan	340	343	PF01048	0.699
MOD_GlcNHglycan	366	369	PF01048	0.650
MOD_GlcNHglycan	405	408	PF01048	0.524
MOD_GlcNHglycan	444	447	PF01048	0.594
MOD_GlcNHglycan	52	55	PF01048	0.726
MOD_GlcNHglycan	70	73	PF01048	0.217
MOD_GlcNHglycan	85	88	PF01048	0.556
MOD_GSK3_1	104	111	PF00069	0.490
MOD_GSK3_1	114	121	PF00069	0.731
MOD_GSK3_1	14	21	PF00069	0.587
MOD_GSK3_1	174	181	PF00069	0.454
MOD_GSK3_1	191	198	PF00069	0.630
MOD_GSK3_1	234	241	PF00069	0.639
MOD_GSK3_1	270	277	PF00069	0.634
MOD_GSK3_1	31	38	PF00069	0.412
MOD_GSK3_1	385	392	PF00069	0.606
MOD_GSK3_1	460	467	PF00069	0.535
MOD_LATS_1	13	19	PF00433	0.460
MOD_N-GLC_1	35	40	PF02516	0.303
MOD_N-GLC_1	390	395	PF02516	0.715
MOD_N-GLC_1	42	47	PF02516	0.474
MOD_N-GLC_1	464	469	PF02516	0.535
MOD_NEK2_1	195	200	PF00069	0.442
MOD_NEK2_1	239	244	PF00069	0.556
MOD_NEK2_1	318	323	PF00069	0.633
MOD_NEK2_1	389	394	PF00069	0.610
MOD_NEK2_1	402	407	PF00069	0.642
MOD_NEK2_1	42	47	PF00069	0.645
MOD_NEK2_1	460	465	PF00069	0.543
MOD_PIKK_1	127	133	PF00454	0.472
MOD_PIKK_1	327	333	PF00454	0.699
MOD_PIKK_1	348	354	PF00454	0.470
MOD_PIKK_1	76	82	PF00454	0.522
MOD_PKA_1	31	37	PF00069	0.373
MOD_PKA_2	108	114	PF00069	0.401
MOD_PKA_2	14	20	PF00069	0.710
MOD_PKA_2	303	309	PF00069	0.683
MOD_PKA_2	31	37	PF00069	0.535
MOD_PKA_2	436	442	PF00069	0.639
MOD_Plk_1	390	396	PF00069	0.606
MOD_Plk_1	42	48	PF00069	0.719
MOD_Plk_1	464	470	PF00069	0.535
MOD_Plk_4	178	184	PF00069	0.396
MOD_Plk_4	191	197	PF00069	0.520
MOD_Plk_4	455	461	PF00069	0.515
MOD_ProDKin_1	210	216	PF00069	0.363
MOD_ProDKin_1	292	298	PF00069	0.434
MOD_ProDKin_1	444	450	PF00069	0.587
TRG_DiLeu_BaEn_2	84	90	PF01217	0.666
TRG_DiLeu_BaEn_4	2	8	PF01217	0.718
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.685
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.451
TRG_DiLeu_LyEn_5	2	7	PF01217	0.688
TRG_ENDOCYTIC_2	284	287	PF00928	0.646
TRG_ENDOCYTIC_2	360	363	PF00928	0.446
TRG_ENDOCYTIC_2	414	417	PF00928	0.701
TRG_ER_diArg_1	150	152	PF00400	0.535
TRG_ER_diArg_1	266	268	PF00400	0.593
TRG_ER_diArg_1	303	305	PF00400	0.556
TRG_ER_diArg_1	353	356	PF00400	0.564
TRG_ER_diArg_1	425	427	PF00400	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ4	Leptomonas seymouri	61%	99%
A0A0S4IX55	Bodo saltans	30%	89%
A0A1X0P6L3	Trypanosomatidae	41%	100%
A0A3Q8IGK1	Leishmania donovani	76%	100%
A0A3R7LN85	Trypanosoma rangeli	37%	100%
A4IBT0	Leishmania infantum	77%	100%
C9ZYT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AFL7	Leishmania major	78%	100%
E9B6S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q8C8J0	Mus musculus	27%	85%
Q8N412	Homo sapiens	27%	100%
V5C2R9	Trypanosoma cruzi	35%	100%