Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN62_LEIBR

TriTrypDb:

LbrM.34.3900

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HN62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN62

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.453
CLV_NRD_NRD_1	179	181	PF00675	0.695
CLV_NRD_NRD_1	221	223	PF00675	0.633
CLV_NRD_NRD_1	376	378	PF00675	0.645
CLV_PCSK_KEX2_1	179	181	PF00082	0.702
CLV_PCSK_KEX2_1	209	211	PF00082	0.558
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.604
CLV_PCSK_SKI1_1	14	18	PF00082	0.570
CLV_PCSK_SKI1_1	202	206	PF00082	0.535
CLV_PCSK_SKI1_1	304	308	PF00082	0.712
CLV_PCSK_SKI1_1	35	39	PF00082	0.566
CLV_PCSK_SKI1_1	469	473	PF00082	0.362
CLV_PCSK_SKI1_1	538	542	PF00082	0.424
CLV_PCSK_SKI1_1	550	554	PF00082	0.304
CLV_PCSK_SKI1_1	596	600	PF00082	0.452
CLV_PCSK_SKI1_1	634	638	PF00082	0.427
CLV_PCSK_SKI1_1	725	729	PF00082	0.445
CLV_PCSK_SKI1_1	770	774	PF00082	0.344
DEG_APCC_DBOX_1	201	209	PF00400	0.418
DEG_APCC_DBOX_1	303	311	PF00400	0.491
DEG_APCC_DBOX_1	381	389	PF00400	0.297
DEG_ODPH_VHL_1	76	89	PF01847	0.234
DEG_SPOP_SBC_1	362	366	PF00917	0.457
DOC_CDC14_PxL_1	131	139	PF14671	0.319
DOC_CDC14_PxL_1	188	196	PF14671	0.480
DOC_CDC14_PxL_1	294	302	PF14671	0.387
DOC_CKS1_1	587	592	PF01111	0.739
DOC_CKS1_1	771	776	PF01111	0.524
DOC_CYCLIN_RxL_1	301	311	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.510
DOC_MAPK_gen_1	160	169	PF00069	0.366
DOC_MAPK_gen_1	550	558	PF00069	0.433
DOC_MAPK_MEF2A_6	160	169	PF00069	0.390
DOC_MAPK_MEF2A_6	389	397	PF00069	0.400
DOC_MAPK_RevD_3	165	180	PF00069	0.480
DOC_PP1_RVXF_1	200	207	PF00149	0.391
DOC_PP2B_LxvP_1	103	106	PF13499	0.334
DOC_PP2B_LxvP_1	132	135	PF13499	0.512
DOC_PP2B_LxvP_1	167	170	PF13499	0.450
DOC_PP2B_LxvP_1	621	624	PF13499	0.750
DOC_PP4_FxxP_1	171	174	PF00568	0.406
DOC_PP4_FxxP_1	329	332	PF00568	0.406
DOC_PP4_FxxP_1	762	765	PF00568	0.594
DOC_USP7_MATH_1	123	127	PF00917	0.515
DOC_USP7_MATH_1	150	154	PF00917	0.524
DOC_USP7_MATH_1	289	293	PF00917	0.427
DOC_USP7_MATH_1	362	366	PF00917	0.399
DOC_USP7_MATH_1	532	536	PF00917	0.558
DOC_USP7_MATH_1	747	751	PF00917	0.666
DOC_USP7_MATH_1	78	82	PF00917	0.443
DOC_USP7_UBL2_3	115	119	PF12436	0.437
DOC_USP7_UBL2_3	578	582	PF12436	0.717
DOC_USP7_UBL2_3	611	615	PF12436	0.754
DOC_WW_Pin1_4	118	123	PF00397	0.529
DOC_WW_Pin1_4	345	350	PF00397	0.504
DOC_WW_Pin1_4	354	359	PF00397	0.507
DOC_WW_Pin1_4	424	429	PF00397	0.355
DOC_WW_Pin1_4	586	591	PF00397	0.598
DOC_WW_Pin1_4	770	775	PF00397	0.646
LIG_14-3-3_CanoR_1	125	132	PF00244	0.534
LIG_14-3-3_CanoR_1	213	221	PF00244	0.459
LIG_14-3-3_CanoR_1	237	246	PF00244	0.398
LIG_14-3-3_CanoR_1	271	279	PF00244	0.435
LIG_14-3-3_CanoR_1	315	321	PF00244	0.391
LIG_14-3-3_CanoR_1	377	381	PF00244	0.341
LIG_14-3-3_CanoR_1	382	388	PF00244	0.283
LIG_14-3-3_CanoR_1	531	537	PF00244	0.615
LIG_14-3-3_CanoR_1	574	581	PF00244	0.620
LIG_14-3-3_CanoR_1	778	784	PF00244	0.480
LIG_Actin_WH2_2	537	555	PF00022	0.529
LIG_APCC_ABBA_1	168	173	PF00400	0.461
LIG_BRCT_BRCA1_1	106	110	PF00533	0.393
LIG_BRCT_BRCA1_1	214	218	PF00533	0.439
LIG_BRCT_BRCA1_1	238	242	PF00533	0.415
LIG_BRCT_BRCA1_1	346	350	PF00533	0.480
LIG_BRCT_BRCA1_1	437	441	PF00533	0.396
LIG_BRCT_BRCA1_1	603	607	PF00533	0.573
LIG_BRCT_BRCA1_1	749	753	PF00533	0.660
LIG_BRCT_BRCA1_1	768	772	PF00533	0.601
LIG_BRCT_BRCA1_1	92	96	PF00533	0.370
LIG_BRCT_BRCA1_2	238	244	PF00533	0.290
LIG_CtBP_PxDLS_1	774	778	PF00389	0.619
LIG_deltaCOP1_diTrp_1	411	420	PF00928	0.402
LIG_EH_1	417	421	PF12763	0.421
LIG_eIF4E_1	198	204	PF01652	0.368
LIG_eIF4E_1	796	802	PF01652	0.312
LIG_FHA_1	214	220	PF00498	0.374
LIG_FHA_1	288	294	PF00498	0.355
LIG_FHA_1	311	317	PF00498	0.363
LIG_FHA_1	333	339	PF00498	0.320
LIG_FHA_1	405	411	PF00498	0.358
LIG_FHA_1	523	529	PF00498	0.570
LIG_FHA_1	539	545	PF00498	0.614
LIG_FHA_1	553	559	PF00498	0.570
LIG_FHA_1	589	595	PF00498	0.727
LIG_FHA_1	77	83	PF00498	0.400
LIG_FHA_2	176	182	PF00498	0.427
LIG_FHA_2	283	289	PF00498	0.442
LIG_FHA_2	355	361	PF00498	0.534
LIG_FHA_2	369	375	PF00498	0.278
LIG_FHA_2	597	603	PF00498	0.663
LIG_FHA_2	726	732	PF00498	0.563
LIG_LIR_Apic_2	761	765	PF02991	0.631
LIG_LIR_Gen_1	18	27	PF02991	0.411
LIG_LIR_Gen_1	259	268	PF02991	0.392
LIG_LIR_Gen_1	390	400	PF02991	0.381
LIG_LIR_Gen_1	411	420	PF02991	0.316
LIG_LIR_Gen_1	438	449	PF02991	0.279
LIG_LIR_Gen_1	49	58	PF02991	0.417
LIG_LIR_Gen_1	72	78	PF02991	0.324
LIG_LIR_Gen_1	785	794	PF02991	0.324
LIG_LIR_Nem_3	126	132	PF02991	0.466
LIG_LIR_Nem_3	18	23	PF02991	0.289
LIG_LIR_Nem_3	240	246	PF02991	0.416
LIG_LIR_Nem_3	259	263	PF02991	0.344
LIG_LIR_Nem_3	3	7	PF02991	0.438
LIG_LIR_Nem_3	36	41	PF02991	0.400
LIG_LIR_Nem_3	390	395	PF02991	0.324
LIG_LIR_Nem_3	411	416	PF02991	0.314
LIG_LIR_Nem_3	437	442	PF02991	0.284
LIG_LIR_Nem_3	49	53	PF02991	0.350
LIG_LIR_Nem_3	57	62	PF02991	0.410
LIG_LIR_Nem_3	67	73	PF02991	0.321
LIG_LIR_Nem_3	769	775	PF02991	0.638
LIG_LIR_Nem_3	785	789	PF02991	0.225
LIG_MLH1_MIPbox_1	603	607	PF16413	0.641
LIG_NRBOX	199	205	PF00104	0.369
LIG_NRBOX	651	657	PF00104	0.486
LIG_NRBOX	797	803	PF00104	0.207
LIG_PCNA_yPIPBox_3	222	231	PF02747	0.333
LIG_PCNA_yPIPBox_3	469	483	PF02747	0.596
LIG_PDZ_Class_2	798	803	PF00595	0.367
LIG_Pex14_1	779	783	PF04695	0.542
LIG_Pex14_2	16	20	PF04695	0.405
LIG_Pex14_2	37	41	PF04695	0.432
LIG_Pex14_2	504	508	PF04695	0.524
LIG_Pex14_2	569	573	PF04695	0.632
LIG_PTB_Apo_2	580	587	PF02174	0.739
LIG_PTB_Phospho_1	580	586	PF10480	0.738
LIG_REV1ctd_RIR_1	35	44	PF16727	0.466
LIG_REV1ctd_RIR_1	604	612	PF16727	0.706
LIG_SH2_CRK	243	247	PF00017	0.400
LIG_SH2_CRK	253	257	PF00017	0.286
LIG_SH2_CRK	73	77	PF00017	0.319
LIG_SH2_GRB2like	73	76	PF00017	0.394
LIG_SH2_NCK_1	457	461	PF00017	0.450
LIG_SH2_NCK_1	73	77	PF00017	0.225
LIG_SH2_PTP2	260	263	PF00017	0.404
LIG_SH2_PTP2	533	536	PF00017	0.592
LIG_SH2_PTP2	796	799	PF00017	0.343
LIG_SH2_SRC	73	76	PF00017	0.225
LIG_SH2_STAP1	253	257	PF00017	0.365
LIG_SH2_STAP1	334	338	PF00017	0.415
LIG_SH2_STAP1	668	672	PF00017	0.626
LIG_SH2_STAP1	685	689	PF00017	0.642
LIG_SH2_STAP1	73	77	PF00017	0.225
LIG_SH2_STAT3	25	28	PF00017	0.414
LIG_SH2_STAT3	431	434	PF00017	0.418
LIG_SH2_STAT5	130	133	PF00017	0.434
LIG_SH2_STAT5	19	22	PF00017	0.420
LIG_SH2_STAT5	198	201	PF00017	0.310
LIG_SH2_STAT5	260	263	PF00017	0.350
LIG_SH2_STAT5	264	267	PF00017	0.323
LIG_SH2_STAT5	334	337	PF00017	0.386
LIG_SH2_STAT5	400	403	PF00017	0.410
LIG_SH2_STAT5	408	411	PF00017	0.280
LIG_SH2_STAT5	431	434	PF00017	0.320
LIG_SH2_STAT5	533	536	PF00017	0.547
LIG_SH2_STAT5	586	589	PF00017	0.700
LIG_SH2_STAT5	796	799	PF00017	0.418
LIG_SH3_3	189	195	PF00018	0.435
LIG_SH3_3	20	26	PF00018	0.357
LIG_SH3_3	584	590	PF00018	0.748
LIG_SH3_3	591	597	PF00018	0.750
LIG_SH3_3	768	774	PF00018	0.697
LIG_Sin3_3	201	208	PF02671	0.409
LIG_SUMO_SIM_anti_2	292	297	PF11976	0.424
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.303
LIG_SUMO_SIM_anti_2	554	560	PF11976	0.617
LIG_TRAF2_1	8	11	PF00917	0.434
LIG_TRFH_1	25	29	PF08558	0.401
LIG_TYR_ITIM	794	799	PF00017	0.338
LIG_UBA3_1	200	209	PF00899	0.359
LIG_WRC_WIRS_1	436	441	PF05994	0.339
LIG_WRC_WIRS_1	47	52	PF05994	0.377
MOD_CDK_SPxxK_3	118	125	PF00069	0.346
MOD_CK1_1	104	110	PF00069	0.437
MOD_CK1_1	274	280	PF00069	0.463
MOD_CK1_1	283	289	PF00069	0.397
MOD_CK1_1	342	348	PF00069	0.455
MOD_CK1_1	462	468	PF00069	0.470
MOD_CK1_1	489	495	PF00069	0.608
MOD_CK1_1	601	607	PF00069	0.650
MOD_CK1_1	782	788	PF00069	0.391
MOD_CK2_1	175	181	PF00069	0.433
MOD_CK2_1	368	374	PF00069	0.284
MOD_CK2_1	455	461	PF00069	0.476
MOD_CK2_1	54	60	PF00069	0.437
MOD_CK2_1	596	602	PF00069	0.678
MOD_CK2_1	725	731	PF00069	0.571
MOD_CK2_1	95	101	PF00069	0.368
MOD_DYRK1A_RPxSP_1	770	774	PF00069	0.647
MOD_GlcNHglycan	239	242	PF01048	0.684
MOD_GlcNHglycan	265	268	PF01048	0.642
MOD_GlcNHglycan	461	464	PF01048	0.355
MOD_GlcNHglycan	488	491	PF01048	0.301
MOD_GlcNHglycan	575	578	PF01048	0.385
MOD_GlcNHglycan	93	96	PF01048	0.571
MOD_GSK3_1	101	108	PF00069	0.364
MOD_GSK3_1	150	157	PF00069	0.399
MOD_GSK3_1	175	182	PF00069	0.460
MOD_GSK3_1	283	290	PF00069	0.385
MOD_GSK3_1	29	36	PF00069	0.376
MOD_GSK3_1	310	317	PF00069	0.392
MOD_GSK3_1	339	346	PF00069	0.422
MOD_GSK3_1	451	458	PF00069	0.376
MOD_GSK3_1	486	493	PF00069	0.616
MOD_GSK3_1	520	527	PF00069	0.518
MOD_GSK3_1	538	545	PF00069	0.437
MOD_GSK3_1	573	580	PF00069	0.607
MOD_GSK3_1	634	641	PF00069	0.556
MOD_GSK3_1	705	712	PF00069	0.543
MOD_GSK3_1	725	732	PF00069	0.646
MOD_GSK3_1	766	773	PF00069	0.645
MOD_GSK3_1	78	85	PF00069	0.434
MOD_GSK3_1	91	98	PF00069	0.310
MOD_N-GLC_1	213	218	PF02516	0.452
MOD_N-GLC_1	486	491	PF02516	0.435
MOD_NEK2_1	242	247	PF00069	0.400
MOD_NEK2_1	256	261	PF00069	0.364
MOD_NEK2_1	455	460	PF00069	0.457
MOD_NEK2_1	520	525	PF00069	0.644
MOD_NEK2_1	54	59	PF00069	0.426
MOD_NEK2_1	552	557	PF00069	0.614
MOD_NEK2_1	638	643	PF00069	0.675
MOD_NEK2_1	650	655	PF00069	0.565
MOD_NEK2_1	681	686	PF00069	0.635
MOD_NEK2_1	709	714	PF00069	0.567
MOD_NEK2_1	82	87	PF00069	0.412
MOD_NEK2_2	577	582	PF00069	0.710
MOD_NEK2_2	758	763	PF00069	0.475
MOD_OFUCOSY	706	713	PF10250	0.452
MOD_PIKK_1	180	186	PF00454	0.528
MOD_PIKK_1	426	432	PF00454	0.383
MOD_PIKK_1	472	478	PF00454	0.599
MOD_PKA_1	179	185	PF00069	0.515
MOD_PKA_2	124	130	PF00069	0.535
MOD_PKA_2	179	185	PF00069	0.427
MOD_PKA_2	212	218	PF00069	0.416
MOD_PKA_2	236	242	PF00069	0.292
MOD_PKA_2	314	320	PF00069	0.417
MOD_PKA_2	376	382	PF00069	0.339
MOD_PKA_2	573	579	PF00069	0.610
MOD_Plk_1	280	286	PF00069	0.410
MOD_Plk_1	601	607	PF00069	0.622
MOD_Plk_1	634	640	PF00069	0.664
MOD_Plk_1	747	753	PF00069	0.683
MOD_Plk_4	226	232	PF00069	0.323
MOD_Plk_4	256	262	PF00069	0.398
MOD_Plk_4	289	295	PF00069	0.369
MOD_Plk_4	33	39	PF00069	0.322
MOD_Plk_4	376	382	PF00069	0.328
MOD_Plk_4	383	389	PF00069	0.276
MOD_Plk_4	451	457	PF00069	0.441
MOD_Plk_4	462	468	PF00069	0.520
MOD_Plk_4	54	60	PF00069	0.383
MOD_Plk_4	554	560	PF00069	0.544
MOD_Plk_4	705	711	PF00069	0.596
MOD_Plk_4	758	764	PF00069	0.486
MOD_Plk_4	785	791	PF00069	0.364
MOD_Plk_4	82	88	PF00069	0.365
MOD_ProDKin_1	118	124	PF00069	0.529
MOD_ProDKin_1	345	351	PF00069	0.503
MOD_ProDKin_1	354	360	PF00069	0.510
MOD_ProDKin_1	424	430	PF00069	0.355
MOD_ProDKin_1	586	592	PF00069	0.600
MOD_ProDKin_1	770	776	PF00069	0.642
MOD_SUMO_rev_2	546	555	PF00179	0.645
TRG_DiLeu_BaEn_1	554	559	PF01217	0.614
TRG_DiLeu_BaEn_1	645	650	PF01217	0.593
TRG_DiLeu_BaEn_2	436	442	PF01217	0.333
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.320
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.391
TRG_DiLeu_BaLyEn_6	651	656	PF01217	0.551
TRG_ENDOCYTIC_2	129	132	PF00928	0.378
TRG_ENDOCYTIC_2	198	201	PF00928	0.310
TRG_ENDOCYTIC_2	243	246	PF00928	0.398
TRG_ENDOCYTIC_2	253	256	PF00928	0.266
TRG_ENDOCYTIC_2	260	263	PF00928	0.253
TRG_ENDOCYTIC_2	334	337	PF00928	0.408
TRG_ENDOCYTIC_2	533	536	PF00928	0.567
TRG_ENDOCYTIC_2	73	76	PF00928	0.394
TRG_ENDOCYTIC_2	796	799	PF00928	0.312
TRG_ER_diArg_1	159	162	PF00400	0.427
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.688
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.243
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IID0	Leptomonas seymouri	57%	100%
A0A0S4IXF5	Bodo saltans	24%	83%
A0A1X0P5G3	Trypanosomatidae	32%	99%
A0A3R7K1M8	Trypanosoma rangeli	34%	89%
A0A3S7X9Q6	Leishmania donovani	82%	100%
A4IBS9	Leishmania infantum	82%	100%
C9ZYT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	91%
E9AFL6	Leishmania major	81%	100%
E9B6R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5BTB4	Trypanosoma cruzi	33%	100%