Putative nucleoside diphosphate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoside diphosphate kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HN58_LEIBR

TriTrypDb:

LbrM.34.3850 , LBRM2903_340048100

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HN58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN58

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0044237	cellular metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004550	nucleoside diphosphate kinase activity	5	8
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	8
GO:0019205	nucleobase-containing compound kinase activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.409
CLV_NRD_NRD_1	83	85	PF00675	0.409
CLV_PCSK_KEX2_1	43	45	PF00082	0.372
CLV_PCSK_KEX2_1	48	50	PF00082	0.371
CLV_PCSK_KEX2_1	85	87	PF00082	0.454
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.372
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.371
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.433
CLV_PCSK_PC7_1	44	50	PF00082	0.327
CLV_PCSK_SKI1_1	143	147	PF00082	0.374
CLV_PCSK_SKI1_1	43	47	PF00082	0.357
CLV_PCSK_SKI1_1	85	89	PF00082	0.501
DEG_APCC_DBOX_1	142	150	PF00400	0.190
DOC_CYCLIN_RxL_1	140	150	PF00134	0.308
DOC_MAPK_gen_1	140	149	PF00069	0.359
DOC_MAPK_HePTP_8	137	149	PF00069	0.269
DOC_MAPK_MEF2A_6	140	149	PF00069	0.309
DOC_PP1_RVXF_1	118	124	PF00149	0.451
DOC_PP4_FxxP_1	69	72	PF00568	0.489
DOC_USP7_MATH_1	16	20	PF00917	0.475
DOC_USP7_MATH_1	188	192	PF00917	0.540
DOC_USP7_MATH_1	207	211	PF00917	0.430
DOC_USP7_MATH_1	229	233	PF00917	0.502
DOC_USP7_MATH_1	323	327	PF00917	0.399
DOC_USP7_MATH_1	51	55	PF00917	0.341
DOC_WW_Pin1_4	53	58	PF00397	0.487
LIG_14-3-3_CanoR_1	120	124	PF00244	0.408
LIG_Actin_WH2_2	107	122	PF00022	0.349
LIG_Actin_WH2_2	166	184	PF00022	0.247
LIG_Actin_WH2_2	59	76	PF00022	0.314
LIG_BRCT_BRCA1_1	325	329	PF00533	0.399
LIG_FHA_1	114	120	PF00498	0.473
LIG_FHA_1	168	174	PF00498	0.227
LIG_FHA_1	190	196	PF00498	0.344
LIG_FHA_1	21	27	PF00498	0.306
LIG_FHA_1	40	46	PF00498	0.361
LIG_FHA_1	6	12	PF00498	0.491
LIG_FHA_1	63	69	PF00498	0.318
LIG_FHA_2	234	240	PF00498	0.443
LIG_FHA_2	314	320	PF00498	0.399
LIG_LIR_Apic_2	12	16	PF02991	0.324
LIG_LIR_Gen_1	101	111	PF02991	0.274
LIG_LIR_Gen_1	122	129	PF02991	0.338
LIG_LIR_Gen_1	241	251	PF02991	0.433
LIG_LIR_Nem_3	101	106	PF02991	0.303
LIG_LIR_Nem_3	122	126	PF02991	0.335
LIG_LIR_Nem_3	241	246	PF02991	0.433
LIG_LIR_Nem_3	253	257	PF02991	0.433
LIG_LIR_Nem_3	326	332	PF02991	0.413
LIG_LYPXL_yS_3	52	55	PF13949	0.339
LIG_MLH1_MIPbox_1	325	329	PF16413	0.399
LIG_MYND_1	53	57	PF01753	0.482
LIG_NRP_CendR_1	336	337	PF00754	0.369
LIG_SH2_CRK	103	107	PF00017	0.238
LIG_SH2_CRK	247	251	PF00017	0.399
LIG_SH2_CRK	254	258	PF00017	0.399
LIG_SH2_STAP1	103	107	PF00017	0.238
LIG_SH2_STAT5	13	16	PF00017	0.370
LIG_SH2_STAT5	226	229	PF00017	0.449
LIG_SH2_STAT5	28	31	PF00017	0.247
LIG_SH2_STAT5	61	64	PF00017	0.475
LIG_SH3_3	199	205	PF00018	0.399
LIG_SH3_3	280	286	PF00018	0.400
LIG_SH3_3	291	297	PF00018	0.396
LIG_SUMO_SIM_par_1	125	130	PF11976	0.336
LIG_SUMO_SIM_par_1	144	150	PF11976	0.439
LIG_SUMO_SIM_par_1	93	99	PF11976	0.349
LIG_TRAF2_1	177	180	PF00917	0.415
MOD_CK1_1	164	170	PF00069	0.341
MOD_CK1_1	191	197	PF00069	0.414
MOD_CK2_1	106	112	PF00069	0.451
MOD_CK2_1	313	319	PF00069	0.399
MOD_CK2_1	53	59	PF00069	0.372
MOD_GlcNHglycan	103	106	PF01048	0.358
MOD_GlcNHglycan	149	152	PF01048	0.388
MOD_GlcNHglycan	166	169	PF01048	0.338
MOD_GlcNHglycan	175	178	PF01048	0.433
MOD_GlcNHglycan	209	212	PF01048	0.216
MOD_GlcNHglycan	227	230	PF01048	0.209
MOD_GlcNHglycan	262	265	PF01048	0.206
MOD_GlcNHglycan	90	93	PF01048	0.454
MOD_GSK3_1	157	164	PF00069	0.376
MOD_GSK3_1	16	23	PF00069	0.419
MOD_GSK3_1	167	174	PF00069	0.281
MOD_GSK3_1	225	232	PF00069	0.478
MOD_NEK2_1	106	111	PF00069	0.396
MOD_NEK2_1	119	124	PF00069	0.349
MOD_NEK2_1	129	134	PF00069	0.370
MOD_NEK2_1	147	152	PF00069	0.336
MOD_NEK2_1	173	178	PF00069	0.302
MOD_NEK2_1	181	186	PF00069	0.375
MOD_NEK2_1	20	25	PF00069	0.448
MOD_NEK2_1	225	230	PF00069	0.399
MOD_NEK2_1	328	333	PF00069	0.400
MOD_PIKK_1	113	119	PF00454	0.391
MOD_PIKK_1	127	133	PF00454	0.397
MOD_PIKK_1	138	144	PF00454	0.351
MOD_PIKK_1	167	173	PF00454	0.366
MOD_PK_1	157	163	PF00069	0.368
MOD_PKA_1	85	91	PF00069	0.540
MOD_PKA_2	119	125	PF00069	0.328
MOD_PKA_2	181	187	PF00069	0.358
MOD_PKA_2	5	11	PF00069	0.425
MOD_PKA_2	85	91	PF00069	0.540
MOD_PKB_1	84	92	PF00069	0.311
MOD_Plk_1	31	37	PF00069	0.305
MOD_Plk_2-3	31	37	PF00069	0.304
MOD_Plk_4	106	112	PF00069	0.359
MOD_Plk_4	181	187	PF00069	0.296
MOD_Plk_4	5	11	PF00069	0.494
MOD_ProDKin_1	53	59	PF00069	0.484
MOD_SUMO_rev_2	36	42	PF00179	0.218
TRG_AP2beta_CARGO_1	327	337	PF09066	0.436
TRG_DiLeu_BaEn_1	253	258	PF01217	0.399
TRG_DiLeu_BaEn_4	319	325	PF01217	0.399
TRG_ENDOCYTIC_2	103	106	PF00928	0.250
TRG_ENDOCYTIC_2	247	250	PF00928	0.399
TRG_ENDOCYTIC_2	254	257	PF00928	0.399
TRG_ENDOCYTIC_2	52	55	PF00928	0.324
TRG_ER_diArg_1	84	87	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.223

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJQ8	Leptomonas seymouri	27%	98%
A0A0N1PC23	Leptomonas seymouri	74%	100%
A0A0S4IXH2	Bodo saltans	56%	100%
A0A1X0P5C0	Trypanosomatidae	59%	100%
A0A1X0PAT4	Trypanosomatidae	26%	96%
A0A3Q8IJQ8	Leishmania donovani	91%	100%
A0A3R7M6K1	Trypanosoma rangeli	28%	97%
A0A3R7N390	Trypanosoma rangeli	60%	100%
A0A3S7X855	Leishmania donovani	28%	98%
A4HB17	Leishmania braziliensis	29%	99%
A4IA74	Leishmania infantum	28%	98%
A4IBS5	Leishmania infantum	91%	100%
C9ZM33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
C9ZYU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AFL1	Leishmania major	92%	100%
E9B587	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	98%
E9B6R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2P6	Leishmania major	29%	100%
Q5E9Y9	Bos taurus	33%	89%
Q9QXL7	Rattus norvegicus	36%	85%
Q9QXL8	Mus musculus	34%	85%
Q9Y5B8	Homo sapiens	33%	90%
V5BXY9	Trypanosoma cruzi	59%	97%
V5DLW4	Trypanosoma cruzi	27%	96%