SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN54_LEIBR

TriTrypDb:

LbrM.34.3810 , LBRM2903_340047700

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.283
CLV_NRD_NRD_1	170	172	PF00675	0.270
CLV_PCSK_KEX2_1	163	165	PF00082	0.291
CLV_PCSK_KEX2_1	170	172	PF00082	0.270
CLV_PCSK_SKI1_1	102	106	PF00082	0.337
CLV_PCSK_SKI1_1	239	243	PF00082	0.276
DOC_CYCLIN_RxL_1	99	106	PF00134	0.546
DOC_MAPK_DCC_7	30	38	PF00069	0.425
DOC_MAPK_FxFP_2	282	285	PF00069	0.417
DOC_MAPK_gen_1	170	176	PF00069	0.476
DOC_MAPK_gen_1	23	33	PF00069	0.435
DOC_PP4_FxxP_1	282	285	PF00568	0.425
DOC_USP7_MATH_1	285	289	PF00917	0.459
DOC_USP7_MATH_1	295	299	PF00917	0.577
DOC_USP7_MATH_1	57	61	PF00917	0.540
DOC_WW_Pin1_4	190	195	PF00397	0.460
DOC_WW_Pin1_4	213	218	PF00397	0.487
DOC_WW_Pin1_4	31	36	PF00397	0.418
DOC_WW_Pin1_4	72	77	PF00397	0.415
LIG_14-3-3_CanoR_1	110	116	PF00244	0.492
LIG_Actin_WH2_2	57	75	PF00022	0.501
LIG_BRCT_BRCA1_1	92	96	PF00533	0.487
LIG_FHA_1	142	148	PF00498	0.512
LIG_FHA_1	16	22	PF00498	0.403
LIG_FHA_1	177	183	PF00498	0.573
LIG_FHA_1	39	45	PF00498	0.481
LIG_FHA_1	56	62	PF00498	0.437
LIG_FHA_1	99	105	PF00498	0.537
LIG_FHA_2	10	16	PF00498	0.432
LIG_FHA_2	240	246	PF00498	0.400
LIG_LIR_Apic_2	142	146	PF02991	0.537
LIG_LIR_Apic_2	279	285	PF02991	0.491
LIG_LIR_Gen_1	114	121	PF02991	0.488
LIG_LIR_Gen_1	18	27	PF02991	0.413
LIG_LIR_Gen_1	46	57	PF02991	0.492
LIG_LIR_Gen_1	93	100	PF02991	0.517
LIG_LIR_Nem_3	114	118	PF02991	0.488
LIG_LIR_Nem_3	279	284	PF02991	0.461
LIG_LIR_Nem_3	46	52	PF02991	0.480
LIG_LIR_Nem_3	93	99	PF02991	0.501
LIG_PCNA_yPIPBox_3	198	207	PF02747	0.538
LIG_PCNA_yPIPBox_3	5	17	PF02747	0.572
LIG_PDZ_Class_3	304	309	PF00595	0.532
LIG_Pex14_2	158	162	PF04695	0.476
LIG_Pex14_2	278	282	PF04695	0.395
LIG_SH2_SRC	115	118	PF00017	0.476
LIG_SH2_STAT3	189	192	PF00017	0.553
LIG_SH2_STAT5	115	118	PF00017	0.537
LIG_SH2_STAT5	166	169	PF00017	0.476
LIG_SH2_STAT5	189	192	PF00017	0.562
LIG_SH2_STAT5	248	251	PF00017	0.476
LIG_SH3_3	182	188	PF00018	0.400
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.487
LIG_SUMO_SIM_anti_2	48	54	PF11976	0.487
LIG_SUMO_SIM_par_1	60	67	PF11976	0.512
LIG_UBA3_1	230	239	PF00899	0.344
MOD_CDC14_SPxK_1	75	78	PF00782	0.262
MOD_CDK_SPxK_1	72	78	PF00069	0.262
MOD_CK1_1	60	66	PF00069	0.347
MOD_CK2_1	239	245	PF00069	0.223
MOD_CK2_1	269	275	PF00069	0.328
MOD_CK2_1	300	306	PF00069	0.518
MOD_GSK3_1	177	184	PF00069	0.331
MOD_N-GLC_1	285	290	PF02516	0.458
MOD_NEK2_1	300	305	PF00069	0.515
MOD_PIKK_1	239	245	PF00454	0.392
MOD_PIKK_1	285	291	PF00454	0.470
MOD_PIKK_1	300	306	PF00454	0.658
MOD_PIKK_1	55	61	PF00454	0.430
MOD_PKA_2	4	10	PF00069	0.552
MOD_PKA_2	90	96	PF00069	0.418
MOD_Plk_1	274	280	PF00069	0.407
MOD_Plk_1	285	291	PF00069	0.519
MOD_Plk_1	295	301	PF00069	0.677
MOD_Plk_2-3	274	280	PF00069	0.522
MOD_Plk_4	111	117	PF00069	0.449
MOD_Plk_4	295	301	PF00069	0.486
MOD_Plk_4	57	63	PF00069	0.344
MOD_Plk_4	9	15	PF00069	0.451
MOD_ProDKin_1	190	196	PF00069	0.306
MOD_ProDKin_1	213	219	PF00069	0.344
MOD_ProDKin_1	31	37	PF00069	0.412
MOD_ProDKin_1	72	78	PF00069	0.243
MOD_SUMO_rev_2	303	309	PF00179	0.669
TRG_DiLeu_BaEn_2	244	250	PF01217	0.413
TRG_ENDOCYTIC_2	115	118	PF00928	0.328
TRG_ENDOCYTIC_2	166	169	PF00928	0.328
TRG_ENDOCYTIC_2	248	251	PF00928	0.328
TRG_ER_diArg_1	162	164	PF00400	0.339
TRG_ER_diArg_1	169	171	PF00400	0.321
TRG_NES_CRM1_1	42	56	PF08389	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I289	Leptomonas seymouri	80%	99%
A0A0S4J0X3	Bodo saltans	51%	94%
A0A1X0P6M3	Trypanosomatidae	63%	100%
A0A3R7KQI7	Trypanosoma rangeli	66%	97%
A0A3S7X9T6	Leishmania donovani	83%	98%
A4IBS1	Leishmania infantum	83%	98%
C9ZYV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AFK7	Leishmania major	83%	100%
E9B6R1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
V5BXZ4	Trypanosoma cruzi	66%	97%