Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN53_LEIBR

TriTrypDb:

LbrM.34.3800 , LBRM2903_340047600

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.502
CLV_NRD_NRD_1	17	19	PF00675	0.455
CLV_NRD_NRD_1	259	261	PF00675	0.650
CLV_NRD_NRD_1	98	100	PF00675	0.353
CLV_PCSK_FUR_1	15	19	PF00082	0.487
CLV_PCSK_FUR_1	264	268	PF00082	0.518
CLV_PCSK_KEX2_1	161	163	PF00082	0.502
CLV_PCSK_KEX2_1	17	19	PF00082	0.455
CLV_PCSK_KEX2_1	259	261	PF00082	0.636
CLV_PCSK_KEX2_1	266	268	PF00082	0.490
CLV_PCSK_KEX2_1	98	100	PF00082	0.500
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.513
CLV_PCSK_PC7_1	13	19	PF00082	0.496
CLV_PCSK_SKI1_1	260	264	PF00082	0.443
CLV_PCSK_SKI1_1	87	91	PF00082	0.469
DEG_APCC_DBOX_1	160	168	PF00400	0.500
DEG_APCC_DBOX_1	316	324	PF00400	0.462
DEG_SCF_FBW7_1	167	172	PF00400	0.499
DEG_SPOP_SBC_1	331	335	PF00917	0.480
DOC_CDC14_PxL_1	24	32	PF14671	0.472
DOC_CKS1_1	340	345	PF01111	0.496
DOC_CYCLIN_RxL_1	103	116	PF00134	0.428
DOC_MAPK_gen_1	103	112	PF00069	0.475
DOC_MAPK_gen_1	264	271	PF00069	0.494
DOC_USP7_MATH_1	140	144	PF00917	0.443
DOC_USP7_MATH_1	169	173	PF00917	0.490
DOC_USP7_MATH_1	197	201	PF00917	0.493
DOC_USP7_MATH_1	64	68	PF00917	0.453
DOC_USP7_UBL2_3	301	305	PF12436	0.472
DOC_USP7_UBL2_3	87	91	PF12436	0.327
DOC_WW_Pin1_4	165	170	PF00397	0.701
DOC_WW_Pin1_4	335	340	PF00397	0.490
LIG_14-3-3_CanoR_1	196	206	PF00244	0.495
LIG_14-3-3_CanoR_1	228	236	PF00244	0.511
LIG_14-3-3_CanoR_1	259	265	PF00244	0.448
LIG_Actin_WH2_2	287	303	PF00022	0.497
LIG_Actin_WH2_2	97	115	PF00022	0.449
LIG_Clathr_ClatBox_1	323	327	PF01394	0.480
LIG_FHA_1	154	160	PF00498	0.591
LIG_FHA_1	203	209	PF00498	0.499
LIG_FHA_1	278	284	PF00498	0.477
LIG_FHA_2	343	349	PF00498	0.514
LIG_LIR_Apic_2	345	349	PF02991	0.516
LIG_LIR_Gen_1	149	160	PF02991	0.481
LIG_LIR_Nem_3	123	128	PF02991	0.450
LIG_LIR_Nem_3	149	155	PF02991	0.699
LIG_NRBOX	319	325	PF00104	0.473
LIG_SH2_CRK	125	129	PF00017	0.339
LIG_SH2_CRK	31	35	PF00017	0.450
LIG_SH3_3	337	343	PF00018	0.495
LIG_SUMO_SIM_anti_2	203	210	PF11976	0.497
LIG_TRAF2_1	201	204	PF00917	0.459
MOD_CK1_1	154	160	PF00069	0.706
MOD_CK1_1	335	341	PF00069	0.484
MOD_CK2_1	197	203	PF00069	0.558
MOD_CK2_1	221	227	PF00069	0.501
MOD_CK2_1	342	348	PF00069	0.510
MOD_CK2_1	76	82	PF00069	0.360
MOD_GlcNHglycan	199	202	PF01048	0.575
MOD_GlcNHglycan	230	233	PF01048	0.743
MOD_GlcNHglycan	243	246	PF01048	0.698
MOD_GlcNHglycan	260	263	PF01048	0.492
MOD_GlcNHglycan	49	52	PF01048	0.315
MOD_GlcNHglycan	78	81	PF01048	0.352
MOD_GSK3_1	108	115	PF00069	0.477
MOD_GSK3_1	165	172	PF00069	0.658
MOD_GSK3_1	173	180	PF00069	0.695
MOD_GSK3_1	331	338	PF00069	0.494
MOD_N-GLC_1	133	138	PF02516	0.380
MOD_N-GLC_1	228	233	PF02516	0.575
MOD_NEK2_1	202	207	PF00069	0.524
MOD_NEK2_1	221	226	PF00069	0.485
MOD_NEK2_1	332	337	PF00069	0.485
MOD_NEK2_2	133	138	PF00069	0.460
MOD_PIKK_1	243	249	PF00454	0.480
MOD_PIKK_1	277	283	PF00454	0.506
MOD_PKA_2	112	118	PF00069	0.559
MOD_PKA_2	197	203	PF00069	0.642
MOD_PKA_2	227	233	PF00069	0.684
MOD_PKA_2	258	264	PF00069	0.544
MOD_Plk_1	108	114	PF00069	0.478
MOD_Plk_1	133	139	PF00069	0.481
MOD_Plk_1	202	208	PF00069	0.560
MOD_Plk_2-3	141	147	PF00069	0.420
MOD_Plk_4	204	210	PF00069	0.501
MOD_Plk_4	319	325	PF00069	0.473
MOD_ProDKin_1	165	171	PF00069	0.703
MOD_ProDKin_1	335	341	PF00069	0.493
MOD_SUMO_for_1	90	93	PF00179	0.316
TRG_DiLeu_BaEn_1	204	209	PF01217	0.500
TRG_DiLeu_BaEn_4	92	98	PF01217	0.390
TRG_ENDOCYTIC_2	125	128	PF00928	0.449
TRG_ENDOCYTIC_2	31	34	PF00928	0.458
TRG_ER_diArg_1	15	18	PF00400	0.461
TRG_ER_diArg_1	160	162	PF00400	0.495
TRG_ER_diArg_1	97	99	PF00400	0.363
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3I4	Leptomonas seymouri	37%	100%
A0A3Q8IIM5	Leishmania donovani	75%	100%
A0A3R7NA43	Trypanosoma rangeli	29%	96%
A4IBS0	Leishmania infantum	75%	100%
E9AFK6	Leishmania major	74%	100%
E9B6R0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%