Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN52_LEIBR

TriTrypDb:

LbrM.34.3790 , LBRM2903_340047500

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HN52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.514
CLV_NRD_NRD_1	106	108	PF00675	0.635
CLV_NRD_NRD_1	115	117	PF00675	0.656
CLV_NRD_NRD_1	144	146	PF00675	0.736
CLV_NRD_NRD_1	34	36	PF00675	0.452
CLV_PCSK_KEX2_1	106	108	PF00082	0.635
CLV_PCSK_KEX2_1	144	146	PF00082	0.736
CLV_PCSK_KEX2_1	34	36	PF00082	0.452
CLV_PCSK_KEX2_1	7	9	PF00082	0.433
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.440
CLV_PCSK_SKI1_1	7	11	PF00082	0.445
DOC_MAPK_gen_1	129	139	PF00069	0.428
DOC_MAPK_gen_1	47	57	PF00069	0.492
DOC_MAPK_MEF2A_6	50	59	PF00069	0.335
DOC_PP1_RVXF_1	105	112	PF00149	0.440
DOC_PP4_FxxP_1	27	30	PF00568	0.644
LIG_14-3-3_CanoR_1	37	46	PF00244	0.707
LIG_14-3-3_CterR_2	144	147	PF00244	0.471
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_deltaCOP1_diTrp_1	110	118	PF00928	0.450
LIG_eIF4E_1	51	57	PF01652	0.355
LIG_FHA_2	119	125	PF00498	0.456
LIG_FHA_2	62	68	PF00498	0.447
LIG_LIR_Gen_1	133	139	PF02991	0.430
LIG_LIR_Gen_1	74	85	PF02991	0.413
LIG_LIR_Nem_3	133	137	PF02991	0.428
LIG_LIR_Nem_3	41	46	PF02991	0.602
LIG_NRBOX	61	67	PF00104	0.227
LIG_Pex14_1	48	52	PF04695	0.355
LIG_Pex14_2	27	31	PF04695	0.646
LIG_PTB_Apo_2	96	103	PF02174	0.438
LIG_SH2_STAT5	51	54	PF00017	0.346
LIG_SUMO_SIM_par_1	58	64	PF11976	0.264
LIG_TRAF2_1	30	33	PF00917	0.647
LIG_TYR_ITIM	49	54	PF00017	0.480
MOD_CK1_1	42	48	PF00069	0.625
MOD_CK2_1	124	130	PF00069	0.427
MOD_CK2_1	61	67	PF00069	0.447
MOD_GSK3_1	140	147	PF00069	0.368
MOD_GSK3_1	38	45	PF00069	0.720
MOD_GSK3_1	61	68	PF00069	0.447
MOD_PKA_2	105	111	PF00069	0.457
MOD_PKA_2	118	124	PF00069	0.420
MOD_PKA_2	14	20	PF00069	0.629
MOD_PKA_2	140	146	PF00069	0.477
MOD_PKA_2	33	39	PF00069	0.589
MOD_Plk_2-3	105	111	PF00069	0.487
MOD_Plk_2-3	124	130	PF00069	0.315
MOD_Plk_4	61	67	PF00069	0.424
MOD_SUMO_for_1	9	12	PF00179	0.648
MOD_SUMO_rev_2	104	113	PF00179	0.470
TRG_ENDOCYTIC_2	46	49	PF00928	0.585
TRG_ENDOCYTIC_2	51	54	PF00928	0.339
TRG_ER_diArg_1	34	37	PF00400	0.645
TRG_NLS_MonoExtC_3	6	12	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X2	Leptomonas seymouri	88%	100%
A0A0S4J4A6	Bodo saltans	79%	96%
A0A1X0P575	Trypanosomatidae	84%	99%
A0A3Q8IMS0	Leishmania donovani	97%	100%
A0A3R7M4Q6	Trypanosoma rangeli	76%	99%
A4IBR9	Leishmania infantum	98%	100%
C9ZYV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	75%
E9AFK5	Leishmania major	97%	100%
E9B6Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%