Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN52_LEIBR

TriTrypDb:

LbrM.34.3790 , LBRM2903_340047500

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

A4HN52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN52

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.514
CLV_NRD_NRD_1	106	108	PF00675	0.635
CLV_NRD_NRD_1	115	117	PF00675	0.656
CLV_NRD_NRD_1	144	146	PF00675	0.736
CLV_NRD_NRD_1	34	36	PF00675	0.452
CLV_PCSK_KEX2_1	106	108	PF00082	0.635
CLV_PCSK_KEX2_1	144	146	PF00082	0.736
CLV_PCSK_KEX2_1	34	36	PF00082	0.452
CLV_PCSK_KEX2_1	7	9	PF00082	0.433
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.440

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X2	Leptomonas seymouri	88%	100%
A0A0S4J4A6	Bodo saltans	79%	96%
A0A1X0P575	Trypanosomatidae	84%	99%
A0A3Q8IMS0	Leishmania donovani	97%	100%
A0A3R7M4Q6	Trypanosoma rangeli	76%	99%
A4IBR9	Leishmania infantum	98%	100%
C9ZYV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	75%
E9AFK5	Leishmania major	97%	100%
E9B6Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%

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