Enriched_in_surface-labeled_proteome_protein_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enriched in surface-labeled proteome protein 9, putative

Species:

Leishmania braziliensis

UniProt:

A4HN48_LEIBR

TriTrypDb:

LbrM.34.3750 , LBRM2903_340047000

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 4
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0005768	endosome	7	1
GO:0020023	kinetoplast	2	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HN48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.311
CLV_C14_Caspase3-7	447	451	PF00656	0.401
CLV_NRD_NRD_1	530	532	PF00675	0.660
CLV_NRD_NRD_1	560	562	PF00675	0.525
CLV_PCSK_KEX2_1	378	380	PF00082	0.513
CLV_PCSK_KEX2_1	530	532	PF00082	0.660
CLV_PCSK_KEX2_1	560	562	PF00082	0.525
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.475
CLV_PCSK_SKI1_1	308	312	PF00082	0.471
CLV_PCSK_SKI1_1	34	38	PF00082	0.471
CLV_PCSK_SKI1_1	378	382	PF00082	0.555
CLV_PCSK_SKI1_1	496	500	PF00082	0.637
CLV_PCSK_SKI1_1	622	626	PF00082	0.389
CLV_Separin_Metazoa	597	601	PF03568	0.549
DEG_SPOP_SBC_1	180	184	PF00917	0.331
DEG_SPOP_SBC_1	265	269	PF00917	0.503
DEG_SPOP_SBC_1	438	442	PF00917	0.322
DOC_CKS1_1	534	539	PF01111	0.276
DOC_CYCLIN_RxL_1	31	40	PF00134	0.275
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.276
DOC_MAPK_gen_1	386	396	PF00069	0.433
DOC_MAPK_gen_1	455	464	PF00069	0.263
DOC_MAPK_MEF2A_6	196	203	PF00069	0.297
DOC_MAPK_MEF2A_6	467	475	PF00069	0.269
DOC_PP1_RVXF_1	425	431	PF00149	0.274
DOC_PP2B_LxvP_1	134	137	PF13499	0.276
DOC_PP2B_LxvP_1	161	164	PF13499	0.284
DOC_PP4_FxxP_1	353	356	PF00568	0.377
DOC_PP4_FxxP_1	486	489	PF00568	0.277
DOC_USP7_MATH_1	242	246	PF00917	0.476
DOC_USP7_MATH_1	265	269	PF00917	0.602
DOC_USP7_MATH_1	46	50	PF00917	0.316
DOC_USP7_MATH_1	489	493	PF00917	0.285
DOC_WW_Pin1_4	236	241	PF00397	0.379
DOC_WW_Pin1_4	295	300	PF00397	0.454
DOC_WW_Pin1_4	395	400	PF00397	0.393
DOC_WW_Pin1_4	533	538	PF00397	0.271
LIG_14-3-3_CanoR_1	3	7	PF00244	0.472
LIG_14-3-3_CanoR_1	308	314	PF00244	0.378
LIG_14-3-3_CanoR_1	319	323	PF00244	0.321
LIG_14-3-3_CanoR_1	389	397	PF00244	0.353
LIG_14-3-3_CanoR_1	461	465	PF00244	0.352
LIG_14-3-3_CanoR_1	63	67	PF00244	0.474
LIG_14-3-3_CterR_2	637	640	PF00244	0.610
LIG_BRCT_BRCA1_1	155	159	PF00533	0.251
LIG_BRCT_BRCA1_1	290	294	PF00533	0.300
LIG_BRCT_BRCA1_1	571	575	PF00533	0.193
LIG_Clathr_ClatBox_1	36	40	PF01394	0.359
LIG_deltaCOP1_diTrp_1	335	343	PF00928	0.341
LIG_FHA_1	142	148	PF00498	0.301
LIG_FHA_1	432	438	PF00498	0.358
LIG_FHA_1	600	606	PF00498	0.623
LIG_FHA_1	623	629	PF00498	0.639
LIG_FHA_1	92	98	PF00498	0.346
LIG_FHA_2	102	108	PF00498	0.333
LIG_GBD_Chelix_1	126	134	PF00786	0.478
LIG_GBD_Chelix_1	569	577	PF00786	0.239
LIG_LIR_Apic_2	351	356	PF02991	0.367
LIG_LIR_Apic_2	368	372	PF02991	0.303
LIG_LIR_Apic_2	533	537	PF02991	0.344
LIG_LIR_Gen_1	156	167	PF02991	0.272
LIG_LIR_Gen_1	217	225	PF02991	0.336
LIG_LIR_Gen_1	291	299	PF02991	0.337
LIG_LIR_Gen_1	340	350	PF02991	0.393
LIG_LIR_Gen_1	4	14	PF02991	0.534
LIG_LIR_Gen_1	513	523	PF02991	0.379
LIG_LIR_Gen_1	572	583	PF02991	0.269
LIG_LIR_Nem_3	156	162	PF02991	0.307
LIG_LIR_Nem_3	217	221	PF02991	0.302
LIG_LIR_Nem_3	291	297	PF02991	0.319
LIG_LIR_Nem_3	303	307	PF02991	0.368
LIG_LIR_Nem_3	312	317	PF02991	0.400
LIG_LIR_Nem_3	335	339	PF02991	0.244
LIG_LIR_Nem_3	347	353	PF02991	0.224
LIG_LIR_Nem_3	4	9	PF02991	0.367
LIG_LIR_Nem_3	513	519	PF02991	0.327
LIG_LIR_Nem_3	524	528	PF02991	0.271
LIG_LIR_Nem_3	572	578	PF02991	0.386
LIG_LRP6_Inhibitor_1	538	544	PF00058	0.481
LIG_NRBOX	12	18	PF00104	0.516
LIG_Pex14_2	216	220	PF04695	0.360
LIG_Pex14_2	286	290	PF04695	0.313
LIG_Pex14_2	339	343	PF04695	0.280
LIG_PTAP_UEV_1	47	52	PF05743	0.301
LIG_PTB_Apo_2	210	217	PF02174	0.353
LIG_SH2_CRK	167	171	PF00017	0.403
LIG_SH2_CRK	314	318	PF00017	0.417
LIG_SH2_CRK	484	488	PF00017	0.329
LIG_SH2_CRK	534	538	PF00017	0.463
LIG_SH2_CRK	556	560	PF00017	0.402
LIG_SH2_GRB2like	155	158	PF00017	0.245
LIG_SH2_GRB2like	96	99	PF00017	0.317
LIG_SH2_SRC	96	99	PF00017	0.317
LIG_SH2_STAP1	155	159	PF00017	0.338
LIG_SH2_STAP1	176	180	PF00017	0.299
LIG_SH2_STAP1	334	338	PF00017	0.293
LIG_SH2_STAP1	350	354	PF00017	0.272
LIG_SH2_STAP1	384	388	PF00017	0.354
LIG_SH2_STAT5	103	106	PF00017	0.269
LIG_SH2_STAT5	350	353	PF00017	0.393
LIG_SH2_STAT5	369	372	PF00017	0.335
LIG_SH2_STAT5	525	528	PF00017	0.281
LIG_SH2_STAT5	91	94	PF00017	0.267
LIG_SH2_STAT5	96	99	PF00017	0.263
LIG_SH3_3	226	232	PF00018	0.309
LIG_SH3_3	281	287	PF00018	0.328
LIG_SH3_3	293	299	PF00018	0.279
LIG_SH3_3	396	402	PF00018	0.337
LIG_SH3_3	45	51	PF00018	0.379
LIG_SH3_3	472	478	PF00018	0.335
LIG_SH3_3	494	500	PF00018	0.270
LIG_SH3_3	580	586	PF00018	0.294
LIG_SH3_3	74	80	PF00018	0.391
LIG_SUMO_SIM_anti_2	12	18	PF11976	0.502
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.350
LIG_SUMO_SIM_par_1	12	18	PF11976	0.499
LIG_SUMO_SIM_par_1	566	572	PF11976	0.193
LIG_TYR_ITIM	165	170	PF00017	0.336
LIG_Vh1_VBS_1	567	585	PF01044	0.193
LIG_WRC_WIRS_1	215	220	PF05994	0.343
LIG_WRC_WIRS_1	549	554	PF05994	0.372
MOD_CDK_SPxxK_3	295	302	PF00069	0.326
MOD_CK1_1	117	123	PF00069	0.396
MOD_CK1_1	223	229	PF00069	0.408
MOD_CK1_1	267	273	PF00069	0.502
MOD_CK1_1	275	281	PF00069	0.481
MOD_CK1_1	300	306	PF00069	0.396
MOD_CK1_1	318	324	PF00069	0.300
MOD_CK1_1	387	393	PF00069	0.443
MOD_CK1_1	442	448	PF00069	0.525
MOD_CK1_1	451	457	PF00069	0.444
MOD_CK1_1	5	11	PF00069	0.363
MOD_CK1_1	548	554	PF00069	0.378
MOD_CK1_1	57	63	PF00069	0.328
MOD_CK1_1	576	582	PF00069	0.279
MOD_CK2_1	230	236	PF00069	0.403
MOD_CK2_1	253	259	PF00069	0.419
MOD_GlcNHglycan	172	175	PF01048	0.483
MOD_GlcNHglycan	176	179	PF01048	0.478
MOD_GlcNHglycan	187	190	PF01048	0.512
MOD_GlcNHglycan	23	26	PF01048	0.687
MOD_GlcNHglycan	274	277	PF01048	0.738
MOD_GlcNHglycan	289	293	PF01048	0.441
MOD_GlcNHglycan	326	329	PF01048	0.645
MOD_GlcNHglycan	385	389	PF01048	0.605
MOD_GlcNHglycan	391	394	PF01048	0.578
MOD_GlcNHglycan	44	47	PF01048	0.557
MOD_GlcNHglycan	450	453	PF01048	0.625
MOD_GlcNHglycan	464	467	PF01048	0.461
MOD_GlcNHglycan	48	51	PF01048	0.581
MOD_GlcNHglycan	545	548	PF01048	0.477
MOD_GlcNHglycan	578	581	PF01048	0.253
MOD_GlcNHglycan	59	62	PF01048	0.482
MOD_GlcNHglycan	609	612	PF01048	0.420
MOD_GlcNHglycan	66	69	PF01048	0.554
MOD_GSK3_1	1	8	PF00069	0.644
MOD_GSK3_1	114	121	PF00069	0.358
MOD_GSK3_1	137	144	PF00069	0.332
MOD_GSK3_1	153	160	PF00069	0.310
MOD_GSK3_1	17	24	PF00069	0.470
MOD_GSK3_1	170	177	PF00069	0.408
MOD_GSK3_1	181	188	PF00069	0.353
MOD_GSK3_1	197	204	PF00069	0.327
MOD_GSK3_1	216	223	PF00069	0.274
MOD_GSK3_1	230	237	PF00069	0.337
MOD_GSK3_1	238	245	PF00069	0.484
MOD_GSK3_1	254	261	PF00069	0.498
MOD_GSK3_1	264	271	PF00069	0.464
MOD_GSK3_1	274	281	PF00069	0.546
MOD_GSK3_1	344	351	PF00069	0.354
MOD_GSK3_1	397	404	PF00069	0.429
MOD_GSK3_1	42	49	PF00069	0.421
MOD_GSK3_1	438	445	PF00069	0.354
MOD_GSK3_1	569	576	PF00069	0.428
MOD_GSK3_1	62	69	PF00069	0.252
MOD_GSK3_1	79	86	PF00069	0.300
MOD_GSK3_1	97	104	PF00069	0.287
MOD_N-GLC_1	153	158	PF02516	0.537
MOD_N-GLC_1	223	228	PF02516	0.576
MOD_N-GLC_1	407	412	PF02516	0.572
MOD_N-GLC_1	445	450	PF02516	0.568
MOD_N-GLC_1	54	59	PF02516	0.596
MOD_N-GLC_1	70	75	PF02516	0.584
MOD_N-GLC_1	97	102	PF02516	0.588
MOD_N-GLC_2	212	214	PF02516	0.542
MOD_N-GLC_2	375	377	PF02516	0.526
MOD_NEK2_1	1	6	PF00069	0.485
MOD_NEK2_1	126	131	PF00069	0.302
MOD_NEK2_1	142	147	PF00069	0.347
MOD_NEK2_1	17	22	PF00069	0.406
MOD_NEK2_1	170	175	PF00069	0.285
MOD_NEK2_1	181	186	PF00069	0.337
MOD_NEK2_1	192	197	PF00069	0.383
MOD_NEK2_1	216	221	PF00069	0.350
MOD_NEK2_1	253	258	PF00069	0.457
MOD_NEK2_1	437	442	PF00069	0.345
MOD_NEK2_1	462	467	PF00069	0.361
MOD_NEK2_1	573	578	PF00069	0.372
MOD_NEK2_1	62	67	PF00069	0.333
MOD_NEK2_1	9	14	PF00069	0.376
MOD_NEK2_2	309	314	PF00069	0.344
MOD_NEK2_2	407	412	PF00069	0.372
MOD_PIKK_1	181	187	PF00454	0.338
MOD_PIKK_1	297	303	PF00454	0.255
MOD_PIKK_1	599	605	PF00454	0.560
MOD_PKA_2	2	8	PF00069	0.567
MOD_PKA_2	254	260	PF00069	0.550
MOD_PKA_2	265	271	PF00069	0.420
MOD_PKA_2	278	284	PF00069	0.313
MOD_PKA_2	318	324	PF00069	0.368
MOD_PKA_2	460	466	PF00069	0.354
MOD_PKA_2	599	605	PF00069	0.628
MOD_PKA_2	62	68	PF00069	0.483
MOD_Plk_1	201	207	PF00069	0.334
MOD_Plk_1	258	264	PF00069	0.446
MOD_Plk_1	407	413	PF00069	0.374
MOD_Plk_1	438	444	PF00069	0.467
MOD_Plk_1	445	451	PF00069	0.443
MOD_Plk_1	489	495	PF00069	0.258
MOD_Plk_1	514	520	PF00069	0.329
MOD_Plk_1	54	60	PF00069	0.386
MOD_Plk_1	83	89	PF00069	0.273
MOD_Plk_2-3	101	107	PF00069	0.283
MOD_Plk_4	126	132	PF00069	0.372
MOD_Plk_4	258	264	PF00069	0.453
MOD_Plk_4	300	306	PF00069	0.337
MOD_Plk_4	344	350	PF00069	0.310
MOD_Plk_4	401	407	PF00069	0.276
MOD_Plk_4	439	445	PF00069	0.405
MOD_Plk_4	5	11	PF00069	0.478
MOD_Plk_4	521	527	PF00069	0.325
MOD_Plk_4	54	60	PF00069	0.329
MOD_Plk_4	569	575	PF00069	0.380
MOD_Plk_4	91	97	PF00069	0.251
MOD_ProDKin_1	236	242	PF00069	0.380
MOD_ProDKin_1	295	301	PF00069	0.458
MOD_ProDKin_1	395	401	PF00069	0.393
MOD_ProDKin_1	533	539	PF00069	0.270
TRG_ENDOCYTIC_2	167	170	PF00928	0.329
TRG_ENDOCYTIC_2	314	317	PF00928	0.437
TRG_ENDOCYTIC_2	336	339	PF00928	0.246
TRG_ENDOCYTIC_2	350	353	PF00928	0.247
TRG_ENDOCYTIC_2	520	523	PF00928	0.285
TRG_ENDOCYTIC_2	556	559	PF00928	0.401
TRG_ER_diArg_1	529	531	PF00400	0.436
TRG_ER_diArg_1	559	561	PF00400	0.325
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH70	Leptomonas seymouri	47%	99%
A0A1X0NCX6	Trypanosomatidae	30%	100%
A0A3S5H803	Leishmania donovani	62%	98%
A4IBR6	Leishmania infantum	62%	98%
C9ZYV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AFK1	Leishmania major	61%	100%
E9B6Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%